Dopaminergic D2 receptors activate PKA to inhibit spinal pelvic-urethra reflex in rats

American Journal of Physiology - Renal Physiology

Volumn 299, Issue 3, 2010, Pages

  Wu, Hsi Chin ^a   Chiu, Chun Hsien ^b   Tung, Kwong Chung ^b   Chen, Gin Den ^c   Peng, Hsien Yu ^d,e   Lin, Tzer Bin ^a,c,d,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b Pediatric Dentistry   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

cAMP; D2 receptor; L135; Q110; Rat; Urethra closure

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMINO ACID RECEPTOR STIMULATING AGENT; AMPA RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYLASPARTIC ACID;

ANIMAL; ANIMAL MODEL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ELECTROMYOGRAPHY; FEMALE; INNERVATION; METABOLISM; PELVIS; PHYSIOLOGY; RAT; REFLEX; SPRAGUE DAWLEY RAT; URETHRA;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE D2 RECEPTOR ANTAGONISTS; ELECTROMYOGRAPHY; EXCITATORY AMINO ACID AGONISTS; FEMALE; MODELS, ANIMAL; N-METHYLASPARTATE; PELVIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, DOPAMINE D2; RECEPTORS, N-METHYL-D-ASPARTATE; REFLEX; URETHRA;

EID: 77956469770     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00090.2010     Document Type: Article

References (31)

