-
1
-
-
42149188994
-
Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy
-
Elkord E., Hawkins R.E., Stern P.L. Immunotherapy for gastrointestinal cancer: current status and strategies for improving efficacy. Expert Opin Biol Ther 2008, 8(4):385-395.
-
(2008)
Expert Opin Biol Ther
, vol.8
, Issue.4
, pp. 385-395
-
-
Elkord, E.1
Hawkins, R.E.2
Stern, P.L.3
-
2
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002, 20:4368-4380.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
4
-
-
33746591262
-
Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
-
Morabito A., De Maio E., Di Maio M., et al. Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions. Oncologist 2006, 11:753-764.
-
(2006)
Oncologist
, vol.11
, pp. 753-764
-
-
Morabito, A.1
De Maio, E.2
Di Maio, M.3
-
5
-
-
34547662268
-
Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
-
McCarty M.F., Somcio R.J., Stoeltzing O., et al. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest 2007, 117:2114-2122.
-
(2007)
J Clin Invest
, vol.117
, pp. 2114-2122
-
-
McCarty, M.F.1
Somcio, R.J.2
Stoeltzing, O.3
-
6
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal cell carcinoma
-
Motzer R.J., Hutson T.E., Tomczak P., et al. Sunitinib versus interferon alfa in metastatic renal cell carcinoma. N Engl J Med 2007, 356:115-124.
-
(2007)
N Engl J Med
, vol.356
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
7
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomised controlled trial
-
Demetri G.D., van Oosterom A.T., Garret C.R., et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib: a randomised controlled trial. Lancet 2006, 368:1329-1338.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garret, C.R.3
-
8
-
-
33947504730
-
Sunitinib: from rational design to clinical efficacy
-
Chow L.Q.M., Eckhardt S.G. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007, 25(7):884-896.
-
(2007)
J Clin Oncol
, vol.25
, Issue.7
, pp. 884-896
-
-
Chow, L.Q.M.1
Eckhardt, S.G.2
-
9
-
-
33644847440
-
Safety, Pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S., Delbaldo C., Vera K., et al. Safety, Pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. J Clin Oncol 2006, 24:25-35.
-
(2006)
J Clin Oncol
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
-
10
-
-
36049006487
-
New challenges in kidney cancer therapy: sunitinib
-
Izzedine H., Billemont B., Thibault F., Rixe O. New challenges in kidney cancer therapy: sunitinib. Ann Oncol 2007, 18(Suppl 9):ix83-ix86.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 9
-
-
Izzedine, H.1
Billemont, B.2
Thibault, F.3
Rixe, O.4
-
11
-
-
33646108821
-
Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multitargeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects
-
Bello C.L., Sherman L., Zhou J., et al. Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multitargeted receptor tyrosine kinase inhibitor: results from a phase I study in healthy subjects. Anti-Cancer Drugs 2006, 17:353-358.
-
(2006)
Anti-Cancer Drugs
, vol.17
, pp. 353-358
-
-
Bello, C.L.1
Sherman, L.2
Zhou, J.3
-
13
-
-
35549008418
-
Exposure-response of sunitinib in metastatic renal cell carcinoma (mRCC): a population pharmacokinetic/pharmacodynamic (PKPD) approach
-
No. 18S (June 20 Supplement); 2007: 5027], ASCO Annual Meeting Proceedings Part I
-
Houk E., Bello C., Michaelson D., et al. Exposure-response of sunitinib in metastatic renal cell carcinoma (mRCC): a population pharmacokinetic/pharmacodynamic (PKPD) approach. J Clin Oncol 2007, [vol. 25, No. 18S (June 20 Supplement); 2007: 5027].
