Staphylococcus aureus promoter-lux reporters for drug discovery

Journal of Antibiotics

Volumn 63, Issue 8, 2010, Pages 492-498

  Mesak, Lili R ^a   Qi, Shuhua ^b   Villanueva, Ivan ^a   Miao, Vivian ^a   Davies, Julian ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b SOUTH CHINA SEA INSTITUTE OF OCEANOLOGY   (China)

Author keywords

actinomycete; antibiotic profiling fingerprint; luciferase; promoter lux reporter; Staphylococcus aureus

Indexed keywords

AMINOCOUMARIN DERIVATIVE; ANTIINFECTIVE AGENT; BACITRACIN; CLINDAMYCIN; DAPTOMYCIN; ERYTHROMYCIN; FOSFOMYCIN; GENTAMICIN; IMIPENEM; KANAMYCIN; METICILLIN; MITOMYCIN C; NEOMYCIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; NOVOBIOCIN; OXOPROPALINE D; OXOPROPALINE G; OXYTETRACYCLINE; PENICILLIN G; PHLEOMYCIN; POLYMYXIN B; PRISTINAMYCIN; RIBOSOME RNA; RUFOCROMOMYCIN; SPECTINOMYCIN; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ACTINOBACTERIA; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM CULTURE; BACTERIUM ISOLATE; BACTERIUM ISOLATION; BROTH DILUTION; CULTURE MEDIUM; DNA DAMAGE; DRUG IDENTIFICATION; DRUG RESEARCH; GENE SEQUENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SOIL; SOIL ANALYSIS; STAPHYLOCOCCUS AUREUS; STREPTOMYCES; SUPERNATANT; WHOLE CELL;

ACTINOBACTERIA; ANTI-BACTERIAL AGENTS; DRUG DISCOVERY; GENES, REPORTER; HUMANS; LUCIFERASES; PROMOTER REGIONS, GENETIC; STAPHYLOCOCCUS AUREUS; STREPTOMYCES;

ACTINOBACTERIA (CLASS); KITASATOSPORA; STAPHYLOCOCCUS AUREUS; STREPTOMYCES;

EID: 77956237841     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2010.74     Document Type: Article

References (49)

