Arterial and venous pharmacokinetics of morphine-6-glucuronide and impact of sample site on pharmacodynamic parameter estimates

Anesthesia and Analgesia

Volumn 111, Issue 3, 2010, Pages 626-632

  Olofsen, Erik ^a   Mooren, René ^a   Van Dorp, Eveline ^a   Aarts, Leon ^a   Smith, Terry ^a   Den Hartigh, Jan ^a   Dahan, Albert ^a   Sarton, Elise ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE 6 GLUCURONIDE; MORPHINE DERIVATIVE; MORPHINE-6-GLUCURONIDE; NARCOTIC ANALGESIC AGENT;

ADULT; ARTERIAL BLOOD; ARTICLE; DRUG EFFECT; DRUG HALF LIFE; FEMALE; HUMAN; HUMAN EXPERIMENT; MALE; MATHEMATICAL MODEL; NORMAL HUMAN; PARAMETER; PHARMACODYNAMICS; PRIORITY JOURNAL; RADIAL ARTERY; SIMULATION; STATISTICAL ANALYSIS; VENOUS BLOOD; ALGORITHM; ARTERY; BLOOD; COMPUTER SIMULATION; HALF LIFE TIME; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; VEIN;

ADULT; ALGORITHMS; ANALGESICS, OPIOID; ARTERIES; COMPUTER SIMULATION; FEMALE; HALF-LIFE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MORPHINE DERIVATIVES; VEINS; YOUNG ADULT;

EID: 77956397199     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181e5e8af     Document Type: Article

References (6)

1. Tuk B, Danhof M, Mandema JW. The impact on arteriovenous concentration differences on pharmacodynamic parameter estimates. J Pharmacokinet Biopharm 1997;25:39-62
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3. Sarton E, Olofsen E, Romberg R, den Hartigh J, Kest B, Nieuwenhuijs D, Burm A, Teppema L, Dahan A. Sex differences in morphine analgesia: An experimental study in healthy volunteers. Anesthesiology 2000;95:1245-54
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5. Tuk B, Herben VMM, Mandema JW, Danhof M. Relevance of arteriovenous concentration differences in pharmacokinetic- pharmacodynamic modeling of midazolam. J Pharmacol Exp Ther 1998;284:202-7
6. Gumbleton M, Øie S, Verotta D. Pharmacokinetic-pharmacodynamic (PK-PD) modeling in non-steady-state studies and arteriovenous drug concentration differences. Br J Clin Pharmacol 1994;38:389-400