Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase

Biochemistry

Volumn 49, Issue 37, 2010, Pages 7988-7997

  Tsai, Ping Chuan ^a   Fan, Yubo ^a   Kim, Jungwook ^b   Yang, Lijiang ^a,c   Almo, Steven C ^b   Gao, Yi Qin ^a,c   Raushel, Frank M ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CHIRALITY; CRYSTAL STRUCTURE; ENANTIOMERS; HYDROLYSIS; MOLECULAR DYNAMICS; PHENOLS; STEREOSELECTIVITY;

ACTIVE SITE; BINDING POCKETS; CYCLOSARIN; HIGH RESOLUTION; HIGH RESOLUTION CRYSTAL STRUCTURE; LEAVING GROUPS; MOLECULAR DYNAMICS CALCULATION; MOLECULAR DYNAMICS SIMULATIONS; NERVE AGENTS; NEW HIGH; PHOSPHOTRIESTERASES; STEREO-SELECTIVE; STRUCTURAL CHANGE; STRUCTURAL DETERMINANTS; SUBSTRATE HYDROLYSIS; SUBSTRATE SPECIFICITY; WILD TYPES; X-RAY STRUCTURE;

SUBSTRATES;

CYCLOSARIN; MUTANT PROTEIN; PHOSPHOTRIESTERASE; SARIN; CHEMICAL WARFARE AGENT; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; CATALYSIS; CHIRALITY; CHROMATOPHORE; ENANTIOMER; ENZYME STRUCTURE; HYDROLYSIS; PRIORITY JOURNAL; STEREOCHEMISTRY; CHEMISTRY; ENZYME SPECIFICITY; METABOLISM; MOLECULAR DYNAMICS; STEREOISOMERISM; X RAY;

CATALYSIS; CHEMICAL WARFARE AGENTS; HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHORIC TRIESTER HYDROLASES; SARIN; STEREOISOMERISM; SUBSTRATE SPECIFICITY; X-RAYS;

EID: 77956578780     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101058z     Document Type: Article

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