How does CaMKIIδ phosphorylation of the cardiac ryanodine receptor contribute to inotropy?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 31, 2010, Pages

  Eisner, David A ^a   George, Christopher H ^b   Smith, Godfrey L ^c   Trafford, Andrew W ^a   Venetucci, Luigi A ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II DELTA; CALCIUM ION; RYANODINE RECEPTOR; UNCLASSIFIED DRUG;

CALCIUM SIGNALING; CALCIUM TRANSPORT; ENZYME PHOSPHORYLATION; HEART MUSCLE CONTRACTILITY; INOTROPISM; LETTER; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM; ANIMAL; HEART CONTRACTION; HEART MUSCLE CELL; METABOLISM; NOTE; PHOSPHORYLATION;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PHOSPHORYLATION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

EID: 77956375917     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008809107     Document Type: Letter

References (5)

1. Kushnir A, Shan J, Betzenhauser MJ, Reiken S, Marks AR (2010) Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure. Proc Natl Acad Sci USA 107:10274-10279.
2. 2+/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res 94:e61-e70.
3. 2+-calmodulin-dependent protein kinase II on cardiac excitation-contraction coupling in ferret ventricular myocytes. J Physiol 501:17-31.
4. Eisner DA, Kashimura T, O'Neill SC, Venetucci LA, Trafford AW (2009) What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis? J Mol Cell Cardiol 46:474-481.
5. 2+ leak in heart failure. Circ Res 97:1314-1322.