The association between dopamine DRD2 polymorphisms and working memory capacity is modulated by a functional polymorphism on the nicotinic receptor gene CHRNA4

Journal of Cognitive Neuroscience

Volumn 22, Issue 9, 2010, Pages 1944-1954

  Markett, Sebastian A ^a   Montag, Christian ^a   Reuter, Martin ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; DOPAMINE; DOPAMINE 2 RECEPTOR; NEUROTRANSMITTER; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4;

ADULT; ARTICLE; CHRNA 4 GENE; COGNITION; DNA POLYMORPHISM; DOPAMINE METABOLISM; DRD 2 GENE; FEMALE; GENE; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN EXPERIMENT; MALE; MOLECULAR GENETICS; NORMAL HUMAN; PRIORITY JOURNAL; SCHIZOPHRENIA; SUBSTANCE ABUSE; TASK PERFORMANCE; WORKING MEMORY;

ADOLESCENT; ADULT; FEMALE; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; MALE; MEMORY, SHORT-TERM; PHOTIC STIMULATION; POLYMORPHISM, GENETIC; PSYCHOMOTOR PERFORMANCE; RECEPTORS, DOPAMINE D2; RECEPTORS, NICOTINIC; YOUNG ADULT;

EID: 77956385423     PISSN: 0898929X     EISSN: 15308898     Source Type: Journal    
DOI: 10.1162/jocn.2009.21354     Document Type: Article

References (68)

