HLA-DQ2+ individuals are susceptible to Hu-Ab associated paraneoplastic neurological syndromes

Journal of Neuroimmunology

Volumn 226, Issue 1-2, 2010, Pages 147-149

  de Graaf, Marieke T ^a   de Beukelaar, Janet W K ^a   Haasnoot, Geert W ^b   Levering, Wilfried H B M ^c   Rogemond, Véronique ^d,e,f   Didelot, Adrien ^d,e,f   Honnorat, Jérôme ^d,e,f   Gratama, Jan W ^a   Smitt, Peter A E Sillevis ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Sanquin Bloedbank Regio Zuidwest Rotterdam   (Netherlands)

^d HÔPITAL NEUROLOGIQUE   (France)

^e INSERM   (France)

^f UNIVERSITÉ LYON 1   (France)

Author keywords

HLA; Hu antibodies; Paraneoplastic neurological syndromes; SCLC

Indexed keywords

HLA A ANTIGEN; HLA B ANTIGEN; HLA DQ2 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR3 ANTIGEN; HU ANTIBODY; ANTIBODY; CD4 ANTIGEN; HLA DQ ANTIGEN; HU ANTIGEN;

ADULT; AGED; ALLELE; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FRANCE; GENETIC RISK; HUMAN; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; NETHERLANDS; PARANEOPLASTIC NEUROPATHY; PRIORITY JOURNAL; T LYMPHOCYTE; CONFIDENCE INTERVAL; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; RISK; SMALL CELL LUNG CANCER; VERY ELDERLY; YOUNG ADULT;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODIES; ANTIGENS, CD4; CONFIDENCE INTERVALS; FEMALE; HLA-DQ ANTIGENS; HU PARANEOPLASTIC ENCEPHALOMYELITIS ANTIGENS; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; PARANEOPLASTIC SYNDROMES, NERVOUS SYSTEM; SMALL CELL LUNG CARCINOMA; T-LYMPHOCYTES; YOUNG ADULT;

EID: 77956338902     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2010.05.035     Document Type: Article

References (26)

