A novel composite construct increases the vascularization potential of PEG hydrogels through the incorporation of large fibrin ribbons

Journal of Biomedical Materials Research - Part A

Volumn 95, Issue 1, 2010, Pages 283-293

  Mason, Mariah N ^a   Mahoney, Melissa J ^a  

^a UCB 450   (United States)

Author keywords

Coculture; Endothelial cells; Fibrin ribbons; PEG hydrogel; Scaffold vascularization

Indexed keywords

BULK MODIFICATION; CELL POPULATIONS; CELL TYPES; CO-CULTURES; COCULTURE; COMPOSITE SCAFFOLDS; EMPTY SPACE; FIBRIN RIBBONS; MATERIAL PROPERTY; PANCREATIC ISLET; PEG HYDROGEL; POROUS STRUCTURES; POTENTIAL MECHANISM; SCAFFOLD MATERIALS; TISSUE-ENGINEERED CONSTRUCTS; VASCULARIZATION; VASCULARIZE; VASCULATURE;

BIOLOGICAL MATERIALS; BIOMATERIALS; CELL CULTURE; CELL PROLIFERATION; ETHYLENE; ETHYLENE GLYCOL; HYDROGELS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SCAFFOLDS; SELF ASSEMBLY;

ENDOTHELIAL CELLS;

FIBRIN; FIBRIN RIBBON; MACROGOL; TISSUE SCAFFOLD; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE;

ANASTOMOSIS; ANGIOGENESIS; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL ENCAPSULATION; CELL MIGRATION; CELL POPULATION; CELL SURFACE; CELL TRANSPLANTATION; COCULTURE; COMPOSITE MATERIAL; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HYDROGEL; MOUSE; NONHUMAN; PANCREAS ISLET CELL; VASCULARIZATION; ANIMAL; CELL COUNT; CELL CULTURE; CELL STRAIN 3T3; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; FIBROBLAST; PANCREAS ISLET; PROTEIN SECONDARY STRUCTURE; ANIMAL EXPERIMENT; ANIMAL TISSUE; CELL TYPE; ENCAPSULATION; IMMUNOHISTOCHEMISTRY; TISSUE ENGINEERING;

3T3 CELLS; ANIMALS; CELL COUNT; CELLS, CULTURED; COCULTURE TECHNIQUES; ENDOTHELIAL CELLS; FIBRIN; FIBROBLASTS; HUMANS; HYDROGELS; ISLETS OF LANGERHANS; MICE; MICROSCOPY, CONFOCAL; NEOVASCULARIZATION, PHYSIOLOGIC; POLYETHYLENE GLYCOLS; PROTEIN STRUCTURE, SECONDARY; TISSUE SCAFFOLDS;

EID: 77956482405     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32825     Document Type: Article

References (32)

