Bone mineral density, bone turnover markers and cytokines in alcohol-induced cirrhosis

Alcohol and Alcoholism

Volumn 45, Issue 5, 2010, Pages 427-430

  Díez Ruiz, Antonio ^a   García Saura, Pedro L ^a   García Ruiz, Pablo ^a   González Calvin, Jorge L ^a   Gallego Rojo, Francisco ^a   Fuchs, Dietmar ^b  

^a UNIVERSITY OF GRANADA   (Spain)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALCOHOL; ALKALINE PHOSPHATASE; ALKALINE PHOSPHATASE BONE ISOENZYME; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; DEOXYPYRIDINOLINE; GAMMA GLUTAMYLTRANSFERASE; NEOPTERIN; OSTEOCALCIN; PROTHROMBIN; SEX HORMONE BINDING GLOBULIN; SOLUBLE INTERLEUKIN 2 RECEPTOR; SOMATOMEDIN; TUMOR NECROSIS FACTOR RECEPTOR;

ADULT; ALBUMIN BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BONE DENSITY; BONE MASS; BONE TURNOVER; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DUAL ENERGY X RAY ABSORPTIOMETRY; ENZYME IMMUNOASSAY; FEMUR NECK; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LUMBAR SPINE; MALE; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; OUTCOME ASSESSMENT; PATHOGENESIS; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RISK FACTOR; URINARY EXCRETION;

ADULT; BIOLOGICAL MARKERS; BONE DENSITY; CYTOKINES; HUMANS; LIVER CIRRHOSIS, ALCOHOLIC; MALE; MIDDLE AGED; OSTEOGENESIS; OSTEOPOROSIS;

EID: 77956278137     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/agq037     Document Type: Article

References (34)

