Genetic polymorphisms of interleukin-6 modulate fibrosis progression in mild chronic hepatitis C

Human Immunology

Volumn 71, Issue 10, 2010, Pages 999-1004

  Falleti, Edmondo ^a   Fabris, Carlo ^a   Vandelli, Carmen ^b   Colletta, Cosimo ^c   Cussigh, Annarosa ^a   Smirne, Carlo ^d   Fontanini, Elisabetta ^a   Cmet, Sara ^a   Minisini, Rosalba ^d   Bitetto, Davide ^a   Toniutto, Pierluigi ^a   Pirisi, Mario ^d  

^a UNIVERSITY OF UDINE   (Italy)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c Madonna del Popolo Hospital   (Italy)

^d UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

Hepatitis C; Interleukin 6; Normal alanine aminotransferase; Polymorphisms

Indexed keywords

ALANINE AMINOTRANSFERASE; INTERLEUKIN 6;

ADOLESCENT; ADULT; ARTICLE; CHILD; CHRONIC HEPATITIS; CLINICAL FEATURE; DISEASE COURSE; FEMALE; FOLLOW UP; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC POLYMORPHISM; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHOOL CHILD;

ADOLESCENT; ADULT; CHILD; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; GENOTYPE; HEPATITIS C, CHRONIC; HUMANS; INTERLEUKIN-6; LIVER CIRRHOSIS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC;

EID: 77956619771     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.06.006     Document Type: Article

References (35)

