Improved immunogenicity of recombinant Mycobacterium bovis bacillus Calmette-Guérin strains expressing fusion protein Ag85A-ESAT-6 of Mycobacterium tuberculosis

Scandinavian Journal of Immunology

Volumn 72, Issue 4, 2010, Pages 332-338

  Deng, Y H ^a   Sun, Z ^a   Yang, X L ^a   Bao, L ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; ANTIGEN 85A, MYCOBACTERIUM TUBERCULOSIS; BACTERIAL ANTIGEN; BACTERIAL PROTEIN; BACTERIUM ANTIBODY; BCG VACCINE; ESAT-6 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; GAMMA INTERFERON; HYBRID PROTEIN; IMMUNOGLOBULIN G; INTERLEUKIN 4;

ANIMAL; BAGG ALBINO MOUSE; BLOOD; CD4 CD8 RATIO; CELL PROLIFERATION; CYTOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNIZATION; IMMUNOLOGY; METABOLISM; MOUSE; MYCOBACTERIUM BOVIS; PROCEDURES; SPLEEN; TH1 CELL; TIME;

ACYLTRANSFERASES; ANIMALS; ANTIBODIES, BACTERIAL; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; BCG VACCINE; CD4-CD8 RATIO; CELL PROLIFERATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; IMMUNIZATION; IMMUNOGLOBULIN G; INTERFERON-GAMMA; INTERLEUKIN-4; MICE; MICE, INBRED BALB C; MYCOBACTERIUM BOVIS; RECOMBINANT FUSION PROTEINS; SPLEEN; TH1 CELLS; TIME FACTORS;

EID: 77956312281     PISSN: 03009475     EISSN: 13653083     Source Type: Journal    
DOI: 10.1111/j.1365-3083.2010.02444.x     Document Type: Article

References (22)

1. WHO. Global Tuberculosis Control: Surbeillance, Planning, Financing. Anonymous : World Health Organization, 2008, ISBN: WHO/HTM/TB/2008,393.
2. Migliori GB, Centis R, Lange C, Richardson MD, Sotgiu G. Emerging epidemic of drug-resistant tuberculosis in Europe, Russia, China, South America and Asia: current status and global perspectives. Curr Opin Pulm Med 2010 16 : 171 179.
3. Lazarus JV, Olsen M, Ditiu L, Matic S. Tuberculosis-HIV co-infection: policy and epidemiology in 25 countries in the WHO European region. HIV Med 2008 9 : 406 414.
4. Raviglione MC. The TB epidemic from 1992 to 2002. Tuberculosis (Edinb) 2003 83 : 4 14.
5. Rigano MM, Dreitz S, Kipnis AP, Izzo AA, Walmsley AM. Oral immunogenicity of a plant-made, subunit, tuberculosis vaccine. Vaccine 2006 24 : 691 695.
6. Wang QM, Sun SH, Hu ZL, Yin M, Xiao CJ, Zhang JC. Improved immunogenicity of a tuberculosis DNA vaccine encoding ESAT6 by DNA priming and protein boosting. Vaccine 2004 22 : 3622 3627.
7. Sun R, Skeiky YA, Izzo A et al. Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis. Vaccine 2009 27 : 4412 4423.
8. van Dissel JT, Arend SM, Prins C et al. Ag85B-ESAT-6 adjuvanted with IC31 promotes strong and long-lived Mycobacterium tuberculosis specific T cell responses in naive human volunteers. Vaccine 2010 28 : 3571 3581.
9. Bai Y, Xue Y, Gao H et al. Expression and purification of Mycobacterium tuberculosis ESAT-6 and MPT64 fusion protein and its immunoprophylactic potential in mouse model. Protein Expr Purif 2008 59 : 189 196.
10. Bertholet S, Ireton GC, Kahn M et al. Identification of human T cell antigens for the development of vaccines against Mycobacterium tuberculosis. J Immunol 2008 181 : 7948 7957.
11. Xu Y, Zhu B, Wang Q et al. Recombinant BCG coexpressing Ag85B, ESAT-6 and mouse-IFN-gamma confers effective protection against Mycobacterium tuberculosis in C57BL/6 mice. FEMS Immunol Med Microbiol 2007 51 : 480 487.
12. Harboe M, Oettinger T, Wiker HG, Rosenkrands I, Andersen P. Evidence for occurrence of the ESAT-6 protein in Mycobacterium tuberculosis and virulent Mycobacterium bovis and for its absence in Mycobacterium bovis BCG. Infect Immun 1996 64 : 16 22.
13. Behr MA, Wilson MA, Gill WP et al. Comparative genomics of BCG vaccines by whole-genome DNA microarray. Science 1999 284 : 1520 1523.
14. Yanagisawa S, Koike M, Kariyone A, Nagai S, Takatsu K. Mapping of V beta 11+ helper T cell epitopes on mycobacterial antigen in mouse primed with Mycobacterium tuberculosis. Int Immunol 1997 9 : 227 237.
15. Armitige LY, Jagannath C, Wanger AR, Norris SJ. Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages. Infect Immun 2000 68 : 767 778.
16. Caccamo N, Meraviglia S, La Mendola C, Guggino G, Dieli F, Salerno A. Phenotypical and functional analysis of memory and effector human CD8 T cells specific for mycobacterial antigens. J Immunol 2006 177 : 1780 1785.
17. Stover CK, de la Cruz VF, Fuerst TR et al. New use of BCG for recombinant vaccines. Nature 1991 351 : 456 460.
18. Bao L, Chen W, Zhang H, Wang X. Virulence, immunogenicity, and protective efficacy of two recombinant Mycobacterium bovis bacillus Calmette-Guerin strains expressing the antigen ESAT-6 from Mycobacterium tuberculosis. Infect Immun 2003 71 : 1656 1661.
19. D'Souza S, Rosseels V, Romano M et al. Mapping of murine Th1 helper T-Cell epitopes of mycolyl transferases Ag85A, Ag85B, and Ag85C from Mycobacterium tuberculosis. Infect Immun 2003 71 : 483 493.
20. Munk ME, Emoto M. Functions of T-cell subsets and cytokines in mycobacterial infections. Eur Respir J Suppl 1995 20 : 668s 75s.
21. Sud D, Bigbee C, Flynn JL, Kirschner DE. Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. J Immunol 2006 176 : 4296 4314.
22. Sugawara I, Sun L, Mizuno S, Taniyama T. Protective efficacy of recombinant BCG Tokyo (Ag85A) in rhesus monkeys (Macaca mulatta) infected intratracheally with H37Rv Mycobacterium tuberculosis. Tuberculosis (Edinb) 2009 89 : 62 7.