Directly observed therapy (DOT) for Nonadherent HIV-infected youth: Lessons learned, challenges ahead

AIDS Research and Human Retroviruses

Volumn 26, Issue 9, 2010, Pages 947-953

  Gaur, Aditya H ^a   Belzer, Marvin ^b   Britto, Paula ^c   Garvie, Patricia A ^a   Hu, Chengcheng ^d   Graham, Bobbie ^e   Neely, Michael ^f   McSherry, George ^g   Spector, Stephen A ^h   Flynn, Patricia M ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b CHILDREN S HOSPITAL LOS ANGELES   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e FRONTIER SCIENCE AND TECHNOLOGY RESEARCH FOUNDATION   (United States)

^f UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^g PENNSYLVANIA STATE UNIVERSITY   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CLINICAL ARTICLE; DIRECTLY OBSERVED THERAPY; DRUG SELF ADMINISTRATION; FEMALE; HEALTH SURVEY; HOME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MALE; PILOT STUDY; PRIORITY JOURNAL; UNITED STATES; ADOLESCENT; DRUG EFFECTS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; MEDICATION COMPLIANCE; YOUNG ADULT;

ADOLESCENT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; DIRECTLY OBSERVED THERAPY; FEMALE; HIV; HIV INFECTIONS; HUMANS; MALE; MEDICATION ADHERENCE; PILOT PROJECTS; YOUNG ADULT;

EID: 77956370496     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2010.0008     Document Type: Article

References (29)