1. Langer R, Vacanti JP. Tissue engineering. Science 1993;260:920-926.
2. Mason MN, Arnold CA, Mahoney MJ. Entrapped collagen type 1 promotes differentiation of embryonic pancreatic precursor cells into glucose-responsive beta-cells when cultured in three-dimensional PEG hydrogels. Tissue Eng Part A 2009;15:3799-3808.
3. Burdick JA, Anseth KS. Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials 2002;23:4315-4323.
4. Mann BK, Gobin AS, Tsai AT, Schmedlen RH, West JL. Smooth muscle cell growth in photopolymerized hydrogels with cell adhesive and proteolytically degradable domains: Synthetic ECM analogs for tissue engineering. Biomaterials 2001;22:3045-3051.
5. Bryant SJ, Anseth KS. Controlling the spatial distribution of ECM components in degradable PEG hydrogels for tissue engineering cartilage. J Biomed Mater Res A 2003;64:70-79.
6. Mahoney MJ, Anseth KS. Contrasting effects of collagen and bFGF-2 on neural cell function in degradable synthetic PEG hydrogels. J Biomed Mater Res A 2007;81:269-278.
7. Lee DY, Nam JH, Byun Y. Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocyte and cytokine attacks. J Biomater Sci Polym Ed 2004;15:753-766. (Pubitemid 38923493)
8. Kaully T, Kaufman-Francis K, Lesman A, Levenberg S. Vascularization-the conduit to viable engineered tissues. Tissue Eng Part B Rev 2009;15:159-169.
9. Tannock IF. Oxygen diffusion and the distribution of cellular radiosensitivity in tumours. Br J Radiol 1972;45:515-524.
10. Lehmann R, Zuellig RA, Kugelmeier P, Baenninger PB, Moritz W, Perren A, Clavien PA, Weber M, Spinas GA. Superiority of small islets in human islet transplantation. Diabetes 2007;56:594-603.
11. Ford MC, Bertram JP, Hynes SR, Michaud M, Li Q, Young M, Segal SS, Madri JA, Lavik EB. A macroporous hydrogel for the coculture of neural progenitor and endothelial cells to form functional vascular networks in vivo. Proc Natl Acad Sci USA 2006;103:2512-2517.
12. Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A 2003;65:489-497. (Pubitemid 38075880)
13. Almany L, Seliktar D. Biosynthetic hydrogel scaffolds made from fibrinogen and polyethylene glycol for 3D cell cultures. Biomaterials 2005;26:2467-2477.
14. Nyqvist D, Kohler M, Wahlstedt H, Berggren PO. Donor islet endothelial cells participate in formation of functional vessels within pancreatic islet grafts. Diabetes 2005;54:2287-2293.
15. Laschke MW, Rucker M, Jensen G, Carvalho C, Mulhaupt R, Gellrich NC, Menger MD. Improvement of vascularization of PLGA scaffolds by inosculation of in situ-preformed functional blood vessels with the host microvasculature. Ann Surg 2008;248:939-948.
16. Mason MN, Mahoney MJ. Selective beta-cell differentiation of dissociated embryonic pancreatic precursor cells cultured in synthetic polyethylene glycol hydrogels. Tissue Eng Part A 2009;15:1343-1352.
17. Sawhney A, Pathak C, Hubbell J. Bioerodible hydrogels based on photopolymerized poly(ethylene glycol)-co-poly(alpha-hydroxy acid) diacrylate macromers. Macromolecules 1993;26:581-587.
18. Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev 2007;21:131-142.
19. Bouton MC, Venisse L, Richard B, Pouzet C, Arocas V, Jandrot-Perrus M. Protease nexin-1 interacts with thrombomodulin and modulates its anticoagulant effect. Circ Res 2007;100:1174-1181. (Pubitemid 46684130)
20. Kiran MS, Sameer Kumar VB, Viji RI, Sudhakaran PR. Temporal relationship between MMP production and angiogenic process in HUVECs. Cell Biol Int 2006;30:704-713.
21. Ratel D, Mihoubi S, Beaulieu E, Durocher Y, Rivard GE, Gingras D, Beliveau R. VEGF increases the fibrinolytic activity of endothelial cells within fibrin matrices: Involvement of VEGFR-2, tissue type plasminogen activator and matrix metalloproteinases. Thromb Res 2007;121:203-212.
22. Weber LM, Lopez CG, Anseth KS. Effects of PEG hydrogel crosslinking density on protein diffusion and encapsulated islet survival and function. J Biomed Mater Res A 2009;90:720-729.
23. Rastellini C, Zuber V, Perrone G, Cicalese L, Gaudio E, Benedetti E, Morini S Revascularization and remodeling of transplanted pancreatic islets. Transplant Proc 2001;33:658-659.
24. Chen X, Aledia AS, Ghajar CM, Griffith CK, Putnam AJ, Hughes CC, George SC. Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature. Tissue Eng Part A 2009;15:1363-1371.
25. Laschke MW, Rucker M, Jensen G, Carvalho C, Mulhaupt R, Gellrich NC, Menger MD. Incorporation of growth factor containing Matrigel promotes vascularization of porous PLGA scaffolds. J Biomed Mater Res A 2008;85:397-407.
26. Sun Q, Chen RR, Shen Y, Mooney DJ, Rajagopalan S, Grossman PM. Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb. Pharm Res 2005;22:1110-1116.
27. Black AF, Berthod F, L'Heureux N, Germain L, Auger FA. In vitro reconstruction of a human capillary-like network in a tissue-engineered skin equivalent. Faseb J 1998;12:1331-1340.
28. Wu F, Jagir M, Powell JS. Long-term correction of hyperglycemia in diabetic mice after implantation of cultured human cells derived from fetal pancreas. Pancreas 2004;29:e23-e29.
29. Beattie GM, Montgomery AM, Lopez AD, Hao E, Perez B, Just ML, Lakey JR, Hart ME, Hayek A. A novel approach to increase human islet cell mass while preserving beta-cell function. Diabetes 2002;51:3435-3439.
30. Fournier N, Doillon CJ. Biological molecule-impregnated polyester: An in vivo angiogenesis study. Biomaterials 1996;17:1659-1665. (Pubitemid 26278973)
31. Hall H. Modified fibrin hydrogel matrices: Both, 3D-scaffolds and local and controlled release systems to stimulate angiogenesis. Curr Pharmaceut Des 2007;13:3597-3607.
32. Torio-Padron N, Borges J, Momeni A, Mueller MC, Tegtmeier FT, Stark GB. Implantation of VEGF transfected preadipocytes improves vascularization of fibrin implants on the cylinder chorioallantoic membrane (CAM) model. Minim Invasive Ther Allied Technol 2007;16:155-162.