Solid-state interactions of a drug substance and excipients and their impact on tablet dissolution: A thermal-mechanical facilitated process-induced transformation or PIT

Journal of Pharmaceutical Sciences

Volumn 99, Issue 9, 2010, Pages 3849-3862

  Wang, Jennifer ^a   Davidovich, Martha ^a   Desai, Divyakant ^a   Bu, Dongsheng ^a   Hussain, Munir ^a   Morris, Kenneth ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF HAWAII AT HILO   (United States)

Author keywords

Dissolution; Drying; Mixing; Polymorphic phase transformation; Povidone; Process induced transformation (PIT); Solid state interaction; Stearic acid; Wet granulation

Indexed keywords

EXCIPIENT; POVIDONE; STEARIC ACID;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG TRANSFORMATION; SOLID STATE; TABLET; TEMPERATURE SENSITIVITY; X RAY POWDER DIFFRACTION;

EID: 77956375745     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22222     Document Type: Article

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