The effects of a DTNBP1 gene variant on attention networks: An fMRI study

Behavioral and Brain Functions

Volumn 6, Issue , 2010, Pages

  Thimm, Markus ^a   Krug, Axel ^b   Kellermann, Thilo ^a   Markov, Valentin ^a   Krach, Sören ^b   Jansen, Andreas ^b   Zerres, Klaus ^a   Eggermann, Thomas ^a   Stöcker, Tony ^c   Shah, N Jon ^c   Nöthen, Markus M ^d   Rietschel, Marcella ^e   Kircher, Tilo ^b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d UNIVERSITY OF BONN   (Germany)

^e CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DYSBINDIN; DTNB PROTEIN, HUMAN; DYSTROPHIN ASSOCIATED PROTEIN; NEUROPEPTIDE;

ADULT; ALERTNESS; ARTICLE; ATTENTION; BEHAVIOR; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; FEMALE; FRONTAL CORTEX; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CELL NETWORK; NORMAL HUMAN; ORIENTATION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TASK PERFORMANCE; ADOLESCENT; ALLELE; BRAIN; EXECUTIVE FUNCTION; GENETICS; METHODOLOGY; MIDDLE AGED; NERVE TRACT; NUCLEAR MAGNETIC RESONANCE IMAGING; PHYSIOLOGY; REACTION TIME;

ADOLESCENT; ADULT; ALLELES; ATTENTION; BRAIN; DYSTROPHIN-ASSOCIATED PROTEINS; EXECUTIVE FUNCTION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEURAL PATHWAYS; NEUROPEPTIDES; POLYMORPHISM, SINGLE NUCLEOTIDE; REACTION TIME;

EID: 77956600229     PISSN: 17449081     EISSN: None     Source Type: Journal    
DOI: 10.1186/1744-9081-6-54     Document Type: Article

References (77)

