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Volumn 31, Issue 9, 2010, Pages 1604-1611

Genetic variation in a metabolic signaling pathway and colon and rectal cancer risk: mTOR, PTEN, STK11, RPKAA1, PRKAG2, TSC1, TSC2, PI3K and Akt1

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE PHOSPHATE; FK 506 BINDING PROTEIN; FK506 BINDING PROTEIN 12 RAPAMYCIN ASSOCIATED PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHORYLATES THE ADENOSINE MONOPHOSPHATE DEPENDENT KINASE; PROTEIN KINASE B; PROTEIN KINASE LKB1; TSC1 PROTEIN; TUBERIN; UNCLASSIFIED DRUG;

EID: 77956288187     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq142     Document Type: Article
Times cited : (88)

References (48)
  • 1
    • 74049129388 scopus 로고    scopus 로고
    • Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology
    • Slattery, M.L. et al. (2009) Convergence of hormones, inflammation, and energy-related factors: a novel pathway of cancer etiology. Cancer Prev. Res. (Phila. Pa), 2, 922-930.
    • (2009) Cancer Prev. Res. (Phila. Pa) , vol.2 , pp. 922-930
    • Slattery, M.L.1
  • 2
    • 0031975641 scopus 로고    scopus 로고
    • Body size and the risk of colon cancer in a large case-control study
    • Caan, B.J. et al. (1998) Body size and the risk of colon cancer in a large case-control study. Int. J. Obes. Relat. Metab. Disord., 22, 178-184.
    • (1998) Int. J. Obes. Relat. Metab. Disord. , vol.22 , pp. 178-184
    • Caan, B.J.1
  • 3
    • 0037306342 scopus 로고    scopus 로고
    • Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States)
    • Slattery, M.L. et al. (2003) Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States). Cancer Causes Control, 14, 75-84.
    • (2003) Cancer Causes Control , vol.14 , pp. 75-84
    • Slattery, M.L.1
  • 4
    • 0042127152 scopus 로고    scopus 로고
    • Physical activity and colorectal cancer
    • Slattery, M.L. et al. (2003) Physical activity and colorectal cancer. Am. J. Epidemiol., 158, 214-224.
    • (2003) Am. J. Epidemiol. , vol.158 , pp. 214-224
    • Slattery, M.L.1
  • 5
    • 0031036169 scopus 로고    scopus 로고
    • Energy balance and colon cancer-beyond physical activity
    • Slattery, M.L. et al. (1997) Energy balance and colon cancer-beyond physical activity. Cancer Res., 57, 75-80.
    • (1997) Cancer Res. , vol.57 , pp. 75-80
    • Slattery, M.L.1
  • 6
    • 0030942905 scopus 로고    scopus 로고
    • Hormone replacement therapy, reproductive history, and colon cancer: a multicenter, case-control study in the United States
    • Kampman, E. et al. (1997) Hormone replacement therapy, reproductive history, and colon cancer: a multicenter, case-control study in the United States. Cancer Causes Control, 8, 146-158.
    • (1997) Cancer Causes Control , vol.8 , pp. 146-158
    • Kampman, E.1
  • 7
    • 2942545805 scopus 로고    scopus 로고
    • Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway
    • Slattery, M.L. et al. (2004) Aspirin, NSAIDs, and colorectal cancer: possible involvement in an insulin-related pathway. Cancer Epidemiol. Biomarkers Prev., 13, 538-545.
    • (2004) Cancer Epidemiol. Biomarkers Prev. , vol.13 , pp. 538-545
    • Slattery, M.L.1
  • 8
    • 0036844228 scopus 로고    scopus 로고
    • Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States)
    • Camp, N.J. et al. (2002) Classification tree analysis: a statistical tool to investigate risk factor interactions with an example for colon cancer (United States). Cancer Causes Control, 13, 813-823.
    • (2002) Cancer Causes Control , vol.13 , pp. 813-823
    • Camp, N.J.1
  • 9
    • 0034610730 scopus 로고    scopus 로고
    • Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome
    • Esteller, M. et al. (2000) Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome. Oncogene, 19, 164-168.
