메뉴 건너뛰기




Volumn 12, Issue 4, 2010, Pages 278-283

Bladder cancer: Can we move beyond chemotherapy?

Author keywords

Anti CTLA 4 antibody; Aurora A kinase; Bevacizumab; Bladder cancer; Chemotherapy; Cisplatin; EGFR; EMT (epithelial to mesenchymal transition); Gemcitabine; IFN; Ifosfamide; Immunology; Novel agents; NY ESO 1; Tarceva; Trastuzumab; Urothelial cancer; Vaccine; VEGF

Indexed keywords

ADENOVIRUS VECTOR; ALPHA INTERFERON; ALPHA2B INTERFERON; BCG VACCINE; BEVACIZUMAB; CARBOPLATIN; CISPLATIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; FLUOROURACIL; GEMCITABINE; IFOSFAMIDE; INTERFERON; METHOTREXATE; NY ESO 1 ANTIGEN; PACLITAXEL; PROTEIN P53; TRASTUZUMAB; VINBLASTINE;

EID: 77956394387     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-010-0104-5     Document Type: Review
Times cited : (7)

References (42)
  • 1
    • 0021910302 scopus 로고
    • Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium
    • Sternberg CN, Yagoda A, Scher HI, et al.: Preliminary results of M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) for transitional cell carcinoma of the urothelium. J Urol 1985, 133:403-407.
    • (1985) J Urol , vol.133 , pp. 403-407
    • Sternberg, C.N.1    Yagoda, A.2    Scher, H.I.3
  • 2
    • 0033857218 scopus 로고    scopus 로고
    • Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study
    • von der Maase H, Hansen SW, Roberts JT, et al.: Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: Results of a large, randomized, multinational, multicenter, phase III study. J Clin Oncol 2000, 18:3068-3077.
    • (2000) J Clin Oncol , vol.18 , pp. 3068-3077
    • Von Der Maase, H.1    Hansen, S.W.2    Roberts, J.T.3
  • 3
    • 0041429507 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer
    • erratum appears in
    • Grossman HB, Natale RB, Tangen CM, et al.: Neoadjuvant chemotherapy plus cystectomy compared with cystectomy alone for locally advanced bladder cancer [erratum appears in N Engl J Med 2003, 349:1880]
    • (2003) N Engl J Med , vol.349 , pp. 1880
    • Grossman, H.B.1    Natale, R.B.2    Tangen, C.M.3
  • 4
    • 0041429507 scopus 로고    scopus 로고
    • N Engl J Med 2003, 349:859-866.
    • (2003) N Engl J Med , vol.349 , pp. 859-866
  • 5
    • 0025297496 scopus 로고
    • A prospective randomized trial comparing MVAC and CISCA chemotherapy for patients with metastatic urothelial tumors
    • Logothetis CJ, Dexeus FH, Finn L, et al.: A prospective randomized trial comparing MVAC and CISCA chemotherapy for patients with metastatic urothelial tumors. J Clin Oncol 1990, 8:1050-1055.
    • (1990) J Clin Oncol , vol.8 , pp. 1050-1055
    • Logothetis, C.J.1    Dexeus, F.H.2    Finn, L.3
  • 6
    • 0029131434 scopus 로고
    • Escalated MVAC with or without recombinant human granulocyte-macrophage colonystimulating factor for the initial treatment of advanced malignant urothelial tumors: Results of a randomized trial
    • Logothetis CJ, Finn LD, Smith T, et al.: Escalated MVAC with or without recombinant human granulocyte-macrophage colonystimulating factor for the initial treatment of advanced malignant urothelial tumors: Results of a randomized trial. J Clin Oncol 1995, 13:2272-2277.
    • (1995) J Clin Oncol , vol.13 , pp. 2272-2277
    • Logothetis, C.J.1    Finn, L.D.2    Smith, T.3
  • 7
    • 0027460092 scopus 로고
    • Dose-intensification of MVAC with recombinant granulocyte colony-stimulating factor as initial therapy in advanced urothelial cancer
    • Seidman AD, Scher HI, Gabrilove JL, et al.: Dose-intensification of MVAC with recombinant granulocyte colony-stimulating factor as initial therapy in advanced urothelial cancer. J Clin Oncol 1993, 11:408-414.
