Oral administration of beta-1,3/1,6-glucan Macrogard® fails to enhance the mucosal immune response following oral F4 fimbrial immunisation in gnotobiotic pigs

Veterinary Immunology and Immunopathology

Volumn 137, Issue 3-4, 2010, Pages 291-297

  Stuyven, E ^a   Van den Broeck, W ^a   Nauwynck, H ^a   Goddeeris, B M ^a,b   Cox, E ^a  

^a GHENT UNIVERSITY   (Belgium)

^b LABORATORY OF GENE TECHNOLOGY   (Belgium)

Author keywords

Beta 1,3 1,6 glucan; Gnotobiotic pigs; Mucosal immune response; Oral F4

Indexed keywords

ANTIGEN; BETA 1,3 GLUCAN; BETA 1,6 GLUCAN; F4 FIMBRIA ANTIGEN; IMMUNOGLOBULIN A; INTERLEUKIN 1ALPHA; MACROGARD; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; MESENTERY LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PEYER PATCH; SPLEEN; SWINE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, ORAL; ANIMALS; BETA-GLUCANS; CYTOKINES; FIMBRIAE, BACTERIAL; GERM-FREE LIFE; IMMUNITY, MUCOSAL; IMMUNIZATION; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; PREBIOTICS; RNA, MESSENGER; SWINE;

ANIMALIA; ESCHERICHIA COLI; SUIDAE;

EID: 77956268882     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2010.05.007     Document Type: Article

References (40)

