A murine model for sarin exposure using the carboxylesterase inhibitor CBDP

NeuroToxicology

Volumn 31, Issue 5, 2010, Pages 502-508

  Garrett, Teresa L ^a   Rapp, Christine M ^a   Grubbs, Robert D ^a   Schlager, John J ^b   Lucot, James B ^a  

^a WRIGHT STATE UNIVERSITY   (United States)

^b AIR FORCE RESEARCH LABORATORY   (United States)

Author keywords

Acetylcholinesterase inhibition; Carboxlyesterase inhibitor; CBDP; Dose response curve; Glial fibrillary acidic protein; Organophosphate; Sarin

Indexed keywords

2 (O CRESYL) 4H 1:3:2 BENZODIOXAPHOSPHORIN 2 OXIDE; ACETYLCHOLINESTERASE; CARBOXYLESTERASE; CARBOXYLESTERASE INHIBITOR; CHOLINESTERASE; ENZYME INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; SARIN; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DAMAGE; BRAIN REGION; CONTROLLED STUDY; DENTATE GYRUS; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME INHIBITION; HIPPOCAMPUS; INTOXICATION; MALE; MORTALITY; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; SEIZURE;

ACETYLCHOLINESTERASE; ANIMALS; CARBOXYLESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; GLIAL FIBRILLARY ACIDIC PROTEIN; HIPPOCAMPUS; MALE; MICE; MICE, INBRED C57BL; NEUROGLIA; NEUROTOXICITY SYNDROMES; ORGANOPHOSPHORUS COMPOUNDS; SARIN; SEIZURES; TIME FACTORS;

ANIMALIA; MURINAE; MUS; RODENTIA;

EID: 77956227378     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2010.05.007     Document Type: Article

References (42)