    • (1993) J Clin Oncol , vol.11 , pp. 408-414
    • Seidman, A.D.1    Scher, H.I.2    Gabrilove, J.L.3
  • 8
    • 0028359274 scopus 로고
    • Escalated dosages of methotrexate, vinblastine, doxorubicin, and cisplatin plus recombinant human granulocyte colony-stimulating factor in advanced urothelial carcinoma
    • An Eastern Cooperative Oncology Group trial
    • Loehrer PJ Sr, Elson P, Dreicer R, et al.: Escalated dosages of methotrexate, vinblastine, doxorubicin, and cisplatin plus recombinant human granulocyte colony-stimulating factor in advanced urothelial carcinoma: An Eastern Cooperative Oncology Group trial. J Clin Oncol 1994, 12:483-488.
    • (1994) J Clin Oncol , vol.12 , pp. 483-488
    • Loehrer Sr., P.J.1    Elson, P.2    Dreicer, R.3
  • 9
    • 1342268941 scopus 로고    scopus 로고
    • Docetaxel and cisplatin with granulocyte colony-stimulating factor (G-CSF) versus MVAC with G-CSF in advanced urothelial carcinomaA multicenter, randomized
    • phase III study from the Hellenic Cooperative Oncology Group
    • Bamias A, Aravantinos G, Deliveliotis C, et al.: Docetaxel and cisplatin with granulocyte colony-stimulating factor (G-CSF) versus MVAC with G-CSF in advanced urothelial carcinoma: A multicenter, randomized, phase III study from the Hellenic Cooperative Oncology Group. J Clin Oncol 2004, 22:220-228.
    • (2004) J Clin Oncol , vol.22 , pp. 220-228
    • Bamias, A.1    Aravantinos, G.2    Deliveliotis, C.3
  • 10
    • 0036498768 scopus 로고    scopus 로고
    • Phase III trial of fluorouracil, interferon alpha-2b, and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in metastatic or unresectable urothelial cancer
    • Siefker-Radtke AO, Millikan RE, Tu SM, et al.: Phase III trial of fluorouracil, interferon alpha-2b, and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in metastatic or unresectable urothelial cancer. J Clin Oncol 2002, 20:1361-1367.
    • (2002) J Clin Oncol , vol.20 , pp. 1361-1367
    • Siefker-Radtke, A.O.1    Millikan, R.E.2    Tu, S.M.3
  • 11
    • 0035873915 scopus 로고    scopus 로고
    • Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors
    • European Organization for Research and Treatment of Cancer Protocol no. 30924
    • Sternberg CN, de Mulder PH, Schornagel JH, et al.: Randomized phase III trial of high-dose-intensity methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) chemotherapy and recombinant human granulocyte colony-stimulating factor versus classic MVAC in advanced urothelial tract tumors: European Organization for Research and Treatment of Cancer Protocol no. 30924. J Clin Oncol 2001, 19:2638-2646.
    • (2001) J Clin Oncol , vol.19 , pp. 2638-2646
    • Sternberg, C.N.1    De Mulder, P.H.2    Schornagel, J.H.3
  • 12
    • 77954246751 scopus 로고    scopus 로고
    • A phase II trial of sequential neoadjuvant chemotherapy with ifosfamide, doxorubicin, and gemcitabine (IAG), followed by cisplatin, gemcitabine, and ifosfamide (CGI) in locally advanced urothelial cancer: Final results from the M.D. Anderson cancer center
    • Siefker-Radtke A, Millikan, RE, Kamat, AM, et al.: A phase II trial of sequential neoadjuvant chemotherapy with ifosfamide, doxorubicin, and gemcitabine (IAG), followed by cisplatin, gemcitabine, and ifosfamide (CGI) in locally advanced urothelial cancer: Final results from the M. D. Anderson Cancer Center. J Clin Oncol 2008, 26:269s.
