Role of adipokines in obesity-associated hypertension

Acta Physiologica

Volumn 200, Issue 2, 2010, Pages 107-127

  Vlasova, M ^a   Purhonen, A K ^b   Jarvelin, M R ^b,c,d   Rodilla, E ^e   Pascual, J ^e   Herzig, K H ^b,d,f  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF OULU   (Finland)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY OF VALENCIA   (Spain)

^f KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

adipokines; cytokines; hypertension; inflammation; metabolic syndrome; obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APELIN; INTERLEUKIN 6; LEPTIN; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR EFFECT; CARDIOVASCULAR SYSTEM; DISEASE ASSOCIATION; HUMAN; HYPERTENSION; INFLAMMATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ADIPOKINES; ANIMALS; CARDIOVASCULAR DISEASES; HUMANS; HYPERTENSION; OBESITY;

EID: 77956308468     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02171.x     Document Type: Review

References (243)

1. Achard, V., Boullu-Ciocca, S., Desbriere, R., Nguyen, G. Grino, M. 2007. Renin receptor expression in human adipose tissue. Am J Physiol Regul Integr Comp Physiol 292, R274 R282.
2. Adamczak, M., Wiecek, A., Funahashi, T., Chudek, J., Kokot, F. Matsuzawa, Y. 2003. Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 16, 72 75.
3. Aizawa-Abe, M., Ogawa, Y., Masuzaki, H., Ebihara, K., Satoh, N., Iwai, H., Matsuoka, N., Hayashi, T., Hosoda, K., Inoue, G., Yoshimasa, Y. Nakao, K. 2000. Pathophysiological role of leptin in obesity-related hypertension. J Clin Invest 105, 1243 1252.
4. Antic, V., Dulloo, A. Montani, J.P. 2003. Multiple mechanisms involved in obesity-induced hypertension. Heart Lung Circ 12, 84 93.
5. Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K. et al. 1999. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257, 79 83.
6. Ashley, E.A., Powers, J., Chen, M., Kundu, R., Finsterbach, T., Caffarelli, A., Deng, A., Eichhorn, J., Mahajan, R., Agrawal, R., Greve, J., Robbins, R., Patterson, A.J., Bernstein, D. Quertermous, T. 2005. The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Cardiovasc Res 65, 73 82.
7. Azuma, K., Katsukawa, F., Oguchi, S., Murata, M., Yamazaki, H., Shimada, A. Saruta, T. 2003. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 11, 997 1001.
8. Bagi, Z., Erdei, N., Toth, A., Li, W., Hintze, T.H., Koller, A. Kaley, G. 2005. Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25, 1610 1616.
9. Baker, A.R., Silva, N.F., Quinn, D.W., Harte, A.L., Pagano, D., Bonser, R.S., Kumar, S. Mcternan, P.G. 2006. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. Cardiovasc Diabetol 5, 1.
10. Banerjee, R.R., Rangwala, S.M., Shapiro, J.S., Rich, A.S., Rhoades, B., Qi, Y., Wang, J., Rajala, M.W., Pocai, A., Scherer, P.E., Steppan, C.M., Ahima, R.S., Obici, S., Rossetti, L. Lazar, M.A. 2004. Regulation of fasted blood glucose by resistin. Science 303, 1195 1198.
11. Barba, G., Russo, O., Siani, A., Iacone, R., Farinaro, E., Gerardi, M.C., Russo, P., Della Valle, E. Strazzullo, P. 2003. Plasma leptin and blood pressure in men: graded association independent of body mass and fat pattern. Obes Res 11, 160 166.
12. Bastard, J.P., Jardel, C., Bruckert, E., Blondy, P., Capeau, J., Laville, M., Vidal, H. Hainque, B. 2000. Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab 85, 3338 3342.
13. Baumann, M., Von Eynatten, M., Dan, L., Richart, T., Kouznetsova, T., Heemann, U. Staessen, J.A. 2009. Altered molecular weight forms of adiponectin in hypertension. J Clin Hypertens (Greenwich) 11, 11 16.
14. Bautista, L.E., Vera, L.M., Arenas, I.A. Gamarra, G. 2005. Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-alpha) and essential hypertension. J Hum Hypertens 19, 149 154.
15. Beltowski, J., Jamroz-Wisniewska, A., Borkowska, E. Wojcicka, G. 2004. Up-regulation of renal Na+, K+-ATPase: the possible novel mechanism of leptin-induced hypertension. Pol J Pharmacol 56, 213 222.
16. Bloem, L.J., Manatunga, A.K., Tewksbury, D.A. Pratt, J.H. 1995. The serum angiotensinogen concentration and variants of the angiotensinogen gene in white and black children. J Clin Invest 95, 948 953.
17. Boesen, E.I., Sasser, J.M., Saleh, M.A., Potter, W.A., Woods, M., Warner, T.D., Pollock, J.S. Pollock, D.M. 2008. Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo. Am J Physiol Renal Physiol 295, F446 F453.
18. Boucher, J., Masri, B., Daviaud, D., Gesta, S., Guigne, C., Mazzucotelli, A., Castan-Laurell, I., Tack, I., Knibiehler, B., Carpene, C., Audigier, Y., Saulnier-Blache, J.S. Valet, P. 2005. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 146, 1764 1771.
19. Bouloumie, A., Marumo, T., Lafontan, M. Busse, R. 1999. Leptin induces oxidative stress in human endothelial cells. FASEB J 13, 1231 1238.
20. Boustany, C.M., Bharadwaj, K., Daugherty, A., Brown, D.R., Randall, D.C. Cassis, L.A. 2004. Activation of the systemic and adipose renin-angiotensin system in rats with diet-induced obesity and hypertension. Am J Physiol Regul Integr Comp Physiol 287, R943 R949.
21. Brasier, A.R., Li, J. Wimbish, K.A. 1996. Tumor necrosis factor activates angiotensinogen gene expression by the Rel A transactivator. Hypertension 27, 1009 1017.
22. Bravo, P.E., Morse, S., Borne, D.M., Aguilar, E.A. Reisin, E. 2006. Leptin and hypertension in obesity. Vasc Health Risk Manag 2, 163 169.
23. Brezniceanu, M.L., Liu, F., Wei, C.C., Chénier, I., Godin, N., Zhang, S.L., Filep, J.G., Ingelfinger, J.R. Chan, J.S. 2008. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 57, 451 459.
24. Bullo, M., Garcia-Lorda, P., Megias, I. Salas-Salvado, J. 2003. Systemic inflammation, adipose tissue tumor necrosis factor, and leptin expression. Obes Res 11, 525 531.
25. Carlyle, M., Jones, O.B., Kuo, J.J. Hall, J.E. 2002. Chronic cardiovascular and renal actions of leptin: role of adrenergic activity. Hypertension 39, 496 501.
26. Cassano, P.A., Segal, M.R., Vokonas, P.S. Weiss, S.T. 1990. Body fat distribution, blood pressure, and hypertension: a prospective cohort study of men in the normative aging study. Ann Epidemiol 1, 33 48.
27. Celik, T., Iyisoy, A., Kursaklioglu, H., Kardesoglu, E., Kilic, S., Turhan, H., Yilmaz, M.I., Ozcan, O., Yaman, H., Isik, E. Fici, F. 2006. Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients. J Hypertens 24, 591 596.
28. Chae, C.U., Lee, R.T., Rifai, N. Ridker, P.M. 2001. Blood pressure and inflammation in apparently healthy men. Hypertension 38, 399 403.