-
(2007)
J Clin Oncol
, vol.25
-
-
Houk, E.1
Bello, C.2
Michaelson, D.3
-
14
-
-
2542454710
-
Determination of molecular marker expression can predict clinical outcome in colon carcinomas
-
Galizia G., Lieto E., Ferraraccio F., et al. Determination of molecular marker expression can predict clinical outcome in colon carcinomas. Clin Cancer Res 2004, 10:3490-3499.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3490-3499
-
-
Galizia, G.1
Lieto, E.2
Ferraraccio, F.3
-
15
-
-
84970070220
-
Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer
-
Takahashi Y., Kitadai Y., Bucana C.D., et al. Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer. Cancer Res 1995, 55:3964-3968.
-
(1995)
Cancer Res
, vol.55
, pp. 3964-3968
-
-
Takahashi, Y.1
Kitadai, Y.2
Bucana, C.D.3
-
16
-
-
68949094312
-
Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy
-
Kopetz S., Chang G.J., Overman M.J., et al. Improved survival in metastatic colorectal cancer is associated with adoption of hepatic resection and improved chemotherapy. J Clin Oncol 2009, 27(22):3677-3683.
-
(2009)
J Clin Oncol
, vol.27
, Issue.22
, pp. 3677-3683
-
-
Kopetz, S.1
Chang, G.J.2
Overman, M.J.3
-
17
-
-
36048992408
-
Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy
-
Saltz L.B., Rosen L.S., Marshall J.L., et al. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007, 25:4793-4799.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4793-4799
-
-
Saltz, L.B.1
Rosen, L.S.2
Marshall, J.L.3
-
18
-
-
12244301581
-
In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
-
Mendel D.B., Laird A.D., Xin X., et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003, 9:327-337.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 327-337
-
-
Mendel, D.B.1
Laird, A.D.2
Xin, X.3
-
19
-
-
23844524757
-
Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma
-
Marzola P., Degrassi A., Calderan L., et al. Early antiangiogenic activity of SU11248 evaluated in vivo by dynamic contrast-enhanced magnetic resonance imaging in an experimental model of colon carcinoma. Clin Cancer Res 2005, 11(16):5827-5832.
-
(2005)
Clin Cancer Res
, vol.11
, Issue.16
, pp. 5827-5832
-
-
Marzola, P.1
Degrassi, A.2
Calderan, L.3
-
20
-
-
35948991213
-
A phase I study of sunitinib in combination with modified FOLFOX6 chemotherapy
-
(abstract 285)
-
Leong S., Eckhardt S.G., Chan E., et al. A phase I study of sunitinib in combination with modified FOLFOX6 chemotherapy. Gastrointestinal Cancers Symposium 2007, (abstract 285).
-
(2007)
Gastrointestinal Cancers Symposium
-
-
Leong, S.1
Eckhardt, S.G.2
Chan, E.3
-
21
-
-
67649651712
-
Phase I study to evaluate the safety and efficacy of sunitinib in combination with FOLFIRI in treatment-naïve metastatic colorectal cancer
-
(abstract 3563)
-
Starling N., Vazquez F., Cunningham D., et al. Phase I study to evaluate the safety and efficacy of sunitinib in combination with FOLFIRI in treatment-naïve metastatic colorectal cancer. J Clin Oncol 2008, 26. (abstract 3563).
-
(2008)
J Clin Oncol
, pp. 26
-
-
Starling, N.1
Vazquez, F.2
Cunningham, D.3
-
22
-
-
77956619140
-
-
Pfizer Discontinues Phase 3 Trial of Sutent® in Metastatic Colorectal Cancer. Available at: [Accessed July 20,]
-
Pfizer Discontinues Phase 3 Trial of Sutent® in Metastatic Colorectal Cancer. Available at: [Accessed July 20, 2009]. http://www.pfizer.com/news/press_releases/pfizer_press_releases.jsp.
-
(2009)
-
-
-
23
-
-
33845480977
-
Targeted agents and esophageal cancer-the next step
-
Aklilu M., Ilson D.H. Targeted agents and esophageal cancer-the next step. Semin Radiat Oncol 2006, 17:62-69.