    • (2008) J Clin Oncol , vol.26
    • Siefker-Radtke, A.1    Millikan, R.E.2    Kamat, A.M.3
  • 13
    • 0034177933 scopus 로고    scopus 로고
    • Ifosfamide, paclitaxel, and cisplatin for patients with advanced transitional cell carcinoma of the urothelial tract: Final report of a phase II trial evaluating two dosing schedules
    • Bajorin DF, McCaffrey JA, Dodd PM, et al.: Ifosfamide, paclitaxel, and cisplatin for patients with advanced transitional cell carcinoma of the urothelial tract: Final report of a phase II trial evaluating two dosing schedules. Cancer 2000, 88:1671-1678.
    • (2000) Cancer , vol.88 , pp. 1671-1678
    • Bajorin, D.F.1    McCaffrey, J.A.2    Dodd, P.M.3
  • 14
    • 77956394026 scopus 로고    scopus 로고
    • A phase II randomized four-regimen selection trial incorporating response for sequential chemotherapy in metastatic, unresectable urothelial cancer: Final results from the M.D. Anderson cancer center
    • This clinical trial used a novel statistical design in sequential therapy that incorporates response to continue treatment that is working, with early re-randomization in the setting of suboptimal response
    • Siefker-Radtke A, Kamat A, Williams D, et al.: A phase II randomized four-regimen selection trial incorporating response for sequential chemotherapy in metastatic, unresectable urothelial cancer: Final results from the M. D. Anderson Cancer Center. J Clin Oncol 2009, 27:251s. This clinical trial used a novel statistical design in sequential therapy that incorporates response to continue treatment that is working, with early re-randomization in the setting of suboptimal response.
    • (2009) J Clin Oncol , vol.27
    • Siefker-Radtke, A.1    Kamat, A.2    Williams, D.3
  • 15
    • 70249128736 scopus 로고    scopus 로고
    • Final results of sequential doxorubicin plus gemcitabine and ifosfamide, paclitaxel, and cisplatin chemotherapy in patients with metastatic or locally advanced transitional cell carcinoma of the urothelium
    • This is a sequential clinical trial design using a fixed schedule of chemotherapy
    • Milowsky MI, Nanus DM, Maluf FC, et al.: Final results of sequential doxorubicin plus gemcitabine and ifosfamide, paclitaxel, and cisplatin chemotherapy in patients with metastatic or locally advanced transitional cell carcinoma of the urothelium. J Clin Oncol 2009, 27:4062-4067. This is a sequential clinical trial design using a fixed schedule of chemotherapy.
    • (2009) J Clin Oncol , vol.27 , pp. 4062-4067
    • Milowsky, M.I.1    Nanus, D.M.2    Maluf, F.C.3
  • 16
    • 0034732660 scopus 로고    scopus 로고
    • Evaluating multiple treatment courses in clinical trials
    • Thall PF, Millikan RE, Sung HG: Evaluating multiple treatment courses in clinical trials. Stat Med 2000, 19:1011-1028.
    • (2000) Stat Med , vol.19 , pp. 1011-1028
    • Thall, P.F.1    Millikan, R.E.2    Sung, H.G.3
  • 17
    • 66849110778 scopus 로고    scopus 로고
    • Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer
    • This is the first clinical trial in small cell urothelial cancer. Though it is a small clinical trial, it suggests a potential impact for neoadjuvant chemotherapy in small cell of the bladder
    • Siefker-Radtke AO, Kamat AM, Grossman HB, et al.: Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer. J Clin Oncol 2009, 27:2592-2597. This is the first clinical trial in small cell urothelial cancer. Though it is a small clinical trial, it suggests a potential impact for neoadjuvant chemotherapy in small cell of the bladder.
    • (2009) J Clin Oncol , vol.27 , pp. 2592-2597
    • Siefker-Radtke, A.O.1    Kamat, A.M.2    Grossman, H.B.3
  • 18
    • 0037377320 scopus 로고    scopus 로고
    • Multimodality management of urachal carcinoma: The M.D. Anderson cancer center experience
    • Siefker-Radtke AO, Gee J, Shen Y, et al.: Multimodality management of urachal carcinoma: The M. D. Anderson Cancer Center experience. J Urol 2003, 169:1295-1298.
