Increased seizure susceptibility and up-regulation of nNOS expression in hippocampus following recurrent early-life seizures in rats

Journal of Korean Medical Science

Volumn 25, Issue 6, 2010, Pages 905-911

  Kim, Doo Kwun ^a  

^a Dongguk University College of Medicine   (South Korea)

Author keywords

Early life; Epileptogenesis; Hippocampus; nNOS; Rat; Recurrent seizures; Seizure susceptibility

Indexed keywords

NEURONAL NITRIC OXIDE SYNTHASE; TETANUS TOXIN;

ANIMAL; ARTICLE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DISEASE PREDISPOSITION; ELECTRODE; ELECTROENCEPHALOGRAPHY; ENZYMOLOGY; HIPPOCAMPUS; IMMUNOBLOTTING; METABOLISM; NEWBORN; RAT; RECURRENT DISEASE; SEIZURE; TIME; UPREGULATION; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; IMMUNOBLOTTING; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR; RECURRENCE; SEIZURES; TETANUS TOXIN; TIME FACTORS; UP-REGULATION;

EID: 77956418892     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2010.25.6.905     Document Type: Article

References (30)

1. Jensen FE. Acute and chronic effects of seizures in the developing brain: experimental models. Epilepsia 1999; 40 (Suppl 1): S51-8.
2. Holmes GL. Epilepsy in the developing brain: lessons from the laboratory and clinic. Epilepsia 1997; 38: 12-30.
3. Holmes GL, Khazipov R, Ben-Ari Y. New concepts in neonatal seizures. Neuroreport 2002; 21: A3-8.
4. Swann JW, Pierson MG, Smith KL, Lee CL. Developmental neuroplasticity: roles in early life seizures and chronic epilepsy. Adv Neurol 1999; 79: 203-16.
5. Swann JW, Hablitz JJ. Cellular abnormalities and synaptic plasticity in seizure disorders of the immature nervous system. Ment Retard Dev Disabil Res Rev 2000; 6: 258-67.
6. Hawkins CA, Mellanby JH. Limbic epilepsy induced by tetanus toxin: a longitudinal electroencephalographic study. Epilepsia 1987; 28: 431-44.
7. Jefferys JG, Williams SF. Physiological and behavioral consequences of seizures induced in the rat by intrahippocampal tetanus toxin. Brain 1987; 110: 517-32.
8. Mellanby J, George G, Robinson A, Thompson P. Epileptiform syndrome in rats produced by injecting tetanus toxin into the hippocampus. J Neurol Neurosurg Psychiatry 1977; 40: 404-14.
9. Lee CL, Hrachovy RA, Smith KL, Frost JD Jr, Swann JW. Seizures produced in neonatal rats by stereotaxic injections of tetanus toxin (TT): in vivo and in vitro models of seizures in early infancy. Epilepsia 1993; 34: 59.
10. Dawson TM, Dawson VL, Snyder SH. A novel neuronal messenger molecule in the brain: the free radical, nitric oxide. Ann Neurol 1992; 32: 297-311.
11. Roskams AJ, Bredt DS, Dawson TM, Ronnet GV. Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurons. Neuron 1994; 13: 289-99.
12. Endoh M, Maiese K, Wagner JA. Expression of the neural form of nitric oxide synthase by CA1 hippocampal neurons and other central nervous system neurons. Neuroscience 1994; 63: 679-89.
13. Lee CL, Hrachovy RA, Smith KL, Frost JD Jr, Swann JW. Tetanus toxin-induced seizures in infant rats and their effects on hippocampal excitability in adulthood. Brain Res 1995; 17: 97-109.
14. Smith KL, Lee CL, Swann JW. Local circuit abnormalities in chronically epileptic rats after intrahippocampal tetanus toxin injection in infancy. J Neurophysiol 1998; 79: 106-16.
15. Cha BH, Silveira DC, Liu X, Hu Y, Holmes GL. Effect of topiramate following recurrent and prolonged seizures during early development. Epilepsy Res 2002; 51: 217-32.
16. Cavalheiro EA, de Feo MR, Mecarelli O, Ricci GF. Intracortical and intrahippocampal injections of kainic acid in developing rats: an electrographic study. Electroencephalogr Clin Neurophysiol 1983; 56: 480-6.
17. Tremblay E, Nitecka L, Berger ML, Ben-Ari Y. Maturation of kainic acid seizure-brain damage syndrome in the rat. I. Clinical electrographic and metabolic observations, Neuroscience 1984; 13: 1051-72.
18. Michelson HB, Lothman EW. An ontogenetic study of kindling using rapidly recurring hippocampal seizures. Brain Res Dev Brain Res 1991; 61: 79-85.
19. Moshé SL, Albala BJ. Kindling in developing rats: persistence of seizures into adulthood. Brain Res 1982; 256: 67-71.
20. Haut SR, Velísková J, Moshé SL. Susceptibility of immature and adult brains to seizure effects. Lancet Neurol 2004; 3: 608-17.
21. Baram TZ, Hirsch E, Schultz L. Short interval amygdale kindling in neonatal rats. Brain Res Dev Brain Res 1993; 73: 79-83.
22. Albus U, Habermann E. Tetanus toxin inhibits the evoked outflow of inhibitory (GABA) and excitatory (o-aspartate) amino acid from particulate brain cortex. Toxicon 1983; 21: 97-110.
23. Williamson LC, Fitzgerald SC, Neale EA. Differential effects of tetanus toxin on inhibitory and excitatory neurotransmitter release from mammalian spinal cord cells in culture. J Neurochem 1992; 59: 2148-57.
24. Jefferys JG. Chronic epileptic foci in vitro in hippocampal slices from rats with tetanus toxin epileptic syndrome. J Neurophysiol 1989; 62: 458-68.
25. Haas KZ, Sperber EF, Moshé SL. Kindling in developing animals: expression of severe seizures and enhanced development of bilateral foci. Brain Res Dev Brain Res 1990; 56: 275-80.
26. Swann JW, Al-Noori S, Jiang M, Lee CL. Spine loss and other dendritic abnormalities in epilepsy. Hippocampus 2000; 10: 617-25.
27. Elmér E, Alm P, Kokaia Z, Kokaia M, Larsson B, Keep M, Andersson KE, Lindvall O. Regulation of neuronal nitric oxide synthase mRNA levels in rat brain by seizure activity. Neuroreport 1996; 7: 1335-9.
28. Ohyu J, Takashima S. Developmental characteristics of neuronal nitric oxide synthase (nNOS) immunoreactive neurons in fetal to adolescent human brains. Brain Res Dev Brain Res 1998; 110: 193-202.
29. Bonthius DJ, Tzouras G, Karacay B, Mahoney J, Hutton A, McKim R, Pantazis NJ. Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Brain Res Dev Brain Res 2002; 138: 45-59.
30. Sunico CR, Portillo F, Gonzalez-Forero D, Moreno-Lopez B. Nitricoxide-directed synaptic remodeling in the adult mammal CNS. J Neurosci 2005; 25: 1448-58.