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US Renal Data System. United States Renal Data System Annual Data Report. This reference provides extensive analysis of the definitive ESRD registry in the United States. It provides data tables and figures on the epidemiology of dialysis and its complications. In particular, it makes the point that diabetes is the most common cause of ESRD
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US Renal Data System: United States Renal Data System Annual Data Report. Am J Kid Dis 2007, 49(Suppl 1):S10-S294. This reference provides extensive analysis of the definitive ESRD registry in the United States. It provides data tables and figures on the epidemiology of dialysis and its complications. In particular, it makes the point that diabetes is the most common cause of ESRD.
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Am J Kid Dis
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Diabetic CKD/ESRD 2010: A progress report?
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Feb 22 [Epub ahead of print] Williams discusses the progress and some of the challenges in diabetic CKD and ESRD-diagnosis and treatment
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Williams ME: Diabetic CKD/ESRD 2010: A Progress Report? Semin Dial 2010 Feb 22 [Epub ahead of print]. Williams discusses the progress and some of the challenges in diabetic CKD and ESRD-diagnosis and treatment.
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(2010)
Semin Dial
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Williams, M.E.1
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3
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Association of kidney function with anemia: The third national health and nutrition examination survey (1988-1994)
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Astor BC, Muntner P, Levin A, et al.: Association of kidney function with anemia: the Third National Health and Nutrition Examination Survey (1988-1994). Arch Intern Med 2002, 162:1401-1408.
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Arch Intern Med
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Levin, A.3
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Vlagopoulos PT, Tighiouart H, Weiner DE, et al.: Anemia as a risk factor for cardiovascular disease and all-cause mortality in diabetes: the impact of chronic kidney disease. J Am Soc Nephrol 2005, 16:3403-3410.
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Weiner, D.E.3
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McFarlane SI, Salifu MO, Makaryus J, Sowers JR: Anemia and cardiovascular disease in diabetic nephropathy. Curr Diab Rep 2006, 6:213-218.
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Curr Diab Rep
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McFarlane, S.I.1
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Makaryus, J.3
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6
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The deadly triangle of anemia, renal insufficiency, and cardiovascular disease: Implications for prognosis and treatment
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McCullough PA, Lepor NE: The deadly triangle of anemia, renal insufficiency, and cardiovascular disease: implications for prognosis and treatment. Rev Cardiovasc Med 2005, 6(1):1-10.
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McClellan WM: Epidemiology and risk factors for chronic kidney disease. Med Clin North Am 2005, 89:419-445.
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Keane WF, Lyle PA: Recent advances in management of type 2 diabetes and nephropathy: lessons from the RENAAL study. Am J Kidney Dis 2003, 41(3 Suppl 1):S22-S25.
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Lyle, P.A.2
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PROCRIT (Epoetin alfa) FOR INJECTION. Available at Accessed May 2010
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PROCRIT (Epoetin alfa) FOR INJECTION. Available at http://www. accessdata.fda.gov/drugsatfda-docs/label/2007/103234s5158lbl.pdf. Accessed May 2010.
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10
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70949108082
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A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease
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This is the primary report of the landmark TREAT study. The findings are discussed in detail in the current paper
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Pfeffer MA, Burdmann EA, Chen CY, et al.: A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med 2009, 361:2019-2032. This is the primary report of the landmark TREAT study. The findings are discussed in detail in the current paper.
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Pfeffer, M.A.1
Burdmann, E.A.2
Chen, C.Y.3
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Does TREAT give the boot to ESAs in the treatment of CKD anemia?
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In this article, Singh reviews the evidence from recent trials and makes recommendations for clinical nephrologists for treating anemia using ESAs in nondialysis CKD patients
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Singh AK: Does TREAT give the boot to ESAs in the treatment of CKD anemia? J Am Soc Nephrol 2010, 21:2-6. In this article, Singh reviews the evidence from recent trials and makes recommendations for clinical nephrologists for treating anemia using ESAs in nondialysis CKD patients.
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(2010)
J Am Soc Nephrol
, vol.21
, pp. 2-6
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Singh, A.K.1
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12
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77952504113
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The results of the TREAT study: Lessons and limitations [in Italian]
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Del Vecchio reviews the findings of the TREAT study and is critical of its design and conclusions
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Del Vecchio L: The results of the TREAT study: lessons and limitations [in Italian]. G Ital Nefrol 2010, 27:3. Del Vecchio reviews the findings of the TREAT study and is critical of its design and conclusions.
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(2010)
G Ital Nefrol
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, pp. 3
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Del Vecchio, L.1
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Would prescription of erythropoiesis-stimulating agents in pre-dialysis change after results from TREAT study? [in Spanish]
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Alcázar et al. argue that despite the findings of the TREAT study, no change in management of CKD anemia with ESAs is necessary
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Alcázar R, Tato A, García F, et al.: Would prescription of erythropoiesis-stimulating agents in pre-dialysis change after results from TREAT study? [in Spanish]. Nefrologia 2010, 30:114-18. Alcázar et al. argue that despite the findings of the TREAT study, no change in management of CKD anemia with ESAs is necessary.