    • (2003) J Urol , vol.169 , pp. 1295-1298
    • Siefker-Radtke, A.O.1    Gee, J.2    Shen, Y.3
  • 19
    • 68149179652 scopus 로고    scopus 로고
    • P53 predictive value for pT1-2 N0 disease at radical cystectomy
    • Shariat SF, Lotan Y, Karakiewicz PI, et al.: P53 predictive value for pT1-2 N0 disease at radical cystectomy. J Urol 2009, 182:907-913.
    • (2009) J Urol , vol.182 , pp. 907-913
    • Shariat, S.F.1    Lotan, Y.2    Karakiewicz, P.I.3
  • 20
    • 0035887279 scopus 로고    scopus 로고
    • Integrated therapy for locally advanced bladder cancer: Final report of a randomized trial of cystectomy plus adjuvant M-VAC versus cystectomy with both preoperative and postoperative M-VAC
    • Millikan R, Dinney C, Swanson D, et al.: Integrated therapy for locally advanced bladder cancer: Final report of a randomized trial of cystectomy plus adjuvant M-VAC versus cystectomy with both preoperative and postoperative M-VAC. J Clin Oncol 2001, 19:4005-4013.
    • (2001) J Clin Oncol , vol.19 , pp. 4005-4013
    • Millikan, R.1    Dinney, C.2    Swanson, D.3
  • 21
    • 33646201958 scopus 로고    scopus 로고
    • Raf1, Aurora-A/ STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up
    • Mhawech-Fauceglia P, Fischer G, Beck A, et al.: Raf1, Aurora-A/ STK15 and E-cadherin biomarkers expression in patients with pTa/pT1 urothelial bladder carcinoma; a retrospective TMA study of 246 patients with long-term follow-up. Eur J Surg Oncol 2006, 32:439-444.
    • (2006) Eur J Surg Oncol , vol.32 , pp. 439-444
    • Mhawech-Fauceglia, P.1    Fischer, G.2    Beck, A.3
  • 22
    • 0346499095 scopus 로고    scopus 로고
    • Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy
    • Slaton JW, Millikan R, Inoue K, et al.: Correlation of metastasis related gene expression and relapse-free survival in patients with locally advanced bladder cancer treated with cystectomy and chemotherapy. J Urol 2004, 171:570-574.
    • (2004) J Urol , vol.171 , pp. 570-574
    • Slaton, J.W.1    Millikan, R.2    Inoue, K.3
  • 23
    • 0037019736 scopus 로고    scopus 로고
    • Amplification/overexpression of a mitotic kinase gene in human bladder cancer
    • Sen S, Zhou H, Zhang RD, et al.: Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst 2002, 94:1320-1329.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1320-1329
    • Sen, S.1    Zhou, H.2    Zhang, R.D.3
  • 24
    • 53249129076 scopus 로고    scopus 로고
    • Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection
    • Park HS, Park WS, Bondaruk J, et al.: Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst 2008, 100:1401-1411.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 1401-1411
    • Park, H.S.1    Park, W.S.2    Bondaruk, J.3
  • 25
    • 0028115726 scopus 로고
    • Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis
    • Nguyen PL, Swanson PE, Jaszcz W, et al.: Expression of epidermal growth factor receptor in invasive transitional cell carcinoma of the urinary bladder. A multivariate survival analysis. Am J Clin Pathol 1994, 101:166-176.
    • (1994) Am J Clin Pathol , vol.101 , pp. 166-176
    • Nguyen, P.L.1    Swanson, P.E.2    Jaszcz, W.3
  • 26
    • 33748076132 scopus 로고    scopus 로고
    • Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy
    • Blehm KN, Spiess PE, Bondaruk JE, et al.: Mutations within the kinase domain and truncations of the epidermal growth factor receptor are rare events in bladder cancer: Implications for therapy. Clin Cancer Res 2006, 12:4671-4677.
    • (2006) Clin Cancer Res , vol.12 , pp. 4671-4677
    • Blehm, K.N.1    Spiess, P.E.2    Bondaruk, J.E.3
  • 27
    • 40949091867 scopus 로고    scopus 로고
    • Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells
    • Black PC, Brown GA, Inamoto T, et al.: Sensitivity to epidermal growth factor receptor inhibitor requires E-cadherin expression in urothelial carcinoma cells. Clin Cancer Res 2008, 14:1478-1486.
