A new amido phosphonate derivative of carboxymethylcellulose with an osteogenic activity and which is capable of interacting with any Ti surface

Journal of Biomedical Materials Research - Part A

Volumn 95, Issue 1, 2010, Pages 58-67

  Barbucci, Rolando ^a,b   Arturoni, Enrico ^a   Panariello, Giuseppe ^b   Di Canio, Clara ^a  

^a UNIVERSITY OF SIENA   (Italy)

^b BIOSUMA srl   (Italy)

Author keywords

Amidophosphonated carboxymethylcellulose; Coated titanium implants; Osteogenic activity

Indexed keywords

ACTIVATING AGENTS; ADHESION ANALYSIS; AFM; AMIDE BOND; ATR FTIR; CARBODIIMIDES; CARBOXY METHYLCELLULOSE; CARBOXYLIC GROUP; CELL DIFFERENTIATION; COATED TITANIUM; IMPLANT SURFACE; IN-VITRO; NORMAL HUMAN OSTEOBLASTS; OSTEOGENIC ACTIVITY; PHOSPHONATES; PHOSPHONIC ACIDS; POLYMER BONDING; POTENTIOMETRIC TITRATIONS; SEM; TITANIA; TITANIA SURFACES; TITANIUM SURFACES; TOF-SIMS ANALYSIS;

ADHESION; AMIDES; CARBOXYLIC ACIDS; CELL PROLIFERATION; ORGANIC ACIDS; OSTEOBLASTS; PLASTIC COATINGS; POLYMER FILMS; POLYMERS; SECONDARY ION MASS SPECTROMETRY; TITANIUM; TITANIUM DIOXIDE; TITRATION;

SURFACE MORPHOLOGY;

AMIDE; AMINE; BICARBONATE; CARBOXYLIC ACID DERIVATIVE; CARBOXYMETHYLCELLULOSE; CYANAMIDE; NANOCOATING; PHOSPHONIC ACID DERIVATIVE; POLYMER; POLYSACCHARIDE; TITANIUM; TITANIUM DIOXIDE; 2 AMINOETHYLPHOSPHONIC ACID; CARBOXYLIC ACID; ALKALINE PHOSPHATASE;

ARTICLE; ATOMIC FORCE MICROSCOPY; BIOLOGICAL ACTIVITY; BONE DEVELOPMENT; CELL ADHESION; CELL DIFFERENTIATION; CELL STRUCTURE; CHEMICAL BOND; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMPLANT; INFRARED SPECTROSCOPY; MOLECULAR INTERACTION; OSTEOBLAST; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; POTENTIOMETRIC TITRATION; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; SYNTHESIS; VISCOSITY; CELL PROLIFERATION; CHEMICAL INTERACTION; DRUG SYNTHESIS; IN VITRO STUDY; NORMAL HUMAN; TIME OF FLIGHT MASS SPECTROMETRY; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; ENZYMOLOGY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUTION AND SOLUBILITY; TEMPERATURE; ULTRASTRUCTURE;

ALKALINE PHOSPHATASE; CARBOXYMETHYLCELLULOSE SODIUM; CELL PROLIFERATION; CELLS, CULTURED; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSCOPY, ATOMIC FORCE; OSTEOBLASTS; OSTEOGENESIS; PHOSPHONIC ACIDS; SOLUTIONS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TEMPERATURE; TITANIUM; VISCOSITY;

EID: 77956477721     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.32757     Document Type: Article

References (23)

