Restoring the balance between disease and repair in multiple sclerosis: Insights from mouse models

DMM Disease Models and Mechanisms

Volumn 3, Issue 9-10, 2010, Pages 535-539

  Miller, Robert H ^a   Fyffe Maricich, Sharyl L ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; BETA INTERFERON; CLADRIBINE; ETHIDIUM BROMIDE; GLATIRAMER; MITOXANTRONE; MYELIN; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; NATALIZUMAB; NERVE CELL ADHESION MOLECULE; NOTCH RECEPTOR; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PLATELET DERIVED GROWTH FACTOR; PROTEOLIPID PROTEIN; TRANSCRIPTION FACTOR NKX2.2; TRANSCRIPTION FACTOR SOX10;

CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL REGENERATION; CENTRAL NERVOUS SYSTEM; DEMYELINATION; DISEASE COURSE; HEDGEHOG; IMMUNE SYSTEM; IMMUNOCOMPETENT CELL; MOUSE; MULTIPLE SCLEROSIS; MYELINATION; NERVE CELL; NERVE FIBER; NONHUMAN; NOTE; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; SCHWANN CELL; SPINAL CORD; SPINAL CORD FUNCTION; SPINAL GANGLION; VIRUS INFECTION;

ANIMALIA; MURINAE; VERTEBRATA;

EID: 77956507890     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.001958     Document Type: Note

References (60)

