Skeletal diseases in Cushing's syndrome: Osteoporosis versus arthropathy

Neuroendocrinology

Volumn 92, Issue SUPPL. 1, 2010, Pages 60-64

  Kaltsas, Gregory ^a   Makras, Polyzois ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Avascular necrosis; Bisphosphonates; Bone mineral density; Cortisol; Cushing's syndrome; Osteoporosis

Indexed keywords

CALCIUM; CYTOKINE; GONADOTROPIN; GROWTH HORMONE; HYDROCORTISONE; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; VITAMIN D;

ARTHROPATHY; BONE DENSITY; BONE MASS; CALCIUM INTAKE; CLINICAL FEATURE; CONFERENCE PAPER; CUSHING SYNDROME; CYTOKINE PRODUCTION; DISEASE DURATION; DISEASE SEVERITY; FRACTURE; GONADOTROPIN RELEASE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERCORTISOLISM; ONSET AGE; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK FACTOR; TRABECULAR BONE; VITAMIN SUPPLEMENTATION;

BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; CUSHING SYNDROME; DIPHOSPHONATES; HUMANS; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES;

EID: 77956534331     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000314298     Document Type: Conference Paper

References (20)

1. Chiodini I, Torlontano M, Carnevale V, Trischitta V, Scillitani A: Skeletal involvement in adult patients with endogenous hy-percortisolism. J Endocrinol Invest 2008; 31: 267-276.
2. Mazziotti G, Angeli A, Bilezikian JP, Canalis E, Giustina A: Glucocorticoid-induced osteoporosis: an update. Trends Endocrinol Metab 2006; 17:14 4-149.
3. Manelli F, Giustina A: Glucocorticoid-induced osteoporosis. Trends Endocrinol Metab 2000; 11: 79-85.
4. Karavitaki N, Ioannidis G, Giannakopoulos F, Mavrokefalos P, Thalassinos N: Evaluation of bone mineral density of the peripheral skeleton in pre-and postmenopausal women with newly diagnosed endogenous Cushing's syndrome. Clin Endocrinol (Oxf) 2004; 60: 264-270.
5. Mancini T, Doga M, Mazziotti G, Giustina A: Cushing's syndrome and bone. Pituitary 2004; 7:249-252.
6. Canalis E: Mechanisms of glucocorticoid action in bone. Curr Osteoporos Rep 2005; 3: 98-102.
7. Manolagas SC: Corticosteroids and fractures: a close encounter of the third cell kind. J Bone Miner Res 2000; 15: 10 01-10 05.
8. Lekva T, Bollerslev J, Kristo C, Olstad OK, Ueland T, Jemtland R: The glucocorticoid-induced leucine zipper gene (GILZ) expression decreases after successful treatment of patients with endogenous Cushing's syndrome and may play a role in glucocorticoid-induced osteoporosis. J Clin Endocrinol Metab 2010; 95: 246-255.
9. Shaker JL, Lukert BP: Osteoporosis associated with excess glucocorticoids. Endocrinol Metab Clin Nor th Am 2005; 34: 341-343ix.
10. Tauchmanovà L, Pivonello R, Di SC, Rossi R, De Martino MC, Camera L, Klain M, Salva-tore M, Lombardi G, Colao A: Bone demin-eralization and vertebral fractures in endogenous cortisol excess: role of disease etiology and gonadal status. J Clin Endocrinol Metab 2006; 91:1779-1784.
11. Vestergaard P, Lindholm J, Jorgensen JO, Hagen C, Hoeck HC, Laurberg P, Rejnmark L, Brixen K, Kristensen LO, Feldt-Rasmus-sen U, Mosekilde L: Increased risk of osteo-porotic fractures in patients with Cushing's sy ndrome. Eur J Endocrinol 2002; 14 6: 51-5 6.
12. Torlontano M, Chiodini I, Pileri M, Gugliel-mi G, Cammisa M, Modoni S, Carnevale V, Trischitta V, Scillitani A: Altered bone mass and turnover in female patients w it h adrena l incidentaloma: the effect of subclinical hy-percortisolism. J Clin Endocrinol Metab 1999; 84:2381-2385.
13. Huizenga NA, Koper JW, De Lange P, Pols HA, Stolk RP, Burger H, Grobbee DE, Brink-mann AO, De Jong FH, Lamberts SW: A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo. J Clin Endocrinol Metab 1998; 83:144-151.
14. Tomlinson JW, Walker EA, Bujalska IJ, Draper N, Lavery GG, Cooper MS, Hewison M, Stewart PM: 11beta-hydroxysteroid dehy-drogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev 2004; 25: 831-866.
15. Osella G, Terzolo M, Reimondo G, Piovesan A, Pia A, Termine A, Paccotti P, Angeli A: Serum markers of bone and collagen turnover in patients with Cushing's syndrome and in subjects with adrenal incidentalomas. J Clin Endocrinol Metab 1997; 82: 3303-3307.
16. Kaji H, Yamauchi M, Chihara K, Sugimoto T: Glucocorticoid excess affects cortical bone geometry in premenopausal, but not postmenopausal, women. Calcif Tissue Int 2008; 82: 182-190.
17. Tauchmanovà L, Pivonello R, De Martino MC, Rusciano A, De LM, Ruosi C, Mainolfi C, Lombardi G, Salvatore M, Colao A: Effects of sex steroids on bone in women with subclinical or overt endogenous hypercorti-solism. Eur J Endocrinol 2007; 157:359-366.
18. Cummings SR, San MJ, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C: Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 2009; 361: 756-765.
19. Adachi JD, Papaioannou A: Corticosteroid-Induced osteoporosis: detection and management. Drug Saf 2001; 24: 607-624.
20. Adachi JD: Corticosteroid-induced osteoporosis. Am J Med Sci 1997; 313:41-49.