Paradoxical association of C-Reactive protein with endothelial function in rheumatoid arthritis

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Holmes, Michael V ^a   Jiang, Benyu ^a   McNeill, Karen ^a   Wong, Melinda ^a,c   Oakley, Stephen P ^b,d   Kirkham, Bruce ^b   Chowienczyk, Phil J ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c ST VINCENT S HOSPITAL   (Australia)

^d Royal Newcastle Centre   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; GOLD; HYDROXYCHLOROQUINE; LEFLUNOMIDE; METHOTREXATE; NITRIC OXIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SALAZOSULFAPYRIDINE; PROTECTIVE AGENT;

ADRENERGIC ACTIVITY; ADULT; ARTERIAL WALL THICKNESS; ARTERIOSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PULSE WAVE; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; CASE CONTROL STUDY; INTIMA; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PULSATILE FLOW; TUNICA MEDIA; VASCULAR ENDOTHELIUM; VASODILATATION;

ADULT; ARTERIOSCLEROSIS; ARTHRITIS, RHEUMATOID; ATHEROSCLEROSIS; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; HUMANS; MALE; MIDDLE AGED; NITRIC OXIDE; PROTECTIVE AGENTS; PULSATILE FLOW; TUNICA INTIMA; TUNICA MEDIA; VASODILATION;

EID: 77956497350     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010242     Document Type: Article

References (44)