    • (2008) Clin Cancer Res , vol.14 , pp. 1478-1486
    • Black, P.C.1    Brown, G.A.2    Inamoto, T.3
  • 28
    • 69349087756 scopus 로고    scopus 로고
    • MiR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy
    • This recent publication suggests a role for miR-200 as a regulatory mechanism for EMT in urothelial cancer
    • Adam L, Zhong M, Choi W, et al.: MiR-200 expression regulates epithelial-to-mesenchymal transition in bladder cancer cells and reverses resistance to epidermal growth factor receptor therapy. Clin Cancer Res 2009, 15:5060-5072. This recent publication suggests a role for miR-200 as a regulatory mechanism for EMT in urothelial cancer.
    • (2009) Clin Cancer Res , vol.15 , pp. 5060-5072
    • Adam, L.1    Zhong, M.2    Choi, W.3
  • 29
    • 0034890387 scopus 로고    scopus 로고
    • Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: Prognostic significance and comparative analysis in primary and metastatic tumors
    • Jimenez RE, Hussain M, Bianco FJ Jr, et al.: Her-2/neu overexpression in muscle-invasive urothelial carcinoma of the bladder: Prognostic significance and comparative analysis in primary and metastatic tumors. Clin Cancer Res 2001, 7:2440-2447.
    • (2001) Clin Cancer Res , vol.7 , pp. 2440-2447
    • Jimenez, R.E.1    Hussain, M.2    Bianco Jr., F.J.3
  • 30
    • 0028883362 scopus 로고
    • Prognostic value of amplification of c-erb-B2 in bladder carcinoma
    • Lonn U, Lonn S, Friberg S, et al.: Prognostic value of amplification of c-erb-B2 in bladder carcinoma. Clin Cancer Res 1995, 1:1189-1194.
    • (1995) Clin Cancer Res , vol.1 , pp. 1189-1194
    • Lonn, U.1    Lonn, S.2    Friberg, S.3
  • 31
    • 0027990321 scopus 로고
    • Expression of c-erbB-2 protein in normal and neoplastic urothelium: Lack of adverse prognostic effect in human urinary bladder cancer
    • Lee SE, Chow NH, Chi YC, et al.: Expression of c-erbB-2 protein in normal and neoplastic urothelium: Lack of adverse prognostic effect in human urinary bladder cancer. Anticancer Res 1994, 14:1317-1324.
    • (1994) Anticancer Res , vol.14 , pp. 1317-1324
    • Lee, S.E.1    Chow, N.H.2    Chi, Y.C.3
  • 32
    • 27144445851 scopus 로고    scopus 로고
    • Trastuzumab (T), Paclitaxel (P), Carboplatin (C), and Gemcitabine (G) in advanced HER2-positive urothelial carcinoma: Results of a multi-center phase II NCI trial
    • Hussain M, Petrylak D, Dunn R, et al.: Trastuzumab (T), Paclitaxel (P), Carboplatin (C), and Gemcitabine (G) in advanced HER2-positive urothelial carcinoma: Results of a multi-center phase II NCI trial. J Clin Oncol 2005, 23:379s.
    • (2005) J Clin Oncol , vol.23
    • Hussain, M.1    Petrylak, D.2    Dunn, R.3
  • 33
    • 0037817365 scopus 로고    scopus 로고
    • Microvessel density at presentation predicts subsequent muscle invasion in superficial bladder cancer
    • Goddard JC, Sutton CD, Furness PN, et al.: Microvessel density at presentation predicts subsequent muscle invasion in superficial bladder cancer. Clin Cancer Res 2003, 9:2583-2586.
    • (2003) Clin Cancer Res , vol.9 , pp. 2583-2586
    • Goddard, J.C.1    Sutton, C.D.2    Furness, P.N.3
  • 34
    • 0028884557 scopus 로고
    • Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis
    • Bochner BH, Cote RJ, Weidner N, et al.: Angiogenesis in bladder cancer: Relationship between microvessel density and tumor prognosis. J Natl Cancer Inst 1995, 87:1603-1612.
