Integral pharmacokinetics of multiple lignan components in normal, CCl4-induced hepatic injury and hepatoprotective agents pretreated rats and correlations with hepatic injury biomarkers

Journal of Ethnopharmacology

Volumn 131, Issue 2, 2010, Pages 290-299

  Xie, Yuan ^a   Hao, Haiping ^a   Kang, An ^a   Liang, Yan ^a   Xie, Tong ^a   Sun, Shiqing ^a   Dai, Chen ^a   Zheng, Xiao ^a   Xie, Lin ^a   Li, Juan ^a   Wang, Guangji ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

CYP3A; Hepatoprotective agents; Integral pharmacokinetics; Liver injury; Schisandra lignans

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CARBOXYLIC ACID; CYTOCHROME P450 3A; DEOXYSCHISANDRIN; DIMETHYLDIPHENYLDICARBOXYLIC ACID; GAMMA GLUTAMYLTRANSFERASE; LIGNAN; LIVER PROTECTIVE AGENT; SCHISANDRA CHINENSIS EXTRACT; SCHISANTHERIN B; SCHIZANDRIN; SCHIZANDRIN B; SCHIZANDRIN C; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; DRUG BLOOD LEVEL; DRUG HALF LIFE; ENZYME ACTIVITY; FEMALE; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOLOGY; LIVER INJURY; LIVER PROTECTION; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PROTEIN EXPRESSION; RAT; SCHISANDRACEAE; TIME TO MAXIMUM PLASMA CONCENTRATION;

ALANINE TRANSAMINASE; ANIMALS; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; BIOLOGICAL MARKERS; CARBON TETRACHLORIDE; CYTOCHROME P-450 CYP3A; DIOXOLES; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG-INDUCED LIVER INJURY; FEMALE; FRUIT; HERB-DRUG INTERACTIONS; LIGNANS; MALE; PHYTOTHERAPY; PLANT EXTRACTS; PROTECTIVE AGENTS; RATS; RATS, SPRAGUE-DAWLEY; REFERENCE VALUES; SCHISANDRA;

RATTUS; SCHISANDRA;

EID: 77956266310     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2010.06.038     Document Type: Article

References (35)