1. Brusa L, Petta F, Pisani A, Miano R, Stanzione P, Moschella V, Galati S, Finazzi Agro E. Central acute D2 stimulation worsens bladder function in patients with mild Parkinson's disease. J Urol 175: 205-207, 2006.
2. de Groat WC, Yoshimura N. Pharmacology of the lower urinary tract. Annu Rev Pharmacol Toxicol 4: 691-721, 2001.
3. 3H]SKF 38393, in the rat brain, and spinal cord. Comparison with the distribution of D2 dopamine receptors. Neuroscience 19: 125-137, 1986.
4. Fleetwood-Walker SM, Hope PJ, Mitchell R. Antinociceptive actions of descending dopaminergic tracts on cat, and rat dorsal horn somatosensory neurones. J Physiol 399: 335-348, 1988.
5. Frey U, Huang YY, Kandel ER. Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science 260: 1661-1664, 1993. (Pubitemid 23247151)
6. Greengard P, Allen PB, Nairn AC. Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron 23: 435-447, 1999.
7. Holstege JC, Van Dijken H, Buijs RM, Goedknegt H, Gosens T, Bongers CM. Distribution of dopamine immunoreactive in the rat, cat, and monkey spinal cord. J Comp Neurol 376: 631-652, 1996.
8. Ikeda H, Asai T, Murase K. Robust changes of afferent-induced excitation in the rat spinal dorsal horn after conditioning high-frequency stimulation. J Neurophysiol 83: 2412-2420, 2000.
9. Jay TM. Dopamine: a potential substrate for synaptic plasticity, and memory mechanisms. Prog Neurobiol 69: 375-390, 2003. (Pubitemid 36859925)
10. Kamo I, Cannon TW, Conway DA, Torimoto K, Chancellor MB, de Groat WC, Yoshimura N. The role of bladder-to-urethral reflexes in urinary continence mechanisms in rats. Am J Physiol Renal Physiol 287: F434-F441, 2004.
11. 3 dopamine receptors in rat spinal cord: implications for sensory, and motor function. Neurosci Lett 303: 9-12, 2001.
12. Lin SY, Chen GD, Liao JM, Pan SF, Chen MJ, Chen JC, Peng HY, Ho YC, Ho YC, Huang PC, Lin JJ, Lin TB. Estrogen modulates the spinal N-methyl-D-aspartic acid-mediated pelvic nerve-to-urethra reflex plasticity in rats. Endocrinology 147: 2956-2963, 2006.
13. Lin TB. Dynamic pelvic-pudendal reflex plasticity mediated by glutamate in anesthetized rats. Neuropharmacology 44: 163-170, 2003.
14. McRea-Degueurce A, Milon H. Serotonin, and dopamine afferents to the rat locus coeruleus: a biochemical study after lesioning of the ventral mesencephalic tegmental-A10 region and the raphe dorsalis. Brain Res 263: 344-347, 1983.
15. Nguyen PV, Woo NH. Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog Neurobiol 71: 401-437, 2003.
16. Ogawa T, Seki S, Masuda H, Igawa Y, Nishizawa O, Kuno S, Chancellor MB, de Groat WC, Yoshimura N. Dopaminergic mechanism controlling urethral function in rats. Neurourol Urodyn 25: 480-489, 2006.
17. Peng HY, Chang HM, Lee SD, Huang PC, Chen GD, Lai CH, Lai CY, Chiu CH, Tung KC, Lin TB. TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Am J Physiol Renal Physiol 295: F1324-F1335, 2008.
18. Peng HY, Chen GD, Lai CH, Tung KC, Chang JL, Lin TB. Endogenous ephrinB2 mediates the colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B. Am J Physiol Renal Physiol 298: F109-F117, 2010.
19. A receptor subtypes. Pain 143: 12-20, 2009.
20. Peng HY, Chen GD, Tung KC, Lai CY, Hsien MC, Chiu CH, Lu HT, Liao JM, Lee SD, Lin TB. Colon mustard oil instillation induced cross-organ reflex sensitization on the pelvic-urethra reflex activity in rats. Pain 142: 75-88, 2009.
21. Peng HY, Huang PC, Liao JM, Tung KC, Lee SD, Cheng CL, Shyu JC, Lai CY, Chen GD, Lin TB. Estrous cycle variation of TRPV1-mediated cross-organ sensitization between uterus, and NMDA-dependent pelvic-urethra reflex activity. Am J Physiol Endocrinol Metab 295: E559-E568, 2008.
22. Porreca F, Ossipov MH, Gebhart GF. Chronic pain, and medullary descending facilitation. Trends Neurosci 25: 319-325, 2002. (Pubitemid 34667014)
23. Roche KW, O'Brien RJ, Mammen AL, Bernhardt J, Huganir RL. Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit. Neuron 16: 1179-1188, 1996.
24. Tamae A, Nakatsuka T, Koga K, Kato G, Furue H, Katafuchi T, Yoshimura M. Direct inhibition of substantia gelatinosa neurons in the spinal cord by activation of dopamine D2-like receptors. J Physiol 568: 243-253, 2005.
25. Tsou K, Snyder GL, Greengard P. Nitric oxide/cGMP pathway stimulates phosphorylation of DARPP-32, a dopamine-, and cGMP-regulated phosphoprotein, in the substantia nigra. Proc Natl Acad Sci USA 90: 3462-3465, 1993. (Pubitemid 23111386)
26. UchiyamaT, Sakakibara R, Hattori T, Yamanishi T. Short-term effect of a single levodopa dose on micturition disturbance in Parkinson's disease patients with the wearing-off phenomenon. Mov Disord 18: 573-578, 2003.
27. Vallone D, Ricetti R, Borrelli E. Structure, and function of dopamine receptors. Neurosci Biobehav Rev 24: 125-132, 2000.
28. Van Dijken H, Dijk J, Voom P, Holstege JC. Localization of dopaminergic D2 receptor in the rat spinal cord identified with immunohistochemistry, and in situ hybridization. Eur J Neurosci 8: 621-628, 1996. (Pubitemid 2627008)
29. Yoshimura N, Yoshida O, Sasa M, Takaori S. Dopamine D1 receptor-mediated inhibition of micturition reflex by central dopamine from the substantia nigra. Neurourol Urodyn 11: 535-545, 1992.
30. Yokoyama O, Yoshiyama M, Namiki M, de Groat WC. Glutamatergic, and dopaminergic contributions to rat bladder hyperactivity after cerebral artery occlusion. Am J Physiol Regul Integr Comp Physiol 276: R935-R942, 1999.
31. Yokoyama O, Yoshiyama M, Namiki M, de Groat WC. Changes in dopaminergic, and glutamatergic excitatory mechanisms of micturition reflex after middle cerebral artery occlusion in conscious rats. Exp Neurol 173: 129-135, 2002. (Pubitemid 34081732)