1. Abdel-Rahman A., Shetty A.K., Abou-Donia M.B. Disruption of the blood-brain barrier and neuronal cell death in cingulate cortex, dentate gyrus, thalamus, and hypothalamus in a rat model of Gulf-War syndrome. Neurobiol Dis 2002, 10:306-326.
2. Boskovic B. The influence of 2-/o-cresyl/-4 H-1: 3: 2-benzodioxa-phosphorin-2-oxide (CBDP) on organophosphate poisoning and its therapy. Arch Toxicol 1979, 42:207-216.
3. Casida J.E., Quistad G.B. Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targets. Chem Res Toxicol 2004, 17:983-998.
4. Clement J.G. Variability of sarin-induced hypothermia in mice: investigation into incidence and mechanism. Biochem Pharmacol 1991, 42:1316-1318.
5. Collombet J.M., Four E., Bernabe D., Masqueliez C., Burckhart M.F., Baille V., et al. Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain. Toxicology 2005, 208:319-334.
6. Collombet J.M., Four E., Burckhart M.F., Masqueliez C., Bernabe D., Baubichon D., et al. Effect of cytokine treatment on the neurogenesis process in the brain of soman-poisoned mice. Toxicology 2005, 210:9-23.
7. Collombet J.M., Masqueliez C., Four E., Burckhart M.F., Bernabe D., Baubichon D., et al. Early reduction of NeuN antigenicity induced by soman poisoning in mice can be used to predict delayed neuronal degeneration in the hippocampus. Neurosci Lett 2006, 398:337-342.
8. Collombet J.M., Four E., Fauquette W., Burckhart M.F., Masqueliez C., Bernabe D., et al. Soman poisoning induces delayed astrogliotic scar and angiogenesis in damaged mouse brain areas. Neurotoxicology 2007, 28:38-48.
9. Dusart I., Marty S., Peschanski M. Glial changes following an excitotoxic lesion in the CNS-II. Astrocytes. Neuroscience 1991, 45:541-549.
10. Duysen E.G., Li B., Xie W., Schopfer L.M., Anderson R.S., Broomfield C.A., et al. Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality. J Pharmacol Exp Ther 2001, 299:528-535.
11. Ellman G.L., Courtney K.D., Andres V., Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961, 7:88-95.
12. Filliat P., Baubichon D., Burckhart M.F., Pernot-Marino I., Foquin A., Masqueliez C., et al. Memory impairment after soman intoxication in rat: correlation with central neuropathology. Improvement with anticholinergic and antiglutamatergic therapeutics. Neurotoxicology 1999, 20:535-549.
13. Filliat P., Coubard S., Pierard C., Liscia P., Beracochea D., Four E., et al. Long-term behavioral consequences of soman poisoning in mice. Neurotoxicology 2007, 28:508-519.
14. Fonnum F., Sterri S.H., Aas P., Johnsen H. Carboxylesterases, importance for detoxification of organophosphorus anticholinesterases and trichothecenes. Fundam Appl Toxicol 1985, 5:S29-S38.
15. Grob D. The manifestations and treatment of poisoning due to nerve gas and other organic phosphate anticholinesterase compounds, AMA. Arch Intern Med 1956, 98:221-239.
16. Grob D., Harvey J.C. Effects in man of the anticholinesterase compound sarin (isopropyl methyl phosphonofluoridate). J Clin Invest 1958, 37:350-368.
17. Heaton K.J., Palumbo C.L., Proctor S.P., Killiany R.J., Yurgelun-Todd D.A., White R.F. Quantitative magnetic resonance brain imaging in US army veterans of the 1991 Gulf War potentially exposed to sarin and cyclosarin. Neurotoxicology 2007, 28:761-769.
18. Hoffman A., Eisenkraft A., Finkelstein A., Schein O., Rotman E., Dushnitsky T. A decade after the Tokyo sarin attack: a review of neurological follow-up of the victims. Mil Med 2007, 172:607-610.
19. Huang Y.J., Huang Y., Baldassarre H., Wang B., Lazaris A., Leduc M., et al. Recombinant human butyrylcholinesterase from milk of transgenic animals to protect against organophosphate poisoning. Proc Natl Acad Sci USA 2007, 104:13603-13608.
20. Jimmerson V.R., Shih T.M., Maxwell D.M., Kaminskis A., Mailman R.B. The effect of 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide on tissue cholinesterase and carboxylesterase activities of the rat. Fundam Appl Toxicol 1989, 13:568-575.
21. Jimmerson V.R., Shih T.M., Maxwell D.M., Mailman R.B. Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat. Toxicol Lett 1989, 48:93-103.
22. Kadar T., Shapira S., Cohen G., Sahar R., Alkalay D., Raveh L. Sarin-induced neuropathology in rats. Hum Exp Toxicol 1995, 14:252-259.
23. Lemercier G., Carpentier P., Sentenac-Roumanou H., Morelis P. Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathol 1983, 61:123-129.
24. Mach M., Grubbs R.D., Price W.A., Nagaoka M., Dubovicky M., Lucot J.B. Delayed behavioral and endocrine effects of sarin and stress exposure in mice. J Appl Toxicol 2008, 28:132-139.
25. Marty S., Dusart I., Peschanski M. Glial changes following an excitotoxic lesion in the CNS-I. Microglia/macrophages. Neuroscience 1991, 45:529-539.
26. Maxwell D.M., Brecht K.M., O'Neill B.L. The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. Toxicol Lett 1987, 39:35-42.
27. Maxwell D.M., Brecht K.M., Koplovitz I., Sweeney R.E. Acetylcholinesterase inhibition: does it explain the toxicity of organophosphorus compounds?. Arch Toxicol 2006, 80:756-760.
28. McDonough J.H., Dochterman L.W., Smith C.D., Shih T.M. Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. Neurotoxicology 1995, 16:123-132.
29. Moore D.H., Clifford I.T., Bagett J.M. Review of nerve agent inhibitors and reactivators of acetylcholinesterase. Enzymes of the cholinesterase family 1995, 297-304. Plenum Press, New York. D.M. Quinn, A.S. Balaubramanian, B.P. Doctor, P. Taylor (Eds.).
30. Moser V.C. Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol Teratol 1995, 17:617-625.
31. Murata K., Araki S., Yokoyama K., Okumura T., Ishimatsu S., Takasu N., et al. Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack. J Neurol 1997, 244:601-606.
32. Nishiwaki Y., Maekawa K., Ogawa Y., Asukai N., Minami M., Omae K. Effects of sarin on the nervous system in rescue team staff members and police officers 3 years after the Tokyo subway sarin attack. Environ Health Perspect 2001, 109:1169-1173.
33. Okumura T., Takasu N., Ishimatsu S., Miyanoki S., Mitsuhashi A., Kumada K., et al. Report on 640 victims of the Tokyo subway sarin attack. Ann Emerg Med 1996, 28:129-135.
34. Olson K.B. Aum Shinrikyo: once and future threat?. Emerg Infect Dis 1999, 5:513-516.
35. Pope C.N., Karanth S., Liu J., Yan B. Comparative carboxylesterase activities in infant and adult liver and their in vitro sensitivity to chlorpyrifos oxon. Regul Toxicol Pharmacol 2005, 42:64-69.
36. Raveh L., Grunwald J., Marcus D., Papier Y., Cohen E., Ashani Y. Human butyrylcholinesterase as a general prophylactic antidote for nerve agent toxicity. In vitro and in vivo quantitative characterization. Biochem Pharmacol 1993, 45:2465-2474.
37. Sevelova L., Bajgar J., Saxena A., Doctor B.P. Protective effect of equine butyrylcholinesterase in inhalation intoxication of rats with sarin: determination of blood and brain cholinesterase activities. Inhal Toxicol 2004, 16:531-536.
38. Shih T.M., Romano J.A. The effects of choline on soman-induced analgesia and toxicity. Neurotoxicol Teratol 1988, 10:287-294.
39. Sidell F.R. Soman and sarin: clinical manifestations and treatment of accidental poisoning by organophosphates. Clin Toxicol 1974, 7:1-17.
40. Stojiljkovic M.P., Jokanovic M. Pyridinium oximes: rationale for their selection as causal antidotes against organophosphate poisonings and current solutions for auto-injectors. Arh Hig Rada Toksikol 2006, 57:435-443.
41. U.S. Army Medical Research Institute of Chemical Defense Medical management of chemical casulaties handbook 2000, Chemical Casualty Care Division, Aberdeen Proving Ground, MD. 3rd ed.
42. Zimmer L.A., Ennis M., Shipley M.T. Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions. J Comp Neurol 1997, 378:482-492.