29. Chatterjee, T.K., Stoll, L.L., Denning, G.M., Harrelson, A., Blomkalns, A.L., Idelman, G., Rothenberg, F.G., Neltner, B., Romig-Martin, S.A., Dickson, E.W., Rudich, S. Weintraub, N.L. 2009. Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding. Circ Res 104, 541 549.
30. Chen, H., Montagnani, M., Funahashi, T., Shimomura, I. Quon, M.J. 2003. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem 278, 45021 45026.
31. Chen, C., Jiang, J., Lu, J., Chai, H., Wang, X., Lin, P.H. Yao, Q. 2010. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 299, H193 H201.
32. Cheng, X., Cheng, X.S. Pang, C.C. 2003. Venous dilator effect of apelin, an endogenous peptide ligand for the orphan APJ receptor, in conscious rats. Eur J Pharmacol 470, 171 175.
33. Cheng, K.K., Lam, K.S., Wang, Y., Huang, Y., Carling, D., Wu, D., Wong, C. Xu, A. 2007. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes 56, 1387 1394.
34. Cheng, K.H., Chu, C.S., Lee, K.T., Lin, T.H., Hsieh, C.C., Chiu, C.C., Voon, W.C., Sheu, S.H. Lai, W.T. 2008. Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease. Int J Obes (Lond) 32, 268 274.
35. Chow, W.S., Cheung, B.M., Tso, A.W., Xu, A., Wat, N.M., Fong, C.H., Ong, L.H., Tam, S., Tan, K.C., Janus, E.D., Lam, T.H. Lam, K.S. 2007. Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension 49, 1455 1461.
36. Chuang, S.Y., Chou, P., Hsu, P.F., Cheng, H.M., Tsai, S.T., Lin, I.F. Chen, C.H. 2006. Presence and progression of abdominal obesity are predictors of future high blood pressure and hypertension. Am J Hypertens 19, 788 795.
37. Chun, H.J., Ali, Z.A., Kojima, Y., Kundu, R.K., Sheikh, A.Y., Agrawal, R., Zheng, L., Leeper, N.J., Pearl, N.E., Patterson, A.J., Anderson, J.P., Tsao, P.S., Lenardo, M.J., Ashley, E.A. Quertermous, T. 2008. Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. J Clin Invest 118, 3343 3354.
38. Clasen, R., Schupp, M., Foryst-Ludwig, A., Sprang, C., Clemenz, M., Krikov, M., Thone-Reineke, C., Unger, T. Kintscher, U. 2005. PPARgamma-activating angiotensin type-1 receptor blockers induce adiponectin. Hypertension 46, 137 143.
39. Clement, K., Viguerie, N., Poitou, C., Carette, C., Pelloux, V., Curat, C.A., Sicard, A., Rome, S., Benis, A., Zucker, J.D. et al. 2004. Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 18, 1657 1669.
40. Conneely, K.N., Silander, K., Scott, L.J., Mohlke, K.L., Lazaridis, K.N., Valle, T.T., Tuomilehto, J., Bergman, R.N., Watanabe, R.M., Buchanan, T.A., Collins, F.S. Boehnke, M. 2004. Variation in the resistin gene is associated with obesity and insulin-related phenotypes in Finnish subjects. Diabetologia 47, 1782 1788.
41. Considine, R.V., Sinha, M.K., Heiman, M.L., Kriauciunas, A., Stephens, T.W., Nyce, M.R., Ohannesian, J.P., Marco, C.C., Mckee, L.J. Bauer, T.L. 1996. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334, 292 295.
42. Cooper, R., Mcfarlane-Anderson, N., Bennett, F.I., Wilks, R., Puras, A., Tewksbury, D., Ward, R. Forrester, T. 1997. ACE, angiotensinogen and obesity: a potential pathway leading to hypertension. J Hum Hypertens 11, 107 111.
43. Correia, M.L., Morgan, D.A., Sivitz, W.I., Mark, A.L. Haynes, W.G. 2001. Leptin acts in the central nervous system to produce dose-dependent changes in arterial pressure. Hypertension 37, 936 942.
44. Crandall, D.L., Herzlinger, H.E., Saunders, B.D., Armellino, D.C. Kral, J.G. 1994. Distribution of angiotensin II receptors in rat and human adipocytes. J Lipid Res 35, 1378 1385.
45. De Kloet, A.D., Krause, E.G., Kim, D.H., Sakai, R.R., Seeley, R.J. Woods, S.C. 2009. The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis. Endocrinology 150, 4114 4123.
46. De Mota, N., Reaux-Le Goazigo, A., El Messari, S., Chartrel, N., Roesch, D., Dujardin, C., Kordon, C., Vaudry, H., Moos, F. Llorens-Cortes, C. 2004. Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release. Proc Natl Acad Sci U S A 101, 10464 10469.
47. Delles, C., Raff, U., Mimran, A., Fauvel, J.P., Ruilope, L.M. Schmieder, R.E. 2008. Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes. Am J Hypertens 21, 1330 1336.
48. Delporte, M.L., Funahashi, T., Takahashi, M., Matsuzawa, Y. Brichard, S.M. 2002. Pre- and post-translational negative effect of beta-adrenoceptor agonists on adiponectin secretion: in vitro and in vivo studies. Biochem J 367, 677 685.
49. Djaberi, R., Schuijf, J.D., Van Werkhoven, J.M., Nucifora, G., Jukema, J.W. Bax, J.J. 2008. Relation of epicardial adipose tissue to coronary atherosclerosis. Am J Cardiol 102, 1602 1607.
50. Dunbar, J.C., Hu, Y. Lu, H. 1997. Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats. Diabetes 46, 2040 2043.
51. Ehrhart-Bornstein, M., Lamounier-Zepter, V., Schraven, A., Langenbach, J., Willenberg, H.S., Barthel, A., Hauner, H., Mccann, S.M., Scherbaum, W.A. Bornstein, S.R. 2003. Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A 100, 14211 14216.
52. El Messari, S., Iturrioz, X., Fassot, C., De Mota, N., Roesch, D. Llorens-Cortes, C. 2004. Functional dissociation of apelin receptor signaling and endocytosis: implications for the effects of apelin on arterial blood pressure. J Neurochem 90, 1290 1301.
53. Engeli, S., Gorzelniak, K., Kreutz, R., Runkel, N., Distler, A. Sharma, A.M. 1999. Co-expression of renin-angiotensin system genes in human adipose tissue. J Hypertens 17, 555 560.
54. Engeli, S., Bohnke, J., Gorzelniak, K., Janke, J., Schling, P., Bader, M., Luft, F.C. Sharma, A.M. 2005. Weight loss and the renin-angiotensin- aldosterone system. Hypertension 45, 356 362.
55. Eringa, E.C., Bakker, W., Smulders, Y.M., Serné, E.H., Yudkin, J.S. Stehouwer, C.D. 2007. Regulation of vascular function and insulin sensitivity by adipose tissue: focus on perivascular adipose tissue. Microcirculation 14, 389 402.
56. Fain, J.N., Madan, A.K., Hiler, M.L., Cheema, P. Bahouth, S.W. 2004. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145, 2273 2282.
57. Fasshauer, M., Klein, J., Neumann, S., Eszlinger, M. Paschke, R. 2001. Adiponectin gene expression is inhibited by beta-adrenergic stimulation via protein kinase A in 3T3-L1 adipocytes. FEBS Lett 507, 142 146.
58. Fernandez-Real, J.M., Vayreda, M., Richart, C., Gutierrez, C., Broch, M., Vendrell, J. Ricart, W. 2001. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 86, 1154 1159.
59. Fliser, D., Buchholz, K., Haller, H. EUropean Trial on Olmesartan and Pravastatin in Inflammation and Atherosclerosis (EUTOPIA) Investigators. 2004. Antiinflammatory effects of angiotensin II subtype 1 receptor blockade in hypertensive patients with microinflammation. Circulation 110, 1103 1107.