1. Gordon, R. J. & Lowy, F. D. Pathogenesis of methicillin-resistant Staphylococcus aureus infection. Clin. Infect. Dis. (46 Suppl 5), S350-359 (2008).
2. Levy, S. B. & Marshall, B. Antibacterial resistance worldwide: causes, challenges and responses. Nat. Med. 10, S122-129 (2004).
3. Sievert, D. M. et al. Vancomycin-resistant Staphylococcus aureus in the United States, 2002-2006. Clin. Infect. Dis. 46, 668-674 (2008).
4. DeLeo, F. R. & Chambers, H. F. Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J. Clin. Invest. 119, 2464-2474 (2009).
5. Fischbach, M. A. & Walsh, C. T. Antibiotics for emerging pathogens. Science. 325, 1089-1093 (2009).
6. Projan, S. J. & Youngman, P. J. Antimicrobials: new solutions badly needed. Curr. Opin. Microbiol. 5, 463-465 (2002).
7. Baltz, R. H. Marcel Faber Roundtable: is our antibiotic pipeline unproductive because of starvation, constipation or lack of inspiration? J. Ind. Microbiol. Biotechnol. 33, 507-513 (2006).
8. Loessner, M. J., Rudolf, M. & Scherer, S. Evaluation of luciferase reporter bacterio-phage A511:luxAB for detection of Listeria monocytogenes in contaminated foods. Appl. Environ. Microbiol. 63, 2961-2965 (1997).
9. Kadurugamuwa, J. L. et al. Direct continuous method for monitoring biofilm infection in a mouse model. Infect. Immun. 71, 882-890 (2003).
10. Kadurugamuwa, J. L. et al. Rapid direct method for monitoring antibiotics in a mouse model of bacterial biofilm infection. Antimicrob. Agents Chemother. 47, 3130-3137 (2003).
11. Ptitsyn, L. R. et al. A biosensor for environmental genotoxin screening based on an SOS lux assay in recombinant Escherichia coli cells. Appl. Environ. Microbiol. 63, 4377-4384 (1997).
12. Sanseverino, J. et al. Use of Saccharomyces cerevisiae BLYES expressing bacterial bioluminescence for rapid, sensitive detection of estrogenic compounds. Appl. Environ. Microbiol. 71, 4455-4460 (2005).
13. Mesak, L. R., Yim, G. & Davies, J. Improved lux reporters for use in Staphylococcus aureus. Plasmid 61, 182-187 (2009).
14. Goh, E. B. et al. Transcriptional modulation of bacterial gene expression by subinhi-bitory concentrations of antibiotics. Proc. Natl Acad. Sci. USA 99, 17025-17030 (2002).
15. Bjarnason, J., Southward, C. M. & Surette, M. G. Genomic profiling of iron-responsive genes in Salmonella enterica serovar typhimurium by high-throughput screening of a random promoter library. J. Bacteriol. 185, 4973-4982 (2003).
16. Van Dyk, T. K., DeRose, E. J. & Gonye, G. E. LuxArray, a high-density, genomewide transcription analysis of Escherichia coli using bioluminescent reporter strains. J. Bacteriol. 183, 5496-5505 (2001).
17. Yim, G., de la Cruz, F., Spiegelman, G. B. & Davies, J. Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin. J. Bacteriol. 188, 7988-7991 (2006).
18. Mesak, L. R., Miao, V. & Davies, J. Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus. Antimicrob. Agents Chemother. 52, 3394-3397 (2008).
19. Tsui, W. H. et al. Dual effects of MLS antibiotics: transcriptional modulation and interactions on the ribosome. Chem. Biol. 11, 1307-1316 (2004).
20. Hutter, B. et al. Prediction of mechanisms of action of antibacterial compounds by gene expression profiling. Antimicrob. Agents Chemother. 48, 2838-2844 (2004).
21. Schenk, S. & Laddaga, R. A. Improved method for electroporation of Staphylococcus aureus. FEMS Microbiol Lett. 73, 133-138 (1992).
22. Fujimoto-Nakamura, M., Ito, H., Oyamada, Y., Nishino, T. & Yamagishi, J. Accumulation of mutations in both gyrB and parE genes is associated with high-level resistance to novobiocin in Staphylococcus aureus. Antimicrob. Agents Chemother. 49, 3810-3815 (2005).
23. Mesak, L. R. & Davies, J. Phenotypic changes in ciprofloxacin- resistant Staphylococcus aureus. Res. Microbiol. 160, 785-791 (2009).
24. Wang, Z. X., Li, S. M. & Heide, L. Identification of the coumermycin A(1) biosynthetic gene cluster of Streptomyces rishiriensis DSM 40489. Antimicrob. Agents Chemother. 44, 3040-3048 (2000).
25. Li, B., Furihata, K., Kudo, T. & Yokota, A. Kitasatospora saccharophila sp. nov. and Kitasatospora kazusanensis sp. nov., isolated from soil and transfer of Streptomyces atroaurantiacus to the genus Kitasatospora as Kitasatospora atroaurantiaca comb. nov. J. Gen. Appl. Microbiol. 55, 19-26 (2009).