1. Brown W.R., Butler J.E. Characterization of a C alpha gene of swine. Mol. Immunol. 1994, 31:633-642.
2. Brown W.R., Kacskovics I., Amendt B.A., Blackmore N.B., Rothschild M., Shinde R., Butler J.E. The hinge deletion allelic variant of porcine IgA results from a mutation at the splice acceptor site in the first C alpha intron. J. Immunol. 1995, 154:3836-3842.
3. Butler J.E., Sun J., Weber P., Navarro P., Francis D. Antibody repertoire development in fetal and newborn piglets. III. Colonization of the gastrointestinal tract selectively diversifies the preimmune repertoire in mucosal lymphoid tissues. Immunology 2000, 100:119-130.
4. Cox E., Van der Stede Y., Verdonck F., Snoeck V., Van den Broeck W., Goddeeris B. Oral immunisation of pigs with fimbrial antigens of enterotoxigenic E. coli: an interesting model to study mucosal immune mechanisms. Vet. Immunol. Immunopathol. 2002, 87:287-290.
5. Dritz S.S., Shi J., Kielian T.L., Goodband R.D., Nelssen J.L., Tokach M.D., Chengappa M.M., Smith J.E., Blecha F. Influence of dietary beta-glucan on growth-performance, nonspecific immunity, and resistance to streptococcus-suis infection in weanling pigs. J. Anim. Sci. 1995, 73:3341-3350.
6. Dziaba K.A., Lambrecht G., Petzoldt K. Intestinal and serum antibody response in gnotobiotic piglets to oral immunization with Escherichia coli. Comp. Immunol. Microbiol. Infect. Dis. 1985, 8:267-272.
7. Egberts H.J., de Groot E.C., van Dijk J.E., Vellenga L., Mouwen J.M. Tight junctional structure and permeability of porcine jejunum after enterotoxic Escherichia coli infection. Res. Vet. Sci. 1993, 55:10-14.
8. Eicher S.D., McKee C.A., Carroll J.A., Pajor E.A. Supplemental vitamin C and yeast cell wall beta-glucan as growth enhancers in newborn pigs and as immunomodulators after an endotoxin challenge after weaning. J. Anim. Sci. 2006, 84:2352-2360.
9. Falk P.G., Hooper L.V., Midtvedt T., Gordon J.I. Creating and maintaining the gastrointestinal ecosystem: what we know and need to know from gnotobiology. Microbiol. Mol. Biol. Rev. 1998, 62:1157-1170.
10. Girardeau J.P. A new invitro technique for attachment to intestinal villi using enteropathogenic Escherichia coli. Ann. Inst. Pasteur Microbiol. 1980, B131:31.
11. Gonzalez L., Anderson I., Deane D., Summers C., Buxton D. Detection of immune system cells in paraffin wax-embedded ovine tissues. J. Comp. Pathol. 2001, 125:41-47.
12. Hiss S., Sauerwein H. Influence of dietary ss-glucan on growth performance, lymphocyte proliferation, specific immune response and haptoglobin plasma concentrations in pigs. J. Anim. Physiol. Anim. Nutr. (Berl.) 2003, 87:2-11.
13. Howard C.V., Reed M.G. Unbiased Stereology? Three-dimensional Measurement in Microscopy 1998, BIOS Scientific Publishers Limited, Oxford.
14. Jacobs C., Van Den Broeck W., Simoens P. Quantification of neurons expressing androgen receptor and volume estimation of the basolateral nuclear group of the canine amygdaloid body. Brain Res. Brain Res. Protoc. 2005, 15:92-104.
15. Jensen A.R., Elnif J., Burrin D.G., Sangild P.T. Development of intestinal immunoglobulin absorption and enzyme activities in neonatal pigs is diet dependent. J. Nutr. 2001, 131:3259-3265.
16. Jorgensen, C.B., Cirera, S., Archibald, A.L., Anderson, L., Fredholm, M., Edfors-Lilja, I., 2004. Porcine polymorphisms and methods for detecting them. In International application published under the patent cooperation treaty (PCT). (PCT/DK2003/000807 or WO2004/048606-A2).
17. Jung K., Ha Y., Ha S.K., Han D.U., Kim D.W., Moon W.K., Chae C. Antiviral effect of Saccharomyces cerevisiae beta-glucan to swine influenza virus by increased production of interferon-gamma and nitric oxide. J. Vet. Med. B: Infect. Dis. Vet. Public Health 2004, 51:72-76.
18. Kournikakis B., Mandeville R., Brousseau P., Ostroff G. Anthrax-protective effects of yeast beta 1,3 glucans. MedGenMed 2003, 5:1.
19. Lehne G., Haneberg B., Gaustad P., Johansen P.W., Preus H., Abrahamsen T.G. Oral administration of a new soluble branched beta-1,3-d-glucan is well tolerated and can lead to increased salivary concentrations of immunoglobulin A in healthy volunteers. Clin. Exp. Immunol. 2006, 143:65-69.
