The CXC chemokine-degrading protease SpyCep of Streptococcus pyogenes promotes its uptake into endothelial cells

Journal of Biological Chemistry

Volumn 285, Issue 36, 2010, Pages 27798-27805

  Kaur, Simran Jeet ^a   Nerlich, Andreas ^a   Bergmann, Simone ^a   Rohde, Manfred ^a   Fulde, Marcus ^a   Zähner, Dorothea ^a,d   Hanski, Emanuel ^b   Zinkernagel, Annelies ^c   Nizet, Victor ^c   Chhatwal, Gursharan S ^a   Talay, Susanne R ^a  

^a HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DEGRADATION; PHOSPHATASES; SELF ASSEMBLY;

CAVEOLAE; CELL ENVELOPES; CHEMOATTRACTANTS; CHEMOKINES; DEGRADING ACTIVITIES; ENZYMATIC ACTIVITIES; HUMAN ENDOTHELIAL CELLS; HUMAN EPITHELIAL CELLS; INTERLEUKIN-8; INVASION PATHWAYS; N-TERMINALS; NOVEL FUNCTIONS; POLYCLONAL; PROTEOLYTIC FUNCTIONS; RECOMBINANT EXPRESSION; SECRETED PROTEIN; SERINE PROTEASE; STREPTOCOCCUS PYOGENES; UPTAKE MECHANISM;

ENDOTHELIAL CELLS;

CYTOKINE; INTERLEUKIN 8; SERINE PROTEINASE; SERINE PROTEINASE SPYCEP; UNCLASSIFIED DRUG; ANTIBODY; PEPTIDE HYDROLASE; SPYCEP PROTEIN, STREPTOCOCCUS PYOGENES;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CAVEOLA; CELL INVASION; CONTROLLED STUDY; ENDOCYTOSIS; ENDOSOME; ENDOTHELIUM CELL; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PURIFICATION; STREPTOCOCCUS PYOGENES; WESTERN BLOTTING; ANIMAL; CELL LINE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

ORYCTOLAGUS CUNICULUS; STREPTOCOCCUS PYOGENES;

ANIMALS; ANTIBODIES; CELL LINE; CLONING, MOLECULAR; ENDOCYTOSIS; ENDOSOMES; ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-8; LYSOSOMES; PEPTIDE HYDROLASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STREPTOCOCCUS PYOGENES;

EID: 77956254921     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098053     Document Type: Article

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