1. Nestor PG, O'Donnell BF. The mind adrift: attentional dysregulation in schizophrenia. The Attentive Brain 1998, 527-546. Cambridge, MA: MIT Press, Parasuraman R.
2. Fan J, Raz A, Posner MI. Attentional mechanisms. Encyclopedia of Neurological Sciences 2003, 2:292-299. San Diego: Academic Press, Aminoff MJ, Daroff RB.
3. Posner MI, Petersen SE. The attention system of the human brain. Annu Rev Neurosci 1990, 13:25-42. 10.1146/annurev.ne.13.030190.000325, 2183676.
4. Sturm W, Willmes K. On the functional neuroanatomy of intrinsic and phasic alertness. Neuroimage 2001, 14:76-84.
5. Gouzoulis-Mayfrank E, Balke M, Hajsamou S, Ruhrmann S, Schultze-Lutter F, Daumann J, Heekeren K. Orienting of attention in unmedicated patients with schizophrenia, prodromal subjects and healthy relatives. Schizophr Res 2007, 97:35-42. 10.1016/j.schres.2007.06.028, 17869065.
6. Posner MI, Early TS, Reiman E, Pardo PJ, Dhawan M. Asymmetries in hemispheric control of attention in schizophrenia. Arch Gen Psychiatry 1988, 45:814-821.
7. Wang K, Fan J, Dong Y, Wang CQ, Lee TM, Posner MI. Selective impairment of attentional networks of orienting and executive control in schizophrenia. Schizophr Res 2005, 78:235-241. 10.1016/j.schres.2005.01.019, 16154056.
8. Zahn TP, Rosenthal D, Shakow D. Effects of irregular preparatory intervals on reaction time in schizophrenia. J Abnorm Soc Psychol 1963, 67:44-52. 10.1037/h0049269, 14003031.
9. Gallinat J, Bauer M, Heinz A. Genes and neuroimaging: advances in psychiatric research. Neurodegener Dis 2008, 5:277-285. 10.1159/000135612, 18520162.
10. Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC, Kahn RS. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res 2004, 71:285-295. 10.1016/j.schres.2004.03.007, 15474899.
11. Snitz BE, Macdonald AW, Carter CS. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 2006, 32:179-194. 10.1093/schbul/sbi048, 2632195, 16166612.
12. Chen WJ, Faraone SV. Sustained attention deficits as markers of genetic susceptibility to schizophrenia. Am J Med Genet 2000, 97:52-57. 10.1002/(SICI)1096-8628(200021)97:1<52::AID-AJMG7>3.0.CO;2-6, 10813804.
13. Cornblatt BA, Keilp JG. Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophr Bull 1994, 20:31-46.
14. Fan J, McCandliss BD, Fossella J, Flombaum JI, Posner MI. The activation of attentional networks. Neuroimage 2005, 26:471-479. 10.1016/j.neuroimage.2005.02.004, 15907304.
15. Pardo JV, Fox PT, Raichle ME. Localization of a human system for sustained attention by positron emission tomography. Nature 1991, 349:61-64. 10.1038/349061a0, 1985266.
16. Sturm W, de Simone A, Krause BJ, Specht K, Hesselmann V, Radermacher I, Herzog H, Tellmann L, Muller-Gartner HW, Willmes K. Functional anatomy of intrinsic alertness: evidence for a fronto-parietal-thalamic-brainstem network in the right hemisphere. Neuropsychologia 1999, 37:797-805. 10.1016/S0028-3932(98)00141-9, 10408647.
17. Corbetta M, Miezin FM, Shulman GL, Petersen SE. A PET study of visuospatial attention. J Neurosci 1993, 13:1202-1226.
18. Corbetta M, Kincade JM, Ollinger JM, McAvoy MP, Shulman GL. Voluntary orienting is dissociated from target detection in human posterior parietal cortex. Nat Neurosci 2000, 3:292-297. 10.1038/73009, 10700263.
19. Kastner S, Pinsk MA, De Weerd P, Desimone R, Ungerleider LG. Increased activity in human visual cortex during directed attention in the absence of visual stimulation. Neuron 1999, 22:751-761. 10.1016/S0896-6273(00)80734-5, 10230795.
20. Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD. Conflict monitoring versus selection-for-action in anterior cingulate cortex. Nature 1999, 402:179-181. 10.1038/46035, 10647008.
21. Carter CS, Botvinick MM, Cohen JD. The contribution of the anterior cingulate cortex to executive processes in cognition. Rev Neurosci 1999, 10:49-57.
22. Fan J, Flombaum JI, McCandliss BD, Thomas KM, Posner MI. Cognitive and brain consequences of conflict. Neuroimage 2003, 18:42-57. 10.1006/nimg.2002.1319, 12507442.
