Podocyte membrane vesicles in urine originate from tip vesiculation of podocyte microvilli

Human Pathology

Volumn 41, Issue 9, 2010, Pages 1265-1275

  Hara, Masanori ^a   Yanagihara, Toshio ^a   Hirayama, Yoshiaki ^b   Ogasawara, Shinya ^b   Kurosawa, Hiroyuki ^b   Sekine, Sakari ^b   Kihara, Itaru ^a  

^a Yoshida Hospital   (Japan)

^b DENKA COMPANY LIMITED   (Japan)

Author keywords

Microvilli; Podocyte; Tip vesiculation

Indexed keywords

CD24 ANTIGEN; CD63 ANTIGEN; CREATININE; PODOCALYXIN;

ADOLESCENT; ADULT; ALLERGIC GLOMERULONEPHRITIS; ARTICLE; CELL MEMBRANE; CHILD; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOSKELETON; ELECTRON MICROSCOPY; EXOSOME; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; IMMUNOGLOBULIN A NEPHROPATHY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MEMBRANE VESICLE; MEMBRANOPROLIFERATIVE GLOMERULONEPHRITIS; MICROVILLUS; NEPHROTIC SYNDROME; PODOCYTE; PROTEINURIA; SUPERNATANT; URINE SEDIMENT;

ADOLESCENT; BIOLOGICAL MARKERS; CELL FRACTIONATION; CHILD; CHILD, PRESCHOOL; CYTOPLASMIC VESICLES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLOMERULONEPHRITIS; HUMANS; MALE; MICROSCOPY, FLUORESCENCE; MICROSCOPY, IMMUNOELECTRON; MICROVILLI; NEPHROTIC SYNDROME; PODOCYTES; PROTEINURIA; SIALOGLYCOPROTEINS; URINALYSIS; YOUNG ADULT;

EID: 77956255640     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.02.004     Document Type: Article

References (31)

1. Mundel P., and Kriz W. Structure and function of Pod: an update Anat Embryol 192 1995 385 397
2. Pabst R., and Sterzel R.B. Cell renewal of glomerular cell types in normal rats. An autoradiographic analysis Kidney Int 24 1983 626 631
3. Rasch R., and Norgaard J.O. Renal enlargement: comparative autoradiographic studies of 3H-thymidine uptake in diabetic and uninephrectomized rats Diabetologia 25 1983 280 287
4. Kerjaschki D. The pathogenesis of membranous glomerulonephritis: from morphology to molecules Virchows Arch (B) 58 1990 253 271
5. Rennke H.G., and Klein P.S. Pathogenesis and significance of nonprimary focal and segmental glomerulosclerosis Am J Kidney Dis 13 1989 443 456
6. Olson J.L., and Heptinstall R.H. Nonimmunologic mechanisms of glomerular injury Lab Invest 59 1988 564 576
7. Andrews P. Morphological alterations of the glomerular (visceral) epithelium in response to pathological and experimental situations J Electron Microsc Tech 9 1988 115 144
8. Louvet-Vallee S. ERM proteins: from cellular architecture to cell signaling Biol Cell 92 2000 305 316
9. Pisitkun T., Johnstone R., and Knepper M.A. Discovery of urinary biomarkers Mol Cell Proteomics 5 2006 1760 1771
10. Mori K., and Nakao K. Neutrophil gelatinase-associated lipocalin as the real-time indicator of active kidney damage Kidney Int 71 2007 967 970
11. Hara M., Yamamoto T., and Yanagihara T. Urinary excretion of podocalyxin indicates glomerular epithelial cell injuries in glomerulonephritis Nephron 69 1995 397 403
12. Hara M., Yanagihara T., and Takada T. Urinary excretion of podocytes reflects disease activity in children with glomerulonephritis Am J Nephrol 18 1998 35 41
13. Hara M., Yanagihara T., and Kihara I. Apical cell membranes are shed into urine from injured podocytes: a novel phenomenon of Pod injury J Am Soc Nephrol 16 2005 408 416
14. Pisitkun T., Shen R.F., and Knepper M.A. Identification and proteomic profiling of exosomes in human urine Proc Natl Acad Sci USA 101 2004 13368 13373
15. Kanno K., Kawachi H., and Uchida Y. Urinary sediment PCX in children with glomerular diseases Nephron Clin Pract 95 2003 c91 c99
16. Toyoda Y., Yoshie S., and Fujita T. Glucokinase is located in secretory granules of pancreatic D-cells FEBS Lett 415 1997 281 284
17. Wiggins R.C., Wiggins J.E., and Goyal M. Molecular cloning of cDNAs encoding human GLEPP1, a membrane protein tyrosine phosphatase: characterization of the GLEPP1 protein distribution in human kidney and assignment of the GLEPP1 gene to human chromosome 12p12-p13 Genomics 27 1995 174 181
18. Keller S., Sanderson M.P., and Stoeck A. Exosomes: from biogenesis and secretion to biological function Immunol Lett 107 2006 102 108
19. Keller S., Rupp C., and Stoeck A. CD24 is a marker of exosomes secreted into urine and amniotic fluid Kidney Int 72 2007 1095 1110
20. Pascual M., Steiger G., and Sadallah S. Identification of membrane-bound CR1 (CD35) in human urine: evidence for its release by glomerular podocytes J Exp Med 179 1994 889 899
21. Lehto T., Honkanen E., and Teppo A.M. Urinary excretion of protectin (CD59), complement SC5b-9 and cytokines in membranous glomerulonephritis Kidney Int 47 1995 1403 1411
22. Nielsen J.S., Graves M.L., and Chelliah S. The CD34-related molecule podocalyxin is a potent inducer of microvillus formation PLoS ONE e237 2007 2
23. Wiggins R., Glatfelter A., and Kshirsagar B. Lipid microvesicles and their association with procoagulant activity in urine and glomeruli of rabbits with nephrotoxic nephritis Lab Invest 56 1987 264 272
24. Taraboletti G., D'Ascenzo S., and Borsotti P. Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells Am J Pathol 160 2002 673 680
25. McConnell R.E., and Tyska M.J. Myosin-1a powers the sliding of apical membrane along microvillar actin bundles J Cell Biol 177 2007 671 681
26. Le Hir M., Keller C., and Eschmann V. Podocyte bridges between the tuft and Bowman's capsule: an early event in experimental crescentic glomerulonephritis J Am Soc Nephrol 12 2001 2060 2071
27. Beaudoin A.R., and Grondin G. Shedding of vesicular material from the cell surface of eukaryotic cells: different cellular phenomena Biochi Biophys Acta 1071 1991 203 219
28. Eliakim R., DeSchryver-Kecskemeti K., and Nogee L. Isolation and characterization of a small intestinal surfactant-like particle containing alkaline phosphatase and other digestive enzymes J Biol Chem 264 1989 20614 20619
29. Halbhuber K.J., Schulze M., and Rhode H. Is the brush border membrane of the intestinal mucosa a generator of "chymosomes"? Cell Mol Biol 40 1994 1077 1096
30. van Niel G., Raposo G., and Candalh C. Intestinal epithelial cells secrete exosome-like vesicles Gastroenterology 121 2001 337 349
31. Dougherty W.J. Microblebs of intestinal epithelial cell microvilli of Citellus tridecemlineatus Anat Rec 185 1976 77 83