Agrin binds BMP2, BMP4 and TGFβ1

PLoS ONE

Volumn 5, Issue 5, 2010, Pages

  Bányai, László ^a   Sonderegger, Peter ^b   Patthy, László ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AGRIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; CHOLINERGIC RECEPTOR; FOLLISTATIN RELATED PROTEIN; GROWTH FACTOR; ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA1; BONE MORPHOGENETIC PROTEIN RECEPTOR; SIGNAL PEPTIDE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRUCTURE; CHOLINERGIC SYNAPSE; CONTROLLED STUDY; ENZYME ASSAY; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN ISOLATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE; SYNAPTOGENESIS; AFFINITY CHROMATOGRAPHY; ANIMAL; CELL LINE; CHEMISTRY; GEL CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR EVOLUTION; PROTEIN TERTIARY STRUCTURE; RAT;

RATTUS; VERTEBRATA;

AGRIN; ANIMALS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN RECEPTORS; CELL LINE; CHROMATOGRAPHY, AFFINITY; CHROMATOGRAPHY, GEL; EVOLUTION, MOLECULAR; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; KINETICS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SURFACE PLASMON RESONANCE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77956281103     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010758     Document Type: Article

References (37)

1. Bezakova G, Rüegg MA (2003) New insights into the roles of agrin. Nature Rev Molec Cell Biol 4: 295-308.
2. Kummer TT, Misgeld T, Sanes JR (2006) Assembly of the postsynaptic membrane at the neuromuscular junction: paradigm lost. Curr Opin Neurobiol 16: 74-82.
3. Annies M, Bittcher G, Ramseger R, Loschinger J, Woll S, et al. (2006) Clustering transmembrane-agrin induces filopodia-like processes on axons and dendrites. Mol Cell Neurosci 31: 515-524.
4. McCroskery S, Chaudhry A, Lin L, Daniels MP (2006) Transmembrane agrin regulates filopodia in rat hippocampal neurons in culture. Mol Cell Neurosci 33: 15-28.
5. Ksiazek I, Burkhardt C, Lin S, Seddik R, Maj M (2007) Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death. J Neurosci 27: 7183-7195.
6. Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Luscher D, et al. (2009) Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell 136: 1161-1171.
7. McCroskery S, Bailey A, Lin L, Daniels MP (2009) Transmembrane agrin regulates dendritic filopodia and synapse formation in mature hippocampal neuron cultures. Neuroscience 163: 168-179.
8. Porten E, Seliger B, Schneider VA, Woll S, Stangel D, et al. (2010) The processinducing activity of transmembrane agrin requires follistatin-like domains. J Biol Chem 285: 3114-3125.
9. Patthy L, Nikolics K (1993) Functions of agrin and agrin-related proteins. Trends Neurosci 16: 76-81.
10. Bork P, Patthy L (1995) The SEA module: a new extracellular domain associated with O-glycosylation. Protein Sci 4: 1421-1425.
11. Zhang B, Luo S, Wang Q, Suzuki T, Xiong WC, et al. (2008) LRP4 serves as a coreceptor of agrin. Neuron 60: 285-297.
12. Kim N, Stiegler AL, Cameron TO, Hallock PT, Gomez AM, et al. (2008) Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell 135: 334-342.
13. Scotton P, Bleckmann D, Stebler M, Sciandra F, Brancaccio A, et al. (2006) Activation of muscle-specific receptor tyrosine kinase and binding to dystroglycan are regulated by alternative mRNA splicing of agrin. J Biol Chem 281: 36835-36845.
14. Abe M, Harpel JG, Metz CN, Nunes I, Loskutoff DJ, et al. (1994) An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem 216: 276-284.
15. Zilberberg L, ten Dijke P, Sakai LY, Rifkin DB (2007) A rapid and sensitive bioassay to measure bone morphogenetic protein activity. BMC Cell Biol 8: 41.