60. Fortuno, A., Rodriguez, A., Gomez-Ambrosi, J., Muniz, P., Salvador, J., Diez, J. Fruhbeck, G. 2002. Leptin inhibits angiotensin II-induced intracellular calcium increase and vasoconstriction in the rat aorta. Endocrinology 143, 3555 3560.
61. Fortuno, A., Rodriguez, A., Gomez-Ambrosi, J., Fruhbeck, G. Diez, J. 2003. Adipose tissue as an endocrine organ: role of leptin and adiponectin in the pathogenesis of cardiovascular diseases. J Physiol Biochem 59, 51 60.
62. Fruhbeck, G. 1999. Pivotal role of nitric oxide in the control of blood pressure after leptin administration. Diabetes 48, 903 908.
63. Fry, M., Smith, P.M., Hoyda, T.D., Duncan, M., Ahima, R.S., Sharkey, K.A. Ferguson, A.V. 2006. Area postrema neurons are modulated by the adipocyte hormone adiponectin. J Neurosci 26, 9695 9702.
64. Furuhashi, M., Ura, N., Higashiura, K., Murakami, H. Shimamoto, K. 2003a. Circulating resistin levels in essential hypertension. Clin Endocrinol (Oxf) 59, 507 510.
65. Furuhashi, M., Ura, N., Higashiura, K., Murakami, H., Tanaka, M., Moniwa, N., Yoshida, D. Shimamoto, K. 2003b. Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension. Hypertension 42, 76 81.
66. Furumoto, T., Saito, N., Dong, J., Mikami, T., Fujii, S. Kitabatake, A. 2002. Association of cardiovascular risk factors and endothelial dysfunction in Japanese hypertensive patients: implications for early atherosclerosis. Hypertens Res 25, 475 480.
67. Galletti, F., D'elia, L., Barba, G., Siani, A., Cappuccio, F.P., Farinaro, E., Iacone, R., Russo, O., De Palma, D., Ippolito, R. Strazzullo, P. 2008. High-circulating leptin levels are associated with greater risk of hypertension in men independently of body mass and insulin resistance: results of an eight-year follow-up study. J Clin Endocrinol Metab 93, 3922 3926.
68. Gao, Y.J., Lu, C., Su, L.Y., Sharma, A.M. Lee, R.M. 2007a. Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 151, 323 331.
69. Gao, X., Belmadani, S., Picchi, A., Xu, X., Potter, B.J., Tewari-Singh, N., Capobianco, S., Chilian, W.M. Zhang, C. 2007b. Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 115, 245 254.
70. Gardiner, S.M., Kemp, P.A., March, J.E. Bennett, T. 2000. Regional haemodynamic effects of recombinant murine or human leptin in conscious rats. Br J Pharmacol 130, 805 810.
71. Gelber, R.P., Gaziano, J.M., Manson, J.E., Buring, J.E. Sesso, H.D. 2007. A prospective study of body mass index and the risk of developing hypertension in men. Am J Hypertens 20, 370 377.
72. Goodfriend, T.L., Kelley, D.E., Goodpaster, B.H. Winters, S.J. 1999. Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 7, 355 362.
73. Goodwin, B.L., Pendleton, L.C., Levy, M.M., Solomonson, L.P. Eichler, D.C. 2007. Tumor necrosis factor-alpha reduces argininosuccinate synthase expression and nitric oxide production in aortic endothelial cells. Am J Physiol Heart Circ Physiol 293, H1115 H1121.
74. Goossens, G.H., Jocken, J.W., Blaak, E.E., Schiffers, P.M., Saris, W.H. Van Baak, M.A. 2007. Endocrine role of the renin-angiotensin system in human adipose tissue and muscle: effect of beta-adrenergic stimulation. Hypertension 49, 542 547.
75. Gouni-Berthold, I., Giannakidou, E., Faust, M., Kratzsch, J., Berthold, H.K. Krone, W. 2005. Resistin gene 3′-untranslated region +62G→A polymorphism is associated with hypertension but not diabetes mellitus type 2 in a German population. J Intern Med 258, 518 526.
76. Graham, I., Atar, D., Borch-Johnsen, K., Boysen, G., Burell, G., Cifkova, R., Dallongeville, J., De Backer, G., Ebrahim, S., Gjelsvik, B. et al. 2007. European guidelines on cardiovascular disease prevention in clinical practice: executive summary Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil 14 (Suppl. 2 E1 E40.
77. Greenberg, S., Xie, J., Wang, Y., Cai, B., Kolls, J., Nelson, S., Hyman, A., Summer, W.R. Lippton, H. 1993. Tumor necrosis factor-alpha inhibits endothelium-dependent relaxation. J Appl Physiol 74, 2394 2403.
78. Greenstein, A.S., Khavandi, K., Withers, S.B., Sonoyama, K., Clancy, O., Jeziorska, M., Laing, I., Yates, A.P., Pemberton, P.W., Malik, R.A. Heagerty, A.M. 2009. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119, 1661 1670.
79. Guo, C., Martinez-Vasquez, D., Mendez, G.P., Toniolo, M.F., Yao, T.M., Oestreicher, E.M., Kikuchi, T., Lapointe, N., Pojoga, L., Williams, G.H., Ricchiuti, V. Adler, G.K. 2006. Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus. Endocrinology 147, 5363 5373.
80. Gurantz, D., Cowling, R.T., Villarreal, F.J. Greenberg, B.H. 1999. Tumor necrosis factor-alpha upregulates angiotensin II type 1 receptors on cardiac fibroblasts. Circ Res 85, 272 279.
81. Hajer, G.R., Van Haeften, T.W. Visseren, F.L. 2008. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 29, 2959 2971.
82. Harte, A., Mcternan, P., Chetty, R., Coppack, S., Katz, J., Smith, S. Kumar, S. 2005. Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone. Circulation 111, 1954 1961.
83. Hashimoto, T., Kihara, M., Ishida, J., Imai, N., Yoshida, S., Toya, Y., Fukamizu, A., Kitamura, H. Umemura, S. 2006. Apelin stimulates myosin light chain phosphorylation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 26, 1267 1272.
84. Hattori, Y., Suzuki, M., Hattori, S. Kasai, K. 2003. Globular adiponectin upregulates nitric oxide production in vascular endothelial cells. Diabetologia 46, 1543 1549.
85. Haynes, W.G., Morgan, D.A., Walsh, S.A., Mark, A.L. Sivitz, W.I. 1997. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 100, 270 278.
86. Hector, J., Schwarzloh, B., Goehring, J., Strate, T.G., Hess, U.F., Deuretzbacher, G., Hansen-Algenstaedt, N., Beil, F.U. Algenstaedt, P. 2007. TNF-alpha alters visfatin and adiponectin levels in human fat. Horm Metab Res 39, 250 255.
87. Heinonen, M.V., Purhonen, A.K., Miettinen, P., Paakkonen, M., Pirinen, E., Alhava, E., Akerman, K. Herzig, K.H. 2005. Apelin, orexin-A and leptin plasma levels in morbid obesity and effect of gastric banding. Regul Pept 130, 7 13.
88. Henrichot, E., Juge-Aubry, C.E., Pernin, A., Pache, J.C., Velebit, V., Dayer, J.M., Meda, P., Chizzolini, C. Meier, C.A. 2005. Production of chemokines by perivascular adipose tissue: a role in the pathogenesis of atherosclerosis? Arterioscler Thromb Vasc Biol 25, 2594 2599.