1. Schwartz J, Avaltroni MJ, Danahy MP, Silverman BM, Hanson EL, Schawarzbauer JE, Midwood KS, Gawalt ES. Cell attachment and spreading on metal implant materials. Mater Sci Eng C 2003;23:395-400. (Pubitemid 36211433)
2. Wermelin K, Aspenberg P, Linderbäck P, Tengvall P. Bisphosphonate coating on titanium screws increases mechanical fixation in rat tibia after two weeks. J Biomed Mater Res A 2008;86:220-227.
3. Yu NY, Ruys AJ, Zenios M, Godfrey C, McDonald M, Kiely P, Mikulec K, Little DG, Schindeler A. Bisphosphonate-laden acrylic bone cement: Mechanical properties, elution performance, and in vivo activity. J Biomed Mater Res B Appl Biomater 2008;87:482-491.
4. Fleisch H. Bisphosphonates: A new class of drugs in diseases of bone and calcium metabolism. Cancer Res 1989;116:1-28.
5. Russell RCG, Miihlbauer RC, Bisaz S, Wiilliams DA, Fleisch H. The influence of pyrophosphate, condensed, phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats. Calcif Tissue Res 1970;6:183-186.
6. Reitsma PH, Teitelbaum SL, Bijvoet OLM, Kahn AJ. Differential action of the bisphosphonates (3-amino-1-hydroxypropylidene)-1,1-bisphosphonate (APD) and disodium dichloromethylidene bisphosphonate (CI2MDP) on rat macrophage-mediated bone resorption in vitro. J Clin Invest 1982;70:927-933.
7. Monkkonen H, Auriola S, Lehenkari P, Kellinsalmi M, Hassinen IE, Vepsalainen J, Monkkonen J. A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen-containing bisphosphonates. Br J Pharmacol 2006;147:437-445.
8. Gemeinhart RA, Bare CM, Haasch RT, Gemeinhart EJ. Osteoblast-like cell attachment to and calcification of novel phosphonate-containing polymeric substrates. J Biomed Mater Res A 2006;78:433-440.
9. Chaterji S, Gemeinhart RA. Enhanced osteoblast-like cell adhesion and proliferation using sulphonate-bearing polymeric scaffolds. J Biomed Mater Res A 2007;83:990-998. (Pubitemid 350231759)
10. Baker KC, Anderson MA, Oehlke SA, Astashkina AI, Haikio DC, Drelich J, Donahue SW. Growth, characterization and biocompatibility of bone-like calcium phosphate layers biomimetically deposited on metallic substrata. Mater Sci Eng C 2006;26:1351-1360.
11. Zoulalian V, Monge S, Zürcher S, Textor M, Robin JJ, Tosatti S. Functionalization of titanium oxide surfaces by means of poly (alkyl-phosphonates). J Phys Chem B 2006;110:25603-25605.
12. Adden N, Gamble LG, Castner DG, Hoffmann A, Gross G, Menzel H. Synthesis and characterization of biocompatible polymer interlayers on titanium implant materials. Biomacromolecules 2006;7:2552-2559.
13. Barbucci R, Leone G, Monici M, Pantalone D, Fini M, Giardino R. The effect of amidic moieties on polysaccharides: Evaluation of the physicochemical and biological properties of amidic carboxymethylcellulose (CMCA) in the form of linear polumer and hydrogel. J Mater Chem 2005;15:2234-2241.
14. Middleton JC, Cummings DF, McCormick CL. Rheological properties of hydrophobically modified acrylamide-based polyelectrolytes. In: Shalaby SW, McCormick CL, Butler GB, editors. Water-Soluble Polymers: Synthesis, Solution Properties and Applications. Washington, DC: ACS Symposium Series 497, American Chemical Society; 1991. p 338-348.
15. Gao W, Dickinson L, Grozinger C, Morin FG, Reven L. Self-assembled monolayers of alkylphosphonic acids on metal oxides. Langmuir 1996;12:6429-6435. (Pubitemid 126637964)
16. Randon J, Blanc P, Paterson P. Modification of ceramic membrane surfaces using phosphoric-acid and alkyl phosphoric-acids and its effect on ultrafiltration of BSA protein. J Membr Sci 1995;98:119.
17. Bech GR Jr, Zerler B, Moran E. Phosphate is a specific signal for induction of osteopontin gene expression. Proc Natl Acad Sci USA 2000;97:8352-8357.
18. Lu G, Bernasek SL, Schwartz J. Oxidation of a polycrystalline titanium surface by oxygen and water. J Surf Sci 2000;458:80-90.
19. Gawalt ES, Brault-Rios K, Dixon MS, Tang DC, Schwartz J. Self-assembly and bonding of alkanephosphonic acids on the native oxide surface of titanium. Langmuir 2001;17:6743-6745.
20. Barbucci R, Magnani A, Lamponi S, Pasqui D, Bryan S. The use of hyaluronan and its sulfated derivative patterned with micrometric scale on glass substrate in melanocyte cell behavior. Biomaterials 2003;24:915-926.
21. Textor M, Sittig C, Frauchinger V, Tosatti S, Brunette DM. Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications. Berlin: Springer-Verlag; 2001. p 171-230.
22. Guerrero G, Mutin P, Vioux A. Anchoring of phosphonate and phosphinate coupling molecules on titania particles. Chem Mater 2001;13:4367-4373. (Pubitemid 33095460)
23. Michelmore A, Gong W, Jenkins P, Ralston J. The interaction of linear polyphosphates with titanium dioxide surfaces. Phys Chem Chem Phys 2000;2:2985-2992.