Patient evaluation of the use of follitropin alfa in a prefilled ready-to-use injection pen in assisted reproductive technology: An observational study

Reproductive Biology and Endocrinology

Volumn 8, Issue , 2010, Pages

  Welcker, J T ^a   Nawroth, Frank ^b   Bilger, Wilma ^c  

^a Kinderwunschzentrum   (Germany)

^b Standort Hamburg   (Germany)

^c Merck Serono GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT FOLLITROPIN; FERTILITY PROMOTING AGENT; FOLLITROPIN BETA SUBUNIT;

ADULT; ARTICLE; ASSISTIVE TECHNOLOGY DEVICE; BIOMEDICAL TECHNOLOGY ASSESSMENT; CLINICAL ASSESSMENT; CLINICAL EVALUATION; CLINICAL TRIAL; COMPARATIVE EFFECTIVENESS; COMPREHENSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FREEZE DRYING; GERMANY; HEALTH EDUCATION; HEALTH SURVEY; HUMAN; INFERTILITY THERAPY; INTERMETHOD COMPARISON; LIVE BIRTH; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; OVARY HYPERSTIMULATION; OVULATION INDUCTION; PATIENT ATTITUDE; PATIENT SATISFACTION; PERSONAL EXPERIENCE; POWDER; PREGNANCY OUTCOME; PROSPECTIVE STUDY; QUESTIONNAIRE; REPRODUCTIVE HEALTH; REPRODUCTIVE PROCEDURES; SELF INJECTION; SELF REPORT; SPONTANEOUS ABORTION; SYRINGE; WOMEN'S HEALTH; ALPHA CHAIN; DRUG ADMINISTRATION; DRUG DOSAGE FORM; DRUG SELF ADMINISTRATION; EVALUATION; INSTRUMENTATION; JET INJECTION; METHODOLOGY; OBSERVATION; PSYCHOLOGICAL ASPECT; STATISTICS;

ADULT; DOSAGE FORMS; DRUG ADMINISTRATION SCHEDULE; FEMALE; FERTILITY AGENTS, FEMALE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; GLYCOPROTEIN HORMONES, ALPHA SUBUNIT; HUMANS; INJECTIONS, JET; OBSERVATION; OVULATION INDUCTION; PATIENT SATISFACTION; QUESTIONNAIRES; REPRODUCTIVE TECHNIQUES, ASSISTED; SELF ADMINISTRATION; SYRINGES;

EID: 77956510389     PISSN: None     EISSN: 14777827     Source Type: Journal    
DOI: 10.1186/1477-7827-8-111     Document Type: Article

References (22)