23. Macdonald AW, Cohen JD, Stenger VA, Carter CS. Dissociating the role of the dorsolateral prefrontal and anterior cingulate cortex in cognitive control. Science 2000, 288:1835-1838. 10.1126/science.288.5472.1835, 10846167.
24. Bush G, Luu P, Posner MI. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000, 4:215-222. 10.1016/S1364-6613(00)01483-2, 10827444.
25. Carter CS, Mintun M, Nichols T, Cohen JD. Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performance. Am J Psychiatry 1997, 154:1670-1675.
26. Nestor PG, Kubicki M, Spencer KM, Niznikiewicz M, McCarley RW, Shenton ME. Attentional networks and cingulum bundle in chronic schizophrenia. Schizophr Res 2007, 90:308-315. 10.1016/j.schres.2006.10.005, 1906862, 17150337.
27. Nestor PG, Kubicki M, Gurrera RJ, Niznikiewicz M, Frumin M, McCarley RW, Shenton ME. Neuropsychological correlates of diffusion tensor imaging in schizophrenia. Neuropsychology 2004, 18:629-637. 10.1037/0894-4105.18.4.629, 2790923, 15506830.
28. Macdonald AW, Thermenos HW, Barch DM, Seidman LJ. Imaging Genetic Liability to Schizophrenia: Systematic Review of fMRI Studies of Patients' Nonpsychotic Relatives. Schizophr Bull 2009, 35:1142-1162. 10.1093/schbul/sbn053, 18556667.
29. Becker TM, Kerns JG, Macdonald AW, Carter CS. Prefrontal dysfunction in first-degree relatives of schizophrenia patients during a Stroop task. Neuropsychopharmacology 2008, 33:2619-2625. 10.1038/sj.npp.1301673, 18216774.
30. Macdonald AW, Becker TM, Carter CS. Functional magnetic resonance imaging study of cognitive control in the healthy relatives of schizophrenia patients. Biol Psychiatry 2006, 60:1241-1249. 10.1016/j.biopsych.2006.04.041, 16945345.
31. Filbey FM, Russell T, Morris RG, Murray RM, McDonald C. Functional magnetic resonance imaging (fMRI) of attention processes in presumed obligate carriers of schizophrenia: preliminary findings. Ann Gen Psychiatry 2008, 7:18. 10.1186/1744-859X-7-18, 2569933, 18834530.
32. Fan J, Fossella J, Sommer T, Wu Y, Posner MI. Mapping the genetic variation of executive attention onto brain activity. Proc Natl Acad Sci USA 2003, 100:7406-7411. 10.1073/pnas.0732088100, 165888, 12773616.
33. Jansen A, Krach S, Krug A, Markov V, Eggermann T, Zerres K, Stocker T, Shah NJ, Nothen MM, Treutlein J, Rietschel M, Kircher T. A putative high risk diplotype of the G72 gene is in healthy individuals associated with better performance in working memory functions and altered brain activity in the medial temporal lobe. Neuroimage 2009, 45:1002-1008. 10.1016/j.neuroimage.2008.12.054, 19167508.
34. Kircher T, Krug A, Markov V, Whitney C, Krach S, Zerres K, Eggermann T, Stocker T, Shah NJ, Treutlein J, Nothen MM, Becker T, Rietschel M. Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals. Hum Brain Mapp 2009, 30:3406-3416. 10.1002/hbm.20761, 19350564.
35. Krug A, Markov V, Eggermann T, Krach S, Zerres K, Stocker T, Shah NJ, Schneider F, Nothen MM, Treutlein J, Rietschel M, Kircher T. Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals. Neuroimage 2008, 42:1569-1576. 10.1016/j.neuroimage.2008.05.058, 18606232.
36. Krug A, Markov V, Sheldrick A, Krach S, Jansen A, Zerres K, Eggermann T, Stocker T, Shah NJ, Kircher T. The effect of the COMT val(158)met polymorphism on neural correlates of semantic verbal fluency. Eur Arch Psychiatry Clin Neurosci 2009, 259:459-465. 10.1007/s00406-009-0010-8, 19381707.
37. Markov V, Krug A, Krach S, Whitney C, Eggermann T, Zerres K, Stocker T, Shah NJ, Nothen MM, Treutlein J, Rietschel M, Kircher T. Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals. Neuroimage 2009, 47:2016-2022. 10.1016/j.neuroimage.2009.05.067, 19497374.
38. Thimm M, Krug A, Markov V, Krach S, Jansen A, Zerres K, Eggermann T, Stocker T, Shah NJ, Nothen MM, Rietschel M, Kircher T. The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval. Hum Brain Mapp 2010, 31:203-209.
39. Jansen A, Krach S, Krug A, Markov V, Eggermann T, Zerres K, Thimm M, Nothen MM, Treutlein J, Rietschel M, Kircher T. Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects. BMC Psychiatry 2009, 9:60. 10.1186/1471-244X-9-60, 2761379, 19778423.
