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Protein Science
Volumn 19, Issue 9, 2010, Pages 1796-1800
The pyruvate kinase model system, a cautionary tale for the use of osmolyte perturbations to support conformational equilibria in allostery
Author keywords

Allosteric regulation; Allostery; M1 PYK; Osmolyte; Preexisting equilibrium; Pyruvate kinase
Indexed keywords

AMINO ACID; GLYCEROL; MACROGOL; MANGANESE; OSMOLITE; PROLINE; PROTEIN; PYRUVATE KINASE; PYRUVIC ACID;
EID: 77956374379     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.450     Document Type: Article
Times cited : (17)
References (7)
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  • 2
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    • Modulation of allostery of pyruvate kinase by shifting of an ensemble of microstates
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    • Lee, J.C.1
  • 4
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    • Further evidence for the reliance of catalysis by rabbit muscle pyruvate kinase upon isomerization of the ternary complex between enzyme and products
    • Lonhienne TG, Reilly PE, Winzor DJ (2003) Further evidence for the reliance of catalysis by rabbit muscle pyruvate kinase upon isomerization of the ternary complex between enzyme and products. Biophys Chem 104: 189-198.
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  • 5
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    • Lonhienne TG, Winzor DJ (2002) Calorimetric demonstration of the potential of molecular crowding to emulate the effect of an allosteric activator on pyruvate kinase kinetics. Biochemistry 41:6897-6901.
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    • Lonhienne, T.G.1    Winzor, D.J.2
  • 6
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    • Quantitative Analysis and Interpretation of Allosteric Behavior
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    • Reinhart GD (2004) Quantitative analysis and interpretation of allosteric behavior. Methods Enzymol 380: 187-203. (Pubitemid 38297496)
    • (2004) Methods in Enzymology , vol.380 , pp. 187-203
    • Reinhart, G.D.1
  • 7
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    • Ligand binding and internal equilibria in proteins
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