Physical characterization of TRK-720 hydrate, the very late antigen-4 (VLA-4) inhibitor, as a solid form for inhalation: Preparation of the hydrate by solvent exchange among its solvates and mechanistical considerations

Journal of Pharmaceutical Sciences

Volumn 99, Issue 9, 2010, Pages 3986-4004

  Shiraki, Motohiro ^a  

^a TORAY INDUSTRIES INC   (Japan)

Author keywords

Crystal structure; Desolvation; Dry powder inhaler (DPI); Hydrates solvates; Hydration; Polymorphic screening; Pseudopolymorphism; Solid state stability; Solvent channel; X ray powder diffractometry

Indexed keywords

2 [(2,6 DICHLOROPHENYL)CARBONYLAMINO] 3 [(2,4,8 TRIAZA 2 METHYL 1 OXO 4 PHENYLSPIRO[4.5]DEC 8 YL)CARBONYLAMINO]PROPANOIC ACID; ANTIASTHMATIC AGENT; DRUG CARRIER; METHANOLATE; SOLVENT; TRK 720; UNCLASSIFIED DRUG; WATER;

ARTICLE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMIDITY; HYDRATION; PARTICLE SIZE; SOLID STATE; SOLVATE; SOLVATION; SOLVENT EFFECT; THERMOGRAVIMETRY; WATER VAPOR; X RAY POWDER DIFFRACTION;

EID: 77956364064     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22246     Document Type: Article

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