40. Markov V, Krug A, Krach S, Jansen A, Eggermann T, Zerres K, Stocker T, Shah NJ, Nothen MM, Treutlein J, Rietschel M, Kircher T. Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals. Hum Brain Mapp 2009, 31:266-275.
41. Mechelli A, Viding E, Kumar A, Pettersson-Yeo W, Fusar-Poli P, Tognin S, O'Donovan MC, McGuire P. Dysbindin modulates brain function during visual processing in children. Neuroimage 2010, 49:817-822. 10.1016/j.neuroimage.2009.07.030, 19631276.
42. Harrison PJ, Weinberger DR. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 2005, 10:40-68. 10.1038/sj.mp.4001558, 15263907.
43. O'Tuathaigh CM, Babovic D, O'Meara G, Clifford JJ, Croke DT, Waddington JL. Susceptibility genes for schizophrenia: characterisation of mutant mouse models at the level of phenotypic behaviour. Neurosci Biobehav Rev 2007, 31:60-78. 10.1016/j.neubiorev.2006.04.002, 16782199.
44. Owen MJ, Williams NM, O'Donovan MC. The molecular genetics of schizophrenia: new findings promise new insights. Mol Psychiatry 2004, 9:14-27. 10.1038/sj.mp.4001444, 14581932.
45. Owen MJ, Williams NM, O'Donovan MC. Dysbindin-1 and schizophrenia: from genetics to neuropathology. J Clin Invest 2004, 113:1255-1257. 398436, 15124015.
46. Williams NM, O'Donovan MC, Owen MJ. Is the dysbindin gene (DTNBP1) a susceptibility gene for schizophrenia?. Schizophr Bull 2005, 31:800-805. 10.1093/schbul/sbi061, 16166606.
47. Stefanis NC, Trikalinos TA, Avramopoulos D, Smyrnis N, Evdokimidis I, Ntzani EE, Ioannidis JP, Stefanis CN. Impact of schizophrenia candidate genes on schizotypy and cognitive endophenotypes at the population level. Biol Psychiatry 2007, 62:784-792. 10.1016/j.biopsych.2006.11.015, 17336946.
48. Kircher T, Markov V, Krug A, Eggermann T, Zerres K, Nothen MM, Skowronek MH, Rietschel M. Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects. Psychol Med 2009, 39:1657-1665. 10.1017/S0033291709005388, 19335929.
49. Burdick KE, Lencz T, Funke B, Finn CT, Szeszko PR, Kane JM, Kucherlapati R, Malhotra AK. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet 2006, 15:1563-1568. 10.1093/hmg/ddi481, 16415041.
50. Burdick KE, Goldberg TE, Funke B, Bates JA, Lencz T, Kucherlapati R, Malhotra AK. DTNBP1 genotype influences cognitive decline in schizophrenia. Schizophr Res 2007, 89:169-172. 10.1016/j.schres.2006.09.008, 1828039, 17074466.
51. Zinkstok JR, de Wilde O, van Amelsvoort TA, Tanck MW, Baas F, Linszen DH. Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings. Behav Brain Funct 2007, 3:19. 10.1186/1744-9081-3-19, 1864987, 17445278.
52. Luciano M, Miyajima F, Lind PA, Bates TC, Horan M, Harris SE, Wright MJ, Ollier WE, Hayward C, Pendleton N, Gow AJ, Visscher PM, Starr JM, Deary IJ, Martin NG, Payton A. Variation in the dysbindin gene and normal cognitive function in three independent population samples. Genes Brain Behav 2009, 8:218-227. 10.1111/j.1601-183X.2008.00462.x, 19077176.
53. Hashimoto R, Noguchi H, Hori H, Ohi K, Yasuda Y, Takeda M, Kunugi H. Association between the dysbindin gene (DTNBP1) and cognitive functions in Japanese subjects. Psychiatry Clin Neurosci 2009, 63:550-556. 10.1111/j.1440-1819.2009.01985.x, 19496996.
54. Donohoe G, Morris DW, Clarke S, McGhee KA, Schwaiger S, Nangle JM, Garavan H, Robertson IH, Gill M, Corvin A. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: a preliminary study. Neuropsychologia 2007, 45:454-458. 10.1016/j.neuropsychologia.2006.06.016, 16930638.
55. Hashimoto R, Noguchi H, Hori H, Nakabayashi T, Suzuki T, Iwata N, Ozaki N, Kosuga A, Tatsumi M, Kamijima K, Harada S, Takeda M, Saitoh O, Kunugi H. A genetic variation in the dysbindin gene (DTNBP1) is associated with memory performance in healthy controls. World J Biol Psychiatry 2010, 11:431-438. 10.3109/15622970902736503, 19353385.
56. Wessman J, Paunio T, Tuulio-Henriksson A, Koivisto M, Partonen T, Suvisaari J, Turunen JA, Wedenoja J, Hennah W, Pietilainen OP, Lonnqvist J, Mannila H, Peltonen L. Mixture Model Clustering of Phenotype Features Reveals Evidence for Association of DTNBP1 to a Specific Subtype of Schizophrenia. Biol Psychiatry 2009, 66:990-996. 10.1016/j.biopsych.2009.05.034, 19782967.