1. Jarvisalo MJ, Harmoinen A, Hakanen M, Paakkunainen U, Viikari J, et al. (2002) Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol 22: 1323-1328.
2. Vitale C, Cerquetani E, Wajngarten M, Leonardo F, Silvestri A, et al. (2003) In patients with coronary artery disease endothelial function is associated with plasma levels of C-reactive protein and is improved by optimal medical therapy. Ital Heart J 4: 627-632.
3. Kuller LH, Tracy RP, Shaten J, Meilahn EN (1996) Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. Am J Epidemiol 144: 537-547.
4. Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 336: 973-979.
5. Cook NR, Buring JE, Ridker PM (2006) The effect of including C-reactive protein in cardiovascular risk prediction models for women. Ann Intern Med 145: 21-29.
6. Ridker PM, Glynn RJ, Hennekens CH (1998) C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction. Circulation 97: 2007-2011.
7. Devaraj S, Xu DY, Jialal I (2003) C-reactive protein increases plasminogen activator inhibitor-1 expression and activity in human aortic endothelial cells: implications for the metabolic syndrome and atherothrombosis. Circulation 107: 398-404.
8. Pasceri V, Willerson JT, Yeh ET (2000) Direct proinflammatory effect of Creactive protein on human endothelial cells. Circulation 102: 2165-2168.
9. Ridker PM, Danielson E, Fonseca FA, Genest J, Gotto AM, Jr., et al. (2008) Rosuvastatin to prevent vascular events in men and women with elevated Creactive protein. N Engl J Med 359: 2195-2207.
10. Schunkert H, Samani NJ (2008) Elevated C-reactive protein in atherosclerosis- chicken or egg? N Engl J Med 359: 1953-1955.
11. Solomon DH, Karlson EW, Rimm EB, Cannuscio CC, Mandl LA, et al. (2003) Cardiovascular morbidity and mortality in women diagnosed with rheumatoid arthritis. Circulation 107: 1303-1307.
12. Graf J, Scherzer R, Grunfeld C, Imboden J (2009) Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis. PLoS One 4: e6242.
13. Rossi R, Nuzzo A, Origliani G, Modena MG (2008) Prognostic role of flowmediated dilation and cardiac risk factors in post-menopausal women. J Am Coll Cardiol 51: 997-1002.
14. Shimbo D, Grahame-Clarke C, Miyake Y, Rodriguez C, Sciacca R, et al. (2007) The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis 192: 197-203.
15. Takase B, Matsushima Y, Uehata A, Ishihara M, Kurita A (2008) Endothelial dysfunction, carotid artery plaque burden, and conventional exercise-induced myocardial ischemia as predictors of coronary artery disease prognosis. Cardiovasc Ultrasound 6: 61.
16. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM (2007) Brachial flowmediated dilation predicts incident cardiovascular events in older adults: the Cardiovascular Health Study. Circulation 115: 2390-2397.
17. Hodis HN, Mack WJ, LaBree L, Selzer RH, Liu CR, et al. (1998) The role of carotid arterial intima-media thickness in predicting clinical coronary events. Ann Intern Med 128: 262-269.
18. Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M (2007) Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 115: 459-467.
19. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, et al. (1999) Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 340: 14-22.
20. Matsushima Y, Takase B, Uehata A, Kawano H, Yano K, et al. (2007) Comparative predictive and diagnostic value of flow-mediated vasodilation in the brachial artery and intima media thickness of the carotid artery for assessment of coronary artery disease severity. Int J Cardiol 117: 165-172.
21. Blacher J, Guerin AP, Pannier B, Marchais SJ, Safar ME, et al. (1999) Impact of aortic stiffness on survival in end-stage renal disease. Circulation 99: 2434-2439.
22. Cruickshank K, Riste L, Anderson SG, Wright JS, Dunn G, et al. (2002) Aortic pulse-wave velocity and its relationship to mortality in diabetes and glucose intolerance: an integrated index of vascular function? Circulation 106: 2085-2090.
23. Laurent S, Boutouyrie P, Asmar R, Gautier I, Laloux B, et al. (2001) Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients. Hypertension 37: 1236-1241.
24. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, et al. (2006) Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study. Circulation 113: 657-663.
25. Sutton-Tyrrell K, Najjar SS, Boudreau RM, Venkitachalam L, Kupelian V, et al. (2005) Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults. Circulation 111: 3384-3390.
26. Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, et al. (2006) Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation 113: 664-670.
27. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, et al. (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31: 315-324.
28. Celermajer DS, Sorensen KE, Gooch VM, Spiegelhalter DJ, Miller OI, et al. (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 340: 1111-1115.
29. Elliott P, Chambers JC, Zhang W, Clarke R, Hopewell JC, et al. (2009) Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease. JAMA 302: 37-48.
30. Casas JP, Shah T, Cooper J, Hawe E, McMahon AD, et al. (2006) Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol 35: 922-931.
31. Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, et al. (2008) Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med 359: 1897-1908.
32. Lawlor DA, Harbord RM, Timpson NJ, Lowe GDO, Rumley A, et al. (2008) The Association of C-Reactive Protein and, italic.CRP,/italic. Genotype with Coronary Heart Disease: Findings from Five Studies with 4,610 Cases amongst 18,637 Participants. PLoS One 3: e3011.
33. Kardys I, de Maat MP, Uitterlinden AG, Hofman A, Witteman JC (2006) Creactive protein gene haplotypes and risk of coronary heart disease: the Rotterdam Study. Eur Heart J 27: 1331-1337.
34. Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115: 1285-1295.
35. Joannides R, Haefeli WE, Linder L, Richard V, Bakkali EH, et al. (1995) Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo. Circulation 91: 1314-1319.
36. Landmesser U, Hornig B, Drexler H (2004) Endothelial function: a critical determinant in atherosclerosis? Circulation 109: II27-33.
37. Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43: 109-142.
38. Forstermann U, Munzel T (2006) Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 113: 1708-1714.
39. Clapp BR, Hirschfield GM, Storry C, Gallimore JR, Stidwill RP, et al. (2005) Inflammation and endothelial function: direct vascular effects of human Creactive protein on nitric oxide bioavailability. Circulation 111: 1530-1536.
40. Van Doornum S, McColl G, Jenkins A, Green DJ, Wicks IP (2003) Screening for atherosclerosis in patients with rheumatoid arthritis: comparison of two in vivo tests of vascular function. Arthritis Rheum 48: 72-80.
41. Goodson NJ, Symmons DP, Scott DG, Bunn D, Lunt M, et al. (2005) Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year followup study of a primary care-based inception cohort. Arthritis Rheum 52: 2293-2299.
42. Gonzalez-Gay MA, Gonzalez-Juanatey C, Lopez-Diaz MJ, Pineiro A, Garcia- Porrua C, et al. (2007) HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. Arthritis Rheum 57: 125-132.
43. Ridker PM, Solomon DH (2009) Should patients with rheumatoid arthritis receive statin therapy? Arthritis Rheum 60: 1205-1209.
44. Pereira IA, Laurindo IM, Zimmermann AF, Werner Castro GR, Mello F, et al. (2009) Single measurements of C-reactive protein and disease activity scores are not predictors of carotid atherosclerosis in rheumatoid arthritis patients. Acta Reumatol Port 34: 58-64.