Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex

Cerebral Cortex

Volumn 20, Issue 10, 2010, Pages 2277-2286

  Meyer, Hanno S ^a,b,c   Wimmer, Verena C ^a,d   Oberlaender, M ^a,b,c   De Kock, Christiaan P J ^a,e   Sakmann, Bert ^a,b,c   Helmstaedter, Moritz ^a,b  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^c MAX PLANCK FLORIDA INSTITUTE FOR NEUROSCIENCE   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

cortex layer; neuron density; POm; somatosensory barrel cortex; VPM

Indexed keywords

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ANTIBODY LABELING; BRAIN CORTEX; CELL COUNT; CELL DENSITY; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOARCHITECTURE; MALE; NERVE CELL; NONHUMAN; NOTE; PRIORITY JOURNAL; RAT; SENSORY STIMULATION; SOMATOSENSORY CORTEX; THALAMOCORTICAL TRACT; VIBRISSAL CORTEX;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANIMALS; ANIMALS, NEWBORN; CELL COUNT; DEPENDOVIRUS; ELECTRIC STIMULATION; GLUTAMATE DECARBOXYLASE; LUMINESCENT PROTEINS; MALE; NEURONS; NUMERICAL ANALYSIS, COMPUTER-ASSISTED; PATCH-CLAMP TECHNIQUES; PHOSPHOPYRUVATE HYDRATASE; RATS; RATS, WISTAR; SOMATOSENSORY CORTEX; VENTRAL THALAMIC NUCLEI; VIBRISSAE;

EID: 77956588260     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhq067     Document Type: Note

References (38)