89. Higuchi, K., Masaki, T., Gotoh, K., Chiba, S., Katsuragi, I., Tanaka, K., Kakuma, T. Yoshimatsu, H. 2007. Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice. Endocrinology 148, 2690 2697.
90. Hoyda, T.D., Smith, P.M. Ferguson, A.V. 2009. Adiponectin acts in the nucleus of the solitary tract to decrease blood pressure by modulating the excitability of neuropeptide Y neurons. Brain Res 1256, 76 84.
91. Hung, M.J., Cherng, W.J., Hung, M.Y., Wu, H.T. Pang, J.H. 2010. Interleukin-6 inhibits endothelial nitric oxide synthase activation and increases endothelial nitric oxide synthase binding to stabilized caveolin-1 in human vascular endothelial cells. J Hypertens 28, 940 951.
92. Hurlimann, D., Forster, A., Noll, G., Enseleit, F., Chenevard, R., Distler, O., Bechir, M., Spieker, L.E., Neidhart, M., Michel, B.A., Gay, R.E., Luscher, T.F., Gay, S. Ruschitzka, F. 2002. Anti-tumor necrosis factor-alpha treatment improves endothelial function in patients with rheumatoid arthritis. Circulation 106, 2184 2187.
93. Iacobellis, G., Pistilli, D., Gucciardo, M., Leonetti, F., Miraldi, F., Brancaccio, G., Gallo, P. Di Gioia, C.R. 2005. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine 29, 251 255.
94. Imai, J., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Uno, K., Hasegawa, Y., Gao, J., Ishihara, H., Sasano, H. Oka, Y. 2006. Cold exposure suppresses serum adiponectin levels through sympathetic nerve activation in mice. Obesity (Silver Spring) 14, 1132 1141.
95. Imbeault, P., Depault, I. Haman, F. 2009. Cold exposure increases adiponectin levels in men. Metabolism 58, 552 559.
96. Inui, A. 2002. Leptin-replacement therapy in lipodystrophy. N Engl J Med 346, 2009 author reply : 2009 2010.
97. Ishida, J., Hashimoto, T., Hashimoto, Y., Nishiwaki, S., Iguchi, T., Harada, S., Sugaya, T., Matsuzaki, H., Yamamoto, R., Shiota, N. et al. 2004. Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem 279, 26274 26279.
98. Itani, H., Liu, X., Sarsour, E.H., Goswami, P.C., Born, E., Keen, H.L. Sigmund, C.D. 2009. Regulation of renin gene expression by oxidative stress. Hypertension 53, 1070 1076.
99. Ito, H., Ohshima, A., Tsuzuki, M., Ohto, N., Takao, K., Hijii, C., Yanagawa, M., Ogasawara, M. Nishioka, K. 2001. Association of serum tumour necrosis factor-alpha with serum low-density lipoprotein-cholesterol and blood pressure in apparently healthy Japanese women. Clin Exp Pharmacol Physiol 28, 188 192.
100. Iversen, P.O., Nicolaysen, A., Kvernebo, K., Benestad, H.B. Nicolaysen, G. 1999. Human cytokines modulate arterial vascular tone via endothelial receptors. Pflugers Arch 439, 93 100.
101. Iwashima, Y., Katsuya, T., Ishikawa, K., Ouchi, N., Ohishi, M., Sugimoto, K., Fu, Y., Motone, M., Yamamoto, K., Matsuo, A. et al. 2004. Hypoadiponectinemia is an independent risk factor for hypertension. Hypertension 43, 1318 1323.
102. Jackson, E.K. Li, P. 1997. Human leptin has natriuretic activity in the rat. Am J Physiol 272, F333 F338.
103. Japp, A.G., Cruden, N.L., Amer, D.A., Li, V.K., Goudie, E.B., Johnston, N.R., Sharma, S., Neilson, I., Webb, D.J., Megson, I.L., Flapan, A.D. Newby, D.E. 2008. Vascular effects of apelin in vivo in man. J Am Coll Cardiol 52, 908 913.
104. Japp, A.G., Cruden, N.L., Barnes, G., Van Gemeren, N., Mathews, J., Adamson, J., Johnston, N.R., Denvir, M.A., Megson, I.L., Flapan, A.D. Newby, D.E. 2010. Acute cardiovascular effects of apelin in humans: potential role in patients with chronic heart failure. Circulation 121, 1818 1827.
105. Jayasooriya, A.P., Mathai, M.L., Walker, L.L., Begg, D.P., Denton, D.A., Cameron-Smith, D., Egan, G.F., Mckinley, M.J., Rodger, P.D., Sinclair, A.J., Wark, J.D., Weisinger, H.S., Jois, M. Weisinger, R.S. 2008. Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance. Proc Natl Acad Sci U S A 105, 6531 6536.
106. Jones, B.H., Standridge, M.K. Moustaid, N. 1997. Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells. Endocrinology 138, 1512 1519.
107. Jonsson, J.R., Game, P.A., Head, R.J. Frewin, D.B. 1994. The expression and localisation of the angiotensin-converting enzyme mRNA in human adipose tissue. Blood Press 3, 72 75.
108. Juan, C.C., Chuang, T.Y., Lien, C.C., Lin, Y.J., Huang, S.W., Kwok, C.F. Ho, L.T. 2008. Leptin increases endothelin type A receptor levels in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 294, E481 E487.
109. Kagiyama, S., Fukuhara, M., Matsumura, K., Lin, Y., Fujii, K. Iida, M. 2005. Central and peripheral cardiovascular actions of apelin in conscious rats. Regul Pept 125, 55 59.
110. Kahaleh, M.B. Fan, P.S. 1997. Effect of cytokines on the production of endothelin by endothelial cells. Clin Exp Rheumatol 15, 163 167.
111. Karlsson, C., Lindell, K., Ottosson, M., Sjostrom, L., Carlsson, B. Carlsson, L.M. 1998. Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II. J Clin Endocrinol Metab 83, 3925 3929.
112. Kastarinen, M.J., Nissinen, A.M., Vartiainen, E.A., Jousilahti, P.J., Korhonen, H.J., Puska, P.M. Tuomilehto, J.O. 2000. Blood pressure levels and obesity trends in hypertensive and normotensive Finnish population from 1982 to 1997. J Hypertens 18, 255 262.
113. Katugampola, S.D., Maguire, J.J., Matthewson, S.R. Davenport, A.P. 2001. (125)I]-(Pyr(1))Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132, 1255 1260.
114. Katugampola, S.D., Kuc, R.E., Maguire, J.J. Davenport, A.P. 2002. G-protein-coupled receptors in human atherosclerosis: comparison of vasoconstrictors (endothelin and thromboxane) with recently de-orphanized (urotensin-II, apelin and ghrelin) receptors. Clin Sci (Lond) 103 (Suppl. 48 171S 175S.
115. Kawanami, D., Maemura, K., Takeda, N., Harada, T., Nojiri, T., Imai, Y., Manabe, I., Utsunomiya, K. Nagai, R. 2004. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun 314, 415 419.
116. Kazumi, T., Kawaguchi, A., Sakai, K., Hirano, T. Yoshino, G. 2002. Young men with high-normal blood pressure have lower serum adiponectin, smaller LDL size, and higher elevated heart rate than those with optimal blood pressure. Diabetes Care 25, 971 976.
117. Kern, P.A., Saghizadeh, M., Ong, J.M., Bosch, R.J., Deem, R. Simsolo, R.B. 1995. The expression of tumor necrosis factor in human adipose tissue Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95, 2111 2119.
