Evidence of impact of maternal HIV infection on immunoglobulin levels in HIV-exposed uninfected children

AIDS Research and Human Retroviruses

Volumn 26, Issue 9, 2010, Pages 967-975

  Bunders, Madeleine ^a   Pembrey, Lucy ^b   Kuijpers, Taco ^a   Newell, Marie Louise ^b,c  

^a EMMA CHILDREN S HOSPITAL   (Netherlands)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOGLOBULIN;

ADULT; ARTICLE; EVIDENCE BASED MEDICINE; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; NEWBORN; PREGNANT WOMAN; PRIORITY JOURNAL; PROSPECTIVE STUDY; VIRUS TRANSMISSION; BLOOD; COMPARATIVE STUDY; IMMUNOLOGY; PASSIVE IMMUNIZATION; PREGNANCY; PREGNANCY COMPLICATION; PRESCHOOL CHILD; TRANSMISSION; VERTICAL TRANSMISSION;

CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; IMMUNITY, MATERNALLY-ACQUIRED; IMMUNOGLOBULINS; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; LONGITUDINAL STUDIES; MALE; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS;

EID: 77956363597     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/aid.2009.0241     Document Type: Article

References (43)

1. European Collaborative Study: Mother-to-child transmission of HIV infection in the era of highly active antiretroviral therapy. Clin Infect Dis 2005;40:458-465.
2. European Collaborative Study: Are girls more at risk of intra-uterine-acquired HIV infection than boys? AIDS 2004;18: 344-347.
3. Mandelbrot L, Landreau-Mascaro A, Rekacewicz C, et al.: Lamivudine-zidovudine combination for prevention of maternal-infant transmission of HIV-1. JAMA 2001;285:2083-2093.
4. European Collaborative Study: Levels and patterns of neutrophil cell counts over the first 8 years of life in children of HIV-1-infected mothers. AIDS 2004;18:2009-2017.
5. Bunders M, Thorne C, and Newell ML: Maternal and infant factors and lymphocyte, CD4 and CD8cell counts in uninfected children of HIV-1-infected mothers. AIDS 2005;19: 1071-1079.
6. Titanji K, Chiodi F, Bellocco R, et al.: Primary HIV-1 infection sets the stage for important B lymphocyte dysfunctions. AIDS 2005;19:1947-1955.
7. DOrsogna LJ, Krueger RG, McKinnon EJ, et al.: Circulating memory B-cell subpopulations are affected differently by HIV infection and antiretroviral therapy. AIDS 2007;21: 1747-1752.
8. De Milito A, Nilsson A, Titanji K, et al.: Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity inHIV-1 infection. Blood 2004;103:2180-2186.
9. Ni J, Hembrador E, Di Bisceglie AM, et al.: Accumulation of B lymphocytes with a naive, resting phenotype in a subset of hepatitis C patients. J Immunol 2003;170:3429-3439.
10. Fournillier A, Freida D, Defrance T, et al.: Analysis of Blymphocyte differentiation in patients infected with hepatitis C virus. J Med Virol 2004;72:566-574.
11. European Paediatric HCV Network: A significant sex-but not elective cesarean section-effect on mother-to-child transmission of hepatitis C virus infection. J Infect Dis 2005; 192:1872-1879.
12. European Paediatric HCV Network, Polywka S, Pembrey L, Tovo PA, and Newell ML: Accuracy of HCV-RNA PCR tests for diagnosis or exclusion of vertically acquired HCV infection. J Med Virol 2006;78:305-310.
13. Ammann A: Pediatric Human Immunodeficiency Virus Infection (Stiehm ER, Ochs HD, and Winkelstein JA, eds.). W.B. Saunders Company, Elsevier, Philadelphia, 2004, pp. 878-951.
14. Cleveland WS and Devlin SJ: Locally weighted regression-an approach to regression-analysis by local fitting. J Am Stat Assoc 1988;83:596-610.
15. Leyland AH, Goldstein H, and eds.: Multilevel Modelling of Health Statistics. John Wiley & Sons, Ltd, New York, 2001.
16. Rabe-Hesketh S, Skrondal A, Pickles A. Reliable estimation of generalized linear mixed models using adaptive quadrature. Stata J 2002;2:1-21.
17. Der Zwet WC, Vandenbroucke-Grauls CM, van Elburg RM, et al.: HL. Neonatal antibody titers against varicella-zoster virus in relation to gestational age, birth weight, and maternal titer. Pediatrics 2002;109:79-85.
18. Leineweber B, Grote V, Schaad UB, and Heininger U: Transplacentally acquired immunoglobulin G antibodies against measles, mumps, rubella and varicella-zoster virus in preterm and full term newborns. Pediatr Infect Dis J 2004;23:361-363.
19. Reference values: http://www.copeson.org.mx/Harriet- Lane.pdf.
20. Zemlin M, Hoersch G, Zemlin C, et al.: The postnatal maturation of the immunoglobulin heavy chain IgG repertoire in human preterm neonates is slower than in term neonates. J Immunol 2007;178:1180-1188.
