Ex vivo culture of chimeric antigen receptor T cells generates functional CD8 T cells with effector and central memory-like phenotype

Gene Therapy

Volumn 17, Issue 9, 2010, Pages 1105-1116

  Neeson, P ^a,b   Shin, A ^a   Tainton, K M ^a   Guru, P ^a   Prince, H M ^a,b   Harrison, S J ^a   Peinert, S ^a   Smyth, M J ^a,b   Trapani, J A ^a,b   Kershaw, M H ^a,b   Darcy, P K ^a,b   Ritchie, D S ^a,b  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RA ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 7; PERFORIN; T LYMPHOCYTE RECEPTOR;

ADOPTIVE TRANSFER; ARTICLE; CANCER CELL CULTURE; CD3+ T LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL PROLIFERATION; CELL STRAIN HCT116; CELL STRAIN K 562; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXICITY; DOWN REGULATION; EFFECTOR CELL; EX VIVO GENE TRANSFER; FUNCTIONAL STATUS; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; OVARY ADENOCARCINOMA; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRAL GENE DELIVERY SYSTEM;

ANTIGENS, CD27; ANTIGENS, CD28; ANTIGENS, CD45; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; PHENOTYPE; RECEPTORS, ANTIGEN; RECOMBINANT FUSION PROTEINS;

EID: 77956617361     PISSN: 09697128     EISSN: 14765462     Source Type: Journal    
DOI: 10.1038/gt.2010.59     Document Type: Article

References (0)