16. Baerwald-de la Torre K, Winzen U, Halfter W, Bixby JL (2004) Glycosaminoglycan-dependent and -independent inhibition of neurite outgrowth by agrin. J Neurochem 90: 50-61.
17. Kondás K, Szláma G, Trexler M, Patthy L (2008) Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11. J Biol Chem 283: 23677-23684.
18. Nagy A, Hegyi H, Farkas K, Tordai H, Kozma E, et al. (2008) Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. BMC Bioinformatics 9: 353.
19. Harrow J, Nagy A, Reymond A, Alioto T, Patthy L, et al. (2009) Identifying protein-coding genes in genomic sequences. Genome Biol 10: 201.
20. Patthy L (1987) Detecting homology of distantly related proteins with consensus sequences. J Mol Biol 198: 567-577.
21. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, et al. (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23: 2947-2948.
22. Nieba L, Krebber A, Plückthun A (1996) Competition BIAcore for measuring true affinities: large differences from values determined from binding kinetics. Anal Biochem 234: 155-165.
23. Reif R, Sales S, Hettwer S, Dreier B, Gisler C, et al. (2007) Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J 21: 3468-78.
24. Sonderegger P, Patthy L (2007) Comment on ''Tequila, a neurotrypsin ortholog, regulates long-term memory formation in Drosophila''. Science 316: 1698.
25. Lee SJ, McPherron AC (2001) Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A 98: 9306-9311.
26. Hill JJ, Davies MV, Pearson AA, Wang JH, Hewick RM, et al. (2002) The myostatin propeptide and the follistatin-related gene are inhibitory binding proteins of myostatin in normal serum. J Biol Chem 277: 40735-40741.
27. Nakamura T, Takio K, Eto Y, Shibai H, Titani K, et al. (1990) Activin-binding protein from rat ovary is follistatin. Science 247: 836-838.
28. Tsuchida K, Arai KY, Kuramoto Y, Yamakawa N, Hasegawa Y, et al. (2000) Identification and characterization of a novel follistatin-like protein as a binding protein for the TGF-b family. J Biol Chem 275: 40788-40796.
29. Tortoriello DV, Sidis Y, Holtzman DA, Holmes WE, Schneyer AL (2001) Human follistatin-related protein: a structural homologue of follistatin with nuclear localization. Endocrinology 142: 3426-3434.
30. Sidis Y, Tortoriello DV, Holmes WE, Pan Y, Keutmann HT, et al. (2002) Follistatin-related protein and follistatin differentially neutralize endogenous vs. exogenous activin. Endocrinology 143: 1613-1624.
31. Hill JJ, Qiu Y, Hewick RM, Wolfman NM (2003) Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains. Mol Endocrinol 17: 1144-1154.
32. Feng Z, Ko CP (2008) Schwann cells promote synaptogenesis at the neuromuscular junction via transforming growth factor-beta1. J Neurosci 28: 9599-9609.
33. Moon JI, Birren SJ (2008) Target-dependent inhibition of sympathetic neuron growth via modulation of a BMP signaling pathway. Dev Biol 315: 404-417.
34. Bixby JL, Baerwald-De la Torre K, Wang C, Rathjen FG, Rüegg MA (2002) A neuronal inhibitory domain in the N-terminal half of agrin. J Neurobiol 50: 164-179.
35. Wu H, Xiong WC, Mei L (2010) To build a synapse: signaling pathways in neuromuscular junction assembly. Development 137: 1017-1033.
36. Hrus A, Lau G, Hutter H, Schenk S, Ferralli J, et al. (2007) C. elegans agrin is expressed in pharynx, IL1 neurons and distal tip cells and does not genetically interact with genes involved in synaptogenesis or muscle function. PLoS ONE 2: e731.
37. Srivastava M, Begovic E, Chapman J, Putnam NH, Hellsten U, et al. (2008) The Trichoplax genome and the nature of placozoans. Nature 454: 955-60.