20. Li B., Cramer D., Wagner S., Hansen R., King C., Kakar S., Ding C., Yan J. Yeast glucan particles activate murine resident macrophages to secrete proinflammatory cytokines via MyD88- and Syk kinase-dependent pathways. Clin. Immunol. 2007, 124:170-181.
21. Li J., Xing J., Li D., Wang X., Zhao L., Lv S., Huang D. Effects of beta-glucan extracted from Saccharomyces cerevisiae on humoral and cellular immunity in weaned piglets. Arch. Anim. Nutr. 2005, 59:303-312.
22. Li S., Sauer W.C., Huang S.X., Gabert V.M. Effect of beta-glucanase supplementation to hulless barley- or wheat-soybean meal diets on the digestibilities of energy, protein, beta-glucans, and amino aids in young pigs. J. Anim. Sci. 1996, 74:1649-1656.
23. Melkebeek V., Verdonck F., Goddeeris B.M., Cox E. Comparison of immune responses in parenteral FaeG DNA primed pigs boosted orally with F4 protein or reimmunized with the DNA vaccine. Vet. Immunol. Immunopathol. 2007, 116:199-214.
24. Navarro, P., 1998. The allelic hinge variants of swine IgA. MS Thesis, The University of Iowa.
25. Navarro P., Christensen R.K., Weber P., Rothschild M., Ekhardt G., Butler J.E. Porcine IgA allotypes are not equally transcribed or expressed in heterozygous swine. Mol. Immunol. 2000, 37:653-664.
26. Rasschaert K., Verdonck F., Goddeeris B.M., Duchateau L., Cox E. Screening of pigs resistant to F4 enterotoxigenic Escherichia coli (ETEC) infection. Vet. Microbiol. 2007, 123:249-253.
27. Sauerwein H., Schmitz S., Hiss S. Effects of a dietary application of a yeast cell wall extract on innate and acquired immunity, on oxidative status and growth performance in weanling piglets and on the ileal epithelium in fattened pigs. J. Anim. Physiol. Anim. Nutr. (Berl.) 2007, 91:369-380.
28. Shirkey T.W., Siggers R.H., Goldade B.G., Marshall J.K., Drew M.D., Laarveld B., Van Kessel A.G. Effects of commensal bacteria on intestinal morphology and expression of proinflammatory cytokines in the gnotobiotic pig. Exp. Biol. Med. (Maywood) 2006, 231:1333-1345.
29. Smith M.W., James P.S., Tivey D.R. M-cell numbers increase after transfer of Spf mice to a normal animal house environment. Am. J. Pathol. 1987, 128:385-389.
30. Stuyven E., Cox E., Vancaeneghem S., Arnouts S., Deprez P., Goddeeris B.M. Effect of beta-glucans on an ETEC infection in piglets. Vet. Immunol. Immunopathol. 2009, 128:60-66.
31. Stuyven E., Verdonck F., Van Hoek I., Daminet S., Duchateau L., Remon J.P., Goddeeris B.M., Cox E. Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM. Clin. Vaccine Immunol. 2010, 17:281-285.
32. Van den Broeck W., Cox E., Goddeeris B.M. Induction of immune responses in pigs following oral administration of purified F4 fimbriae. Vaccine 1999, 17:2020-2029.
33. Van den Broeck W., Cox E., Goddeeris B.M. Receptor-dependent immune responses in pigs after oral immunization with F4 fimbriae. Infect. Immun. 1999, 67:520-526.
34. Van den Broeck W., Cox E., Goddeeris B.M. Receptor-specific binding of purified F4 to isolated villi. Vet. Microbiol. 1999, 68:255-263.
35. van Nevel C.J., Decuypere J.A., Dierick N., Molly K. The influence of Lentinus edodes (Shiitake mushroom) preparations on bacteriological and morphological aspects of the small intestine in piglets. Arch. Tierernahr. 2003, 57:399-412.
36. Van Zaane D., Hulst M.M. Monoclonal antibodies against porcine immunoglobulin isotypes. Vet. Immunol. Immunopathol. 1987, 16:23-36.
37. Verdonck F., Cox E., van Gog K., Van der Stede Y., Duchateau L., Deprez P., Goddeeris B.M. Different kinetic of antibody responses following infection of newly weaned pigs with an F4 enterotoxigenic Escherichia coli strain or an F18 verotoxigenic Escherichia coli strain. Vaccine 2002, 20:2995-3004.
38. Verdonck F., Snoeck V., Goddeeris B.M., Cox E. Cholera toxin improves the F4(K88)-specific immune response following oral immunization of pigs with recombinant FaeG. Vet. Immunol. Immunopathol. 2005, 103:21-29.
39. Verfaillie T., Cox E., Goddeeris B.M. Immunostimulatory capacity of DNA vaccine vectors in porcine PBMC: a specific role for CpG-motifs?. Vet. Immunol. Immunopathol. 2005, 103:141-151.
40. Wang Z., Shao Y., Guo Y., Yuan J. Enhancement of peripheral blood CD8+ T cells and classical swine fever antibodies by dietary beta-1,3/1,6-glucan supplementation in weaned piglets. Transbound Emerg. Dis. 2008, 55:369-376.