118. Kimura, K., Tsuda, K., Baba, A., Kawabe, T., Boh-Oka, S., Ibata, M., Moriwaki, C., Hano, T. Nishio, I. 2000. Involvement of nitric oxide in endothelium-dependent arterial relaxation by leptin. Biochem Biophys Res Commun 273, 745 749.
119. Kleinz, M.J., Skepper, J.N. Davenport, A.P. 2005. Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells. Regul Pept 126, 233 240.
120. Klouche, M., Bhakdi, S., Hemmes, M. Rose-John, S. 1999. Novel path to activation of vascular smooth muscle cells: up-regulation of gp130 creates an autocrine activation loop by IL-6 and its soluble receptor. J Immunol 163, 4583 4589.
121. Knight, W.D., Seth, R., Boron, J. Overton, J.M. 2009. Short-term physiological hyperleptinemia decreases arterial blood pressure. Regul Pept 154, 60 68.
122. Komiya, N., Hirose, H., Kawabe, H., Itoh, H. Saito, I. 2009. Effects of telmisartan therapy on metabolic profiles and serum high molecular weight (HMW)-adiponectin level in Japanese male hypertensive subjects with abdominal obesity. J Atheroscler Thromb 16, 137 142.
123. Kos, K., Harte, A.L., Da Silva, N.F., Tonchev, A., Chaldakov, G., James, S., Snead, D.R., Hoggart, B., O'hare, J.P., Mcternan, P.G. Kumar, S. 2007. Adiponectin and resistin in human cerebrospinal fluid and expression of adiponectin receptors in the human hypothalamus. J Clin Endocrinol Metab 92, 1129 1136.
124. Kosugi, R., Shioi, T., Watanabe-Maeda, K., Yoshida, Y., Takahashi, K., Machida, Y. Izumi, T. 2006. Angiotensin II receptor antagonist attenuates expression of aging markers in diabetic mouse heart. Circ J 70, 482 488.
125. Kramer, C.K., Von Mühlen, D. Barrett-Connor, E. 2010. Does leptin predict incident hypertension in older adults? Clin Endocrinol (Oxf) pp. 201 205.
126. Kubota, N., Terauchi, Y., Yamauchi, T., Kubota, T., Moroi, M., Matsui, J., Eto, K., Yamashita, T., Kamon, J., Satoh, H. et al. 2002. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277, 25863 25866.
127. Langenberg, C., Bergstrom, J., Scheidt-Nave, C., Pfeilschifter, J. Barrett-Connor, E. 2006. Cardiovascular death and the metabolic syndrome: role of adiposity-signaling hormones and inflammatory markers. Diabetes Care 29, 1363 1369.
128. Lee, D.K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A.P., Liu, Y., Osmond, D.H., George, S.R. O'dowd, B.F. 2000. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74, 34 41.
129. Lee, D.L., Sturgis, L.C., Labazi, H., Osborne, J.B., Jr., Fleming, C., Pollock, J.S., Manhiani, M., Imig, J.D. Brands, M.W. 2006. Angiotensin II hypertension is attenuated in interleukin-6 knockout mice. Am J Physiol Heart Circ Physiol 290, H935 H940.
130. Lee, R.M., Lu, C., Su, L.Y. Gao, Y.J. 2009. Endothelium-dependent relaxation factor released by perivascular adipose tissue. J Hypertens 27, 782 790.
131. Lely, A.T., Krikken, J.A., Bakker, S.J., Boomsma, F., Dullaart, R.P., Wolffenbuttel, B.H. Navis, G. 2007. Low dietary sodium and exogenous angiotensin II infusion decrease plasma adiponectin concentrations in healthy men. J Clin Endocrinol Metab 92, 1821 1826.
132. Lembo, G., Vecchione, C., Fratta, L., Marino, G., Trimarco, V., D'amati, G. Trimarco, B. 2000. Leptin induces direct vasodilation through distinct endothelial mechanisms. Diabetes 49, 293 297.
133. Lockwood, C.J., Yen, C.F., Basar, M., Kayisli, U.A., Martel, M., Buhimschi, I., Buhimschi, C., Huang, S.J., Krikun, G. Schatz, F. 2008. Preeclampsia-related inflammatory cytokines regulate interleukin-6 expression in human decidual cells. Am J Pathol 172, 1571 1579.
134. Loffreda, S., Yang, S.Q., Lin, H.Z., Karp, C.L., Brengman, M.L., Wang, D.J., Klein, A.S., Bulkley, G.B., Bao, C., Noble, P.W., Lane, M.D. Diehl, A.M. 1998. Leptin regulates proinflammatory immune responses. FASEB J 12, 57 65.
135. Lohn, M., Dubrovska, G., Lauterbach, B., Luft, F.C., Gollasch, M. Sharma, A.M. 2002. Periadventitial fat releases a vascular relaxing factor. FASEB J 16, 1057 1063.
136. MacEwan, D.J. 2002. TNF ligands and receptors - a matter of life and death. Br J Pharmacol 135, 855 875.
137. Maeda, K., Okubo, K., Shimomura, I., Funahashi, T., Matsuzawa, Y. Matsubara, K. 1996. cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1). Biochem Biophys Res Commun 221, 286 289.
138. Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y. et al. 2002. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8, 731 737.
139. Maguire, J.J., Kleinz, M.J., Pitkin, S.L. Davenport, A.P. 2009. Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Hypertension 54, 598 604.
140. Maki-Petaja, K.M., Hall, F.C., Booth, A.D., Wallace, S.M., Yasmin, Bearcroft, P.W., Harish, S., Furlong, A., Mceniery, C.M., Brown, J. Wilkinson, I.B. 2006. Rheumatoid arthritis is associated with increased aortic pulse-wave velocity, which is reduced by anti-tumor necrosis factor-alpha therapy. Circulation 114, 1185 1192.
141. Makita, S., Abiko, A., Naganuma, Y., Moriai, Y. Nakamura, M. 2008. Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance. Metabolism 57, 1473 1478.
142. Mark, A.L., Shaffer, R.A., Correia, M.L., Morgan, D.A., Sigmund, C.D. Haynes, W.G. 1999. Contrasting blood pressure effects of obesity in leptin-deficient ob/ob mice and agouti yellow obese mice. J Hypertens 17, 1949 1953.
143. Mark, A.L., Agassandian, K., Morgan, D.A., Liu, X., Cassell, M.D. Rahmouni, K. 2009. Leptin signaling in the nucleus tractus solitarii increases sympathetic nerve activity to the kidney. Hypertension 53, 375 380.
144. Marsh, A.J., Fontes, M.A., Killinger, S., Pawlak, D.B., Polson, J.W. Dampney, R.A. 2003. Cardiovascular responses evoked by leptin acting on neurons in the ventromedial and dorsomedial hypothalamus. Hypertension 42, 488 493.
145. Massiera, F., Bloch-Faure, M., Ceiler, D., Murakami, K., Fukamizu, A., Gasc, J.M., Quignard-Boulange, A., Negrel, R., Ailhaud, G., Seydoux, J., Meneton, P. Teboul, M. 2001a. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J 15, 2727 2729.
146. Massiera, F., Seydoux, J., Geloen, A., Quignard-Boulange, A., Turban, S., Saint-Marc, P., Fukamizu, A., Negrel, R., Ailhaud, G. Teboul, M. 2001b. Angiotensinogen-deficient mice exhibit impairment of diet-induced weight gain with alteration in adipose tissue development and increased locomotor activity. Endocrinology 142, 5220 5225.
147. Mathew, B., Patel, S.B., Reams, G.P., Freeman, R.H., Spear, R.M. Villarreal, D. 2007. Obesity-hypertension: emerging concepts in pathophysiology and treatment. Am J Med Sci 334, 23 30.
