Association between anti-β2 glycoprotein i antibodies and renal glomerular C4d deposition in lupus nephritis patients with glomerular microthrombosis: A prospective study of 155 cases

Lupus

Volumn 19, Issue 10, 2010, Pages 1195-1203

  Shen, Y ^a   Chen, X W ^a   Sun, C Y ^a   Dai, M ^a   Yan, Y C ^a   Yang, C D ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

anti 2 glycoprotein I antibodies; C4d; glomerular microthrombosis; lupus nephritis

Indexed keywords

BETA2 GLYCOPROTEIN 1 ANTIBODY; COMPLEMENT COMPONENT C4D; IMMUNOGLOBULIN; IMMUNOGLOBULIN G; AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

ADULT; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLOMERULAR MICROTHROMBOSIS; GLOMERULUS BASEMENT MEMBRANE; HUMAN; KIDNEY BIOPSY; KIDNEY DISEASE; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MICROTHROMBUS; PRIORITY JOURNAL; PROSPECTIVE STUDY; STAINING; BIOPSY; GLOMERULUS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; THROMBOSIS;

ADULT; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; BIOPSY; COMPLEMENT C4B; FEMALE; HUMANS; IMMUNOGLOBULIN G; KIDNEY GLOMERULUS; LUPUS NEPHRITIS; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; PROSPECTIVE STUDIES; THROMBOSIS; YOUNG ADULT;

EID: 77956238195     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310368409     Document Type: Article

References (35)