26. Cheenpracha, S. et al. Coumabiocins A-F, Aminocoumarins from an organic extract of Streptomyces sp. L-4-4. J. Nat. Prod. 73, 880-884 (2010).
27. Anderson, K. L. et al. Characterization of the Staphylococcus aureus heat shock, cold shock, stringent, and SOS responses and their effects on log-phase mRNA turnover. J. Bacteriol. 188, 6739-6756 (2006).
28. Cirz, R. T. et al. Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin. J. Bacteriol. 189, 531-539 (2007).
29. Rao, K. V. & Cullen, W. P. Streptonigrin, an antitumor substance. I. Isolation and characterization. Antibiot. Annu. 7, 950-953 (1959).
30. Jin, Y. Y. et al. Kitasatospora sp. MJM383 strain producing two antitumor agents, streptonigrin and oxopropaline G. J. Microbiol. Biotechnol. 15, 1140-1145 (2005).
31. Wang, H. et al. Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis. J. Nat. Prod. 65, 721-724 (2002).
32. Abe, N. et al. Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. II. Physico-chemical properties and structure elucidations. J. Antibiot. (Tokyo) 46, 1678-1686 (1993).
33. Abe, N. et al. Novel cytocidal compounds, oxopropalines from Streptomyces sp. G324 producing lavendamycin. I. Taxonomy of the producing organism, fermentation, isolation and biological activities. J. Antibiot. (Tokyo) 46, 1672-1677 (1993).
34. Vicente, M. et al. The fallacies of hope: will we discover new antibiotics to combat pathogenic bacteria in time? FEMS Microbiol. Rev. 30, 841-852 (2006).
35. Hutter, B., Fischer, C., Jacobi, A., Schaab, C. & Loferer, H. Panel of Bacillus subtilis reporter strains indicative of various modes of action. Antimicrob. Agents Chemother. 48, 2588-2594 (2004).
36. Urban, A. et al. Novel whole-cell antibiotic biosensors for compound discovery. Appl. Environ. Microbiol. 73, 6436-6443 (2007).
37. Shapiro, E. & Baneyx, F. Stress-activated bioluminescent Escherichia coli sensors for antimicrobial agents detection. J. Biotechnol. 132, 487-493 (2007).
38. Fischer, H. P. et al. Identification of antibiotic stress-inducible promoters: a systematic approach to novel pathway-specific reporter assays for antibacterial drug discovery. Genome Res. 14, 90-98 (2004).
39. Oyamada, Y. et al. A nucleate cell blue assay: a useful tool for identifying novel type II topoisomerase inhibitors. Antimicrob. Agents Chemother. 50, 348-350 (2006).
40. Bianchi, A. A. & Baneyx, F. Stress responses as a tool to detect and characterize the mode of action of antibacterial agents. Appl. Environ. Microbiol. 65, 5023-5027 (1999).
41. Shapiro, E. & Baneyx, F. Stress-based identification and classification of antibacterial agents: second-generation Escherichia coli reporter strains and optimization of detection. Antimicrob. Agents Chemother. 46, 2490-2497 (2002).
42. Kraemer, G. R. & Iandolo, J. J. High-frequency transformation of Staphylococcus aureus by electroporation. Curr. Microbiol. 21, 373-376 (1990).
43. Francis, K. P. et al. Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct. Infect. Immun. 68, 3594-3600 (2000).
44. Chang, W., Small, D. A., Toghrol, F. & Bentley, W. E. Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide. J. Bacteriol. 188, 1648-1659 (2006).
45. Utaida, S. et al. Genome-wide transcriptional profiling of the response of Staphylo-coccus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon. Microbiology 149, 2719-2732 (2003).
46. Pietiainen, M. et al. Transcriptome analysis of the responses of Staphylococcus aureus to antimicrobial peptides and characterization of the roles of vraDE and vraSR in antimicrobial resistance. BMC. Genomics 10, 429 (2009).
47. Wang, D. et al. Global transcriptional profiles of Staphylococcus aureus treated with berberine chloride. FEMS Microbiol. Lett. 279, 217-225 (2008).
48. Bolzan, A. D. & Bianchi, M. S. Genotoxicity of streptonigrin: a review. Mutat. Res. 488, 25-37 (2001).
49. Kreiswirth, B. N. et al. The toxic shock syndrome exotoxin structural gene is not detectably transmitted by a prophage. Nature. 305, 709-712 (1983).