Clinical guidelines: HFE hemochromatosis-screening, diagnosis and management

Nature Reviews Gastroenterology and Hepatology

Volumn 7, Issue 9, 2010, Pages 482-484

  Barton, James C ^a   Adams, Paul C ^b  

^a SOUTHERN IRON DISORDERS CENTER   (United States)

^b LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; HFE PROTEIN; IRON; TRANSFERRIN;

BLOOD TRANSFUSION; CLINICAL ASSESSMENT; CLINICAL DECISION MAKING; CLINICAL PRACTICE; DIET THERAPY; DISEASE ASSOCIATION; EUROPE; EVIDENCE BASED MEDICINE; FAMILY HISTORY; FERRITIN BLOOD LEVEL; FOLLOW UP; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC SCREENING; GENOTYPE; HEMOCHROMATOSIS; HOMOZYGOSITY; HUMAN; HYPERFERRITINEMIA; IRON BLOOD LEVEL; IRON DEPLETION; IRON OVERLOAD; LIVER BIOPSY; MUTATIONAL ANALYSIS; ORGAN INJURY; PATIENT CARE; PENETRANCE; PHENOTYPE; PHLEBOTOMY; PHYSICIAN ATTITUDE; PRACTICE GUIDELINE; PREDICTION; PREVALENCE; PRIORITY JOURNAL; SHORT SURVEY; SURVIVAL; THERAPY EFFECT; TRANSFERRIN BLOOD LEVEL; TREATMENT PLANNING;

EUROPE; FEMALE; FERRITINS; GENETIC TESTING; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMOZYGOTE; HUMANS; MALE; MEMBRANE PROTEINS; PRACTICE GUIDELINES AS TOPIC; PREVALENCE;

EID: 77956361163     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2010.132     Document Type: Short Survey

References (10)

1. European Association For The study Of The Liver. eAsL clinical practice guidelines for HFE hemochromatosis. J. Hepatol. 53, 322 (2010)
2. Adams, P. C. et al. Comparison of the unsaturated iron-binding capacity with transferrin saturation as a screening test to detect C282Y homozygotes for hemochromatosis in 101,168 participants in the hemochromatosis and iron overload screening (HeiRs) study. Clin. Chem. 51, 10481052 (2005).
3. Asberg, A., Hveem, K., Kannelonning, K. & irgens, w. O. Penetrance of the C28Y/C282Y genotype of the HFE gene. Scand. J. Gastroenterol. 42, 10731077 (2007).
4. Allen, K. J. et al. iron-overload-related disease in HFE hereditary hemochromatosis. N. Engl. J. Med. 358, 221230 (2008).
5. Adhoute, X. et al. Diagnosis of liver fibrosis using Fibroscan and other noninvasive methods in patients with hemochromatosis: a prospective study. Gastroenterol. Clin. Biol. 32, 180187 (2008).
6. Wojcik, J. P., speechley, M. R., Kertesz, A. e., Chakrabarti, s. & Adams, P. C. natural history of C282Y homozygotes for hemochromatosis. Can. J. Gastroenterol. 16, 297302 (2002).
7. Ellervik, C., Tybjaerg-Hansen, A., Grande, P., Appleyard, M. & nordestgaard, B. G. Hereditary hemochromatosis and risk of ischemic heart disease: a prospective study and a case-control study. Circulation 112, 185193 (2005).
8. Pankow, J. s. et al. HFE C282Y homozygotes have reduced low-density lipoprotein cholesterol: the Atherosclerosis Risk in Communities (ARiC) study. Transl. Res. 152, 310 (2008).
9. Barton, J. C. & Acton, R. T. Hemochromatosis and Vibrio vulnificus wound infections. J. Clin. Gastroenterol. 43, 890893 (2009).
10. Hall, M. A. et al. Genetic screening for iron overload: no evidence of discrimination at 1 year. J. Fam. Pract. 56, 829834 (2007).