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Volumn 11, Issue 14, 2010, Pages 2437-2442

Does the p38 MAP kinase inhibitor pamapimod have potential for the treatment of rheumatoid arthritis?

Author keywords

Clinical trials; Methotrexate; P38 inhibition; Pamapimod; Pharmacokinetics; Rheumatoid arthritis

Indexed keywords

ALANINE AMINOTRANSFERASE; CREATINE KINASE; METHOTREXATE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PAMAPIMOD; UNCLASSIFIED DRUG;

EID: 77956607528     PISSN: 14656566     EISSN: None     Source Type: Journal    
DOI: 10.1517/14656566.2010.507631     Document Type: Note
Times cited : (5)

References (11)
  • 1
    • 77956606533 scopus 로고    scopus 로고
    • Available from. Rheumatoid arthritis Accessed 28th April, 2010
    • Available from: http://emedicine. medscape.com/article/331715-print Smith HR. Rheumatoid arthritis [Accessed 28th April 2010]
  • 2
    • 34548800403 scopus 로고    scopus 로고
    • P38 pathway kinases as anti-inflammatory drug targets
    • Schindler JF, Monahan JB, Smith WG. p38 pathway kinases as anti-inflammatory drug targets. J Dent Res 2007;86:800-811
    • (2007) J Dent Res , vol.86 , pp. 800-811
    • Schindler, J.F.1    Monahan, J.B.2    Smith, W.G.3
  • 3
    • 57349130600 scopus 로고    scopus 로고
    • Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: Preclinical analysis of efficacy and selectivity
    • Hill RJ, Dabbagh K, Phippard D, et al. Pamapimod, a novel p38 mitogen-activated protein kinase inhibitor: preclinical analysis of efficacy and selectivity. J Pharmacol Exp Ther 2008;327:610-619
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 610-619
    • Hill, R.J.1    Dabbagh, K.2    Phippard, D.3
  • 4
    • 59649114148 scopus 로고    scopus 로고
    • Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis
    • Cohen SB, Cheng TT, Chindalore V, et al. Evaluation of the efficacy and safety of pamapimod, a p38 MAP kinase inhibitor, in a double-blind, methotrexate-controlled study of patients with active rheumatoid arthritis. Arthritis Rheum 2009;60:335-344
    • (2009) Arthritis Rheum , vol.60 , pp. 335-344
    • Cohen, S.B.1    Cheng, T.T.2    Chindalore, V.3
  • 5
    • 77956566269 scopus 로고    scopus 로고
    • A proof-of-concept and drug-drug interaction of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis
    • [Epub ahead of print]
    • Zhang X, Huang Y, Navarro M, et al. A proof-of-concept and drug-drug interaction of pamapimod, a novel p38 MAP kinase inhibitor, with methotrexate in patients with rheumatoid arthritis. J Clin Pharmacol 2010. [Epub ahead of print]
    • (2010) J Clin Pharmacol
    • Zhang, X.1    Huang, Y.2    Navarro, M.3
  • 6
    • 75749115980 scopus 로고    scopus 로고
    • Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy
    • Alten RE, Zerbini C, Jeka S, et al. Efficacy and safety of pamapimod in patients with active rheumatoid arthritis receiving stable methotrexate therapy. Ann Rheum Dis 2010;69:364-367
    • (2010) Ann Rheum Dis , vol.69 , pp. 364-367
    • Alten, R.E.1    Zerbini, C.2    Jeka, S.3
  • 7
    • 66049086274 scopus 로고    scopus 로고
    • Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MARK inhibitor, in rheumatoid arthritis: Results of two randomized, double-blind, placebo-controlled clinical studies
    • Damjanow N, Kauffman RS, Spencer-Green GT. Efficacy, pharmacodynamics, and safety of VX-702, a novel p38 MARK inhibitor, in rheumatoid arthritis: results of two randomized, double-blind, placebo-controlled clinical studies. Arthritis Rheum 2009;60:1232-1241
    • (2009) Arthritis Rheum , vol.60 , pp. 1232-1241
    • Damjanow, N.1    Kauffman, R.S.2    Spencer-Green, G.T.3
  • 8
    • 14944358676 scopus 로고    scopus 로고
    • R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models
    • Wada Y, Nakajima-Yamada T, Yamada K, et al. R-130823, a novel inhibitor of p38 MAPK, ameliorates hyperalgesia and swelling in arthritis models. Eur J Pharmacol 2005;506:285-295
    • (2005) Eur J Pharmacol , vol.506 , pp. 285-295
    • Wada, Y.1    Nakajima-Yamada, T.2    Yamada, K.3
  • 9
    • 0018967509 scopus 로고
    • Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: Studies with carrageenan-induced inflammation in rats
    • Almeida AP, Bayer BM, Horakova Z, Beaven MA. Influence of indomethacin and other anti-inflammatory drugs on mobilization and production of neutrophils: studies with carrageenan-induced inflammation in rats. J Pharmacol Exp Ther 1980;214:74-79
    • (1980) J Pharmacol Exp Ther , vol.214 , pp. 74-79
    • Almeida, A.P.1    Bayer, B.M.2    Horakova, Z.3    Beaven, M.A.4
  • 10
    • 77949489123 scopus 로고    scopus 로고
    • Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase
    • Chopa P, Kulkarni O, Gupta S, et al. Pharmacological profile of AW-814141, a novel, potent, selective and orally active inhibitor of p38 MAP kinase. Int Immunopharmacol 2010;10:467-473
    • (2010) Int Immunopharmacol , vol.10 , pp. 467-473
    • Chopa, P.1    Kulkarni, O.2    Gupta, S.3
  • 11
    • 33644756429 scopus 로고    scopus 로고
    • Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Schreiber S, Feagan B, D'Haens G, et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006;4:325-334
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 325-334
    • Schreiber, S.1    Feagan, B.2    D'Haens, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.