57. Wirgenes KV, Djurovic S, Agartz I, Jonsson EG, Werge T, Melle I, Andreassen OA. Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. Neuropsychobiology 2009, 60:31-36. 10.1159/000235799, 19729970.
58. Fallgatter AJ, Herrmann MJ, Hohoff C, Ehlis AC, Jarczok TA, Freitag CM, Deckert J. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals. Neuropsychopharmacology 2006, 31:2002-2010. 10.1038/sj.npp.1301003, 16407900.
59. Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR, Kleinman JE. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 2004, 61:544-555. 10.1001/archpsyc.61.6.544, 15184234.
60. Straub RE, Jiang Y, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, Cesare AJ, Gibberman A, Wang X, O'Neill FA, Walsh D, Kendler KS. Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. Am J Hum Genet 2002, 71:337-348. 10.1086/341750, 379166, 12098102.
61. Schizophrenia Research Forum Schizophrenia Research Forum., http://www.schizophreniaforum.org
62. Funke B, Finn CT, Plocik AM, Lake S, DeRosse P, Kane JM, Kucherlapati R, Malhotra AK. Association of the DTNBP1 locus with schizophrenia in a U.S. population. Am J Hum Genet 2004, 75:891-898. 10.1086/425279, 1182119, 15362017.
63. Fan J, McCandliss BD, Sommer T, Raz A, Posner MI. Testing the efficiency and independence of attentional networks. J Cogn Neurosci 2002, 14:340-347. 10.1162/089892902317361886, 11970796.
64. Oldfield RC. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 1971, 9:97-113. 10.1016/0028-3932(71)90067-4, 5146491.
65. Elston RC, Forthofer R. Testing for Hardy-Weinberg equilibrium in small samples. Biometrics 1977, 33:536-542.
66. Wellcome Trust Centre for Neuroimaging Wellcome Trust Centre for Neuroimaging., http://www.fil.ion.ucl.ac.uk/spm
67. Thirion B, Pinel P, Mériaux S, Roche A, Dehaene S, Poline JB. Analysis of a large fMRI cohort: Statistical and methodological issues for group analyses. Neuroimage 2007, 35:105-120. 10.1016/j.neuroimage.2006.11.054, 17239619.
68. Fletcher P, McKenna PJ, Friston KJ, Frith CD, Dolan RJ. Abnormal cingulate modulation of fronto-temporal connectivity in schizophrenia. Neuroimage 1999, 9:337-342. 10.1006/nimg.1998.0411, 10075903.
69. Weinberger DR, Egan MF, Bertolino A, Callicott JH, Mattay VS, Lipska BK, Berman KF, Goldberg TE. Prefrontal neurons and the genetics of schizophrenia. Biol Psychiatry 2001, 50:825-844. 10.1016/S0006-3223(01)01252-5, 11743939.
70. Liddle PF, Morris DL. Schizophrenic syndromes and frontal lobe performance. Br J Psychiatry 1991, 158:340-345. 10.1192/bjp.158.3.340, 2036532.
71. Barch DM. The cognitive neuroscience of schizophrenia. Annu Rev Clin Psychol 2005, 1:321-353. 10.1146/annurev.clinpsy.1.102803.143959, 17716091.
72. Fossella J, Sommer T, Fan J, Wu Y, Swanson JM, Pfaff DW, Posner MI. Assessing the molecular genetics of attention networks. BMC Neurosci 2002, 3:14. 10.1186/1471-2202-3-14, 130047, 12366871.
73. Benes FM. Emerging principles of altered neural circuitry in schizophrenia. Brain Res Brain Res Rev 2000, 31:251-269. 10.1016/S0165-0173(99)00041-7, 10719152.
74. Numakawa T, Yagasaki Y, Ishimoto T, Okada T, Suzuki T, Iwata N, Ozaki N, Taguchi T, Tatsumi M, Kamijima K, Straub RE, Weinberger DR, Kunugi H, Hashimoto R. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 2004, 13:2699-2708. 10.1093/hmg/ddh280, 15345706.
75. Davidson MC, Marrocco RT. Local infusion of scopolamine into intraparietal cortex slows covert orienting in rhesus monkeys. J Neurophysiol 2000, 83:1536-1549.
76. Marrocco RT, Davidson MC. Neurochemistry of attention. The Attentive Brain 1998, 35-50. Cambridge, MA: MIT Press, Parasuraman R.
77. Gooding DC, Braun JG, Studer JA. Attentional network task performance in patients with schizophrenia-spectrum disorders: evidence of a specific deficit. Schizophr Res 2006, 88:169-178. 10.1016/j.schres.2006.07.009, 16950603.