148. Mazurek, T., Zhang, L., Zalewski, A., Mannion, J.D., Diehl, J.T., Arafat, H., Sarov-Blat, L., O'brien, S., Keiper, E.A., Johnson, A.G., Martin, J., Goldstein, B.J. Shi, Y. 2003. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 108, 2460 2466.
149. Mendall, M.A., Patel, P., Asante, M., Ballam, L., Morris, J., Strachan, D.P., Camm, A.J. Northfield, T.C. 1997. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart 78, 273 277.
150. Mikhail, N. Tuck, M.L. 2000. Epidemiological and clinical aspects of obesity related hypertension. J Clin Hypertens (Greenwich) 2, 41 45.
151. Mitchell, J.L., Morgan, D.A., Correia, M.L., Mark, A.L., Sivitz, W.I. Haynes, W.G. 2001. Does leptin stimulate nitric oxide to oppose the effects of sympathetic activation? Hypertension 38, 1081 1086.
152. Mitra, A., Katovich, M.J., Mecca, A. Rowland, N.E. 2006. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats. Physiol Behav 89, 221 225.
153. Mohamed-Ali, V., Goodrick, S., Rawesh, A., Katz, D.R., Miles, J.M., Yudkin, J.S., Klein, S. Coppack, S.W. 1997. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo. J Clin Endocrinol Metab 82, 4196 4200.
154. Moitra, J., Mason, M.M., Olive, M., Krylov, D., Gavrilova, O., Marcus-Samuels, B., Feigenbaum, L., Lee, E., Aoyama, T., Eckhaus, M., Reitman, M.L. Vinson, C. 1998. Life without white fat: a transgenic mouse. Genes Dev 12, 3168 3181.
155. Morgan, D.A., Thedens, D.R., Weiss, R. Rahmouni, K. 2008. Mechanisms mediating renal sympathetic activation to leptin in obesity. Am J Physiol Regul Integr Comp Physiol 295, R1730 R1736.
156. Moriyama, T., Oka, K., Ueda, H. Imai, E. 2004. Nilvadipine attenuates mesangial expansion and glomerular hypertrophy in diabetic db/db mice, a model for type 2 diabetes. Clin Exp Nephrol 8, 230 236.
157. Murakami, H., Ura, N., Furuhashi, M., Higashiura, K., Miura, T. Shimamoto, K. 2003. Role of adiponectin in insulin-resistant hypertension and atherosclerosis. Hypertens Res 26, 705 710.
158. Nagase, M. Fujita, T. 2009. Mineralocorticoid receptor activation in obesity hypertension. Hypertens Res 32, 649 657.
159. Nishimura, H., Sanaka, T., Tanihata, Y., Naito, T., Higuchi, C. Otsuka, K. 2008. Losartan elevates the serum high-molecular weight-adiponectin isoform and concurrently improves insulin sensitivity in patients with impaired glucose metabolism. Hypertens Res 31, 1611 1618.
160. Nowak, L., Adamczak, M. Wiecek, A. 2005. Blockade of sympathetic nervous system activity by rilmenidine increases plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 18, 1470 1475.
161. Ohashi, K., Kihara, S., Ouchi, N., Kumada, M., Fujita, K., Hiuge, A., Hibuse, T., Ryo, M., Nishizawa, H., Maeda, N., Maeda, K., Shibata, R., Walsh, K., Funahashi, T. Shimomura, I. 2006. Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47, 1108 1116.
162. Ohtani, R., Yayama, K., Takano, M., Itoh, N. Okamoto, H. 1992. Stimulation of angiotensinogen production in primary cultures of rat hepatocytes by glucocorticoid, cyclic adenosine 3',5'-monophosphate, and interleukin-6. Endocrinology 130, 1331 1338.
163. Orshal, J.M. Khalil, R.A. 2004. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension 43, 434 444.
164. Osawa, H., Ochi, M., Tabara, Y., Kato, K., Yamauchi, J., Takata, Y., Nishida, W., Onuma, H., Shimizu, I., Fujii, Y., Miki, T., Ohashi, J. Makino, H. 2008. Serum resistin is positively correlated with the accumulation of metabolic syndrome factors in type 2 diabetes. Clin Endocrinol (Oxf) 69, 74 80.
165. Ostlund, R.E., Jr., Yang, J.W., Klein, S. Gingerich, R. 1996. Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81, 3909 3913.
166. Ouchi, N. Walsh, K. 2007. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 380, 24 30.
167. Ouchi, N., Ohishi, M., Kihara, S., Funahashi, T., Nakamura, T., Nagaretani, H., Kumada, M., Ohashi, K., Okamoto, Y., Nishizawa, H. et al. 2003. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension 42, 231 234.
168. Ouedraogo, R., Gong, Y., Berzins, B., Wu, X., Mahadev, K., Hough, K., Chan, L., Goldstein, B.J. Scalia, R. 2007. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest 117, 1718 1726.
169. Ozata, M., Ozdemir, I.C. Licinio, J. 1999. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab 84, 3686 3695.
170. Papadopoulos, D.P., Makris, T.K., Krespi, P.G., Poulakou, M., Stavroulakis, G., Hatzizacharias, A.N., Perrea, D. Votteas, V.V. 2005. Adiponectin and resistin plasma levels in healthy individuals with prehypertension. J Clin Hypertens (Greenwich) 7, 729 733.
171. Picchi, A., Gao, X., Belmadani, S., Potter, B.J., Focardi, M., Chilian, W.M. Zhang, C. 2006. Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 99, 69 77.
172. Pischon, T., Boeing, H., Hoffmann, K., Bergmann, M., Schulze, M.B., Overvad, K., Van Der Schouw, Y.T., Spencer, E., Moons, K.G., Tjønneland, A. et al. 2008. General and abdominal adiposity and risk of death in Europe. N Engl J Med 359, 2105 2120.
173. Poirier, P., Lemieux, I., Mauriege, P., Dewailly, E., Blanchet, C., Bergeron, J. Despres, J.P. 2005. Impact of waist circumference on the relationship between blood pressure and insulin: the Quebec Health Survey. Hypertension 45, 363 367.
174. Porreca, E., Di Febbo, C., Vitacolonna, E., Baccante, G., Di Castelnuovo, A., Angelini, A., Febo, F., Di Nisio, M. Cuccurullo, F. 2002. Transforming growth factor-beta1 levels in hypertensive patients: association with body mass index and leptin. Am J Hypertens 15, 759 765.
175. Poyhonen-Alho, M.K., Manhem, K., Katzman, P., Kibarskis, A., Antikainen, R.L., Erkkola, R.U., Tuomilehto, J.O., Ebeling, P.E. Kaaja, R.J. 2008. Central sympatholytic therapy has anti-inflammatory properties in hypertensive postmenopausal women. J Hypertens 26, 2445 2449.
176. Puerta, M., Abelenda, M., Rocha, M. Trayhurn, P. 2002. Effect of acute cold exposure on the expression of the adiponectin, resistin and leptin genes in rat white and brown adipose tissues. Horm Metab Res 34, 629 634.
177. Quehenberger, P., Exner, M., Sunder-Plassmann, R., Ruzicka, K., Bieglmayer, C., Endler, G., Muellner, C., Speiser, W. Wagner, O. 2002. Leptin induces endothelin-1 in endothelial cells in vitro. Circ Res 90, 711 718.
178. Rabe, K., Lehrke, M., Parhofer, K.G. Broedl, U.C. 2008. Adipokines and insulin resistance. Mol Med 14, 741 751.
179. Rahmouni, K. Morgan, D.A. 2007. Hypothalamic arcuate nucleus mediates the sympathetic and arterial pressure responses to leptin. Hypertension 49, 647 652.