1. Lima VD, Harrigan R, Bangsberg DR, et al.: The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time. J Acquir Immune Defic Syndr 2009;50(5):529-536.
2. Murphy DA, Wilson CM, Durako SJ, Muenz LR, and Belzer M: Antiretroviral medication adherence among the REACH HIV-infected adolescent cohort in the USA. AIDS Care 2001;13(1):27-40.
3. Lindsey J, Bosch RJ, Rudy BJ, Flynn PM, and the PACTG 381 Study Team: Early patterns of adherence in adolescents initiating HAART predict long-term adherence, virologic and immunologic control. AIDS Patient Care STDs 2009; 23(10):799-801.
4. Murphy DA, Sarr M, Durako SJ, et al.: Barriers to HAART adherence among human immunodeficiency virus-infected adolescents. Arch Pediatr Adolesc Med 2003;157(3):249-255.
5. Rudy BJ, Murphy DA, Harris DR, Muenz L, and Ellen J: Patient-related risks for nonadherence to antiretroviral therapy among HIV-infected youth in the United States: A study of prevalence and interactions. AIDS Patient Care STDs 2009;23(3):185-194.
6. Reisner SL, Mimiaga MJ, Skeer M, et al.: A review of HIV antiretroviral adherence and intervention studies among HIV-infected youth. Top HIV Med 2009;17(1):14-25.
7. Wohl DA, Stephenson BL, Golin CE, et al.: Adherence to directly observed antiretroviral therapy among human immunodeficiency virus-infected prison inmates. Clin Infect Dis 2003;36(12):1572-1576.
8. Lucas GM, Mullen BA, Weidle PJ, et al.: Directly administered antiretroviral therapy in methadone clinics is associated with improved HIV treatment outcomes, compared with outcomes among concurrent comparison groups. Clin Infect Dis 2006;42(11):1628-1635.
9. Altice FL, Maru DS, Bruce RD, Springer SA, and Friedland GH: Superiority of directly administered antiretroviral therapy over self-administered therapy among HIV-infected drug users: A prospective, randomized, controlled trial. Clin Infect Dis 2007;45(6):770-778.
10. Macalino GE, Hogan JW, Mitty JA, et al.: A randomized clinical trial of community-based directly observed therapy as an adherence intervention for HAART among substance users. AIDS 2007;21(11):1473-1477.
11. Pearson CR, Micek MA, Simoni JM, et al.: Randomized control trial of peer-delivered, modified directly observed therapy for HAART in Mozambique. J Acquir Immune Defic Syndr 2007;46(2):238-244.
12. Wohl AR, Garland WH, Valencia R, et al.: A randomized trial of directly administered antiretroviral therapy and adherence case management intervention. Clin Infect Dis 2006;42(11):1619-1627.
13. Glikman D, Walsh L, Valkenburg J, Mangat PD, and Marcinak JF: Hospital-based directly observed therapy for HIV-infected children and adolescents to assess adherence to antiretroviral medications. Pediatrics 2007;119(5):e1142-e1148.
14. Parsons GN, Siberry GK, Parsons JK, et al.: Multidisciplinary, inpatient directly observed therapy for HIV-1-infected children and adolescents failing HAART: A retrospective study. AIDS Patient Care STDs 2006;20(4):275-284.
15. Purdy JB, Freeman AF, Martin SC, et al.: Virologic response using directly observed therapy in adolescents with HIV: An adherence tool. J Assoc Nurses AIDS Care 2008;19(2): 158-165.
16. Garvie PA, Lawford J, Flynn PM, et al.: Development of a directly observed therapy adherence intervention for adolescents with human immunodeficiency virus-1: Application of focus group methodology to inform design, feasibility, and acceptability. J Adolesc Health 2009;44(2):124-132.
17. Janz NK and Becker MH: The Health Belief Model: A decade later. Health Educ Quart 1984;11(1):1-47.
18. Bandura A: Self-efficacy: Toward a unifying theory of behavioral change. Psychol Rev 1977;84(2):191-215.
19. Puccio JA, Belzer M, Olson J, et al.: The use of cell phone reminder calls for assisting HIV-infected adolescents and young adults to adhere to highly active antiretroviral therapy: A pilot study. AIDS Patient Care STDs 2006;20(6): 438-444.
20. Sarna A, Luchters S, Geibel S, et al.: Short- and long-term efficacy of modified directly observed antiretroviral treatment in Mombasa, Kenya: A randomized trial. J Acquir Immune Defic Syndr 2008;48(5):611-619.
21. Murphy DA, Belzer M, Durako SJ, et al.: Longitudinal antiretroviral adherence among adolescents infected with human immunodeficiency virus. Arch Pediatr Adolesc Med 2005;159(8):764-770.
22. Simoni JM, Pearson CR, Pantalone DW, Marks G, and Crepaz N: Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials. J Acquir Immune Defic Syndr 2006;43(Suppl 1):S23-S35.
23. Wagner GJ, Kanouse DE, Golinelli D, et al.: Cognitive-behavioral intervention to enhance adherence to antiretroviral therapy: A randomized controlled trial (CCTG 578). AIDS 2006;20(9):1295-1302.
24. Golin CE, Earp J, Tien HC, et al.: A 2-arm, randomized, controlled trial of a motivational interviewing-based intervention to improve adherence to antiretroviral therapy (ART) among patients failing or initiating ART. J Acquir Immune Defic Syndr 2006;42(1):42-51.
25. Marcus MT, Walker T, Swint JM, et al.: Community-based participatory research to prevent substance abuse and HIV/AIDS in African-American adolescents. J Interprof Care 2004;18(4):347-359.
26. Simoni JM, Huh D, Frick PA, et al.: Peer support and pager messaging to promote antiretroviral modifying therapy in Seattle: A randomized controlled trial. J Acquir Immune Defic Syndr 2009;52(4):465-473.
27. Behforouz HL, Farmer PE, and Mukherjee JS: From directly observed therapy to accompagnateurs: Enhancing AIDS treatment outcomes in Haiti and in Boston. Clin Infect Dis 2004;38(Suppl 5):S429-S436.
28. Ford N, Nachega JB, Engel ME, and Mills EJ: Directly observed antiretroviral therapy: A systematic review and meta-analysis of randomised clinical trials. Lancet 2009; 374(9707):2064-2071.
29. Goldie SJ, Paltiel AD, Weinstein MC, et al.: Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection. Am J Med 2003; 115(8):632-641.