1. Bartoccioni E., Scuderi F., Augugliaro A., Chiatamone Ranieri S., Sauchelli D., Alboino P., Marino M., Evoli A. HLA class II allele analysis in MuSK-positive myasthenia gravis suggests a role for DQ5. Neurology 2009, 72:195-197.
2. Benyahia B., Liblau R., Merle-Beral H., Tourani J.M., Dalmau J., Delattre J.Y. Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. Ann. Neurol. 1999, 45:162-167.
3. Bernal F., Graus F., Pifarre A., Saiz A., Benyahia B., Ribalta T. Immunohistochemical analysis of anti-Hu-associated paraneoplastic encephalomyelitis. Acta Neuropathol. (Berl) 2002, 103:509-515.
4. Caillat-Zucman S. Molecular mechanisms of HLA association with autoimmune diseases. Tissue Antigens 2009, 73:1-8.
5. de Beukelaar J.W., Sillevis Smitt P.A. Managing paraneoplastic neurological disorders. Oncologist 2006, 11:292-305.
6. Graus F., Dalmou J., Rene R., Tora M., Malats N., Verschuuren J.J., Cardenal F., Vinolas N., Garcia del Muro J., Vadell C., Mason W.P., Rosell R., Posner J.B., Real F.X. Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J. Clin. Oncol. 1997, 15:2866-2872.
7. Graus F., Keime-Guibert F., Rene R., Benyahia B., Ribalta T., Ascaso C., Escaramis G., Delattre J.Y. Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain 2001, 124:1138-1148.
8. Graus F., Delattre J.Y., Antoine J.C., Dalmau J., Giometto B., Grisold W., Honnorat J., Smitt P.S., Vedeler C., Verschuuren J.J., Vincent A., Voltz R. Recommended diagnostic criteria for paraneoplastic neurological syndromes. J. Neurol. Neurosurg. Psychiatry 2004, 75:1135-1140.
9. Jean W.C., Dalmau J., Ho A., Posner J.B. Analysis of the IgG subclass distribution and inflammatory infiltrates in patients with anti-Hu-associated paraneoplastic encephalomyelitis. Neurology 1994, 44:140-147.
10. Knip M., Siljander H. Autoimmune mechanisms in type 1 diabetes. Autoimmun. Rev. 2008, 7:550-557.
11. Manley G.T., Smitt P.S., Dalmau J., Posner J.B. Hu antigens: reactivity with Hu antibodies, tumor expression, and major immunogenic sites. Ann. Neurol. 1995, 38:102-110.
12. Mercier B., al Daccak R., Samaan A., David F., Carta A., Cracco P., Raguenes O., Dufosse F., Ferec C., Charron D., et al. HLA-DRB and -DBQ typing by PCR amplification using sequence-specific primers (PCR-SSP): assessment after 1year of routine use by three laboratories. Eur. J. Immunogenet. 1994, 21:105-123.
13. Moll J.W., Antoine J.C., Brashear H.R., Delattre J., Drlicek M., Dropcho E.J., Giometto B., Graus F., Greenlee J., Honnorat J., et al. Guidelines on the detection of paraneoplastic anti-neuronal-specific antibodies: report from the Workshop to the Fourth Meeting of the International Society of Neuro-Immunology on paraneoplastic neurological disease, held October 22-23, 1994, in Rotterdam, The Netherlands. Neurology 1995, 45:1937-1941.
14. Monstad S.E., Knudsen A., Salvesen H.B., Aarseth J.H., Vedeler C.A. Onconeural antibodies in sera from patients with various types of tumours. Cancer Immunol. Immunother. 2009, 58:1795-1800.
15. Noreen H.J., Yu N., Setterholm M., Ohashi M., Baisch J., Endres R., Fernandez-Vina M., Heine U., Hsu S., Kamoun M., Mitsuishi Y., Monos D., Perlee L., Rodriguez-Marino S., Smith A., Yang S.Y., Shipp K., Hegland J., Hurley C.K. Validation of DNA-based HLA-A and HLA-B testing of volunteers for a bone marrow registry through parallel testing with serology. Tissue Antigens 2001, 57:221-229.
16. Olerup O. HLA-B27 typing by a group-specific PCR amplification. Tissue Antigens 1994, 43:253-256.
17. Price P., Witt C., Allcock R., Sayer D., Garlepp M., Kok C.C., French M., Mallal S., Christiansen F. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol. Rev. 1999, 167:257-274.
18. Rauer S., Kaiser R. Demonstration of anti-HuD specific oligoclonal bands in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Qualitative evidence of anti-HuD specific IgG-synthesis in the central nervous system. J. Neuroimmunol. 2000, 111:241-244.
19. Roberts W.K., Deluca I.J., Thomas A., Fak J., Williams T., Buckley N., Dousmanis A.G., Posner J.B., Darnell R.B. Patients with lung cancer and paraneoplastic Hu syndrome harbor HuD-specific type 2 CD8+ T cells. J. Clin. Invest. 2009, 119:2042-2051.
20. Rousseau A., Benyahia B., Dalmau J., Connan F., Guillet J.G., Delattre J.Y., Choppin J. T cell response to Hu-D peptides in patients with anti-Hu syndrome. J. Neurooncol. 2005, 71:231-236.
21. Schipper R.F., Schreuder G.M., D'Amaro J., Oudshoorn M. HLA gene and haplotype frequencies in Dutch blood donors. Tissue Antigens 1996, 48:562-574.
22. Svejgaard A., Ryder L.P. HLA and disease associations: detecting the strongest association. Tissue Antigens 1994, 43:18-27.
23. Tanaka M., Tanaka K., Nakano R., Inuzuka T., Tsuji S., Shinozawa K., Kojo T., Mastui T., Kumamoto T., Suzumura A. Lack of association between human leukocyte antigens and anti-Hu syndrome in patients with small-cell lung cancer. Neurology 1999, 52:431.
24. Tani T., Tanaka K., Idezuka J., Nishizawa M. Regulatory T cells in paraneoplastic neurological syndromes. J. Neuroimmunol. 2008, 196:166-169.
25. Uchuya M., Fleury A., Graus F., Costagliola D., Liblau R., Merle-Beral H., Theodorou I., Delattre J.Y. Lack of association between human leukocyte antigens and the anti-Hu syndrome in patients with small-cell lung cancer. Neurology 1998, 50:565-566.
26. Wolters V.M., Wijmenga C. Genetic background of celiac disease and its clinical implications. Am. J. Gastroenterol. 2008, 103:190-195.