A latent variable approach for modeling categorical endpoints among patients with rheumatoid arthritis treated with golimumab plus methotrexate

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 37, Issue 4, 2010, Pages 309-321

  Hu, Chuanpu ^a   Xu, Zhenhua ^a   Rahman, Mahboob U ^a,b   Davis, Hugh M ^a   Zhou, Honghui ^a  

^a CENTOCOR INC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Discrete data; NONMEM; Population pharmacokinetic pharmacodynamic modeling

Indexed keywords

GOLIMUMAB; METHOTREXATE; PLACEBO;

ACCURACY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG EXPOSURE; HUMAN; MAJOR CLINICAL STUDY; MATHEMATICAL MODEL; PHASE 3 CLINICAL TRIAL; POPULATION MODEL; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STRUCTURAL EQUATION MODELING;

ANTIBODIES, MONOCLONAL; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; DRUG THERAPY, COMBINATION; ENDPOINT DETERMINATION; HUMANS; METHOTREXATE; MODELS, BIOLOGICAL; TREATMENT OUTCOME;

EID: 77956618638     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-010-9162-4     Document Type: Article

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