1. Aguirre, A. A., Chittajallu, R., Belachew, S. and Gallo, V. (2004). NG2-expressing cells in the subventricular zone are type C-like cells and contribute to interneuron generation in the postnatal hippocampus. J. Cell Biol. 165, 575-589. (Pubitemid 38679622)
2. Arnett, H. A., Fancy, S. P., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. and Stiles, C. D. (2004). bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science 306, 2111-2115.
3. Bando, Y., Takakusaki, K., Ito, S., Terayama, R., Kashiwayanagi, M. and Yoshida, S. (2008). Differential changes in axonal conduction following CNS demyelination in two mouse models. Eur. J. Neurosci. 28, 1731-1742.
4. Bansal, R., Kumar, M., Murray, K., Morrison, R. S. and Pfeiffer, S. E. (1996). Regulation of FGF receptors in the oligodendrocyte lineage. Mol. Cell. Neurosci. 7, 263-275.
5. Baxter, A. G. (2007). The origin and application of experimental autoimmune encephalomyelitis. Nat. Rev. Immunol. 7, 904-912. (Pubitemid 350006239)
6. Ben-Hur, T. and Goldman, S. A. (2008). Prospects of cell therapy for disorders of myelin. Ann. NY Acad. Sci. 1142, 218-249.
7. Bielekova, B. and Becker, B. L. (2010). Monoclonal antibodies in MS: mechanisms of action. Neurology 74, S31-S40.
8. Birgbauer, E., Rao, T. S. and Webb, M. (2004). Lysolecithin induces demyelination in vitro in a cerebellar slice culture system. J. Neurosci. Res. 78, 157-166. (Pubitemid 39313787)
9. Blakemore, W. F. and Franklin, R. J. (2008). Remyelination in experimental models of toxin-induced demyelination. Curr. Top. Microbiol. Immunol. 318, 193-212.
10. Blewett, M. M. (2010). Lipid autoreactivity in multiple sclerosis. Med. Hypotheses 74, 433-442.
11. Brockschnieder, D., Pechmann, Y., Sonnenberg-Riethmacher, E. and Riethmacher, D. (2006). An improved mouse line for Cre-induced cell ablation due to diphtheria toxin A, expressed from the Rosa26 locus. Genesis 44, 322-327. (Pubitemid 44182448)
12. Chen, Z., Ma, Z., Wang, Y., Li, Y., Lu, H., Fu, S., Hang, Q. and Lu, P. H. (2010). Oligodendrocyte-spinal cord explant co-culture: an in vitro model for the study of myelination. Brain Res. 1309, 9-18.
13. Coetzee, T., Fujita, N., Dupree, J., Shi, R., Blight, A., Suzuki, K. and Popko, B. (1996). Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability. Cell 86, 209-219. (Pubitemid 26286104)
14. Coles, A. J., Compston, D. A., Selmaj, K. W., Lake, S. L., Moran, S., Margolin, D. H., Norris, K. and Tandon, P. K. (2008). Alemtuzumab vs. interferon beta-1a in early multiple sclerosis. N. Engl. J. Med. 359, 1786-1801.
15. Dhib-Jalbut, S. and Marks, S. (2010). Interferon-beta mechanisms of action in multiple sclerosis. Neurology 74, S17-S24.
16. Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H. and Barres, B. A. (2009). Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination. Cell 138, 172-185.
17. Fex Svenningsen, A., Shan, W. S., Colman, D. R. and Pedraza, L. (2003). Rapid method for culturing embryonic neuron-glial cell cocultures. J. Neurosci. Res. 72, 565-573.
18. Fortin, D., Rom, E., Sun, H., Yayon, A. and Bansal, R. (2005). Distinct fibroblast growth factor (FGF)/FGF receptor signaling pairs initiate diverse cellular responses in the oligodendrocyte lineage. J. Neurosci. 25, 7470-7479.
19. Furlan, R., Cuomo, C. and Martino, G. (2009). Animal models of multiple sclerosis. Methods Mol. Biol. 549, 157-173.
20. Giovannoni, G., Comi, G., Cook, S., Rammohan, K., Rieckmann, P., Soelberg Sorensen, P., Vermersch, P., Chang, P., Hamlett, A., Musch, B. et al. (2010). A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N. Engl. J. Med. 362, 416-426.
21. Holtmaat, A. and Svoboda, K. (2009). Experience-dependent structural synaptic plasticity in the mammalian brain. Nat. Rev. Neurosci. 10, 647-658.
22. Kassmann, C. M. and Nave, K. A. (2008). Oligodendroglial impact on axonal function and survival-a hypothesis. Curr. Opin. Neurol. 21, 235-241.
23. Kipp, M., Clarner, T., Dang, J., Copray, S. and Beyer, C. (2009). The cuprizone animal model: new insights into an old story. Acta Neuropathol. 118, 723-736.
24. Kriesel, J. D. and Sibley, W. A. (2005). The case for rhinoviruses in the pathogenesis of multiple sclerosis. Mult. Scler. 11, 1-4.
25. Krishnamoorthy, G. and Wekerle, H. (2009). EAE: an immunologist's magic eye. Eur. J. Immunol. 39, 2031-2035.
26. Lako, M., Armstrong, L. and Stojkovic, M. (2010). Induced pluripotent stem cells: it looks simple but can looks deceive? Stem Cells 28, 845-850.
27. Li, H. and Richardson, W. (2008). The evolution of Olig genes and their roles in myelination. Neuron Glia Biol. 4, 129-135.
28. Lindner, M., Fokuhl, J., Linsmeier, F., Trebst, C. and Stangel, M. (2009). Chronic toxic demyelination in the central nervous system leads to axonal damage despite remyelination. Neurosci. Lett. 453, 120-125.
29. Low, H. P., Greco, B., Tanahashi, Y., Gallant, J., Jones, S. N., Billings-Gagliardi, S., Recht, L. D. and Schwartz, W. J. (2009). Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice. J. Neurol. Sci. 276, 133-137.
30. Lunn, K. F., Fanarraga, M. L. and Duncan, I. D. (1995). Myelin mutants: new models and new observations. Microsc. Res. Tech. 32, 183-203.
31. McCoy, P. A., Huang, H. S. and Philpot, B. D. (2009). Advances in understanding visual cortex plasticity. Curr. Opin. Neurobiol. 19, 298-304.
32. Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M. et al. (2005). LINGO-1 negatively regulates myelination by oligodendrocytes. Nat. Neurosci. 8, 745-751.
33. Mi, S., Hu, B., Hahm, K., Luo, Y., Kam Hui, E. S., Yuan, Q., Wong, W. M., Wang, L., Su, H., Chu, T. H. et al. (2007). LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis. Nat. Med. 10, 1228-1233.
34. Mi, S., Miller, R. H., Tang, W., Lee, X., Hu, B., Wu, W., Zhang, Y., Shields, C. B., Miklasz, S., Shea, D. et al. (2009). Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells. Ann. Neurol. 65, 304-315.
35. Miller, R. H. (2002). Regulation of oligodendrocyte development in the vertebrate CNS. Prog. Neurobiol. 67, 451-467.
36. Mix, E., Meyer-Rienecker, H. and Zettl, U. K. (2008). Animal models of multiple sclerosis for the development and validation of novel therapies-potential and limitations. J. Neurol. 255, 7-14.
37. Notterpek, L. M., Bullock, P. N., Malek-Hedayat, S., Fisher, R. and Rome, L. H. (1993). Myelination in cerebellar slice cultures: development of a system amenable to biochemical analysis. J. Neurosci. Res. 36, 621-634.
38. Oksenberg, J. R., Baranzini, S. E., Sawcer, S. and Hauser, S. L. (2008). The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat. Rev. Genet. 9, 516-526.
39. Orentas, D. M. and Miller, R. H. (1996). The origin of spinal cord oligodendrocytes is dependent on local influences from the notochord. Dev. Biol. 177, 43-53.
40. Paivalainen, S., Nissinen, M., Honkanen, H., Lahti, O., Kangas, S. M., Peltonen, J., Peltonen, S. and Heape, A. M. (2008). Myelination in mouse dorsal root ganglion/Schwann cell cocultures. Mol. Cell Neurosci. 37, 568-578.
41. Prineas, J. W. (1985). The neuropathology of multiple sclerosis. In Handbook of Clinical Neurology (ed. J. C. Koestier). Amsterdam: Elsevier.
42. Pringle, N. P., Yu, W., Guthrie, S., Roelink, H., Lumsden, A., Peterson, A. C. and Richardson, W. D. (1996). Determination of neuroepithelial cell fate: induction of the oligodendrocyte lineage by ventral midline cells and sonic hedgehog. Dev. Biol. 177, 30-42.
43. Racke, M. K., Lovett-Racke, A. E. and Karandikar, N. J. (2010). The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology 1, S25-S30.
44. Raine, C. S. (1984). Biology of disease. The analysis of autoimmune demyelination: its impact upon multiple sclerosis. Lab. Invest. 50, 608-635.
45. Rammohan, K. W. and Shoemaker, J. (2010). Emerging multiple sclerosis oral therapies. Neurology 74, S47-S53.
46. Richardson, W. D., Pringle, N., Mosley, M. J., Westermark, B. and Dubois-Dalcq, M. (1988). A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 53, 309-319.
47. Rivers, L. E., Young, K. M., Rizzi, M., Jamen, F., Psachoulia, K., Wade, A., Kessaris, N. and Richardson, W. D. (2008). PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice. Nat. Neurosci. 11, 1392-1401.
48. Rowitch, D. (2004). Glial specification in the vertebrate neural tube. Nat. Rev. Neurosci. 5, 409-419.
49. Salvetti, M., Giovannoni, G. and Aloisi, F. (2009). Epstein-Barr virus and multiple sclerosis. Curr. Opin. Neurol. 22, 201-206.
50. Skripuletz, T., Bussmann, J. H., Gudi, V., Koutsoudaki, P. N., Pul, R., Moharregh- Khiabani, D., Lindner, M. and Stangel, M. (2010). Cerebellar cortical demyelination in the murine cuprizone model. Brain Pathol. 20, 301-312.
51. Talbott, J. F., Cao, Q., Bertram, J., Nkansah, M., Benton, R. L., Lavik, E. and Whittemore, S. R. (2007). CNTF promotes the survival and differentiation of adult spinal cord-derived oligodendrocyte precursor cells in vitro but fails to promote remyelination in vivo. Exp. Neurol. 204, 485-489.
52. Thomson, C. E., Hunter, A. M., Griffiths, I. R., Edgar, J. M. and McCulloch, M. C. (2006). Murine spinal cord explants: a model for evaluating axonal growth and myelination in vitro. J. Neurosci. Res. 84, 1703-1715.
53. Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mork, S. and Bo, L. (1998). Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338, 278- 285.
54. Tsai, H.-H., Tessier-Lavinge, M. and Miller, R. H. (2003). Netrin I mediates spinal cord oligodendrocyte precursor dispersal. Development 130, 2095-2105.
55. Vollmer, T., Stewart, T. and Baxter, N. (2010). Mitoxantrone and cytotoxic drugs' mechanisms of action. Neurology 74, S41-S46.
56. Wang, S., Sdrulla, A. D., diSibio, G., Bush, G., Nofziger, D., Hicks, C., Weinmaster, G. and Barres, B. A. (1998). Notch receptor activation inhibits oligodendrocyte differentiation. Neuron 21, 63-75.
57. Wang, Y., Wu, C., Caprariello, A. V., Somoza, E., Zhu, W., Wang, C. and Miller, R. H. (2009). In vivo quantification of myelin changes in the vertebrate nervous system. J. Neurosci. 29, 14663-14669.
58. Wang, Z., Colognato, H. and Ffrench-Constant, C. (2007). Contrasting effects of mitogenic growth factors on myelination in neuron-oligodendrocyte co-cultures. Glia 55, 537-545. (Pubitemid 46383183)
59. Watkins, T. A., Emery, B., Mulinyawe, S. and Barres, B. A. (2008). Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system. Neuron 60, 555-569.
60. Windrem, M. S., Schanz, S. J., Guo, M., Tian, G. F., Washco, V., Stanwood, N., Rasband, M., Roy, N. S., Nedergaard, M., Havton, L. A. et al. (2008). Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse. Cell Stem Cell 2, 553-565. (Pubitemid 351729215)