180. Rahmouni, K., Jalali, A., Morgan, D.A. Haynes, W.G. 2005a. Lack of dilator effect of leptin in the hindlimb vascular bed of conscious rats. Eur J Pharmacol 518, 175 181.
181. Rahmouni, K., Morgan, D.A., Morgan, G.M., Mark, A.L. Haynes, W.G. 2005b. Role of selective leptin resistance in diet-induced obesity hypertension. Diabetes 54, 2012 2018.
182. Ran, J., Hirano, T., Fukui, T., Saito, K., Kageyama, H., Okada, K. Adachi, M. 2006. Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance. Metabolism 55, 478 488.
183. Reaux, A., De Mota, N., Skultetyova, I., Lenkei, Z., El Messari, S., Gallatz, K., Corvol, P., Palkovits, M. Llorens-Cortes, C. 2001. Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain. J Neurochem 77, 1085 1096.
184. Reaux, A., Gallatz, K., Palkovits, M. Llorens-Cortes, C. 2002. Distribution of apelin-synthesizing neurons in the adult rat brain. Neuroscience 113, 653 662.
185. Ridker, P.M., Rifai, N., Stampfer, M.J. Hennekens, C.H. 2000. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 101, 1767 1772.
186. Rodriguez, A., Fortuno, A., Gomez-Ambrosi, J., Zalba, G., Diez, J. Fruhbeck, G. 2007. The inhibitory effect of leptin on angiotensin II-induced vasoconstriction in vascular smooth muscle cells is mediated via a nitric oxide-dependent mechanism. Endocrinology 148, 324 331.
187. Rodriguez-Pacheco, F., Martinez-Fuentes, A.J., Tovar, S., Pinilla, L., Tena-Sempere, M., Dieguez, C., Castaño, J.P. Malagon, M.M. 2007. Regulation of pituitary cell function by adiponectin. Endocrinology 148, 401 410.
188. Rossi, G.P., Belfiore, A., Bernini, G., Fabris, B., Caridi, G., Ferri, C., Giacchetti, G., Letizia, C., Maccario, M., Mannelli, M. et al. 2008. Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab 93, 2566 2571.
189. Ruan, H., Miles, P.D., Ladd, C.M., Ross, K., Golub, T.R., Olefsky, J.M. Lodish, H.F. 2002. Profiling gene transcription in vivo reveals adipose tissue as an immediate target of tumor necrosis factor-alpha: implications for insulin resistance. Diabetes 51, 3176 3188.
190. Sacks, H.S. Fain, J.N. 2007. Human epicardial adipose tissue: a review. Am Heart J 153, 907 917.
191. Salcedo, A., Garijo, J., Monge, L., Fernandez, N., Luis Garcia-Villalon, A., Sanchez Turrion, V., Cuervas-Mons, V. Dieguez, G. 2007. Apelin effects in human splanchnic arteries Role of nitric oxide and prostanoids. Regul Pept 144, 50 55.
192. Satou, R., Gonzalez-Villalobos, R.A., Miyata, K., Ohashi, N., Urushihara, M., Acres, O.W., Navar, L.G. Kobori, H. 2009. IL-6 augments angiotensinogen in primary cultured renal proximal tubular cells. Mol Cell Endocrinol 311, 24 31.
193. Saura, M., Zaragoza, C., Bao, C., Herranz, B., Rodriguez-Puyol, M. Lowenstein, C.J. 2006. Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression. J Biol Chem 281, 30057 30062.
194. Savage, D.B., Sewter, C.P., Klenk, E.S., Segal, D.G., Vidal-Puig, A., Considine, R.V. O'rahilly, S. 2001. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 50, 2199 2202.
195. Schinzari, F., Armuzzi, A., De Pascalis, B., Mores, N., Tesauro, M., Melina, D. Cardillo, C. 2008. Tumor necrosis factor-alpha antagonism improves endothelial dysfunction in patients with Crohn's disease. Clin Pharmacol Ther 83, 70 76.
196. Schling, P., Mallow, H., Trindl, A. Loffler, G. 1999. Evidence for a local renin angiotensin system in primary cultured human preadipocytes. Int J Obes Relat Metab Disord 23, 336 341.
197. Schrader, L.I., Kinzenbaw, D.A., Johnson, A.W., Faraci, F.M. Didion, S.P. 2007. IL-6 deficiency protects against angiotensin II induced endothelial dysfunction and hypertrophy. Arterioscler Thromb Vasc Biol 27, 2576 2581.
198. Schwartz, M.W., Seeley, R.J., Campfield, L.A., Burn, P. Baskin, D.G. 1996. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98, 1101 1106.
199. Senador, D., Kanakamedala, K., Irigoyen, M.C., Morris, M. Elased, K.M. 2009. Cardiovascular and autonomic phenotype of db/db diabetic mice. Exp Physiol 94, 648 658.
200. Serradeil-Le Gal, C., Raufaste, D., Brossard, G., Pouzet, B., Marty, E., Maffrand, J.P. Le Fur, G. 1997. Characterization and localization of leptin receptors in the rat kidney. FEBS Lett 404, 185 191.
201. Seyedabadi, M., Goodchild, A.K. Pilowsky, P.M. 2002. Site-specific effects of apelin-13 in the rat medulla oblongata on arterial pressure and respiration. Auton Neurosci 101, 32 38.
202. Shek, E.W., Brands, M.W. Hall, J.E. 1998. Chronic leptin infusion increases arterial pressure. Hypertension 31, 409 414.
203. Sheu, W.H.H., Lee, W.J., Chang, R.L. Chen, Y.T. 2000. Plasma tumor necrosis factor alpha levels and insulin sensitivity in hypertensive subjects. Clin Exp Hypertens 22, 595 606.
204. Sierra-Honigmann, M.R., Nath, A.K., Murakami, C., Garcia-Cardena, G., Papapetropoulos, A., Sessa, W.C., Madge, L.A., Schechner, J.S., Schwabb, M.B., Polverini, P.J. Flores-Riveros, J.R. 1998. Biological action of leptin as an angiogenic factor. Science 281, 1683 1686.
205. Skurk, T., Van Harmelen, V., Blum, W.F. Hauner, H. 2005. Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway. Obes Res 13, 969 973.
206. Soltis, E.E. Cassis, L.A. 1991. Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 13, 277 296.
207. Spranger, J., Verma, S., Gohring, I., Bobbert, T., Seifert, J., Sindler, A.L., Pfeiffer, A., Hileman, S.M., Tschop, M. Banks, W.A. 2006. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes 55, 141 147.
208. Steppan, C.M., Bailey, S.T., Bhat, S., Brown, E.J., Banerjee, R.R., Wright, C.M., Patel, H.R., Ahima, R.S. Lazar, M.A. 2001. The hormone resistin links obesity to diabetes. Nature 409, 307 312.
209. Su, W., Guo, Z., Randall, D.C., Cassis, L., Brown, D.R. Gong, M.C. 2008. Hypertension and disrupted blood pressure circadian rhythm in type 2 diabetic db/db mice. Am J Physiol Heart Circ Physiol 295, H1634 H1641.
210. Szokodi, I., Tavi, P., Foldes, G., Voutilainen-Myllyla, S., Ilves, M., Tokola, H., Pikkarainen, S., Piuhola, J., Rysa, J., Toth, M. Ruskoaho, H. 2002. Apelin, the novel endogenous ligand of the orphan receptor APJ, regulates cardiac contractility. Circ Res 91, 434 440.
