Regulation of apoptosis through cysteine oxidation: Implications for fibrotic lung disease

Annals of the New York Academy of Sciences

Volumn 1203, Issue , 2010, Pages 23-28

  Janssen Heininger, Yvonne M W ^a   Aesif, Scott W ^a   Van Der Velden, Jos ^a   Guala, Amy S ^a   Reiss, Jessica N ^a   Roberson, Elle C ^a   Budd, Ralph C ^a   Reynaert, Niki L ^b   Anathy, Vikas ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

apoptosis; Fas; fibrosis; glutaredoxin; lung; S glutathionylation

Indexed keywords

FAS ANTIGEN;

APOPTOSIS; CONFERENCE PAPER; HUMAN; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN MODIFICATION;

EID: 77956251878     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2010.05553.x     Document Type: Conference Paper

References (40)

1. Kinnula, V.L. et al. 2005. Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy. Am. J. Respir. Crit. Care Med. 172 : 417 422.
2. Janssen-Heininger, Y.M. et al. 2008. Redox-based regulation of signal transduction: principles, pitfalls, and promises. Free Radic. Biol. Med. 45 : 1 17.
3. Cho, H.Y. et al. 2004. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J. 18 : 1258 1260.
4. Fattman, C.L. et al. 2006. Increased sensitivity to asbestos-induced lung injury in mice lacking extracellular superoxide dismutase. Free Radic. Biol. Med. 40 : 601 607.
5. Hagiwara, S.I., Y. Ishii S. Kitamura. 2000. Aerosolized administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am. J. Respir. Crit. Care Med. 162 : 225 231.
6. Hecker, L. et al. 2009. NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury. Nat. Med. 15 : 1077 1081.
7. Kuwano, K. et al. 2003. Oxidative stress in lung epithelial cells from patients with idiopathic interstitial pneumonias. Eur. Respir. J. 21 : 232 240.
8. Demedts, M. et al. 2005. High-dose acetylcysteine in idiopathic pulmonary fibrosis. N. Engl. J. Med. 353 : 2229 2242.
9. Sundaresan, M. et al. 1995. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 270 : 296 299.
10. Lambeth, J.D. 2004. NOX enzymes and the biology of reactive oxygen. Nat. Rev. Immunol. 4 : 181 189.
11. Shackelford, R.E. et al. 2005. Cellular and molecular targets of protein S-glutathiolation. Antioxid. Redox Signal. 7 : 940 950.
12. Pineda-Molina, E. et al. 2001. Glutathionylation of the p50 subunit of NF-kappaB: a mechanism for redox-induced inhibition of DNA binding. Biochemistry 40 : 14134 14142.
13. Ward, N.E. et al. 2000. Oxidant-induced S-glutathiolation inactivates protein kinase C-alpha (PKC-alpha): a potential mechanism of PKC isozyme regulation. Biochemistry 39 : 10319 10329.
14. Reynaert, N.L. et al. 2006. Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc. Natl. Acad. Sci. USA 103 : 13086 13091.
15. Adachi, T. et al. 2004. S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. Nat. Med. 10 : 1200 1207.
16. Adachi, T. et al. 2004. S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells. J. Biol. Chem. 279 : 29857 29862.
17. Shelton, M.D., P.B. Chock J.J. Mieyal. 2005. Glutaredoxin: role in reversible protein S-glutathionylation and regulation of redox signal transduction and protein translocation. Antioxid. Redox Signal. 7 : 348 366.
18. Fernandes, A.P. A. Holmgren. 2004. Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid. Redox Signal. 6 : 63 74.
