Is love passion an addictive disorder

American Journal of Drug and Alcohol Abuse

Volumn 36, Issue 5, 2010, Pages 261-267

  Reynaud, Michel ^a,b,c   Karila, Laurent ^a,b,c   Blecha, Lisa ^a,b,c   Benyamina, Amine ^a,b,c  

^a INSERM   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c HÔPITAL PAUL BROUSSE   (France)

Author keywords

" "love addiction; " "love neuropsychology; " "love passion."; "behavioral addiction

Indexed keywords

DOPAMINE; GONADORELIN; NEUROTRANSMITTER; OXYTOCIN; TESTOSTERONE;

ANHEDONIA; ATTENTION; BRAIN REGION; CINGULATE GYRUS; COMORBIDITY; DIAGNOSTIC PROCEDURE; DRUG INTOXICATION; EUPHORIA; GENETICS; IMPULSE CONTROL DISORDER; INSULA; LOVE; MATING; NEUROBIOLOGY; NEUROIMAGING; NEUROPSYCHOLOGY; NOMENCLATURE; PATHOLOGICAL GAMBLING; PSYCHOTHERAPY; REVIEW; RISK FACTOR; SELF CONTROL; SEXUAL ADDICTION; SLEEP DISORDER; SOCIAL ASPECT; STIMULUS; SUBSTANCE ABUSE; THINKING; WITHDRAWAL SYNDROME;

AFFECT; ANIMALS; BEHAVIOR, ADDICTIVE; BRAIN; DOPAMINE; EMOTIONS; FEMALE; HUMANS; LOVE; MALE; NEUROTRANSMITTER AGENTS; OXYTOCIN; RISK FACTORS; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS;

EID: 77956316762     PISSN: 00952990     EISSN: 10979891     Source Type: Journal    
DOI: 10.3109/00952990.2010.495183     Document Type: Review

References (79)