    • (2000) Oncogene , vol.19 , pp. 164-168
    • Esteller, M.1
  • 10
    • 0035992276 scopus 로고    scopus 로고
    • The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma
    • Shen, Z. et al. (2002) The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma. Clin. Cancer Res., 8, 2085-2090.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2085-2090
    • Shen, Z.1
  • 12
    • 0344081177 scopus 로고    scopus 로고
    • Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status
    • Hardie, D.G. (2003) Minireview: the AMP-activated protein kinase cascade: the key sensor of cellular energy status. Endocrinology, 144, 5179-5183.
    • (2003) Endocrinology , vol.144 , pp. 5179-5183
    • Hardie, D.G.1
  • 13
    • 0347318052 scopus 로고    scopus 로고
    • The AMP-activated protein kinase cascade-a unifying system for energy control
    • Carling, D. (2004) The AMP-activated protein kinase cascade-a unifying system for energy control. Trends Biochem. Sci., 29, 18-24.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 18-24
    • Carling, D.1
  • 14
    • 0037326307 scopus 로고    scopus 로고
    • Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models
    • Viollet, B. et al. (2003) Physiological role of AMP-activated protein kinase (AMPK): insights from knockout mouse models. Biochem. Soc. Trans., 31, 216-219.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 216-219
    • Viollet, B.1
  • 15
    • 10744230065 scopus 로고    scopus 로고
    • LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
    • Woods, A. et al. (2003) LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr. Biol., 13, 2004-2008.
    • (2003) Curr. Biol. , vol.13 , pp. 2004-2008
    • Woods, A.1
  • 16
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMPactivated protein kinase cascade
    • Hawley, S.A. et al. (2003) Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMPactivated protein kinase cascade. J. Biol., 2, 28.
    • (2003) J. Biol. , vol.2 , pp. 28
    • Hawley, S.A.1
  • 17
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw, R.J. et al. (2004) The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl Acad. Sci. USA, 101, 3329-3335.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 3329-3335
    • Shaw, R.J.1
  • 18
    • 72949083368 scopus 로고    scopus 로고
    • Common corruption of the mTOR signaling network in human tumors
    • Menon, S. et al. (2008) Common corruption of the mTOR signaling network in human tumors. Oncogene, 27 (suppl 2), S43-S51.
    • (2008) Oncogene , vol.27 , Issue.SUPPL 2
    • Menon, S.1
  • 19
    • 2342458960 scopus 로고    scopus 로고
    • Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome
    • Pilarski, R. et al. (2004) Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome. J. Med. Genet., 41, 323-326.
    • (2004) J. Med. Genet. , vol.41 , pp. 323-326
    • Pilarski, R.1
  • 20
    • 13944269898 scopus 로고    scopus 로고
    • The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin
    • Agarwal, A. et al. (2005) The AKT/I kappa B kinase pathway promotes angiogenic/metastatic gene expression in colorectal cancer by activating nuclear factor-kappa B and beta-catenin. Oncogene, 24, 1021-1031.
    • (2005) Oncogene , vol.24 , pp. 1021-1031
    • Agarwal, A.1
  • 21
    • 0028102891 scopus 로고
    • Objective system for interviewer performance evaluation for use in epidemiologic studies
    • Edwards, S. et al. (1994) Objective system for interviewer performance evaluation for use in epidemiologic studies. Am. J. Epidemiol., 140, 1020-1028.
    • (1994) Am. J. Epidemiol. , vol.140 , pp. 1020-1028
    • Edwards, S.1
  • 22
    • 0028291596 scopus 로고
    • A computerized diet history questionnaire for epidemiologic studies
    • Slattery, M.L. et al. (1994) A computerized diet history questionnaire for epidemiologic studies. J. Am. Diet. Assoc., 94, 761-766.
    • (1994) J. Am. Diet. Assoc. , vol.94 , pp. 761-766
    • Slattery, M.L.1
  • 23
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a maximally informative set of singlenucleotide polymorphisms for association analyses using linkage disequilibrium
    • Carlson, C.S. et al. (2004) Selecting a maximally informative set of singlenucleotide polymorphisms for association analyses using linkage disequilibrium. Am. J. Hum. Genet., 74, 106-120.
    • (2004) Am. J. Hum. Genet. , vol.74 , pp. 106-120
    • Carlson, C.S.1
  • 24
    • 0025066941 scopus 로고
    • More powerful procedures for multiple significance testing
    • Hochberg, Y. et al. (1990) More powerful procedures for multiple significance testing. Stat. Med., 9, 811-818.