1. Beaulieu C. 1993. Numerical data on neocortical neurons in adult rat, with special reference to the GABA population. Brain Res. 609:284-292.
2. Beaulieu C, Kisvarday Z, Somogyi P, Cynader M, Cowey A. 1992. Quantitative distribution of GABA-immunopositive and-immunonegative neurons and synapses in the monkey striate cortex (area 17). Cereb Cortex. 2:295-309.
3. de Kock CP, Bruno RM, Spors H, Sakmann B. 2007. Layer-and cell-type-specific suprathreshold stimulus representation in rat primarysomatosensory cortex. J Physiol. 581:139-154.
4. Douglas RJ, Martin KA. 2007. Mapping the matrix: the ways ofneocortex. Neuron. 56:226-238.
5. Feldmeyer D, Egger V, Lubke J, Sakmann B. 1999. Reliable synapticconnections between pairs of excitatory layer 4 neurones withina single 'barrel' of developing rat somatosensory cortex. J Physiol.521(Pt 1):169-190.
6. Fleischhauer K, Petsche H, Wittkowski W. 1972. Vertical bundles ofdendrites in the neocortex. Z Anat Entwicklungsgesch.136:213-223.
7. Groh A, Meyer HS, Schmidt EF, Heintz N, Sakmann B, Krieger P. 2009.Cell-type specific properties of pyramidal neurons in neocortexunderlying a layout that is modifiable depending on the corticalarea. Cereb Cortex. 20(4):826-836.
8. Heintz N. 2004. Gene expression nervous system atlas (GENSAT). NatNeurosci. 7:483.
9. Helmstaedter M, de Kock CP, Feldmeyer D, Bruno RM, Sakmann B.2007. Reconstruction of an average cortical column in silico. BrainRes Rev. 55:193-203.
10. Herkenham M. 1980. Laminar organization of thalamic projections tothe rat neocortex. Science. 207:532-535.
11. Horton JC, Adams DL. 2005. The cortical column: a structurewithout a function. Philos Trans R Soc Lond B Biol Sci.360:837-862.
12. Hubel DH, Wiesel TN. 1968. Receptive fields and functional architecture of monkey striate cortex. J Physiol. 195:215-243.
13. Hubel DH, Wiesel TN. 1969. Anatomical demonstration of columns inthe monkey striate cortex. Nature. 221:747-750.
14. Jones EG. 2000. Microcolumns in the cerebral cortex. Proc Natl AcadSci. 97:5019-5021.
15. Julien JF, Samama P, Mallet J. 1990. Rat brain glutamic aciddecarboxylase sequence deduced from a cloned cDNA. J Neuro-chem. 54:703-705.
16. Kaufman DL, McGinnis JF, Krieger NR, Tobin AJ. 1986. Brain glutamatedecarboxylase cloned in lambda gt-11: fusion protein producesgamma-aminobutyric acid. Science. 232:1138-1140.
17. Keller A, Carlson GC. 1999. Neonatal whisker clipping alters intra-cortical, but not thalamocortical projections, in rat barrel cortex.J Comp Neurol. 412:83-94.
18. Kobayashi Y, Kaufman DL, Tobin AJ. 1987. Glutamic acid decarboxylasecDNA: nucleotide sequence encoding an enzymatically active fusionprotein. J Neurosci. 7:2768-2772.
19. Koralek KA, Jensen KF, Killackey HP. 1988. Evidence for twocomplementary patterns of thalamic input to the rat somatosensorycortex. Brain Res. 463:346-351.
20. Krieger P, Kuner T, Sakmann B. 2007. Synaptic connections betweenlayer 5B pyramidal neurons in mouse somatosensory cortex areindependent of apical dendrite bundling. J Neurosci.27:11473-11482.
21. Lin CS, Lu SM, Schmechel DE. 1985. Glutamic acid decarboxylaseimmunoreactivity in layer IV of barrel cortex of rat and mouse.J Neurosci. 5:1934-1939.
22. Meyer HS, Wimmer VC, Hemberger M, Bruno RM, de Kock CP,Frick A, Sakmann B, Helmstaedter M. 2010. Cell-type specificthalamic innervation in a column of rat vibrissal cortex. CerebCortex. doi: 10.1093/cercor/bhq069.
23. Mountcastle VB. 1957. Modality and topographic properties of singleneurons of cat's somatic sensory cortex. J Neurophysiol.20:408-434.
24. Mountcastle VB. 1997. The columnar organization of the neocortex.Brain. 120(Pt 4):701-722.
25. Mullen RJ, Buck CR, Smith AM. 1992. NeuN, a neuronal specific nuclearprotein in vertebrates. Development. 116:201-211.
26. Oberlaender M, Dercksen VJ, Egger R, Gensel M, Sakmann B, Hege HC.2009. Automated three-dimensional detection and counting ofneuron somata. J Neurosci Methods. 180:147-160.
27. Peters A, Walsh TM. 1972. A study of the organization of apicaldendrites in the somatic sensory cortex of the rat. J Comp Neurol.144:253-268.
28. Rakic P. 1976. Prenatal genesis of connections subserving ocular dominance in the rhesus monkey. Nature. 261:467-471.
29. Rakic P. 1988. Specification of cerebral cortical areas. Science. 241:170-176.
30. Rockland KS, Ichinohe N. 2004. Some thoughts on cortical mini-columns. Exp Brain Res. 158:265-277.
31. Schubert D, Kotter R, Luhmann HJ, Staiger JF. 2006. Morphology, electrophysiology and functional input connectivity of pyramidal neurons characterizes a genuine layer va in the primary somato-sensory cortex. Cereb Cortex. 16:223-236.
32. Schubert D, Staiger JF, Cho N, Kotter R, Zilles K, Luhmann HJ. 2001. Layer-specific intracolumnar and transcolumnar functional connectivity of layer V pyramidal cells in rat barrel cortex. J Neurosci. 21:3580-3592.
33. Sterio DC. 1984. The unbiased estimation of number and sizes of arbitrary particles using the disector. J Microsc. 134:127-136.
34. Torii M, Hashimoto-Torii K, Levitt P, Rakic P. 2009. Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature. 461:524-528.
35. Tsai PS, Kaufhold JP, Blinder P, Friedman B, Drew P, Karten HJ, Lyden PD, Kleinfeld D. 2009. Correlations of Neuronal and Microvascular Densities in Murine Cortex Revealed by Direct Counting and Colocalization of Nuclei and Vessels. J Neurosci. 29:14553-14570.
36. Wimmer VC, Bruno RM, de Kock CP, Kuner T, Sakmann B. Dimensions of a projection column and architecture of VPM-and POm-axons in rat vibrissal cortex. Cereb Cortex. doi: 10.1093/cercor/bhq068.
37. Wimmer VC, Nevian T, Kuner T. 2004. Targeted in vivo expression of proteins in the calyx of Held. Pflugers Arch. 449:319-333.
38. Yu YC, Bultje RS, Wang X, Shi SH. 2009. Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature. 458:501-504.