β2-Glycoprotein I-derived peptides as antigenic structures for the detection of antiphospholipid antibodies

Journal of Thrombosis and Haemostasis

Volumn 8, Issue 9, 2010, Pages 2073-2075

  MuLler C ^a   Thaler, M ^a   Schlichtiger, A ^a   Schreiegg, A ^a   Balling, G ^b   Steigerwald, U ^b   Luppa, P B ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; MONOCLONAL ANTIBODY; PHOSPHOLIPID ANTIBODY;

AMINO ACID SEQUENCE; ANTIGEN STRUCTURE; ANTIPHOSPHOLIPID SYNDROME; AREA UNDER THE CURVE; CRYSTAL STRUCTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; LETTER; PRIORITY JOURNAL; PROTEIN TERTIARY STRUCTURE; RECEIVER OPERATING CHARACTERISTIC;

ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; BIOSENSING TECHNIQUES; CASE-CONTROL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; PEPTIDES; PREGNANCY; SURFACE PLASMON RESONANCE; THROMBOSIS;

EID: 77956476410     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2010.03987.x     Document Type: Letter

References (9)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, Pg G, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006, 4:295-306.
2. Metzger J, von Landenberg P, Kehrel M, Buhl A, Lackner KJ, Luppa PB. Biosensor analysis of beta2-glycoprotein I-reactive autoantibodies: evidence for isotype-specific binding and differentiation of pathogenic from infection-induced antibodies. Clin Chem 2007, 53:1137-43.
3. Lozier J, Takahashi N, Putnam FW. Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci USA 1984, 81:3640-4.
4. Steinkasserer A, Estaller C, Weiss EH, Sim RB, Day AJ. Complete nucleotide and deduced amino acid sequence of human beta 2-glycoprotein I. Biochem J 1991, 277(Pt 2):387-91.
5. Blank M, Shoenfeld Y, Cabilly S, Heldman Y, Fridkin M, Katzir K. Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides. Proc Natl Acad Sci USA 1999, 96:5164-8.
6. Shoenfeld Y, Krause I, Kvapil F, Sulkes J, Lev S, von Landenberg P, Font J, Zaech J, Cervera R, Piette JC, Boffa MC, Khamashta MA, Bertolaccini ML, Hughes GR, Youinou P, Meroni PL, Pengo V, Alves JD, Tincani A, Szegedi G. Prevalence and clinical correlations of antibodies against six beta2-glycoprotein-I-related peptides in the antiphospholipid syndrome. J Clin Immunol 2003, 23:377-83.
7. Kindermann M, George N, Johnsson N, Johnsson K. Covalent and selective immobilization of fusion proteins. J Am Chem Soc 2003, 125:7810-1.
8. Agar C, van Os GM, Morgelin M, Sprenger RR, Marquart JA, Urbanus RT, Derksen RH, Meijers JC, de Groot PG. beta-2-Glycoprotein I can exist in two conformations: implications for our understanding of the antiphospholipid syndrome. Blood 2010
9. Blank M, Krause I, Fridkin M, Keller N, Kopolovic J, Goldberg I, Tobar A, Shoenfeld Y. Bacterial induction of autoantibodies to beta2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome. J Clin Invest 2002, 109:797-804.