    • (1995) J Natl Cancer Inst , vol.87 , pp. 1603-1612
    • Bochner, B.H.1    Cote, R.J.2    Weidner, N.3
  • 35
    • 0030678133 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer
    • Crew JP, O'Brien T, Bradburn M, et al.: Vascular endothelial growth factor is a predictor of relapse and stage progression in superficial bladder cancer. Cancer Res 1997, 57:5281-5285.
    • (1997) Cancer Res , vol.57 , pp. 5281-5285
    • Crew, J.P.1    O'Brien, T.2    Bradburn, M.3
  • 36
    • 2142760062 scopus 로고    scopus 로고
    • The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression
    • Yang CC, Chu KC, Yeh WM: The expression of vascular endothelial growth factor in transitional cell carcinoma of urinary bladder is correlated with cancer progression. Urol Oncol 2004, 22:1-6.
    • (2004) Urol Oncol , vol.22 , pp. 1-6
    • Yang, C.C.1    Chu, K.C.2    Yeh, W.M.3
  • 37
    • 0034827699 scopus 로고    scopus 로고
    • Serum levels of vascular endothelial growth factor as a prognostic factor in bladder cancer
    • Bernardini S, Fauconnet S, Chabannes E, et al.: Serum levels of vascular endothelial growth factor as a prognostic factor in bladder cancer. J Urol 2001, 166:1275-1279.
    • (2001) J Urol , vol.166 , pp. 1275-1279
    • Bernardini, S.1    Fauconnet, S.2    Chabannes, E.3
  • 38
    • 4444234852 scopus 로고    scopus 로고
    • Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFNalpha protein
    • Benedict WF, Tao Z, Kim CS, et al.: Intravesical Ad-IFNalpha causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFNalpha protein. Mol Ther 2004, 10:525-532.
    • (2004) Mol Ther , vol.10 , pp. 525-532
    • Benedict, W.F.1    Tao, Z.2    Kim, C.S.3
  • 39
    • 34548129602 scopus 로고    scopus 로고
    • Enhancement of intravesical delivery with Syn3 potentiates interferonalpha2b gene therapy for superficial bladder cancer
    • Nagabhushan TL, Maneval DC, Benedict WF, et al.: Enhancement of intravesical delivery with Syn3 potentiates interferonalpha2b gene therapy for superficial bladder cancer. Cytokine Growth Factor Rev 2007, 18:389-394.
    • (2007) Cytokine Growth Factor Rev , vol.18 , pp. 389-394
    • Nagabhushan, T.L.1    Maneval, D.C.2    Benedict, W.F.3
  • 40
    • 34247271873 scopus 로고    scopus 로고
    • CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma
    • This recent tissue-based study suggests the potential impact of tumor recognition by the immune system
    • Sharma P, Shen Y, Wen S, et al.: CD8 tumor-infiltrating lymphocytes are predictive of survival in muscle-invasive urothelial carcinoma. Proc Natl Acad Sc U S A 2007, 104:3967-3972. This recent tissue-based study suggests the potential impact of tumor recognition by the immune system.
    • (2007) Proc Natl Acad Sc USA , vol.104 , pp. 3967-3972
    • Sharma, P.1    Shen, Y.2    Wen, S.3
  • 41
    • 3042820773 scopus 로고    scopus 로고
    • Frequency of NY-ESO- 1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer
    • Sharma P, Gnjatic S, Jungbluth AA, et al.: Frequency of NY-ESO- 1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. Cancer Immun 2003, 3:19.
    • (2003) Cancer Immun , vol.3 , pp. 19
    • Sharma, P.1    Gnjatic, S.2    Jungbluth, A.A.3
  • 42
    • 63549129407 scopus 로고    scopus 로고
    • Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF
    • This clinical trial uses vaccine to induce immune responses in urothelial cancer patients
    • Sharma P, Bajorin DF, Jungbluth AA, et al.: Immune responses detected in urothelial carcinoma patients after vaccination with NY-ESO-1 protein plus BCG and GM-CSF. J Immunother 2008, 31:849-857. This clinical trial uses vaccine to induce immune responses in urothelial cancer patients.
    • (2008) J Immunother , vol.31 , pp. 849-857
    • Sharma, P.1    Bajorin, D.F.2    Jungbluth, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.