-
(2006)
Semin Radiat Oncol
, vol.17
, pp. 62-69
-
-
Aklilu, M.1
Ilson, D.H.2
-
24
-
-
44849093414
-
A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumor activities
-
Christensen J.G. A preclinical review of sunitinib, a multitargeted receptor tyrosine kinase inhibitor with anti-angiogenic and antitumor activities. Ann Oncol 2007, 18(Suppl 10):x3-x10.
-
(2007)
Ann Oncol
, vol.18
, Issue.SUPPL. 10
-
-
Christensen, J.G.1
-
25
-
-
42449148017
-
Sunitinib as second line treatment for advanced gastric cancer: preliminary results from a phase II study
-
(abstract 4603)
-
Bang Y., Kang Y., Kang W., et al. Sunitinib as second line treatment for advanced gastric cancer: preliminary results from a phase II study. J Clin Oncol 2007, 25(18S). (abstract 4603).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Bang, Y.1
Kang, Y.2
Kang, W.3
-
26
-
-
38049080992
-
Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma
-
Zhu A.X. Development of sorafenib and other molecularly targeted agents in hepatocellular carcinoma. Cancer 2008, 112:250-259.
-
(2008)
Cancer
, vol.112
, pp. 250-259
-
-
Zhu, A.X.1
-
27
-
-
47949116252
-
Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial (SHARP trial)
-
Llovet J., Ricci S., Mazzaferro V., et al. Sorafenib improves survival in advanced hepatocellular carcinoma (HCC): results of a phase III randomized placebo-controlled trial (SHARP trial). N Engl J Med 2008, 359:378-390.
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.1
Ricci, S.2
Mazzaferro, V.3
-
28
-
-
67651165187
-
Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study
-
August (8), [Epub 2009 July 6]
-
Faivre S., Raymond E., Boucher E., et al. Safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma: an open-label, multicentre, phase II study. Lancet Oncol 2009, 10(August (8)):794-800. [Epub 2009 July 6].
-
(2009)
Lancet Oncol
, vol.10
, pp. 794-800
-
-
Faivre, S.1
Raymond, E.2
Boucher, E.3
-
29
-
-
67649946279
-
Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
-
Zhu A.X., Sahani D.V., Duda D.G., et al. Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study. J Clin Oncol 2009, 27(18):3027-3035.
-
(2009)
J Clin Oncol
, vol.27
, Issue.18
, pp. 3027-3035
-
-
Zhu, A.X.1
Sahani, D.V.2
Duda, D.G.3
-
30
-
-
77956615170
-
Circulating biomarkers of sunitinib in patients with unresectable hepatocellular carcinoma (HCC): analysis of correlations with outcome and tumor imaging parameters
-
(abstract 4593)
-
De Primo S.E., Cheng A.L., Lanzalone S., et al. Circulating biomarkers of sunitinib in patients with unresectable hepatocellular carcinoma (HCC): analysis of correlations with outcome and tumor imaging parameters. J Clin Oncol 2008, 26. (abstract 4593).
-
(2008)
J Clin Oncol
, vol.26
-
-
De Primo, S.E.1
Cheng, A.L.2
Lanzalone, S.3
-
31
-
-
0034657029
-
High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
-
Seo Y., Baba H., Fukuda T., et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000, 88:2239-2245.
-
(2000)
Cancer
, vol.88
, pp. 2239-2245
-
-
Seo, Y.1
Baba, H.2
Fukuda, T.3
-
32
-
-
44349119079
-
SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation
-
Cuneo K.C., Geng L., Fu A., et al. SU11248 (sunitinib) sensitizes pancreatic cancer to the cytotoxic effects of ionizing radiation. Int J Radiation Oncol Biol Phys 2008, 71:873-879.
-
(2008)
Int J Radiation Oncol Biol Phys
, vol.71
, pp. 873-879
-
-
Cuneo, K.C.1
Geng, L.2
Fu, A.3
-
33
-
-
54349087049
-
A phase II trial of sunitinib in previously treated pancreas adenocarcinoma, CALGB 80603
-
(abstract 4515)
-
O'Reilly E.M., Niedzwiecki D., Hollis D., et al. A phase II trial of sunitinib in previously treated pancreas adenocarcinoma, CALGB 80603. J Clin Oncol 2008, 26. (abstract 4515).