1. Lunenfeld B. Historical perspectives in gonadotrophin therapy. Hum Reprod Update 2004, 10:453-467. 10.1093/humupd/dmh044, 15388674.
2. Bassett RM, Driebergen R. Continued improvements in the quality and consistency of follitropin alfa, recombinant human FSH. Reprod Biomed Online 2005, 10:169-177. 10.1016/S1472-6483(10)60937-6, 15823219.
3. Balasch J, Fabregues F, Penarrubia J, Creus M, Manau D, Vidal E, Casamitjana R, Vanrell JA. Outcome from consecutive assisted reproduction cycles in patients treated with recombinant follitropin alfa filled-by-bioassay and those treated with recombinant follitropin alfa filled-by-mass. Reprod Biomed Online 2004, 8:408-413. 10.1016/S1472-6483(10)60924-8, 15149563.
4. Hugues JN, Barlow DH, Rosenwaks Z, Cedrin-Durnerin I, Robson S, Pidoux L, Loumaye E. Improvement in consistency of response to ovarian stimulation with recombinant human follicle stimulating hormone resulting from a new method for calibrating the therapeutic preparation. Reprod Biomed Online 2003, 6:185-190. 10.1016/S1472-6483(10)61709-9, 12675998.
5. Martinez G, Sanguineti F, Sepulveda J, Dorey J, Arici A, Patrizio P. A comparison between follitropin alpha filled by mass and follitropin alpha filled by bioassay in the same egg donors. Reprod Biomed Online 2007, 14:26-28. 10.1016/S1472-6483(10)60759-6, 17207327.
6. Wikland M, Hugues JN, Howles C. Improving the consistency of ovarian stimulation: follitropin alfa filled-by-mass. Reprod Biomed Online 2006, 12:663-668. 10.1016/S1472-6483(10)61078-4, 16792840.
7. Bohannon NJ. Insulin delivery using pen devices. Simple-to-use tools may help young and old alike. Postgrad Med 1999, 106(57-4):68.
8. Brunton S. Initiating insulin therapy in type 2 diabetes: benefits of insulin analogs and insulin pens. Diabetes Technol Ther 2008, 10:247-256. 10.1089/dia.2008.0287, 18715198.
9. Hanestad BR, Albrektsen G. Quality of life, perceived difficulties in adherence to a diabetes regimen, and blood glucose control. Diabet Med 1991, 8:759-764. 10.1111/j.1464-5491.1991.tb01696.x, 1838068.
10. Pfutzner A, Asakura T, Sommavilla B, Lee W. Insulin delivery with FlexPen: dose accuracy, patient preference and adherence. Expert Opin Drug Deliv 2008, 5:915-925. 10.1517/17425247.5.8.915, 18713000.
11. Somkuti SG, Schertz JC, Moore M, Ferrande L, Kelly E. Patient experience with follitropin alfa prefilled pen versus previously used injectable gonadotropins for ovulation induction in oligoanovulatory women. Curr Med Res Opin 2006, 22:1981-1996. 10.1185/030079906X132604, 17022858.
12. Aghssa MM, Azargoon A, Ramezanzadeh F, Bagheri M. A comparison of the efficacy, tolerability, and convenience of two formulations of follitropin-alpha in Iranian woman undergoing intracytoplasmic sperm injection cycles. Fertil Steril 2008, 90:1043-1048. 10.1016/j.fertnstert.2007.08.001, 18053995.
13. Rama Raju GA, Suryanarayana K, Jaya PG, Murali KK. Comparison of follitropin-beta administered by a pen device with conventional syringe in an ART programme - a retrospective study. J Clin Pharm Ther 2008, 33:401-407. 10.1111/j.1365-2710.2008.00931.x, 18613858.
14. Sedbon E, Wainer R, Perves C. Quality of life of patients undergoing ovarian stimulation with injectable drugs in relation to medical practice in France. Reprod Biomed Online 2006, 12:298-303. 10.1016/S1472-6483(10)61001-2, 16569316.
15. Porter R, Kissel C, Saunders H, Keck C. Patient and nurse evaluation of recombinant human follicle-stimulating hormone administration methods: comparison of two follitropin injection pens. Curr Med Res Opin 2008, 24:727-735. 10.1185/030079908X273291, 18230195.
16. Weiss N. Gonadotrophin products: empowering patients to choose the product that meets their needs. Reprod Biomed Online 2007, 15:31-37. 10.1016/S1472-6483(10)60688-8, 17623531.
17. Deutches IVF-Register. , http://www.deutsches-ivf-register.de/
18. Olivennes F, Frydman R. Friendly IVF: the way of the future?. Hum Reprod 1998, 13:1121-1124. 10.1093/humrep/13.5.1121, 9647528.
19. Verberg MF, Eijkemans MJ, Heijnen EM, Broekmans FJ, de KC, Fauser BC, Macklon NS. Why do couples drop-out from IVF treatment? A prospective cohort study. Hum Reprod 2008, 23:2050-2055. 10.1093/humrep/den219, 18544578.
20. Chen LN, Quan S, Li H, Yang XP, Chen SM, Zhang XY, Lin L, Xing FQ, Chen SL, Wan ZJ, Wang Y. [Clinical application of prefilled pen and conventional syringe during controlled ovarian stimulation for in vitro fertilization]. Nan Fang Yi Ke Da Xue Xue Bao 2009, 29:100-104.
21. Christianson MS, Barker MA, Schouweiler C, Lindheim SR. A retrospective comparison of clinical outcomes and satisfaction using reconstituted recombinant gonadotropins (rFSH) or cartridge rFSH with a pen device in donor oocyte cycles. Curr Med Res Opin 2007, 23:865-870. 10.1185/030079907X178784, 17407643.
22. Insight Health Nationale Pharmainformation, Apothekenmarkt Germany, Insight Health.