19. Yang, Y. et al. 1998. Reactivity of the human thioltransferase (glutaredoxin) C7S, C25S, C78S, C82S mutant and NMR solution structure of its glutathionyl mixed disulfide intermediate reflect catalytic specificity. Biochemistry 37 : 17145 17156.
20. Starke, D.W., P.B. Chock J.J. Mieyal. 2003. Glutathione-thiyl radical scavenging and transferase properties of human glutaredoxin (thioltransferase). Potential role in redox signal transduction. J. Biol. Chem. 278 : 14607 14613.
21. Barrios, R. et al. 2001. Oxygen-induced pulmonary injury in gamma-glutamyl transpeptidase-deficient mice. Lung 179 : 319 330.
22. Ho, Y.S. et al. 2007. Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia. Free Radic. Biol. Med. 43 : 1299 1312.
23. Peltoniemi, M. et al. 2004. Expression of glutaredoxin is highly cell specific in human lung and is decreased by transforming growth factor-beta in vitro and in interstitial lung diseases in vivo. Hum. Pathol. 35 : 1000 1007.
24. Reynaert, N.L., E.F. Wouters Y.M. Janssen-Heininger. 2007. Modulation of glutaredoxin-1 expression in a mouse model of allergic airway disease. Am. J. Respir. Cell Mol Biol. 36 : 147 151.
25. Peter, M.E. et al. 2007. The CD95 receptor: apoptosis revisited. Cell 129 : 447 450.
26. Wajant, H. 2002. The Fas signaling pathway: more than a paradigm. Science 296 : 1635 1636.
27. Hamann, K.J. et al. 1998. Expression of Fas (CD95) and FasL (CD95L) in human airway epithelium. Am. J. Respir. Cell Mol Biol. 19 : 537 542.
28. Hagimoto, N. et al. 1997. Induction of apoptosis and pulmonary fibrosis in mice in response to ligation of Fas antigen. Am. J. Respir. Cell Mol Biol. 17 : 272 278.
29. Kuwano, K. et al. 1999. Essential roles of the Fas-Fas ligand pathway in the development of pulmonary fibrosis. J. Clin. Invest. 104 : 13 19.
30. Lee, C.G. et al. 2004. Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J. Exp. Med. 200 : 377 389.
31. Kuwano, K. et al. 2001. Attenuation of bleomycin-induced pneumopathy in mice by a caspase inhibitor. Am. J. Physiol. Lung Cell Mol. Physiol. 280 : L316 L325.
32. Hagimoto, N. et al. 2002. TGF-beta 1 as an enhancer of Fas-mediated apoptosis of lung epithelial cells. J. Immunol. 168 : 6470 6478. (Pubitemid 34620072)
33. Kuwano, K. et al. 1996. P21Waf1/Cip1/Sdi1 and p53 expression in association with DNA strand breaks in idiopathic pulmonary fibrosis. Am. J. Respir. Crit. Care Med. 154 : 477 483.
34. Hagimoto, N. et al. 1997. Apoptosis and expression of Fas/Fas ligand mRNA in bleomycin-induced pulmonary fibrosis in mice. Am. J. Respir. Cell Mol Biol. 16 : 91 101. (Pubitemid 127497440)
35. Golan-Gerstl, R. et al. 2007. Epithelial cell apoptosis by fas ligand-positive myofibroblasts in lung fibrosis. Am. J. Respir. Cell Mol Biol. 36 : 270 275.
36. Wallach-Dayan, S.B., R. Golan-Gerstl R. Breuer. 2007. Evasion of myofibroblasts from immune surveillance: a mechanism for tissue fibrosis. Proc. Natl. Acad. Sci. USA 104 : 20460 20465.
37. Benhar, M. et al. 2008. Regulated protein denitrosylation by cytosolic and mitochondrial thioredoxins. Science 320 : 1050 1054.
38. Mannick, J.B. et al. 1999. Fas-induced caspase denitrosylation. Science 284 : 651 654.
39. Anathy, V. et al. 2009. Redox amplification of apoptosis by caspase-dependent cleavage of glutaredoxin 1 and S-glutathionylation of Fas. J. Cell Biol. 184 : 241 252.
40. Forrester, M.T. J.S. Stamler. 2007. A classification scheme for redox-based modifications of proteins. Am. J. Respir. Cell Mol Biol. 36 : 135 137.