1. Badger D.A., Sauer J.M., Hoglen N.C., Jolley C.S., Sipes I.G. The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol. Toxicol. Appl. Pharmacol. 1996, 141:507-519.
2. Chang H.F., Lin Y.H., Chu C.C., Wu S.J., Tsai Y.H., Chao J.C. Protective effects of Ginkgo biloba, Panax ginseng and Schizandra chinensis extract on liver injury in rats. Am. J. Chin. Med. 2007, 35:995-1009.
3. Deng X., Chen X., Yin R., Shen Z., Qiao L., Bi K. Determination of deoxyschizandrin in rat plasma by LC-MS. J. Pharm. Biomed. Anal. 2008, 46:121-126.
4. Diaz Gomez M.I., de Castro C.R., D'Acosta N., de Fenos O.M., de Ferreyra E.C., Castro J.A. Species differences in carbon tetrachloride-induced hepatotoxicity: the role of CCl4 activation and of lipid peroxidation. Toxicol. Appl. Pharmacol. 1975, 34:102-114.
5. Hancke J.L., Burgos R.A., Ahumada F. Schisandra chinensis_Turcz./Baill. Fitoterapia 1999, 20.
6. Huang X., Song F., Liu Z., Liu S. Studies on lignan constituents from Schisandra chinensis (Turcz.) Baill. fruits using high-performance liquid chromatography/electrospray ionization multiple-stage tandem mass spectrometry. J. Mass Spectrom. 2007, 42:1148-1161.
7. Ip S.P., Ko K.M. The crucial antioxidant action of schisandrin B in protecting against carbon tetrachloride hepatotoxicity in mice: a comparative study with butylated hydroxytoluene. Biochem. Pharmacol. 1996, 52:1687-1693.
8. Ip S.P., Poon M.K., Che C.T., Ng K.H., Kong Y.C., Ko K.M. Schisandrin B protects against carbon tetrachloride toxicity by enhancing the mitochondrial glutathione redox status in mouse liver. Free Radic. Biol. Med. 1996, 21:709-712.
9. Ip S.P., Yiu H.Y., Ko K.M. Differential effect of schisandrin B and dimethyl-diphenyl-bicarboxylate (DDB) on hepatic mitochondrial glutathione redox status in carbon tetrachloride intoxicated mice. Mol. Cell. Biochem. 2000, 205:111-114.
10. Kamataki T., Kitagawa H. Effects of EDTA on stability of drug metabolizing enzymes in liver microsomes of rats. Chem. Pharm. Bull. (Tokyo) 1974, 22:1041-1045.
11. Kaul K.L., Novak R.F. Inhibition and induction of rabbit liver microsomal cytochrome P-450 by pyridine. J. Pharmacol. Exp. Ther. 1987, 243:384-390.
12. Kim S.H., Kim Y.S., Kang S.S., Bae K., Hung T.M., Lee S.M. Anti-apoptotic and hepatoprotective effects of gomisin A on fulminant hepatic failure induced by d-galactosamine and lipopolysaccharide in mice. J. Pharmacol. Sci. 2008, 106:225-233.
13. Kose N., Yamamoto K., Sai Y., Isawa M., Suwa T., Nakashima E. Prediction of theophylline clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test. Drug. Metab. Pharmacokinet. 2005, 20:168-176.
14. Lai L., Hao H., Wang Q., Zheng C., Zhou F., Liu Y., Wang Y., Yu G., Kang A., Peng Y., Wang G., Chen X. Effects of short-term and long-term pretreatment of Schisandra lignans on regulating hepatic and intestinal CYP3A in rats. Drug. Metab. Dispos. 2009, 37:2399-2407.
15. LEE F.Y., Groszmann R.J. Experimental models in the investigation of portal hypertension. Ascites. Ren. Dysfunct. Liv. Dis Pathog. Diagn. Treat. 1999, 13.
16. Li X.Y., Hao H.P., Wang G.J., Sun J.G., Liang Y., Xi L., Zheng Y., Yan B. Integrated pharmacokinetic study of mutiple effects components contained in total panax notoginsenoside. Chin. J. Nat. Med. 2008, 6:5.
17. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
18. Lu H., Liu G.T. Effect of dibenzo[a,c]cyclooctene lignans isolated from Fructus schizandrae on lipid peroxidation and anti-oxidative enzyme activity. Chem. Biol. Interact. 1991, 78:77-84.
19. Matsunaga N.K., Isawa M., Kizu J., Miyazaki N., Takanaka A., Nakashima E. Application of the PKCYP test to predict caffeine clearance mediated by CYP1A2 in a rat acute liver injury model. Drug. Metab. Pharmacokinet. 2003, 18:296-302.
20. Matsuzaki Y., Ishibashi E., Koguchi S., Wakui Y., Takeda S., Aburada M., Oyama T. Determination of gomisin A (TJN-101) and its metabolite in rat serum by gas chromatography-mass spectrometry. Yakugaku Zasshi 1991, 111:617-620.
21. +-taurocholate-cotransporting polypeptide, organic cation transporter 1, and organic anion-transporting peptide-C correlates with the progression of liver fibrosis in chronic hepatitis C patients. Drug Metab. Dispos. 2008, 36:1786-1793.
22. Opletal L., Sovova H., Bartlova M. Dibenzo[a,c]cyclooctadiene lignans of the genus Schisandra: importance, isolation and determination. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2004, 812:357-371.
23. Ota M., Sato N., Uemura H., Obara K. Lowering effect of carbon tetrachloride on microsomal cytochrome P-450 of rat liver. Chem. Biol. Interact. 1975, 11:265-276.
24. Pan S.Y., Yu Z.L., Dong H., Xiang C.J., Fong W.F., Ko K.M. Ethanol extract of fructus schisandrae decreases hepatic triglyceride level in mice fed with a high fat/cholesterol diet, with attention to acute toxicity. Evid Based Complement Alternat. Med. 2009.
25. Qiu F., Zhang R., Sun J., Jiye A., Hao H., Peng Y., Ai H., Wang G. Inhibitory effects of seven components of danshen extract on catalytic activity of cytochrome P450 enzyme in human liver microsomes. Drug Metab. Dispos. 2008, 36:1308-1314.
26. Sanzgiri U.Y., Kim H.J., Muralidhara S., Dallas C.E., Bruckner J.V. Effect of route and pattern of exposure on the pharmacokinetics and acute hepatotoxicity of carbon tetrachloride. Toxicol. Appl. Pharmacol. 1995, 134:148-154.
27. Schlatter C., Egger S.S., Tchambaz L., Krahenbuhl S. Pharmacokinetic changes of psychotropic drugs in patients with liver disease: implications for dose adaptation. Drug Saf. 2009, 32:561-578.
28. Schrieber S.J., Wen Z., Vourvahis M., Smith P.C., Fried M.W., Kashuba A.D., Hawke R.L. The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. Drug Metab. Dispos. 2008, 36:1909-1916.
29. Xu L., Gao J., Wang Y., Yu W., Zhao X., Yang X., Zhong Z., Qian Z.M. Myrica rubra Extracts Protect the Liver from CCl4-Induced Damage. Evid Based Complement Alternat. Med. 2009.
30. Xu M., Wang G., Xie H., Wang R., Wang W., Li X., Li H., Zhu D., Yue L. Determination of schizandrin in rat plasma by high-performance liquid chromatography-mass spectrometry and its application in rat pharmacokinetic studies. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 2005, 828:55-61.
31. Xu M.J., Wang G.J., Xie H.T., Li H., Huang Q., Wang R., Jia Y.W., Lv T. Gender difference regarding schizandrin pharmacokinetics in rats. Eur. J. Drug Metab. Pharmacokinet. 2008, 33:65-68.
32. Yan F., Zhang Q.Y., Jiao L., Han T., Zhang H., Qin L.P., Khalid R. Synergistic hepatoprotective effect of Schisandra lignans with Astragalus polysaccharides on chronic liver injury in rats. Phytomedicine 2009, 16:805-813.
33. Yim H.K., Jung Y.S., Kim S.Y., Kim Y.C. Contrasting changes in phase I and phase II metabolism of acetaminophen in male mice pretreated with carbon tetrachloride. Basic Clin. Pharmacol. Toxicol. 2006, 98:225-230.
34. Zhu M., Lin K.F., Yeung R.Y., Li R.C. Evaluation of the protective effects of Schisandra chinensis on Phase I drug metabolism using a CCl4 intoxication model. J. Ethnopharmacol. 1999, 67:61-68.
35. Zhu M., Yeung R.Y., Lin K.F., Li R.C. Improvement of phase I drug metabolism with Schisandra chinensis against CCl4 hepatotoxicity in a rat model. Planta. Med. 2000, 66:521-525.