1. Wasley A., Alter M.J. Epidemiology of hepatitis C: Geographic differences and temporal trends. Semin Liver Dis 2000, 20:1-16.
2. Afdhal N.H. The natural history of hepatitis C. Semin Liver Dis 2004, 24(Suppl):2. 3-8.
3. Feld J.J., Liang T.J. Hepatitis C - identifying patients with progressive liver injury. J Hepatol 2006, 43:S194-S206.
4. Massard J., Ratziu V., Thabut D., Moussalli J., Lebray P., Benhamou Y., Poynard T. Natural history and predictors of disease severity in chronic hepatitis C. J Hepatol 2006, 44:S19-S24.
5. Alberti A., Benvegnu L., Boccato S., Ferrari A., Sebastiani G. Natural history of initially mild chronic hepatitis C. Dig Liver Dis 2004, 36:646-654.
6. Mathurin P., Moussalli J., Cadranel J.F., Thibault V., Charlotte F., Dumouchel P., et al. Slow progression rate of fibrosis in hepatitis C virus patients with persistently normal alanine transaminase activity. J Hepatol 1998, 27:868-872.
7. Martinot-Peignoux M., Boyer N., Cazals-Hatem D., Pham B.N., Gervais A., Le Breton V., et al. Prospective study on anti-hepatitis C virus-positive patients with persistently normal serum alanine transaminase with or without detectable serum hepatitis C virus RNA. J Hepatol 2001, 34:1000-1005.
8. Persico M., Perrotta S., Persico E., Terracciano L., Folgori A., Ruggeri L., et al. Hepatitis C virus carriers with persistently normal ALT levels: Biological peculiarities and update of the natural history of liver disease at 10 years. J Viral Hepat 2006, 13:290-296.
9. Hui C.K., Belaye T., Montegrande K., Wright T.L. A comparison in the progression of liver fibrosis in chronic hepatitis C between persistently normal and elevated transaminase. J Hepatol 2003, 38:511-517.
10. Boccato S., Pistis R., Noventa F., Guido M., Benvegnu L., Alberti A. Fibrosis progression in initially mild chronic hepatitis C. J Viral Hepat 2006, 13:297-302.
11. Kumada T., Toyoda H., Kiriyama S., Sone Y., Tanikawa M., Hisanaga Y., et al. Incidence of hepatocellular carcinoma in hepatitis C carriers with normal alanine aminotransferase levels. J Hepatol 2009, 50:729-735.
12. Lawson A. Hepatitis C virus-infected patients with a persistently normal alanine aminotransferase: Do they exist and is this really a group with mild disease?. J Viral Hepat 2010, 17:51-58.
13. Williams M.J., Lang-Lenton M. Progression of initially mild hepatic fibrosis in patients with chronic hepatitis C infection. J Viral Hepat 2010.
14. Barrett S., Collins M., Kenny C., Ryan E., Keane C.O., Crowe J. Polymorphisms in tumour necrosis factor-alpha, transforming growth factor-beta, interleukin-10, interleukin-6, interferon-gamma, and outcome of hepatitis C virus infection. J Med Virol 2003, 71:212-218.
15. Yee L.J., Im K., Borg B., Yang H., Liang T.J. Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection. Genes Immun 2009, 10:365-372.
16. Fabris C., Toniutto P., Bitetto D., Fattovich G., Falleti E., Fontanini E., et al. Gene polymorphism at the interleukin 6 -174 G > C locus affects the outcome of chronic hepatitis B. J Infect 2009, 59:144-145.
17. Ishak K., Baptista A., Bianchi L., Callea F., De Groote J., Gudat F., et al. Histological grading and staging of chronic hepatitis. J Hepatol 1995, 22:696-699.
18. Brunt E.M., Janney C.G., Di Bisceglie A.M., Neuschwander-Tetri B.A., Bacon B.R. Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am J Gastroenterol 1999, 94:2467-2474.
19. Tseng L.H., Chen P.J., Lin M.T., Singleton K., Martin E.G., Yen A.H., et al. Simultaneous genotyping of single nucleotide polymorphisms in the IL-6, IL-10, TNFalpha and TNFbeta genes. Tissue Antigens 2002, 59:280-286.
20. Excoffier L., Laval G., Schneider S. Arlequin (version 3.0): An integrated software package for population genetics data analysis. Evol Bioinform Online 2005, 1:47-50.
21. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
22. Fishman D., Faulds G., Jeffery R., Mohamed-Ali V., Yudkin J.S., Humphries S., Woo P. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998, 102:1369-1376.
23. Cox E.D., Hoffmann S.C., DiMercurio B.S., Wesley R.A., Harlan D.M., Kirk A.D., Blair P.J. Cytokine polymorphic analyses indicate ethnic differences in the allelic distribution of interleukin-2 and interleukin-6. Transplantation 2001, 72:720-726.
24. Meenagh A., Williams F., Ross O.A., Patterson C., Gorodezky C., Hammond M., et al. Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America. Hum Immunol 2002, 63:1055-1061.
25. de-Madaria E., Martinez J., Sempere L., Lozano B., Sanchez-Paya J., Uceda F., et al. Cytokine genotypes in acute pancreatitis: Association with etiology, severity, and cytokine levels in blood. Pancreas 2008, 37:295-301.
26. Gordon A., Kiss-Toth E., Stockley I., Eastell R., Wilkinson J.M. Polymorphisms in the interleukin-1 receptor antagonist and interleukin-6 genes affect risk of osteolysis in patients with total hip arthroplasty. Arthritis Rheum 2008, 58:3157-3165.
27. Park B.L., Lee H.S., Kim Y.J., Kim J.Y., Jung J.H., Kim L.H., Shin H.D. Association between interleukin 6 promoter variants and chronic hepatitis B progression. Exp Mol Med 2003, 35:76-82.
28. Ambruzova Z., Mrazek F., Raida L., Jindra P., Vidan-Jeras B., Faber E., et al. Association of IL6 and CCL2 gene polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 2009, 44:227-235.
29. Cozen W., Gebregziabher M., Conti D.V., Van Den Berg D.J., Coetzee G.A., Wang S.S., et al. Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. Cancer Epidemiol Biomarkers Prev 2006, 15:2285-2291.
30. Ferrari S.L., Ahn-Luong L., Garnero P., Humphries S.E., Greenspan S.L. Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women. J Clin Endocrinol Metab 2003, 88:255-259.
31. Hirano T. Interleukin 6 and its receptor: Ten years later. Int Rev Immunol 1998, 16:249-284.
32. Heinrich P.C., Behrmann I., Haan S., Hermanns H.M., Muller-Newen G., Schaper F. Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J 2003, 374:1-20.
33. Scheller J., Rose-John S. Interleukin-6 and its receptor: From bench to bedside. Med Microbiol Immunol 2006, 195:173-183.
34. Naugler W.E., Karin M. The wolf in sheep's clothing: The role of interleukin-6 in immunity, inflammation and cancer. Trends Mol Med 2008, 14:109-119.
35. Migita K., Miyazoe S., Maeda Y., Daikoku M., Abiru S., Ueki T., et al. Cytokine gene polymorphisms in Japanese patients with hepatitis B virus infection - association between TGF-beta1 polymorphisms and hepatocellular carcinoma. J Hepatol 2005, 42:505-510.