211. Takata, Y., Osawa, H., Kurata, M., Kurokawa, M., Yamauchi, J., Ochi, M., Nishida, W., Okura, T., Higaki, J. Makino, H. 2008. Hyperresistinemia is associated with coexistence of hypertension and type 2 diabetes. Hypertension 51, 534 539.
212. Tan, M.S., Chang, S.Y., Chang, D.M., Tsai, J.C. Lee, Y.J. 2003. Association of resistin gene 3'-untranslated region +62G→A polymorphism with type 2 diabetes and hypertension in a Chinese population. J Clin Endocrinol Metab 88, 1258 1263.
213. Tan, K.C., Xu, A., Chow, W.S., Lam, M.C., Ai, V.H., Tam, S.C. Lam, K.S. 2004. Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation. J Clin Endocrinol Metab 89, 765 769.
214. Tanida, M., Shen, J., Horii, Y., Matsuda, M., Kihara, S., Funahashi, T., Shimomura, I., Sawai, H., Fukuda, Y., Matsuzawa, Y. Nagai, K. 2007. Effects of adiponectin on the renal sympathetic nerve activity and blood pressure in rats. Exp Biol Med (Maywood) 232, 390 397.
215. Tatemoto, K., Hosoya, M., Habata, Y., Fujii, R., Kakegawa, T., Zou, M.X., Kawamata, Y., Fukusumi, S., Hinuma, S., Kitada, C., Kurokawa, T., Onda, H. Fujino, M. 1998. Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251, 471 476.
216. Tatemoto, K., Takayama, K., Zou, M.X., Kumaki, I., Zhang, W., Kumano, K. Fujimiya, M. 2001. The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism. Regul Pept 99, 87 92.
217. Teijeira-Fernandez, E., Eiras, S., Grigorian-Shamagian, L., Fernandez, A., Adrio, B. Gonzalez-Juanatey, J.R. 2008. Epicardial adipose tissue expression of adiponectin is lower in patients with hypertension. J Hum Hypertens 22, 856 863.
218. Tilg, H. Moschen, A.R. 2006. Adipocytokines: mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6, 772 783.
219. Tran, T.T., Yamamoto, Y., Gesta, S. Kahn, C.R. 2008. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 7, 410 420.
220. Trayhurn, P. Wood, I.S. 2004. Adipokines: inflammation and the pleiotropic role of white adipose tissue. Br J Nutr 92, 347 355.
221. Trayhurn, P., Wang, B. Wood, I.S. 2008. Hypoxia and the endocrine and signalling role of white adipose tissue. Arch Physiol Biochem 114, 267 276.
222. Ukkola, O., Kunnari, A. Kesaniemi, Y.A. 2008. Genetic variants at the resistin locus are associated with the plasma resistin concentration and cardiovascular risk factors. Regul Pept 149, 56 59.
223. Umemura, S., Nyui, N., Tamura, K., Hibi, K., Yamaguchi, S., Nakamaru, M., Ishigami, T., Yabana, M., Kihara, M., Inoue, S. Ishii, M. 1997. Plasma angiotensinogen concentrations in obese patients. Am J Hypertens 10, 629 633.
224. Vazquez-Oliva, G., Fernandez-Real, J.M., Zamora, A., Vilaseca, M. Badimon, L. 2005. Lowering of blood pressure leads to decreased circulating interleukin-6 in hypertensive subjects. J Hum Hypertens 19, 457 462.
225. Vecchione, C., Maffei, A., Colella, S., Aretini, A., Poulet, R., Frati, G., Gentile, M.T., Fratta, L., Trimarco, V., Trimarco, B. Lembo, G. 2002. Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 51, 168 173.
226. Verlohren, S., Dubrovska, G., Tsang, S.Y., Essin, K., Luft, F.C., Huang, Y. Gollasch, M. 2004. Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 44, 271 276.
227. Verma, S., Li, S.H., Wang, C.H., Fedak, P.W., Li, R.K., Weisel, R.D. Mickle, D.A. 2003. Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation 108, 736 740.
228. Vila, E. Salaices, M. 2005. Cytokines and vascular reactivity in resistance arteries. Am J Physiol Heart Circ Physiol 288, H1016 H1021.
229. Villarreal, D., Reams, G., Freeman, R.H. Taraben, A. 1998. Renal effects of leptin in normotensive, hypertensive, and obese rats. Am J Physiol 275, R2056 R2060.
230. Virdis, A. Schiffrin, E.L. 2003. Vascular inflammation: a role in vascular disease in hypertension? Curr Opin Nephrol Hypertens 12, 181 187.
231. Wei, L., Hou, X. Tatemoto, K. 2005. Regulation of apelin mRNA expression by insulin and glucocorticoids in mouse 3T3-L1 adipocytes. Regul Pept 132, 27 32.
232. Willett, W.C., Dietz, W.H. Colditz, G.A. 1999. Guidelines for healthy weight. N Engl J Med 341, 427 434.
233. Wort, S.J., Woods, M., Warner, T.D., Evans, T.W. Mitchell, J.A. 2002. Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension. Mol Pharmacol 62, 1147 1153.
234. Wort, S.J., Ito, M., Chou, P.C., Mc Master, S.K., Badiger, R., Jazrawi, E., Desouza, P., Evans, T.W., Mitchell, J.A., Pinhu, L., Ito, K. Adcock, I.M. 2009. Synergistic induction of endothelin-1 by TNF{alpha} and IFN{gamma} is due to enhanced NF-{kappa}B binding and histone acetylation at specific {kappa}B sites. J Biol Chem 284, 24297 24305.
235. Yamamoto, Y., Hirose, H., Saito, I., Tomita, M., Taniyama, M., Matsubara, K., Okazaki, Y., Ishii, T., Nishikai, K. Saruta, T. 2002. Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population. Clin Sci (Lond) 103, 137 142.
236. Yilmaz, M.I., Sonmez, A., Caglar, K., Celik, T., Yenicesu, M., Eyileten, T., Acikel, C., Oguz, Y., Yavuz, I. Vural, A. 2007. Effect of antihypertensive agents on plasma adiponectin levels in hypertensive patients with metabolic syndrome. Nephrology (Carlton) 12, 147 153.
237. Zeidan, A., Purdham, D.M., Rajapurohitam, V., Javadov, S., Chakrabarti, S. Karmazyn, M. 2005. Leptin induces vascular smooth muscle cell hypertrophy through angiotensin II- and endothelin-1-dependent mechanisms and mediates stretch-induced hypertrophy. J Pharmacol Exp Ther 315, 1075 1084.
238. Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L. Friedman, J.M. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425 432.
239. Zhang, Q., Yao, F., Raizada, M.K., O'rourke, S.T. Sun, C. 2009a. Apelin gene transfer into the rostral ventrolateral medulla induces chronic blood pressure elevation in normotensive rats. Circ Res 104, 1421 1428.
240. Zhang, H., Park, Y., Wu, J., Chen, X., Lee, S., Yang, J., Dellsperger, K.C. Zhang, C. 2009b. Role of TNF-alpha in vascular dysfunction. Clin Sci (Lond) 116, 219 230.
241. Zhang, L., Curhan, G.C. Forman, J.P. 2010. Plasma resistin levels associate with risk for hypertension among nondiabetic women. J Am Soc Nephrol 21, 1185 1191.
242. Zhu, W., Cheng, K.K., Vanhoutte, P.M., Lam, K.S. Xu, A. 2008. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clin Sci (Lond) 114, 361 374.
243. Zinman, B., Hanley, A.J., Harris, S.B., Kwan, J. Fantus, I.G. 1999. Circulating tumor necrosis factor-alpha concentrations in a native Canadian population with high rates of type 2 diabetes mellitus. J Clin Endocrinol Metab 84, 272 278.