Description and defense of prenatal diagnosis and treatment with low-dose dexamethasone for congenital adrenal hyperplasia

American Journal of Bioethics

Volumn 10, Issue 9, 2010, Pages 48-51

  New, Maria ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; GLUCOCORTICOID; STEROID 21 MONOOXYGENASE;

ADRENAL HYPERPLASIA, CONGENITAL; ALGORITHM; COMPLICATION; DISORDERS OF SEX DEVELOPMENT; DRUG ADMINISTRATION; ENZYMOLOGY; ETHICS; FEMALE; FEMALE GENITAL SYSTEM; FETAL DISEASES; HUMAN; HUMAN EXPERIMENT; METABOLISM; PATIENT REFERRAL; PLASTIC SURGERY; PRENATAL DIAGNOSIS; PROFESSIONAL STANDARD; SURGERY; UNITED STATES; VIRILISM;

ADRENAL HYPERPLASIA, CONGENITAL; ALGORITHMS; DEXAMETHASONE; DISORDERS OF SEX DEVELOPMENT; DRUG ADMINISTRATION SCHEDULE; ETHICS COMMITTEES, RESEARCH; FEMALE; FETAL DISEASES; GENITALIA, FEMALE; GLUCOCORTICOIDS; HUMANS; PRENATAL DIAGNOSIS; RECONSTRUCTIVE SURGICAL PROCEDURES; REFERRAL AND CONSULTATION; STEROID 21-HYDROXYLASE; THERAPEUTIC HUMAN EXPERIMENTATION; UNITED STATES; VIRILISM;

EID: 77956419230     PISSN: 15265161     EISSN: 15360075     Source Type: Journal    
DOI: 10.1080/15265161.2010.507652     Document Type: Article

References (10)

1. David, M., and M. G. Forest. 1984. Prenatal treatment of congenital adrenal hyperplasia resulting from 21-hydroxylase deficiency. Journal of Pediatrics 105: 799-803.
2. McCullough, L. B., F. A. Chervenak, R. L. Brent, and B. Hippen. 2010. A case study in unethical transgressive bioethics: "Letter of concern from bioethicists" about the prenatal administration of dexamethasone. American Journal of Bioethics 10(9): 35-45.
3. New, M. 2010. Presented at the 2nd World Conference: Hormonal and Genetic Basis of Sexual Disorders, January, Miami, FL.
4. New, M., et al. 1999. Steroid disorders in children: Congenital adrenal hyperplasia and apparent mineralocorticoid excess. Proceedings of the National Academy of Sciences of the United States of America 96(22): 12790-12797.
5. New, M. I., et al. 2001. Prenatal diagnosis for congenital adrenal hyperplasia in 532 pregnancies. Journal of Clinical Endocrinology and Metabolism 86: 5651-5657.
6. New, M., et al. 2003. Update: prenatal diagnosis for congenital adrenal hyperplasia in 595 pregnancies. Endocrinologist 13: 233-239.
7. Nimkarn S., and M. I. New. 2009. Prenatal diagnosis and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Molecular Cell Endocrinology 300(1-2): 192-196.
8. Nordenström, A., L. Frisén, H. Falhammar, H. Filipsson, G. Holmdahl, P. O. Janson, M. Thorén, K. Hagenfeldt, A. Nordenskjöld. 2010. Sexual function and surgical outcome in women with congenital adrenal hyperplasia due to CYP21A2 deficiency: Clinical perspective and the patients' perception. Journal of Clinical Endocrinology and Metabolism (epub ahead of print).
9. Prader, A., and H. P. Gurtner. 1955. The syndrome of male pseudohermaphrodism in congenital adrenocortical hyperplasia without overproduction of androgens (adrenal male pseudohermaphrodism). Helvetica Paediatrica Acta 10: 397-412.
10. Wajnrajch, M. and M. New. 2010. Defects of adrenal steroidogenesis. In J.L. Jameson, and L.J. DeGroot, eds., Endocrinology (5th ed.) Philadelphia: Elsevier.