1. Peele S. Love and Addiction. New York: Taplinger Publishing Company, 1975.
2. Freud S. The Complete Correspondence of Sigmund Freud and Karl Abraham, 1907-1925. Falzeder E (ed.) Karnac, London, 2002.
3. Fisher H. Why We Love? New York: Owl Books, 2004.
4. Aron, A.; Fisher, H.; Mashek, D.J.; Strong, G.; Li, H.; Brown, L.L. Reward, motivation, and emotion systems associated with early-stage intense romantic love. J Neurophysiol 2005; 94(1):327-337.
5. Reynaud M. Lamour est une drogue douce. . . en général. Paris: Robert Laffont, 2005.
6. Plato. Complete Works. Cooper JM, ed., Hackett Publishing Co. 1997.
7. Dante A. The Divine Comedy. New York: Oxford University Press, 2008.
8. Shakespeare W. Romeo and Juliet. Penguin Classics, London 2007.
9. Racine J. Phèdre. Paris: Folio Poche, 2000.
10. Jankowiak W, Fischer E. A cross cultural perspective on romantic love. Ethnology 1992; 31(2):149.
11. Jankowiak W. Romantic Passion: A Universal Experience? New York: Columbia University Press, 1995.
12. Acevedo BP, Aron A. Does a long-term relationship kill romantic love? American Psychological Association 2009; 13(1):59-65.
13. Esch T, Stefano GB. The neurobiology of pleasure, reward processes, addiction and their health implications. Neuro Endocrinol Lett 2004; 25(4):235-251.
14. Fisher HE, Aron A, Brown LL. Romantic love: A mammalian brain system for mate choice. Philos Trans R Soc Lond B Biol Sci 2006; 361(1476):2173-2186.
15. Potenza MN. Should addictive disorders include non-substance-related conditions? Addiction 2006; 101(Suppl 1):142-151.
16. Di Chiara G, Imperato A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 1988; 85(14):5274-5278.
17. Pierce RC, Kumaresan V. The mesolimbic dopamine system: the final common pathway for the reinforcing effect of drugs of abuse? Neurosci Biobehav Rev 2006; 30(2):215-238.
18. Wise RA. Neurobiology of addiction. Curr Opin Neurobiol 1996; 6(2):243-251.
19. Volkow ND, Fowler JS, Wang GJ, Goldstein RZ. Role of dopamine, the frontal cortex and memory circuits in drug addiction: Insight from imaging studies. Neurobiol Learn Mem 2002; 78(3):610-624.
20. Kelley AE, Berridge KC. The neuroscience of natural rewards: Relevance to addictive drugs. J Neurosci 2002; 22(9):3306-3311.
21. Becker JB, Rudick CN, Jenkins WJ. The role of dopamine in the nucleus accumbens and striatum during sexual behavior in the female rat.JNeurosci 2001; 21(9):3236-3241.
22. Potenza MN. Review. The neurobiology of pathological gambling and drug addiction: An overview and new findings. Philos Trans R Soc Lond B Biol Sci 2008; 363(1507):3181-3189.
23. Insel TR. Is social attachment an addictive disorder? Physiol Behav 2003; 79(3):351-357.
24. McGregor IS, Callaghan PD, Hunt GE. From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use? Br J Pharmacol 2008; 154(2):358-368.
25. Goodman A. Neurobiology of addiction An integrative review. Biochem Pharmacol 2008; 75(1):266-322.
26. Ventura R, Cabib S, Alcaro A, Orsini C, Puglisi-Allegra S. Norepinephrine in the prefrontal cortex is critical for amphetamine-induced reward andmesoaccumbens dopamine release. J Neurosci 2003; 23(5):1879-1885.
27. Tassin JP. Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse. Biochem Pharmacol 2008; 75(1):85-97.
28. Spanagel R, Herz A, Shippenberg TS. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proc Natl Acad Sci USA 1992; 89(6):2046-2050.
29. Goeders NE. The HPA axis and cocaine reinforcement. Psychoneuroendocrinology 2002; 27(1-2):13-33.
30. Piazza PV, Le Moal M. The role of stress in drug self-administration. Trends Pharmacol Sci 1998; 19(2):67-74.
31. Koob G, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry 2007; 164(8):1149-1159.
32. Esch T, Stefano GB. The neurobiology of love. Neuro Endocrinol Lett 2005; 26(3):175-192.
33. Carter CS. Neuroendocrine perspectives on social attachment and love. Psychoneuroendocrinology 1998; 23(8):779-818.
34. Marazziti D, Canale D. Hormonal changeswhen falling in love. Psychoneuroendocrinology 2004; 29(7):931-936.