-
(2008)
J Clin Oncol
, vol.26
-
-
O'Reilly, E.M.1
Niedzwiecki, D.2
Hollis, D.3
-
34
-
-
33846813582
-
A review of the current clinical trials for gastroenteropancreatic neuroendocrine tumors
-
Strosberg J.R., Kvols L.K. A review of the current clinical trials for gastroenteropancreatic neuroendocrine tumors. Expert Opin Investig Drugs 2007, 16:219-224.
-
(2007)
Expert Opin Investig Drugs
, vol.16
, pp. 219-224
-
-
Strosberg, J.R.1
Kvols, L.K.2
-
35
-
-
0033401823
-
Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis
-
Hager J.H., Hanahan D. Tumor cells utilize multiple pathways to down-modulate apoptosis. Lessons from a mouse model of islet cell carcinogenesis. Ann N Y Acad Sci 1999, 887:150-163.
-
(1999)
Ann N Y Acad Sci
, vol.887
, pp. 150-163
-
-
Hager, J.H.1
Hanahan, D.2
-
36
-
-
14644446018
-
A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
-
Pietras K., Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J Clin Oncol 2005, 23:939-952.
-
(2005)
J Clin Oncol
, vol.23
, pp. 939-952
-
-
Pietras, K.1
Hanahan, D.2
-
37
-
-
49149114782
-
Activity of sunitinib in patients with advanced neuroendocrine tumors
-
Kulke M.H., Lenz H.J., Meropol N.J., et al. Activity of sunitinib in patients with advanced neuroendocrine tumors. J Clin Oncol 2008, 26:3403-3410.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3403-3410
-
-
Kulke, M.H.1
Lenz, H.J.2
Meropol, N.J.3
-
38
-
-
77956613383
-
Phase III, randomized, double-blind trial of Sunitinib vs placebo in patients with progressive, well-differentiated, malignant pancreatic islet cell tumors
-
(abstract O-0013)
-
Raymond E., Raoul J.L., Niccoli P., et al. Phase III, randomized, double-blind trial of Sunitinib vs placebo in patients with progressive, well-differentiated, malignant pancreatic islet cell tumors. Presented as oral communication at the World Gastrointestinal Congress 2009, (abstract O-0013).
-
(2009)
Presented as oral communication at the World Gastrointestinal Congress
-
-
Raymond, E.1
Raoul, J.L.2
Niccoli, P.3
-
39
-
-
38549139744
-
Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
-
Yoshikawa D., Ojima H., Iwasaki M., et al. Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma. Br J Cancer 2008, 29:418-425.
-
(2008)
Br J Cancer
, vol.29
, pp. 418-425
-
-
Yoshikawa, D.1
Ojima, H.2
Iwasaki, M.3
-
40
-
-
36549014381
-
Phase II study of gemcitabine, oxaliplatin in combination with bevacizumab (GEMOX-B) in patients with unresectable or metastatic billiary tract and gallbladder cancers
-
(abstract 4625)
-
Clark J.W., Meyerhardt J.A., Sahani D.V., et al. Phase II study of gemcitabine, oxaliplatin in combination with bevacizumab (GEMOX-B) in patients with unresectable or metastatic billiary tract and gallbladder cancers. J Clin Oncol 2007, 25(18S). (abstract 4625).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Clark, J.W.1
Meyerhardt, J.A.2
Sahani, D.V.3
-
41
-
-
33947508735
-
Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma
-
Huether A., Höpfner M., Baradari V., et al. Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma. Biochem Pharmacol 2007, 73:1308-1317.
-
(2007)
Biochem Pharmacol
, vol.73
, pp. 1308-1317
-
-
Huether, A.1
Höpfner, M.2
Baradari, V.3
|