21. Hobbs JR and Davis JA: Serum gamma-G-globulin levels and gestational age in premature babies. Lancet 1967;1:757-759.
22. Lugada ES, Mermin J, Asjo B, et al.: Immunoglobulin levels amongst persons with and without human immunodeficiency virus type 1 infection in Uganda and Norway. Scand J Immunol 2004;59:203-208.
23. Fosarelli P, Winkelstein J, De Angelis C, et al.: Serum immunoglobulins in the first year of life. Clin Pediatr 1985;24: 84-88.
24. Stiehm ER and Fudenberg HH: Serum levels of immune globulins in health and disease: A survey. Pediatrics 1966;37: 715-727.
25. Moraes-Pinto MI, Almeida AC, Kenj G, et al.: Placental transfer and maternally acquired neonatal IgG immunity in human immunodeficiency virus infection. J Infect Dis 1996; 173:1077-1084.
26. Manz RA, Hauser AE, Hiepe F, and Radbruch A: Maintenance of serum antibody levels. Annu Rev Immunol 2005;23:367-386.
27. Ghetie V and Ward ES: Multiple roles for the major histocompatibility complex class I- related receptor FcRn. Annu Rev Immunol 2000;18:739-766.
28. Lane HC, Masur H, Edgar LC, et al.: Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome. N Engl J Med 1983; 309:453-458.
29. Chong Y, Ikematsu H, Yamamoto M, et al.: Increased frequency of CD27- (naive) B cells and their phenotypic alteration in HIV type 1 infected patients. AIDS Res Hum Retroviruses 2004;20:621-629.
30. Chong Y, Ikematsu H, Kikuchi K, et al.: Selective CD27- (memory) B cell reduction and characteristic B cell alteration in drug-naive and HAART-treated HIV type 1-infected patients. AIDS Res Hum Retroviruses 2004;20:219-226.
31. Muller F, Aukrust P, Nordoy I, and Froland SS: Possible role of interleukin-10 (IL-10) and CD40 ligand expression in the pathogenesis of hypergammaglobulinemia in human immunodeficiency virus infection: modulation of IL-10 and Ig production after intravenous Ig infusion. Blood 1998;92: 3721-3729.
32. Macchia D, Almerigogna F, Parronchi P, et al.: Membrane tumour necrosis factor-alpha is involved in the polyclonal Bcell activation induced by HIV-infected human T cells. Nature 1993;363:464-466.
33. Kacani L, Stoiber H, and Dierich MP: Role of IL-15 in HIV-1-associated hypergammaglobulinaemia. Clin Exp Immunol 1997;108:14-18.
34. Tranquilli AL, Landi B, Corradetti A, et al.: Inflammatory cytokines patterns in the placenta of pregnancies complicated by HELLP (hemolysis, elevated liver enzyme, and low platelet) syndrome. Cytokine 2007;40:82-88.
35. Fiore S, Newell ML, Trabattoni D, et al.: Antiretroviral therapy-associated modulation of Th1 and Th2 immune responses in HIV-infected pregnant women. J Reprod Immunol 2006;70:143-150.
36. Kfutwah A, Mary JY, Lemen B, et al.: Plasmodium falciparum and placental cytokine profiles among pregnant women in relation to their HIV-1 status: Possible implications for motherto-child transmission of HIV-1 in Cameroon [Abstract]. 4th Dominique Dormont International Conference, O14, 2007.
37. Morris L, Binley JM, Clas BA, et al.: HIV-1 antigen-specific and -nonspecific B cell responses are sensitive to combination antiretroviral therapy. J Exp Med 1998;188:233-245.
38. The Italian Register for HIV Infection in Children: Combined antiretroviral therapy reduces hyperimmunoglobulinemia in HIV-1 infected children. AIDS 2004;18:1423-1428.
39. Bekker V, Scherpbier H, Pajkrt D, et al.: Persistent humoral immune defect in highly active antiretroviral therapy-treated children with HIV-1 infection: Loss of specific antibodies against attenuated vaccine strains and natural viral infection. Pediatrics 2006;118:e315-e322.
40. Aurpibul L, Puthanakit T, Siriaksorn S, et al.: Prevalence of protective antibody against measles in HIV-infected children with immune recovery after highly active antiretroviral therapy. HIV Med 2006;7:467-470.
41. Helfand RF, Witte D, Fowlkes A, et al.: Evaluation of the immune response to a 2-dose measles vaccination schedule administered at 6 and 9 months of age to HIV-infected and HIV-uninfected children in Malawi. J Infect Dis 2008; 198:1457-1465.
42. Embree JE, Datta P, Stackiw W, et al.: Increased risk of early measles in infants of HIV type 1-seropositive mothers. J Infect Dis 1992;165:262-267.
43. Moss WJ, Monze M, Ryon JJ, et al.: Prospective study of measles in hospitalized, human immunodeficiency virus (HIV)-infected and HIV-uninfected children in Zambia. Clin Infect Dis 2002;35:189-196.