1. Aalto, S., Brück, A., Laine, M., Någren, K., & Rinne, J. (2005). Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: A positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457. Journal of Neuroscience, 25, 2471-2477.
2. Ackermann, P. L., Beyer, M. E., & Boyle, M. O. (2005). Working memory and intelligence: The same or different constructs? Psychological Bulletin, 131, 30-60.
3. Alexander, G. E., DeLong, M. R., & Strick, P. L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357-381.
4. Baddeley, A. D. (1986). Working memory. Oxford: University Press.
5. Barch, D. M., & Smith, E. (2008).The cognitive neuroscience of working memory: Relevance to CNTRICS and schizophrenia. Biological Psychiatry, 64, 11-17.
6. Braver, T. S., & Cohen, J. D. (2000). On the control of control: The role of dopamine in regulating prefrontal function and working memory. In S. Monsell & J. Driver (Eds.), Attention and performance: XVIII. Control of cognitive processes (pp. 713-737). Cambridge, MA: MIT Press.
7. Brozoski, T. J., Brown, R. M., Rosvold, H. E., & Goldman, P. S. (1979). Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey. Science, 205, 929-932.
8. Camps, M., Cortes, R., Gueye, B., Probst, A., & Palacios, J. M. (1989). Dopamine receptors in human brain: Autoradiographic distribution of D2 sites. Neuroscience, 28, 275-290. (Pubitemid 19053074)
9. Conway, A. R. A., Kane, M. J., & Engle, R. W. (2003). Working memory capacity and its relation to general intelligence. Trends in Cognitive Sciences, 7, 547-552.
10. Cools, R., Gibbs, S. E., Miyakawa, A., Jagust, W., & D'Esposito, M. (2008). Working memory capacity predicts dopamine synthesis capacity in the human striatum. Journal of Neuroscience, 28, 1208-1212.
11. Cools, R., & Robbins, T. W. (2004). Chemistry of the adaptive mind. Philosophical Transactions of the Royal Society of London: Section A, 362, 2871-2888.
12. Cools, R., Sheridan, M., Jacobs, E., & D'Esposito, M. (2007). Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory. Journal of Neuroscience, 27, 5506-5514.
13. Cowan, N. (1999). An embedded-process model of working memory. In A. Miyake & P. Shah (Eds.), Models of working memory. Mechanisms of active maintenance and executive control. Cambridge: Cambridge University Press.
14. Cowan, N. (2000). The magical number 4 in short-term memory. A consideration of mental storage capacity. Behavioral and Brain Sciences, 24, 87-185.
15. Cowan, N. (2001). Author's response. Commentary on Cowan, N. (2000). The magical number 4 in short-term memory. A consideration of mental storage capacity. Behavioral and Brain Sciences, 24, 87-185.
16. Daneman, P., & Merikle, P. M. (1996). Working memory and language comprehension: A meta-analysis. Psychonomic Bulletin & Review, 3, 422-433.
17. Dehaene, S., Kerszberg, M., & Changeux, J.-P. (1998). A neuronal model of a global workspace in effortful cognitive tasks. Proceedings of the National Academy of Sciences, U.S.A., 95, 14529-14534.
18. D'Esposito, M. (2007). From cognitive to neural models of working memory. Philosophical Transactions of the Royal Society of London, Series B, Biological Sciences, 362, 761-772.
19. Egan, M. F., Goldberg, T. E., Kolachana, B. S., Callicott, J. H., Mazzanti, C. M., Straub, R. E., et al. (2001). Effect of COMT val105/158met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences, U.S.A., 98, 6917-6922.
20. Espeseth, T., Endestad, T., Rootwelt, H., & Reinvang, I. (2007). Nicotine receptor gene CHRNA4 modulated early event-related potentials in auditory and visual oddball target detection tasks. Neuroscience, 147, 974-985.
21. Evans, D. E., & Drobes, D. J. (2009). Nicotine self-medication of cognitive-attentional processing. Addiction Biology, 14, 32-42.
22. Exley, R., & Cragg, S. J. (2008). Presynaptic nicotinic receptors: A dynamic and diverse cholinergic filter of striatal dopamine neurotransmission. British Journal of Pharmacology, 153, S283-S297.
23. Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blkumenstiel, B., et al. (2002). The structure of haplotype blocks in the human genome. Science, 296, 2225-2229.
24. Gosso, M. F., de Geus, E. J. C., Poldermann, T. J. C., Boomsma, D. I., Heutink, P., & Posthuma, D. (2008). Catechol-O-methyltransferase and dopamine d2 receptor gene polymorphisms: Evidence of positive heterosis and gene-gene interaction on working memory functioning. European Journal of Human Genetics, 16, 1075-1082.
25. Greenwood, P. M., Fossella, J. A., & Parasuraman, R. (2006). Specificity of the effect of a nicotinic receptor polymorphism on individual differences in visuospatial attention. Journal of Cognitive Neuroscience, 17, 1611-1620.
26. Greenwood, P. M., Sundararajan, R., Lin, M.-K., Kumar, R., Fryxell, K. J., & Parasuraman, R. (2008). Both a nicotinic SNP and a noradrenergic SNP modulate working memory performance when attention is manipulated. Journal of Cognitive Neuroscience, 10, 1-15.
27. Hirvonen, M., Laakso, A., Någren, K., Rinne, J. O., Pohjalainen, T., & Hietala, J. (2006). C957T polymorphism of the dopamine d2 receptor (DRD2) gene affects striatal DRD2 availability in vivo. Molecular Psychiatry, 9, 1060-1066.
28. Jacobsen, L. K., Pugh, K. R., Mencl, W. E., & Gelernter, J. (2006). C957T polymorphism of the dopamine d2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiency. Psychopharmacology, 188, 530-540.
29. Kremen, W. S., Jacobsen, K. C., Xian, H., Eisen, S. A., Eaves, L. J., Tsuang, M. T., et al. (2007). Genetics of verbal working memory processes: A twin study of middle-aged men. Neuropsychology, 21, 569-580.
30. Levin, E. D., Castonguay, M., & Ellison, G. D. (1987). Effects of the nicotinic receptor blocker mecamylamine on radial-maze performance in rats. Behavioral and Neural Biology, 48, 206-212.
31. Levin, E. D., Conners, C. K., Silva, D., Hinston, S. C., Meck, W. H., March, J., et al. (1998). Transdermal nicotine effect on attention. Psychopharmacology, 140, 135-141.
32. Levin, E. D., McGurk, S. R., Rose, J. E., & Butcher, L. L. (1989). Reversal of mecamylamine-induced cognitive deficit with the D2-agonist, LY 171555. Pharmacology Biochemistry and Behavior, 33, 919-922.
