Large intestinal mast cell count and proteinase expression is associated with larval burden in cyathostomin-infected horses

Equine Veterinary Journal

Volumn 42, Issue 7, 2010, Pages 652-657

  Pickles, K J ^a,b   Mair, J A ^a   Lopez Villalobos, N ^b   Shaw, D J ^a   Scott, I ^b   Pomroy, W ^a  

^a MASSEY UNIVERSITY   (New Zealand)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Chymase; Cyathostomin; Horse; Mast cell; Tryptase

Indexed keywords

PEPTIDE HYDROLASE;

ANIMAL; ANIMAL DISEASE; ARTICLE; CECUM; CYTOLOGY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HORSE; HORSE DISEASE; LARVA; MALE; MAST CELL; METABOLISM; NEMATODIASIS; PARASITOLOGY; PATHOLOGY; PHYSIOLOGY;

ANIMALS; CECUM; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HORSE DISEASES; HORSES; LARVA; MALE; MAST CELLS; NEMATODE INFECTIONS; PEPTIDE HYDROLASES;

EQUIDAE; ORYCTOLAGUS CUNICULUS;

EID: 77956566220     PISSN: 04251644     EISSN: 20423306     Source Type: Journal    
DOI: 10.1111/j.2042-3306.2010.00106.x     Document Type: Article

References (25)

1. Castro GA, Harari Y, Russell DA. Mediators of anaphylaxis-induced ion transport changes in small intestine. Am. J. Physiol. 1987, 253:540-548.
2. Collobert-Laugier C, Hoste H, Sevin C, Chartier C, Dorchies P. Mast cell and eosinophil mucosal reponses in the large intestine of horses naturally infected with cyathostomes. Vet. Parasitol. 2002, 107:251-264.
3. Dacre KJ. Involvement of Mast Cells and Mast Cell Proteinases in Equine Heaves. 2005, PhD Thesis, University of Edinburgh
4. Davidson AJ, Hodgkinson JE, Proudman CJ, Matthews JB. Cytokine responses to cyathostominae larvae in the equine large intestinal wall. Res. vet. Sci. 2005, 78:169-176.
5. Friend DS, Ghildyal N, Austen FK, Gurish MF, Matsumoto R, Stevens RL. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J. Cell Biol. 1996, 135:279-290.
6. Friend DS, Ghildyal N, Gurish MF, Hunt J, Hu X, Austen KF, Stevens RL. Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J. Immunol. 1998, 160:5537-5545.
7. Huntley JF, Gibson S, Brown D, Smith WD, Jackson F, Miller HRP. Systemic release of a mast cell proteinase following nematode infections in sheep. Parasite Immunol. 1987, 9:603-614.
8. Jacob C, Yang P-C, Darmoul D, Amadesi S, Saito T, Cottrell GS, Coelho A-M, Singh P, Grady EF, Perdue M, Bunnett NW. Mast cell tryptase controls paracellular permeability of the intestine. J. biol. Chem. 2005, 36:31936-31948.
9. Klei TR, Chapman MR. Immunity in equine cyathostome infections. Vet. Parasitol. 1999, 85:123-136.
10. Knight PA, Wright SH, Lawerence CE, Paterson YYP, Miller HRP. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J. Exploratory Med. 2000, 192:1849-1856.
11. Lichtenfels JR. Helminths of domestic equids. Illustrated keys to genera and species with emphasis on the North American forms. Proc. Helminthol. Soc. Wash. 1975, 42:10-74.
12. Love S, Murphy D, Mellor D. Pathogenicity of cyathostome infection. Vet. Parasitol. 1999, 85:113-122.
13. McDermott JR, Bartram RE, Knight PA, Miller HPR, Garrod DR. Mast cells disrupt epithelial barrier function during enteric nematode infection. Proc. Natl. Acad. Sci. USA 2003, 100:7761-7766.
14. Miller HRP, Pemberton AD. Tissue-specific expression of mast cell granule serine proteinases and their role in inflammation in the lung and gut. Immunol. 2002, 105:375-390.
15. Ogbourne CP. The prevalence, relative abundance and site distribution of nematodes of the subfamily Cyathostominae in horses killed in Britain. J. Helminthol. 1976, 50:203-214.
16. Pemberton AD, McEuen AR, Scudamore CL. Characterisation of tryptase and a granzyme H-like chymase isolated from equine mastocytoma tissue. Vet. Immunol. Immunopathol. 2001, 83:253-267.
17. Perdue MH, Masson S, Wershil BK, Galli SJ. Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. J. Clin. Invest. 1991, 87:687-693.
18. Sangster NC. Pharmacology of anthelmintic resistance in cyathostomes: will it occur with the avermectin/milbemycins? Vet. Parasitol. 1999, 85:189-204.
19. Scudamore CL, Jepson MA, Hirst BH, Miller HPR. The rat mucosal mast cell chymase, RMCP-II, alters epithelial cell monolayer permeability in association with altered distribution of the tight junction proteins ZO-1 and occludin. Eur. J. Cell Biol. 1998, 75:321-330.
20. Scudamore CL, Thornton EM, McMillan L, Newlands GF, Millar HR. Release of the mucosal mast cell granule chymase, rat mast cell protease-II, during anaphylaxis is associated with the rapid development of paracellular permeability to macromolecules in rat jejunum. J. expt. Med. 1995, 182:1871-1881.
21. Shin K, Watts GFM, Oettgen HC, Friend DS, Pemberton AD, Gurish MF, Lee DM. Mouse mast cell tryptase mMCP-6 is a critical link between adaptive and innate immunity in the chronic phase of Trichinella spiralis infection. J. Immunol. 2008, 180:4885-4891.
22. Steinbach T, Bauer C, Sasse H, Baumgartner W, Rey-Moreno C, Hermosilla C, Damriyasa IM, Zahner H. Small strongyle infection: Consequences of larvicidal treatment of horses with fenbendazole and moxidectin. Vet. Parasitol. 2006, 139:115-131.
23. du Toit N, McGorum BC, Pemberton AD, Brown J, Dacre KJ. The involvement of mast cells and mast cell proteinases in the intestinal response to equine cyathostomin infection. Vet. Immunol. Immunopathol. 2007, 115:35-42.
24. Wastling JM, Scudamore CL, Thornton EM, Newlands GFJ, Miller HRP. Constitutive expression of mouse mast cell protease-1 in normal BALB/c mice and its up-regulation during intestinal nematode infection. Immunol. 1997, 90:308-313.
25. Woodbury RG, Miller HRP, Huntley JF, Newlands GFJ, Paliser AC, Wakelin D. Mucosal mast cells are functionally active during the spontaneous expulsion of primary intestinal nematode infection in the rat. Nature 1984, 312:450-452.