The crystal structure of a constitutively active mutant RON Kinase suggests an intramolecular autophosphorylation hypothesis

Biochemistry

Volumn 49, Issue 37, 2010, Pages 7972-7974

  Wang, Jing ^a   Steinbacher, Stefan ^b   Augustin, Martin ^b   Schreiner, Patrick ^b   Epstein, David ^a   Mulvihill, Mark J ^a   Crew, Andrew P ^a  

^a OSI PHARMACEUTICALS INC   (United States)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; PHOSPHATASES; PHOSPHORYLATION;

AUTOPHOSPHORYLATION; CONSTITUTIVELY ACTIVES; RECEPTOR TYROSINE KINASE;

CRYSTAL STRUCTURE;

ADENYLYLIMIDODIPHOSPHATE; MAGNESIUM ION; RON KINASE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG; PHOSPHOTRANSFERASE; PROTEIN TYROSINE KINASE;

ARTICLE; AUTOPHOSPHORYLATION; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; LIGAND BINDING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; CHEMISTRY; GENETICS; METABOLISM; PHOSPHORYLATION;

ADENYLYL IMIDODIPHOSPHATE; PHOSPHORYLATION; PHOSPHOTRANSFERASES; RECEPTOR PROTEIN-TYROSINE KINASES;

EID: 77956598858     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100409w     Document Type: Article

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