    • (1990) Stat. Med. , vol.9 , pp. 811-818
    • Hochberg, Y.1
  • 25
    • 0036605096 scopus 로고    scopus 로고
    • Prognostic significance of p53 mutations in colon cancer at the population level
    • Samowitz, W.S. et al. (2002) Prognostic significance of p53 mutations in colon cancer at the population level. Int. J. Cancer, 99, 597-602.
    • (2002) Int. J. Cancer , vol.99 , pp. 597-602
    • Samowitz, W.S.1
  • 26
    • 0034669076 scopus 로고    scopus 로고
    • Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors
    • Slattery, M.L. et al. (2000) Associations between cigarette smoking, lifestyle factors, and microsatellite instability in colon tumors. J. Natl Cancer Inst., 92, 1831-1836.
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1831-1836
    • Slattery, M.L.1
  • 27
    • 0033739215 scopus 로고    scopus 로고
    • Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study
    • Samowitz, W.S. et al. (2000) Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study. Cancer Epidemiol. Biomarkers Prev., 9, 1193-1197.
    • (2000) Cancer Epidemiol. Biomarkers Prev. , vol.9 , pp. 1193-1197
    • Samowitz, W.S.1
  • 28
    • 33845691410 scopus 로고    scopus 로고
    • Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer
    • Slattery, M.L. et al. (2007) Diet and lifestyle factor associations with CpG island methylator phenotype and BRAF mutations in colon cancer. Int. J. Cancer, 120, 656-663.
    • (2007) Int. J. Cancer , vol.120 , pp. 656-663
    • Slattery, M.L.1
  • 29
    • 33748592876 scopus 로고    scopus 로고
    • On estimation of the variance in Cochran-Armitage trend tests for genetic association using case-control studies
    • Zheng, G. et al. (2006) On estimation of the variance in Cochran-Armitage trend tests for genetic association using case-control studies. Stat. Med., 25, 3150-3159.
    • (2006) Stat. Med. , vol.25 , pp. 3150-3159
    • Zheng, G.1
  • 30
    • 66149134084 scopus 로고    scopus 로고
    • A breast cancer risk haplotype in the caspase-8 gene
    • Shephard, N.D. et al. (2009) A breast cancer risk haplotype in the caspase-8 gene. Cancer Res., 69, 2724-2728.
    • (2009) Cancer Res. , vol.69 , pp. 2724-2728
    • Shephard, N.D.1
  • 31
    • 36749079336 scopus 로고    scopus 로고
    • So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests
    • Conneely, K.N. et al. (2007) So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am. J. Hum. Genet., 81, 1158-1168.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 1158-1168
    • Conneely, K.N.1
  • 32
    • 73349115207 scopus 로고    scopus 로고
    • Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer
    • Curtin, K. et al. (2009) Assessing tumor mutations to gain insight into base excision repair sequence polymorphisms and smoking in colon cancer. Cancer Epidemiol. Biomarkers Prev., 18, 3384-3388.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , pp. 3384-3388
    • Curtin, K.1
  • 33
    • 68549112818 scopus 로고    scopus 로고
    • Tumor markers and rectal cancer: support for an inflammation-related pathway
    • Slattery, M.L. et al. (2009) Tumor markers and rectal cancer: support for an inflammation-related pathway. Int. J. Cancer, 125, 1698-1704.
    • (2009) Int. J. Cancer , vol.125 , pp. 1698-1704
    • Slattery, M.L.1
  • 34
    • 67650721735 scopus 로고    scopus 로고
    • A comparison of colon and rectal somatic DNA alterations
    • Slattery, M.L. et al. (2009) A comparison of colon and rectal somatic DNA alterations. Dis. Colon Rectum, 52, 1304-1311.
    • (2009) Dis. Colon Rectum , vol.52 , pp. 1304-1311
    • Slattery, M.L.1
  • 35
    • 10344234243 scopus 로고    scopus 로고
    • Signaling pathways: the benefits of good communication
    • Fisher, T.L. et al. (2004) Signaling pathways: the benefits of good communication. Curr. Biol., 14, R1005-R7.
    • (2004) Curr. Biol. , vol.14
    • Fisher, T.L.1
  • 36
    • 0037458733 scopus 로고    scopus 로고
    • The tuberin-hamartin complex negatively regulates beta-catenin signaling activity
    • Mak, B.C. et al. (2003) The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J. Biol. Chem., 278, 5947-5951.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5947-5951
    • Mak, B.C.1
  • 37
    • 10944247187 scopus 로고    scopus 로고
    • The AMP-activated protein kinase pathway-new players upstream and downstream
    • Hardie, D.G. (2004) The AMP-activated protein kinase pathway-new players upstream and downstream. J. Cell Sci., 117, 5479-5487.