35. Hansenne M, Pinto E, Pitchot W, Reggers J, Scantamburlo G, Moor M, Ansseau M. Further evidence on the relationship between dopamine and novelty seeking: A neuroendocrine study. Personality and Individual Differences 2002; 33(6):967-977.
36. Suhara T, Yasuno F, Sudo Y, Yamamoto M, Inoue M, Okubo Y, Suzuki K. Dopamine D2 receptors in the insular cortex and the personality trait of novelty seeking. NeuroImage 2001; 13(5):891-895.
37. Kluger AN, Siegfried Z, Ebstein RP. A meta-analysis of the association between DRD4 polymorphism and novelty seeking. Mol Psychiatry 2002; 7(7):712-717.
38. Kotler M, Cohen H, Segman R, Gritsenko I, Nemanov L, Lerer B, Kramer I, Zer-Zion M, Kletz I, Ebstein RP. Excess dopamine D4 receptor (D4DR) exon III seven repeat allele in opioid-dependent subjects. Mol Psychiatry 1997; 2(3):251-254.
39. Ben Zion, I.Z.; Tessler, R.; Cohen, L.; Lerer, E.; Raz, Y.; Bachner-Melman, R.; Gritsenko, I.; Nemanov, L.; Zohar, A.H.; Belmaker, R.H.; Benjamin, J.; Ebstein, R.P. Polymorphisms in the dopamine D4 receptor gene (DRD4) contribute to individual differences in human sexual behavior: Desire, arousal and sexual function. Mol Psychiatry 2006; 11(8):782-786.
40. Miller,W.B.; Pasta, D.J.; MacMurray, J.; Chiu, C.;Wu, H.; Comings, D.E. Dopamine receptor genes are associated with age at first sexual intercourse. J Biosoc Sci 1999; 31(1):43-54.
41. Dunn KM, Cherkas LF, Spector TD. Genetic influences on variation in female orgasmic function: A twin study. Biol Lett 2005; 1(3):260-263.
42. Pfaus JG. Revisiting the concept of sexual motivation. Annu Rev Sex Res 1999; 10:120-156.
43. Gingrich, B.; Liu, Y.; Cascio, C.; Wang, Z.; Insel, T.R. Dopamine D2 receptors in the nucleus accumbens are important for social attachment in female prairie voles (Microtus ochrogaster). Behav Neurosci 2000; 114(1):173-183.
44. Wang, Z.;Yu, G.; Cascio, C.; Liu,Y.;Gingrich, B.; Insel, T.R. Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): A mechanism for pair bonding? Behav Neurosci 1999; 113(3):602-611.
45. Adinoff B. Neurobiologic processes in drug reward and addiction. Harv Rev Psychiatry 2004; 12(6):305-320.
46. Neumann ID. Stimuli and consequences of dendritic release of oxytocin within the brain. Biochem Soc Trans 2007; 35(Pt 5):1252-1257.
47. Lim MM, Young LJ. Neuropeptidergic regulation of affiliative behavior and social bonding in animals. Horm Behav 2006; 50(4):506-517.
48. Holstege, G.; Georgiadis, J.R.; Paans, A.M.; Meiners, L.C.; van der Graaf, F.H.; Reinders, A.A. Brain activation during human male ejaculation. J Neurosci 2003; 23(27):9185-9193.
49. Grewen, K.M.; Girdler, S.S.; Amico, J.; Light, K.C. Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact. Psychosom Med 2005; 67(4):531-538.
50. Winslow JT, Insel TR. Social status in pairs of male squirrel monkeys determines the behavioral response to central oxytocin administration. J Neurosci 1991; 11(7):2032-2038.
51. Aragona, B.J.; Liu, Y.; Curtis, J.T.; Stephan, F.K.; Wang, Z. A critical role for nucleus accumbens dopamine in partner-preference formation in male prairie voles. J Neurosci 2003; 23(8):3483-3490.
52. Young, L.J.; Lim, M.M.; Gingrich, B.; Insel, T.R. Cellular mechanisms of social attachment. Horm Behav 2001; 40(2):133-138.
53. Walum, H.; Westberg, L.; Henningsson, S.; Neiderhiser, J.M.; Reiss, D.; Igl,W.; Ganiban, J.M.; Spotts, E.L.; Pedersen, N.L.; Eriksson, E.; Lichtenstein, P. Genetic variation in the vasopressin receptor 1a gene (AVPR1A) associates with pair-bonding behavior in humans. Proc Natl Acad Sci USA 2008; 105(37):14153-14156.
54. Ferguson, J.N.; Young, L.J.; Hearn, E.F.; Matzuk, M.M.; Insel, T.R.; Winslow, J.T. Social amnesia in mice lacking the oxytocin gene. Nat Genet 2000; 25(3):284-288.
55. Hollander, E.; Bartz, J.; Chaplin, W.; Phillips, A.; Sumner, J.; Soorya, L.; Anagnostou, E.; Wasserman, S. Oxytocin increases retention of social cognition in autism. Biol Psychiatry 2007; 61(4):498-503.
