The effect of transcatheter injections on cell viability and cytokine release of mononuclear cells

American Journal of Neuroradiology

Volumn 31, Issue 8, 2010, Pages 1488-1492

  El Khoury, R ^a   Misra, V ^a   Sharma, S ^a   Cox, C S ^b   Walker, P ^b   Grotta, J C ^a   Gee, A ^c   Suzuki, S ^b   Savitz, Sean I ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c CENTER FOR CELL AND GENE THERAPY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; HEPARIN; INTERLEUKIN 10; IODINE; IOHEXOL; SOMATOMEDIN C; TRYPAN BLUE; VASCULOTROPIN;

ARTICLE; BONE MARROW CELL; CATHETER; CATHETERIZATION; CELL FUNCTION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXICITY; FLOW RATE; HUMAN; HUMAN CELL; INJECTION; LIPID PEROXIDATION; MONONUCLEAR CELL; STROKE;

ANTICOAGULANTS; CATHETERIZATION; CELL DEATH; CELL SURVIVAL; CONTRAST MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPARIN; HUMANS; INSULIN-LIKE GROWTH FACTOR I; INTERLEUKIN-10; IODINE COMPOUNDS; LEUKOCYTES, MONONUCLEAR; STROKE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77956593876     PISSN: 01956108     EISSN: 1936959X     Source Type: Journal    
DOI: 10.3174/ajnr.A2092     Document Type: Article

References (18)

1. Stem Cell Therapies as an Emerging Paradigm in Stroke Participants. Stem Cell Therapies as an Emerging Paradigm in Stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke. Stroke 2009;40:510-15. Epub 2008 Dec 18
2. Savitz SI, Misra V. Launching intravenous bone marrow cell trials for acute stroke. Regen Med 2009;4:639-41
3. Wechsler LR. Clinical trials of stroke therapy: which cells, which patients? Stroke 2009;40:S149-151
4. Savitz SI, Dinsmore J, Wu J, et al. Neurotransplantation of fetal porcine cells in patients with basal ganglia infarcts: a preliminary safety and feasibility study. Cerebrovasc Dis 2005;20:101-07
5. Fischer UM, Harting MT, Jimenez F, et al. Pulmonary passage is a major obstacle for intravenous stem cell delivery: the pulmonary first pass effect. Stem Cells Dev 2008;18:683-92
6. Kamiya N, Ueda M, Igarashi H, et al. Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in rats. Life Sci 2008;83:433-37
7. US Food and Drug Administration. Draft Guidance for Industry: Somatic Cell Therapy for Cardiac Disease. March 2009. US Department of Health and Human Services Web site. Vaccines, Blood, and Biologics. http://www.fda.gov/ BiologicsBloodVaccines/GuidanceComplianceRegulatoryInformation/Guidances/ CellularandGeneTherapy/ucm164265.htm. Accessed December 9, 2009
8. Brenneman M, Sharma S, Harting M, et al. Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats. J Cereb Blood Flow Metab 2010;30:140-49. Epub 2009 Sep 23
9. Baker AH, Sica V, Work LM, et al. Brain protection using autologous bone marrow cell, metalloproteinase inhibitors, and metabolic treatment in cerebral ischemia. Proc Natl Acad Sci U S A 2007;104:3597-602
10. Lipinski MJ, Biondi-Zoccai GG, Abbate A, et al. Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction: a collaborative systematic review and meta-analysis of controlled clinical trials. J Am Coll Cardiol 2007;50:1761-67
11. Correa PL, Mesquita CT, Felix RM, et al. Assessment of intra-arterial injected autologous bone marrow mononuclear cell distribution by radioactive labeling in acute ischemic stroke. Clin Nucl Med 2007;32:839-41
12. Harting MT, Cox CS, Day MC, et al. Bone marrow-derived mononuclear cell populations in pediatric and adult patients. Cytotherapy 2009;11:480-84
13. Tol M, Akar AR, Durdu S, et al. Comparison of different needle diameters and flow rates on bone marrow mononuclear stem cell viability: an ex vivo experimental study. Cytotherapy 2008;10:98-99
14. Yoon W, Park MS, Cho KH. Low-dose intra-arterial urokinase and aggressive mechanical clot disruption for acute ischemic stroke after failure of intravenous thrombolysis. AJNR Am J Neuroradiol 2010;31:161-64. Epub 2009 Aug 27
15. Sangchot P, Sharma S, Chetsawang B, et al. Deferoxamine attenuates iron-induced oxidative stress and prevents mitochondrial aggregation and alpha-synuclein translocation in SK-N-SH cells in culture. Dev Neurosci 2002;24:143-53
16. Takahashi M, Li TS, Suzuki R, et al. Cytokines produced by bone marrow cells can contribute to functional improvement of the infarcted heart by protecting cardiomyocytes from ischemic injury. Am J Physiol Heart Circ Physiol 2006;291:H886-93
17. Iihoshi S, Honmou O, Houkin K, et al. A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats. Brain Res 2004;1007:1-9
18. Heng BC, Hsu SH, Cowan CM, et al. Trans-catheter injection induced changes in human bone marrow-derived mesenchymal stem cells. Cell Transplant 2009;18:1111-21. Epub 2009 Jun 22