Statistics in experimental cerebrovascular research: Comparison of more than two groups with a continuous outcome variable

Journal of Cerebral Blood Flow and Metabolism

Volumn 30, Issue 9, 2010, Pages 1558-1563

  Schlattmann, Peter ^a   Dirnagl, Ulrich ^b  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

contrast; factorial design; multiple comparisons; one way ANOVA; Tukeys procedure; two way ANOVA

Indexed keywords

EOSIN; HEMATOXYLIN; NEUROPROTECTIVE AGENT; VARDENAFIL;

ANALYSIS OF VARIANCE; BLOOD VESSEL DIAMETER; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; COMPARATIVE STUDY; COMPUTER PROGRAM; HYPOTHESIS; IMMUNOHISTOCHEMISTRY; MEDICAL RESEARCH; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; OUTCOME VARIABLE; PRIORITY JOURNAL; REVIEW; STATISTICAL MODEL; STATISTICS; STROKE; BRAIN CIRCULATION; CEREBRAL ARTERY DISEASE; HUMAN; IMAGE PROCESSING; PATHOLOGY; PHYSIOLOGY; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; DATA INTERPRETATION, STATISTICAL; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INFARCTION, MIDDLE CEREBRAL ARTERY; SOFTWARE; TREATMENT OUTCOME;

EID: 77956266130     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2010.95     Document Type: Review

References (12)

1. Armitage P, Berry G, Matthews J (2002) Statistical Methods in Medical Research, 4th ed. Oxford: Blackwell Science
2. Bender R, Lange S (2001) Adjusting for multiple testing-when and how? J Clin Epi 54:343-9
3. Ford I (1983) Can statistics cause brain damage? J Cereb Blood Flow Metab 3:259-262
4. Godfrey K (1985) Comparing means of several groups. N Engl J Med 313:1450-1456
5. Jaccard J, Becker M.A., Wood G (1984) Pairwise multiple comparison procedures: a review. Psychol Bull 96: 589-596
6. Kilkenny C, Parsons N, Kadyszewski E, Festing MF, Cuthill IC, Fry D, Hutton J, Altman DG (2009) Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS One 4:e7824
7. Murphy JR (2004) Statistical errors in immunologic research. J Allergy Clin Immunol 114:1259-1263
8. Royl G, Balkaya M, Lehmann S, Lehnardt S, Stohlmann K, Lindauer U, Endres M, Dirnagl U, Meisel A (2009) Effects of the PDE5-inhibitor vardenafil in a mouse stroke model. Brain Res 1265:148-157
9. Schlattmann P, Dirnagl U (2010) Statistics in experimental cerebrovascular research-comparison of two groups with a continuous outcome variable. J Cereb Blood Flow Metab 30:474-479
10. Seaman M.A., Levin JR, Serlin RC (1991) New developments in pairwise multiple comparisons: some powerful and practicable procedures. Psychol Bull 110:577-586
11. Stoline MR (1981) The status of multiple comparisons: simultaneous estimation of all pairwise comparisons in one-way ANOVA designs. Am Stat 35:134-41; http://www.jstor.org/stable/2683979
12. Williams JL, Hathaway CA, Kloster KL, Layne BH (1997) Low power, type II errors, and other statistical problems in recent cardiovascular research. Am J Physiol 273:H487-93