56. Mayerhofer, A.; Steger, R.W.; Gow, G.; Bartke, A. Catecholamines stimulate testicular testosterone release of the immature golden hamster via interactionwith alpha- and beta-adrenergic receptors. Acta Endocrinol (Copenh) 1992; 127(6):526-530.
57. Huber D, Veinante P, Stoop R. Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala. Science 2005; 308(5719):245-248.
58. Beech AR, Mitchell IJ. A neurobiological perspective on attachment problems in sexual offenders and the role of selective serotonin re-uptake inhibitors in the treatment of such problems. Clin Psychol Rev 2005; 25(2):153-182.
59. Motofei IG. A dual physiological character for sexual function: the role of serotonergic receptors. BJU Int 2007.
60. Zeki S. The neurobiology of love. FEBS Lett 2007; 581(14):2575-2579.
61. Fowler, J.S.; Volkow, N.D.; Kassed, C.A.; Chang, L. Imaging the addicted human brain. Sci Pract Perspect 2007; 3(2):4-16.
62. Volkow, N.D.; Fowler, J.S.; Wang, G.J.; Swanson, J.M.; Telang, F. Dopamine in drug abuse and addiction: results of imaging studies and treatment implications. Arch Neurol 2007; 64(11):1575-1579.
63. Childress, A.R.; Ehrman, R.N.; Wang, Z.; Li, Y.; Sciortino, N.; Hakun, J.; Jens, W.; Suh, J.; Listerud, J.; Marquez, K.; Franklin, T.; Langleben, D.; Detre, J.; OBrien, C.P. Prelude to passion: limbic activation by unseen drug and sexual cues. PLoS ONE 2008; 3(1):e1506.
64. Dackis C, OBrien C. Neurobiology of addiction: treatment and public policy ramifications. Nat Neurosci 2005; 8(11):1431-11416
65. van Holst, R.J.; van den Brink, W.; Veltman, D.J.; Goudriaan, A.E. Why gamblers fail to win: a review of cognitive and neuroimaging findings in pathological gambling. Neurosci Biobehav Rev 34(1):87-107.
66. Miedl, S.F.; Fehr, T.; Meyer, G.; Herrmann, M. Neurobiological correlates of problem gambling in a quasi-realistic blackjack scenario as revealed by fMRI. Psychiatry Res 181(3):165-173.
67. Ko, C.H.; Liu, G.C.; Hsiao, S.; Yen, J.Y.; Yang, M.J.; Lin,W.C.; Yen, C.F.; Chen, C.S. Brain activities associated with gaming urge of online gaming addiction. J Psychiatr Res 2009; 43(7):739-747.
68. Redoute, J.; Stoleru, S.; Gregoire, M.C.; Costes, N.; Cinotti, L.; Lavenne, F.; Le Bars, D.; Forest, M.G.; Pujol, J.F. Brain processing of visual sexual stimuli in human males. Hum Brain Mapp 2000; 11(3):162-177.
69. Ferretti, A.; Caulo, M.; Del Gratta, C.; Di Matteo, R.; Merla, A.; Montorsi, F.; Pizzella, V.; Pompa, P.; Rigatti, P.; Rossini, P.M.; Salonia, A.; Tartaro, A.; Romani, G.L. Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI. NeuroImage 2005; 26(4):1086-1096.
70. 2O PET study in heterosexual men. Neuroimage 2001; 14(1 Pt 1):105-117.
71. Komisaruk, B.R.;Whipple, B.;Crawford, A.; Liu,W.C.;Kalnin, A.; Mosier, K. Brain activation during vaginocervical self-stimulation and orgasm in women with complete spinal cord injury: fMRI evidence of mediation by the vagus nerves. Brain Res 2004; 1024(1-2):77-88.
72. Meston, C.M.; Levin, R.J.; Sipski,M.L.; Hull, E.M.;Heiman, J.R.Womens orgasm. Annu Rev Sex Res 2004; 15:173-257.
73. Bartels A, Zeki S. The neural basis of romantic love. Neuroreport 2000; 11(17):3829-3834.
74. Bartels A, Zeki S. The neural correlates of maternal and romantic love. Neuroimage 2004; 21(3):1155-1166.
75. Frith CD, Frith U. Interacting minds-A biological basis. Science 1999; 286(5445):1692-1695.
76. Najib, A.; Lorberbaum, J.P.; Kose, S.; Bohning, D.E.; George, M.S. Regional brain activity in women grieving a romantic relationship breakup. Am J Psychiatry 2004; 161(12):2245-2256.
77. Halpern H. Finally Getting It Right. New York: Bantam Books, 1994.
78. Fonagy P, Leigh T, Steele M. The relation of attachment status, psychiatric classification and response to psychotherapy. Journal of Consulting and Clinical Psychology 1996; 64:22-31.
79. Peabody S. Addiction to love: Overcoming obsession and dependency in relationships. Celestial Arts; Berekley, CA, USA, 2005.