33. Levin, E. D., & Rezvani, A. H. (2007). Nicotinic interactions with antipsychotic drugs, models of schizophrenia and impacts on cognitive function. Biochemical Pharmacology, 74, 1182-1191.
34. Levin, E. D., & Rose, J. E. (1991). Nicotinic and muscarinic interactions and choice accuracy in the radial-arm maze. Brain Research Bulletin, 27, 125-128.
35. 2 dopamine receptor agonist. Journal of Cognitive Neuroscience, 4, 58-68.
36. Luck, S. J., & Vogel, E. K. (1997). The capacity of visual working memory for features and conjunctions. Nature, 390, 279-281.
37. Mancuso, G., Andres, P., Ansseau, M., & Tirelli, E. (1999). Effects of nicotine administered via a transdermal delivery system on vigilance: A repeated measurement study. Psychopharmacology, 142, 18-23.
38. Martinussen, R., Hayden, J., Hogg-Johnson, S., & Tannock, R. (2005). A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 44, 377-384.
39. Mattay, V. S., Goldberg, T. E., Fera, F., Hariri, A. R., Tessitore, A., Egan, M. F., et al. (2003). Catechol-O-methyltransferase val158met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences, U.S.A., 100, 6186-6191.
40. McEvoy, J. P., Freudenreich, O., Levin, E. D., & Rose, J. E. (1995). Haloperidol increases smoking in patients with schizophrenia. Psychopharmacology, 119, 124-126.
41. McGurk, S. R., Levin, E. D., & Butcher, L. L. (1989). Radial-arm maze performance in rats is impaired by a combination of nicotinic-cholinergic and D2 dopaminergic antagonist drugs. Psychopharmacology, 99, 371-373.
42. McNab, F., & Klingberg, T. (2008). Prefrontal cortex and basal ganglia control access to working memory. Nature Neuroscience, 11, 103-107.
43. Miller, G. A. (1956). The magical number seven, plus or minus two. Some limits on our capacity for processing information. Psychological Review, 101, 343-352.
44. Norman, D. A., & Shallice, T. (1980). Attention to action. Willed and automatic control of behavior. In R. J. Davidson, G. E. Schwartz, & D. Shapiro (Eds.), Consciousness and self-regulation: Advances in research and theory (1986). New York: Plenum.
45. Owen, A. M., McMillan, K. M., Laird, A. R., & Bullmore, E. (2005). N-back working memory paradigm: A meta-analysis of normative functional neuroimaging studies. Human Brain Mapping, 25, 46-59.
46. Parasuraman, R., Greenwood, P. M., Kumar, R., & Fossella, J. (2005). Beyond heritability. Neurotransmitter genes differentially modulate visuospatial attention and working memory. Psychological Science, 16, 200-207.
47. Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., Horney, K., et al. (1994). DNA markers associated with high vs. low IQ: The IQ quantitative trait loci (QTL) project. Behavior Genetics, 24, 107-118.
48. Pohjalainen, T., Rinne, J. O., Någren, K., Lehikoinen, P., Anttila, K., Syvalahti, E. K. G., et al. (1998). The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Molecular Psychiatry, 3, 256-260.
49. Posner, M. I., & Dehaene, S. (1994). Attentional networks. Trends in Neurosciences, 17, 75-79.
50. Provost, S. C., & Woodward, R. (1991). Effects of nicotine gum on repeated administration of the Stroop test. Psychopharmacology, 104, 536-540.
51. Reinvang, I., Lundervold, A. J., Rootwelt, H., Wehling, E., & Espeseth, T. (2009). Individual variation in a cholinergic receptor gene modulates attention. Neuroscience Letters, 453, 3, 131-134.
52. Savitz, J., Solms, M., & Ramesar, R. (2006). The molecular genetics of cognition: Dopamine, COMT and BDNF. Genes, Brain and Behavior, 5, 311-328.
53. Song, J.-H., & Jiang, Y. (2006). Visual working memory for simple and complex features: An fMRI study. Neuroimage, 30, 963-972.
54. Stelzel, C., Basten, U., Montag, C., Reuter, M., & Fiebach, C. J. (2009). Effects of dopamine-related gene-gene interactions on working memory component processes. European Journal of Neuroscience, 29, 1056-1063.
55. Stephens, M., Smith, N. J., & Donnelly, P. (2001). A new statistical method for haplotype reconstruction from population data. American Journal of Human Genetics, 68, 978-989.
56. Sternberg, S. (1969). Memory-scanning: Mental processes revealed by reaction-time experiments. American Scientist, 57, 421-457.
57. The International HapMap Consortium. (2003). The international HapMap project. Nature, 426, 789-796.
58. Todd, J. J., & Marois, R. (2004). Capacity limit of visual short-term memory in human posterior parietal cortex. Nature, 428, 751-754.
59. Todd, J. J., & Marois, R. (2005). Posterior parietal cortex activity predicts individual differences in visual short-term memory capacity. Cognitive, Affective, & Behavioral Neuroscience, 5, 144-155.
60. Tukey, J. W. (1977). Exploratory data analysis (2nd ed.). Reading, MA: Addison-Wesley.
61. Vogel, E. K., & Machizawa, M. G. (2004). Neural activity predicts individual differences in working memory. Nature, 428, 748-751.
62. Vogel, E. K., McCollough, A. W., & Machizawa, M. G. (2005). Neural measures reveal individual differences in controlling access to working memory. Nature, 438, 500-503.
63. Weiser, M., Reichenberg, A., Grotto, I., Yasvitzky, R., Rabinowitz, J., Lubin, G., et al. (2004). Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: A historical-prospective cohort study. American Journal of Psychiatry, 161, 1219-1223.
64. Winterer, G., Musso, F., Konrad, A., Vucurevic, G., Stoeter, P., Sander, T., et al. (2007). Association of attentional network function with exon 5 variations of the CHRNA4 gene. Human Molecular Genetics, 16, 18, 1265-2174.
65. Winterer, G., & Weinberger, D. R. (2004). Genes, dopamine and cortical signal-to-noise ratio in schizophrenia. Trends in Neurosciences, 27, 683-690.
66. Xu, H., Kellendonk, C. B., Sompson, E. H., Keilp, J. G., Bruder, G. E., Polan, H. J., et al. (2007). DRD2 c957t polymorphisms interacts with COMT val158met polymorphism in human working memory ability. Schizophrenia Research, 90, 104-107.
67. Zhang, Y., Bertolino, A., Fazio, L., Blasi, G., Rampino, A., Romano, R., et al. (2007). Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. Proceedings of the National Academy of Sciences, U.S.A., 104, 20552-20557.
68. Zhou, F., Wilson, C., & Dani, J. A. (2003). Muscarinic and nicotinergic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist, 9, 23-36.