    • (2004) J. Cell Sci. , vol.117 , pp. 5479-5487
    • Hardie, D.G.1
  • 38
    • 27644596642 scopus 로고    scopus 로고
    • Glucose and lipid metabolism in relation to novel polymorphisms in the 5'-AMP-activated protein kinase gamma2 gene in Chinese
    • Xu, M. et al. (2005) Glucose and lipid metabolism in relation to novel polymorphisms in the 5'-AMP-activated protein kinase gamma2 gene in Chinese. Mol. Genet. Metab., 86, 372-378.
    • (2005) Mol. Genet. Metab. , vol.86 , pp. 372-378
    • Xu, M.1
  • 39
    • 3142594193 scopus 로고    scopus 로고
    • The LKB1 tumor suppressor negatively regulates mTOR signaling
    • Shaw, R.J. et al. (2004) The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell, 6, 91-99.
    • (2004) Cancer Cell , vol.6 , pp. 91-99
    • Shaw, R.J.1
  • 40
    • 0032497842 scopus 로고    scopus 로고
    • The role of PI 3-kinase in insulin action
    • Alessi, D.R. et al. (1998) The role of PI 3-kinase in insulin action. Biochim. Biophys. Acta, 1436, 151-164.
    • (1998) Biochim. Biophys. Acta , vol.1436 , pp. 151-164
    • Alessi, D.R.1
  • 41
    • 6944238452 scopus 로고    scopus 로고
    • Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway
    • DeGraffenried, L.A. et al. (2004) Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway. Ann. Oncol., 15, 1510-1516.
    • (2004) Ann. Oncol. , vol.15 , pp. 1510-1516
    • DeGraffenried, L.A.1
  • 42
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco, I. et al. (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer, 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1
  • 43
    • 38149108890 scopus 로고    scopus 로고
    • All roads lead to mTOR: integrating inflammation and tumor angiogenesis
    • Lee, D.F. et al. (2007) All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle, 6, 3011-3014.
    • (2007) Cell Cycle , vol.6 , pp. 3011-3014
    • Lee, D.F.1
  • 44
    • 34547605613 scopus 로고    scopus 로고
    • IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway
    • Lee, D.F. et al. (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell, 130, 440-455.
    • (2007) Cell , vol.130 , pp. 440-455
    • Lee, D.F.1
  • 45
    • 0034643955 scopus 로고    scopus 로고
    • Accommodating haploinsufficient tumor suppressor genes in Knudson's model
    • Cook, W.D. et al. (2000) Accommodating haploinsufficient tumor suppressor genes in Knudson's model. Oncogene, 19, 3434-3438.
    • (2000) Oncogene , vol.19 , pp. 3434-3438
    • Cook, W.D.1
  • 46
    • 33646372991 scopus 로고    scopus 로고
    • Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation
    • Wagner, T.M. et al. (2006) Reactive lipid species from cyclooxygenase-2 inactivate tumor suppressor LKB1/STK11: cyclopentenone prostaglandins and 4-hydroxy-2-nonenal covalently modify and inhibit the AMP-kinase kinase that modulates cellular energy homeostasis and protein translation. J. Biol. Chem., 281, 2598-2604.
    • (2006) J. Biol. Chem. , vol.281 , pp. 2598-2604
    • Wagner, T.M.1
  • 47
    • 34548159221 scopus 로고    scopus 로고
    • Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor
    • Covey, T.M. et al. (2007) Akt activation by arachidonic acid metabolism occurs via oxidation and inactivation of PTEN tumor suppressor. Oncogene, 26, 5784-5792.
    • (2007) Oncogene , vol.26 , pp. 5784-5792
    • Covey, T.M.1
  • 48
    • 0345170661 scopus 로고    scopus 로고
    • Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index
    • Slattery, M.L. et al. (2003) Energy balance and rectal cancer: an evaluation of energy intake, energy expenditure, and body mass index. Nutr. Cancer, 46, 166-171.
    • (2003) Nutr. Cancer , vol.46 , pp. 166-171
    • Slattery, M.L.1


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