The use of lactate as a biomarker

Journal of Intensive Care Medicine

Volumn 25, Issue 5, 2010, Pages 301-302

  Watson, Nicholas C ^a   Heard, Stephen O ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BICARBONATE; GLUCOSE; LACTIC ACID; LIVER ENZYME;

ACID BASE BALANCE; ACIDOSIS; ACUTE DISEASE; AEROBIC METABOLISM; ANAEROBIC METABOLISM; AREA UNDER THE CURVE; BIOCHEMISTRY; EDITORIAL; HUMAN; HYPERLACTATEMIA; HYPOVOLEMIA; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; LEUKOCYTE COUNT; LIVER DYSFUNCTION; METABOLIC ACIDOSIS; MITOCHONDRIAL RESPIRATION; MULTIPLE ORGAN FAILURE; PERFUSION; PH; PRIORITY JOURNAL; PROTEIN HYDROLYSIS; RECEIVER OPERATING CHARACTERISTIC; SEPTIC SHOCK; STOICHIOMETRY; TISSUE OXYGENATION; VITAL SIGN;

CRITICAL CARE; FEMALE; HUMANS; LACTIC ACID; MALE;

EID: 77956292217     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066610371631     Document Type: Editorial

References (21)

1. Benninga H. A History of Lactate Acid Making: A Chapter in the History of Biotechnology. Boston, MA: Kluwer Academic Publishers ; 1990.
2. Nobel Laureates. http://www.nobelprize.org. Accessed December 10, 2009.
3. Huckabee WE Abnormal resting blood lactate. I. The significance of hyperlactatemia in hospitalized patients. Am J Med. 1961 ; 30 (6). 833-839.
4. Huckabee WE Abnormal resting blood lactate. II. Lactic acidosis. Am J Med. 1961 ; 30 (6). 840-848.
5. Mikkelsen ME, Miltiades AN, Gaieski DF, et al. Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock. Crit Care Med. 2009 ; 37 (5). 1670-1677.
6. Hanisch F., Muller T., Muser A., Deschauer M., Zierz S. Lactate increase and oxygen desaturation in mitochondrial disorders- evaluation of two diagnostic screening protocols. J Neurol. 2006 ; 253 (4). 417-423.
7. Schmidt LE, Larsen FS Prognostic implications of hyperlactatemia, multiple organ failure, and systemic inflammatory response syndrome in patients with acetaminophen-induced acute liver failure. Crit Care Med. 2006 ; 34 (2). 337-343.
8. Howell MD, Donnino M., Clardy P., Talmor D., Shapiro NI Occult hypoperfusion and mortality in patients with suspected infection. Intensive Care Med. 2007 ; 33 (11). 1892-1899.
9. Porter JM, Ivatury RR In search of the optimal end points of resuscitation in trauma patients: a review. J Trauma. 1998 ; 44 (5). 908-914.
10. Rivers E., Nguyen B., Havstad S., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 ; 345 (19). 1368-1377.
11. Vincent JL, Dufaye P., Berre J., Leeman M., Degaute JP, Kahn RJ Serial lactate determinations during circulatory shock. Crit Care Med. 1983 ; 11 (6). 449-451.
12. Cohen RD, Woods HF Clinical and Biochemical Aspects of Lactic Acidosis. Oxford: Blackwell Scientific ; 1976.
13. Boning D., Maassen N. Point: lactic acid is the only physicochemical contributor to the acidosis of exercise. J Appl Physiol. 2008 ; 105 (1). 358-359.
14. Prakash ES Good bye "lactic acid"; hello lactate and acid. J Appl Physiol. 2008 ; 105 (1). 363.
15. Robergs RA, Ghiasvand F., Parker D. Biochemistry of exercise-induced metabolic acidosis. Am J Physiol Regul Integr Comp Physiol. 2004 ; 287 (3). R502 - R516.
16. Kjelland CB, Djogovic D. The role of serum lactate in the acute care setting. J Intensive Care Med. 2010.
17. Hollenberg SM, Ahrens TS, Annane D., et al. Practice parameters for hemodynamic support of sepsis in adult patients: 2004 update. Crit Care Med. 2004 ; 32 (9). 1928-1948.
18. Fink MP Bench-to-bedside review: cytopathic hypoxia. Crit Care. 2002 ; 6 (6). 491-499.
19. Jansen TC, van Bommel J., Mulder PG, Rommes JH, Schieveld SJ, Bakker J. The prognostic value of blood lactate levels relative to that of vital signs in the pre-hospital setting: a pilot study. Crit Care. 2008 ; 12 (6). R160.
20. Aduen J., Bernstein WK, Khastgir T., et al. The use and clinical importance of a substrate-specific electrode for rapid determination of blood lactate concentrations. JAMA. 1994 ; 272 (21). 1678-1685.
21. Bakker J., Gris P., Coffernils M., Kahn RJ, Vincent JL Serial blood lactate levels can predict the development of multiple organ failure following septic shock. Am J Surg. 1996 ; 171 (2). 221-226.