1. Mok CC Prognostic factors in lupus nephritis. Lupus 2005 ; 14: 39-44.
2. Cameron JS Lupus nephritis. J Am Soc Nephrol 1999 ; 10: 413-424.
3. Jain R., Chartash E., Susin M., Furie R. Systemic lupus erythematosus complicated by thrombotic microangiopathy. Semin Arthritis Rheum 1994 ; 24: 173-182.
4. Hughson MD, Nadasdy T., McCarty GA, Sholer C., Min KW, Silva F. Renal thrombotic microangiopathy in patients with systemic lupus erythematosus and the antiphospholipid syndrome. Am J Kidney Dis 1992 ; 20: 150-158.
5. Loizou S., Samarkos M., Norsworthy PJ, Cazabon JK, Walport MJ, Davies KA Significance of anticardiolipin and anti-beta2-glycoprotein I antibodies in lupus nephritis. Rheumatology (Oxford) 2000 ; 39: 962-968.
6. Nochy D., Daugas E., Huong DL, Piette JC, Hill G. Kidney involvement in the antiphospholipid syndrome. J Autoimmun 2000 ; 15: 127-132.
7. Tektonidou MG, Sotsiou F., Nakopoulou L., Vlachoyiannopoulos PG, Moutsopoulos HM Antiphospholipid syndrome nephropathy in patients with systemic lupus erythematosus and antiphospholipid antibodies: prevalence, clinical associations, and long-term outcome. Arthritis Rheum 2004 ; 50: 2569-2579.
8. Bhandari S., Harnden P., Brownjohn AM, Turney JH Association of anticardiolipin antibodies with intraglomerular thrombi and renal dysfunction in lupus nephritis. QJM 1998 ; 91: 401-409.
9. Cohen D., Koopmans M., Kremer Hovinga IC, et al. Potential for glomerular C4d as an indicator of thrombotic microangiopathy in lupus nephritis. Arthritis Rheum 2008 ; 58: 2460-2469.
10. Gong R., Liu Z., Li L. Epistatic effect of plasminogen activator inhibitor 1 and beta-fibrinogen genes on risk of glomerular microthrombosis in lupus nephritis: interaction with environmental/ clinical factors. Arthritis Rheum 2007 ; 56: 1608-1617.
11. Miranda JM, Garcia-Torres R., Jara LJ, Medina F., Cervera H., Fraga A. Renal biopsy in systemic lupus erythematosus: significance of glomerular thrombosis. Analysis of 108 cases. Lupus 1994 ; 3: 25-29.
12. Zheng H., Chen Y., Ao W., et al. Antiphospholipid antibody profiles in lupus nephritis with glomerular microthrombosis: a prospective study of 124 cases. Arthritis Res Ther 2009 ; 11: R93.
13. Pierangeli SS, Girardi G., Vega-Ostertag M., Liu X., Espinola RG, Salmon J. Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005 ; 52: 2120-2124.
14. Pierangeli SS, Chen PP, Gonzalez EB Antiphospholipid antibodies and the antiphospholipid syndrome: an update on treatment and pathogenic mechanisms. Curr Opin Hematol 2006 ; 13: 366-375.
15. Navratil JS, Manzi S., Kao AH, et al. Platelet C4d is highly specific for systemic lupus erythematosus. Arthritis Rheum 2006 ; 54: 670-674.
16. Peerschke EI, Yin W., Alpert DR, Roubey RA, Salmon JE, Ghebrehiwet B. Serum complement activation on heterologous platelets is associated with arterial thrombosis in patients with systemic lupus erythematosus and antiphospholipid antibodies. Lupus 2009 ; 18: 530-538.
17. Feucht HE, Opelz G. The humoral immune response towards HLA class II determinants in renal transplantation. Kidney Int 1996 ; 50: 1464-1475.
18. Racusen LC, Colvin RB, Solez K., et al. Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejection. Am J Transplant 2003 ; 3: 708-714.
19. Hochberg MC Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997 ; 40: 1725.
20. Salmon JE, Girardi G. Antiphospholipid antibodies and pregnancy loss: a disorder of inflammation. J Reprod Immunol 2008 ; 77: 51-56.
21. Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol 2004 ; 15: 241-250.
22. Austin HA, Muenz LR, Joyce KM, Antonovych TT, Balow JE Diffuse proliferative lupus nephritis: identification of specific pathologic features affecting renal outcome. Kidney Int 1984 ; 25: 689-695.
23. Wakai S., Matsumura O., Koike T., Maruyama N., Yumura W. Anti-cardiolipin antibody and renal microthrombi in lupus nephritis. Ryumachi 1991 ; 31: 481-487.
24. Kant KS, Pollak VE, Weiss MA, Glueck HI, Miller AN, Hess EV Glomerular thrombosis in systemic lupus erythematosus: prevalence and significance. Medicine (Baltimore) 1981 ; 60: 71-86.
25. Levine JS, Branch DW, Rauch J. The antiphospholipid syndrome. N Engl J Med 2002 ; 346: 752-763.
26. Giannakopoulos B., Passam F., Rahgozar S., Krilis SA Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 2007 ; 109: 422-430.
27. Truedsson L., Bengtsson AA, Sturfelt G. Complement deficiencies and systemic lupus erythematosus. Autoimmunity 2007 ; 40: 560-566.
28. Yang DH, Chang DM, Lai JH, Lin FH, Chen CH Usefulness of erythrocyte-bound C4d as a biomarker to predict disease activity in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2009 ; 48: 1083-1087.
29. Pierangeli SS, Colden-Stanfield M., Liu X., Barker JH, Anderson GL, Harris EN Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999 ; 99: 1997-2002.
30. Nangaku M., Quigg RJ, Shankland SJ, Okada N., Johnson RJ, Couser WG Overexpression of Crry protects mesangial cells from complement-mediated injury. J Am Soc Nephrol 1997 ; 8: 223-233.
31. Fischetti F., Durigutto P., Pellis V., et al. Thrombus formation induced by antibodies to beta2-glycoprotein I is complement dependent and requires a priming factor. Blood 2005 ; 106: 2340-2346.
32. Seshan SV, Franzke CW, Redecha P., Monestier M., Mackman N., Girardi G. Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid antibodies. Blood 2009 ; 114: 1675-1683.
33. Suzuki T., Horita S., Kadoya K., et al. C4d Immunohistochemistry in glomerulonephritis with different antibodies. Clin Exp Nephrol 2007 ; 11: 287-291.
34. Zwirner J., Felber E., Herzog V., Riethmuller G., Feucht HE Classical pathway of complement activation in normal and diseased human glomeruli. Kidney Int 1989 ; 36: 1069-1077.
35. Kusunoki Y., Itami N., Tochimaru H., Takekoshi Y., Nagasawa S., Yoshiki T. Glomerular deposition of C4 cleavage fragment (C4d) and C4-binding protein in idiopathic membranous glomerulonephritis. Nephron 1989 ; 51: 17-19.