1. Bonkovsky HL, Hawkins M, Steinberg K et al. (1990) Prevalence and prediction of osteopenia in chronic liver disease. Hepatology 12:273-80.
2. Collier J. (2007) Bone disorders in chronic liver disease. Hepatology 46:1271-8.
3. Corazza GR, Trevisani F, Di Stefano M et al. (2000) Early increase of bone resorption in patients with liver cirrhosis secondary to viral hepatitis. Dig Dis Sci 45:1392-9.
4. Crawford BA, Kam C, Donaghy AJ et al. (2003) The heterogeneity of bone disease in cirrhosis: a multivariate analysis. Osteoporos Int 14:987-94.
5. Delmas P, Gineyts E, Bertholin A et al. (1993) Immunoassay of pyridoline crosslink excretion in normal adults and in Paget's disease. J Bone Miner Res 5:643-9.
6. Diamond T, Stiel D, Lunzer M et al. (1990) Osteoporosis and skeletal fractures in chronic liver disease. Gut 31:82-7.
7. Díez-Ruiz A, Tilz GP, Gutierrez-Gea F et al. (1995) Neopterin and soluble tumor necrosis factor receptor type I in alcohol-induced cirrhosis. Hepatology 21:976-8.
8. Feng X. (2005) Regulatory roles and molecular signalling of TNF family members in osteoclasts. Gene 350:1-13.
9. Gallego-Rojo FJ, González-Calvín JL, Muñoz-Torres M et al. (1998) Bone mineral density serum insulin-like growth factor I and bone turnover markers in viral cirrhosis. Hepatology 28:695-9.
10. García-Ruiz P, Canora-Lebrato J, Díez-Ruiz A et al. (2004) Soluble interleukin-2 and tumor necrosis factor receptor in liver cirrhosis. Relationship with clinical severity and prognosis. Med Clin (Barc) 122:457-8.
11. García-Sánchez A, González-Calvín JL, Díez-Ruiz A et al. (1995) Effect of acute alcohol ingestion on mineral metabolism and osteoblastic function. Alcohol Alcohol 30:449-53.
12. García-Valdecasas E, González-Reimers E, Santolaria-Fernández F et al. (2006) Serum osteoprotegerin and RANKL levels in chronic alcoholic liver disease. Alcohol Alcohol 41:261-6.
13. Giouleme OI, Vyzantiadis TA, Nikolaidis NL et al. (2006) Pathogenesis of osteoporosis in liver cirrhosis. Hepatogastroenterology 53:938-43.
14. Gonzalez-Calvin JL, Gallego-Rojo F, Fernández-Pérez R et al. (2004) Osteoporosis mineral metabolism, and serum soluble tumor necrosis factor receptor p55 in viral cirrhosis. J Clin Endocrinol Metab 89:4325-30.
15. González-Calvín JL, García-Sánchez A, Mundi JL. (1999) Effect of alcohol consumption on adult bone mineral density and bone turnover markers. Alcohol Clin Exp Res 23:1416-7.
16. González-Reimers E, Santolaria-Fernández F, Rodríguez-Rodríguez E et al. (1993) Serum neopterin levels in alcoholic liver disease. Drug Alcohol Depend 33:151-6.
17. Johannsson AG, Forslund A, Hambraeus L et al. (1994) Growth hormone dependent insulin like growth factor binding protein is a major determinant of bone mineral density in healthy men. J Bone Miner Res 9:915-21.
18. Kanis JA. (2000) An update on the diagnosis of osteoporosis. Curr Rheumatol Rep 2:62-6.
19. Kimble RB. (1997) Alcohol cytokines and estrogens in the control of bone remodelling. Alcohol Clin Exp Res 21:385-91.
20. Kitaoka S, Shiota G, Kawasaki H. (2003) Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C. Hepatogastroenterology 50:1569-74.
21. Leevy CB, Elbeshbeshy HA. (2005) Immunology of alcoholic liver disease. Clin Liver Dis 9:55-66.
22. Maran A, Zhang M, Spelsberg TC et al. (2001) The dose-response effects of ethanol on the human fetal osteoblastic cell line. J Bone Miner Res 16:270-6.
23. Murr C, Widner B, Wirleitner B et al. (2002) Neopterin as a marker for immune system activation. Curr Drug Metabol 3:175-87.
24. Neuman MG. (2003) Cytokines-central factors in alcoholic liver disease. Alcohol Res Health 27:307-16.
25. Oelzner P, Franke S, Muller A et al. (1999) Relationship between soluble markers of immune activation and bone turnover in post-menopausal women with rheumatoid arthritis. Rheumatology (Oxford) 38:841-7.
26. Parés A, Guañabens N. (2008) Osteoporosis in primary cirrhosis: pathogenesis and treatment. Clin Liver Dis 12:407-24.
27. Pugh RN, Murray-Lyon IM, Dawson JL et al. (1973) Transsection of the oesophagus for bleeding oesophageal varices. Br J Surg 60:646-9.
28. Rouillard S, Lane NE. (2001) Hepatic osteodystrophy. Hepatology 33:301-7.
29. Santolaria F, González-Reimers E, Pérez-Manzano JL et al. (2000) Osteopenia assessed by body composition analysis is related to malnutrition in alcoholic patients. Alcohol 22:147-57.
30. Schiefke I, Fach A, Wiedmann M et al. (2005) Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection. Gastroenterol 11:1843-7.
31. Sugai E, Chernavsky A, Pedreira S et al. (2002) Bone-specific antibodies in serum from patients with celiac disease: characterization and implications on osteoporosis. J Clin Immunol 22:353-62.
32. Tsuneoka K, Tameda Y, Takase K et al. (1996) Osteodystrophy in patients with chronic hepatitis and liver cirrhosis. J Gastroenterol 31:669-78.
33. Turner RT. (2000) Skeletal responses to alcohol. Alcohol Clin Exp Res 24:1693-701.
34. Wilmer A, Nölchen B, Tilg H et al. (1995) Serum neopterin concentrations in chronic liver disease. Gut 37:108-12.