Histopathologic features of the tumor budding in adenocarcinoma of the lung: Tumor budding as an index to predict the potential aggressiveness

Journal of Thoracic Oncology

Volumn 5, Issue 9, 2010, Pages 1361-1368

  Yamaguchi, Yoko ^a   Ishii, Genichiro ^a   Kojima, Motohiro ^a   Yoh, Kiyotaka ^a   Otsuka, Hajime ^a   Otaki, Yoichi ^a   Aokage, Keiju ^a   Yanagi, Shingo ^a   Nagai, Kanji ^a   Nishiwaki, Yutaka ^a   Ochiai, Atsushi ^a  

^a NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

Author keywords

Lung cancer; Papillary subtype; Prognostic factor; Small adenocarcinoma; Tumor budding

Indexed keywords

BETA CATENIN; CELL ADHESION MOLECULE; KALININ; LAMININ5 GAMMA2; SURFACTANT PROTEIN A; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER SIZE; CANCER STAGING; FEMALE; HISTOLOGY; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ADENOCARCINOMA; LUNG ALVEOLUS CELL CARCINOMA; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MORPHOLOGY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; SURVIVAL RATE;

EID: 77956261960     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181eaf2f3     Document Type: Article

References (34)

1. Molina JR, Yang P, Cassivi SD, et al. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc 2008;83:584-594.
2. Noguchi M, Morikawa A, Kawasaki M, et al. Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer 1995;75: 2844-2852.
3. Beadsmoore CJ, Screaton NJ. Classification, staging and prognosis of lung cancer. Eur J Radiol 2003;45:8-17.
4. Naruke T, Tsuchiya R, Kondo H, et al. Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 TNM-staging classification: the Japanese experience. Ann Thorac Surg 2001;71:1759-1764.
5. Morodomi T, Isomoto H, Shirouzu K, et al. An index for estimating the probability of lymph node metastasis in rectal cancers. Lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer 1989;63:539-543.
6. Hase K, Shatney C, Johnson D, et al. Prognostic value of tumor "budding" in patients with colorectal cancer. Dis Colon Rectum 1993; 36:627-635.
7. Hase K, Shatney CH, Mochizuki H, et al. Long-term results of curative resection of "minimally invasive" colorectal cancer. Dis Colon Rectum 1995;38:19-26.
8. Sobin LH, Wittekind C, (Eds.), TNM Classification of Malignant Tumors. New York, NY: Wiley; 2002.
9. Travis WD, Brambilla E, Muller-Hermelin HK, et al. (Eds.), Tumours of the Lung, Pleura, Thymus and Hearts. Lyon: IAR, 2004.
10. Ueno H, Murphy J, Jass JR, et al. Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopatholo- gy2002;40:127-132.
11. Tsuta K, Ishii G, Nitadori J, et al. Comparison of the immunophenotypes of signet-ring cell carcinoma, solid adenocarcinoma with mucin production, and mucinous bronchioloalveolar carcinoma of the lung characterized by the presence of cytoplasmic mucin. J Pathol 2006;209:78-87.
12. Ueno H, Mochizuki H, Shinto E, et al. Histologic indices in biopsy specimens for estimating the probability of extended local spread in patients with rectal carcinoma. Cancer 2002;94:2882-2891.
13. Nakamura T, Mitomi H, Kikuchi S, et al. Evaluation of the usefulness of tumor budding on the prediction of metastasis to the lung and liver after curative excision of colorectal cancer. Hepatogastroenterology 2005;52: 1432-1435.
14. Tanaka M, Hashiguchi Y, Ueno H, et al. Tumor budding at the invasive margin can predict patients at high risk of recurrence after curative surgery for stage II, T3 colon cancer. Dis Colon Rectum 2003;46:1054-1059.
15. Ueno H, Price AB, Wilkinson KH, et al. A new prognostic staging system for rectal cancer. Ann Surg 2004;240:832-839.
16. Maeshima AM, Maeshima A, Asamura H, et al. Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung. Lung Cancer 2006;52:53-58.
17. Koike M, Kodera Y, Itoh Y, et al. Multivariate analysis of the pathologic features of esophageal squamous cell cancer: tumor budding is a significant independent prognostic factor. Ann Surg Oncol 2008;15:1977-1982.
18. Prall F. Tumour budding in colorectal carcinoma. Histopathology 2007; 50:151-162.
19. Zlobec I, Lugli A, Baker K, et al. Role of APAF-1, E-cadherin and peritumoral lymphocytic infiltration in tumour budding in colorectal cancer. J Pathol 2007;212:260-268.
20. Hlubek F, Jung A, Kotzor N, et al. Expression of the invasion factor laminin gamma2 in colorectal carcinomas is regulated by beta-catenin. Cancer Res 2001;61:8089-8093.
21. Shinto E, Tsuda H, Ueno H, et al. Prognostic implication of laminin-5 gamma 2 chain expression in the invasive front of colorectal cancers, disclosed by area-specific four-point tissue microarrays. Lab Invest 2005;85:257-266.
22. El-Bahrawy MA, Poulsom R, Jeffery R, et al. The expression of E-cadherin and catenins in sporadic colorectal carcinoma. Hum Pathol 2001;32:1216-1224.
23. Moriya Y, Niki T, Yamada T, et al. Increased expression of laminin-5 and its prognostic significance in lung adenocarcinomas of small size. An immunohistochemical analysis of 102 cases. Cancer 2001;91:1129-1141.
24. Hida T, Yatabe Y, Achiwa H, et al. Increased expression of cyclooxy-genase 2 occurs frequently in human lung cancers, specifically in adenocarcinomas. Cancer Res 1998;58:3761-3764.
25. Niki T, Kohno T, Iba S, et al. Frequent co-localization of Cox-2 and laminin-5 gamma2 chain at the invasive front of early-stage lung adenocarcinomas. Am J Pathol 2002;160:1129-1141.
26. Bingle CD. Thyroid transcription factor-1. Int J Biochem Cell Biol 1997;29:1471-1473.
27. Yatabe Y, Mitsudomi T, Takahashi T. TTF-1 expression in pulmonary adenocarcinomas. Am J Surg Pathol 2002;26:767-773.
28. Brabletz T, Spaderna S, Kolb J, et al. Down-regulation of the homeodo-main factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res 2004;64:6973-6977.
29. Nieto MA. Epithelial-mesenchymal transitions in development and disease: old views and new perspectives. Int J Dev Biol 2009;53:1541-1547.
30. Voulgari A, Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009;1796:75-90.
31. Amin MB, Tamboli P, Merchant SH, et al. Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Pathol 2002;26:358-364.
32. Miyoshi T, Satoh Y, Okumura S, et al. Early-stage lung adenocarcino-mas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol 2003;27:101-109.
33. Kawakami T, Nabeshima K, Makimoto Y, et al. Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors. Mod Pathol 2007;20:514-521.
34. Nagano T, Ishii G, Nagai K, et al. Structural and biological properties of a papillary component generating a micropapillary component in lung adenocarcinoma. Lung Cancer 2010;67:282-289.