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Nefrologia
, vol.30
, pp. 114-18
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Alcázar, R.1
Tato, A.2
García, F.3
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14
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77449141354
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Anaemia correction in diabetic patients with chronic kidney disease without substitutive treatment: Teachings from TREAT study [in Spanish]
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de Francisco et al. review the TREAT study, particularly its strength as a placebo-controlled study, although the rescue feature in the placebo arm concerns the authors that TREAT was not truly placebo controlled
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de Francisco AL, Aljama P, Arias M, et al.: Anaemia correction in diabetic patients with chronic kidney disease without substitutive treatment: teachings from TREAT study [in Spanish]. Nefrologia 2010, 30:15-20. de Francisco et al. review the TREAT study, particularly its strength as a placebo-controlled study, although the rescue feature in the placebo arm concerns the authors that TREAT was not truly placebo controlled.
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Nefrologia
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De Francisco, A.L.1
Aljama, P.2
Arias, M.3
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15
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The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin
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Besarab A, Bolton WK, Browne JK, et al.: The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 1998, 339:584-590.
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Bolton, W.K.2
Browne, J.K.3
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Normalization of hemoglobin level in patients with chronic kidney disease and anemia
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Drueke TB, Locatelli F, Clyne N, et al.: Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006, 355:2071-2084.
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Correction of anemia with epoetin alfa in chronic kidney disease
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Singh AK, Szczech L, Tang KL, et al.: Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006, 355:2085-2098.
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Singh, A.K.1
Szczech, L.2
Tang, K.L.3
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Surrogate end points in clinical trials: Are we being misled?
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Fleming TR, DeMets DL: Surrogate end points in clinical trials: are we being misled? Ann Intern Med 1996, 125:605-613.
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Prentice RL: Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med 1989, 8:431-440.
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33646339958
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Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease in adults
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KDOQI; National Kidney Foundation: II
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KDOQI; National Kidney Foundation: II. Clinical practice guidelines and clinical practice recommendations for anemia in chronic kidney disease in adults. Am J Kidney Dis 2006, 47:S16-S85.
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Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia
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Bennett et al. present a meta-analysis that reports heightened risk of mortality and thromboembolism in cancer patients treated with ESAs. The meta-analysis has been influential in raising concerns among oncologists and the FDA regarding the safety of ESAs
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Bennett CL, Silver SM, Djulbegovic B, et al.: Venous thromboembolism and mortality associated with recombinant erythropoietin and darbepoetin administration for the treatment of cancer-associated anemia. JAMA 2008, 299:914-924. Bennett et al. present a meta-analysis that reports heightened risk of mortality and thromboembolism in cancer patients treated with ESAs. The meta-analysis has been influential in raising concerns among oncologists and the FDA regarding the safety of ESAs.
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JAMA
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Bennett, C.L.1
Silver, S.M.2
Djulbegovic, B.3
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22
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70449503461
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An open-label, randomized, parallel-group study of perioperative epoetin alfa versus standard of care for blood conservation in major elective spinal surgery: Safety analysis
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This multicenter RCT shows that in relatively healthy patients undergoing orthopedic spine surgery, exposure to ESA was associated with a higher risk of thromboembolism. This study has been cited by the FDA in its safety review of ESAs
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Stowell CP, Jones SC, Enny C, et al.: An open-label, randomized, parallel-group study of perioperative epoetin alfa versus standard of care for blood conservation in major elective spinal surgery: safety analysis. Spine (Phila Pa 1976) 2009, 34:2479-2485. This multicenter RCT shows that in relatively healthy patients undergoing orthopedic spine surgery, exposure to ESA was associated with a higher risk of thromboembolism. This study has been cited by the FDA in its safety review of ESAs.
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Spine (Phila Pa 1976)
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, pp. 2479-2485
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Stowell, C.P.1
Jones, S.C.2
Enny, C.3
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Efficacy and safety of epoetin alfa in critically ill patients
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Corwin HL, Gettinger A, Fabian TC, et al.: Efficacy and safety of epoetin alfa in critically ill patients. N Engl J Med 2007, 357:965-976.
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N Engl J Med
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Corwin, H.L.1
Gettinger, A.2
Fabian, T.C.3
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Darbepoetin alfa and chronic kidney disease
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author reply 655
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Wright RJ, Kanagasundaram NS, Quinton R, et al.: Darbepoetin alfa and chronic kidney disease. N Engl J Med 2010, 362:653; author reply 655.
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N Engl J Med
, vol.362
, pp. 653
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Wright, R.J.1
Kanagasundaram, N.S.2
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